SLC7A6OS Gene
protein-coding GIFtS: 39
GCID: GC16M068320
|
|
solute carrier family 7, member 6 opposite strand
| |
Aliases
for SLC7A6OS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 7, Member 6 Opposite Strand1 2 | | Solute Carrier Family 7 Member 6 Opposite Strand Transcript2 3 | | ADAMS Proteinase-Related Protein2 3 | | FLJ132911 | | Probable RNA Polymerase II Nuclear Localization Protein SLC7A6OS2 | | Protein SLC7A6OS2 |
Export aliases for SLC7A6OS gene to outside databasesPrevious GC identifers: GC16M066890 GC16M068332 GC16M054207 |
Summaries
for SLC7A6OS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: S7A6O_HUMAN, Q96CW6Function: Directs RNA polymerase II nuclear import (By similarity)
|
Genomic Views
for SLC7A6OS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC7A6OS gene promoter:
GR ER-alpha Pax-5 NCX/Ncx NF-E2 p45 GATA-2 GATA-1 COMP1 GR-alpha NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC7A6OS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC7A6OS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1SLC7A6OS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M068320: view genomic region
(about GC identifiers)
Start:
|
68,318,406 bp from pter |
End:
|
68,344,868 bp from pter |
Size:
|
26,463 bases |
Orientation:
|
minus strand |
|
Proteins
for SLC7A6OS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S7A6O_HUMAN, Q96CW6 (See
protein sequence)Recommended Name: Probable RNA polymerase II nuclear localization protein SLC7A6OS Size: 309 amino acids; 35028 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Miscellaneous: When transfected to S.cerevisiae cells, able to partially restore polymerase II mislocalization andcellular shape in IWR1 mutant cells (PubMed:21504834)
Sequence caution: Sequence=AAL79958.1; Type=Frameshift; Positions=234;
Secondary accessions: Q8TCZ3 Q9H8R8Explore the universe of human proteins at neXtProt for SLC7A6OS: NX_Q96CW6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96CW6
SLC7A6OS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115554.2
ENSEMBL proteins: ENSP00000462436 ENSP00000263997 ENSP00000461470 ENSP00000460713
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SLC7A6OS for ontologies About GeneDecksing
SLC7A6OS Antibody Products:
Assay Products for SLC7A6OS: |
Protein
Domains /
Families
for SLC7A6OS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96CW6 UniProtKB/Swiss-Prot: S7A6O_HUMAN, Q96CW6Similarity: Belongs to the IWR1/SLC7A6OS family |
Function
for SLC7A6OS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S7A6O_HUMAN, Q96CW6Function: Directs RNA polymerase II nuclear import (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC7A6OS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC7A6OS (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC7A6OS (NM_032178) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC7A6OS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC7A6OS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A6OS |
1 GenomeRNAi human phenotype for SLC7A6OS:
|
Pathways & Interactions
for SLC7A6OS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC7A6OS
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SLC7A6OS (ENSP000002639974) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- |
SLC7A6OS for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC7A6OS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC7A6OS
Search CenterWatch for drugs/clinical trials and news about SLC7A6OS / S7A6O
|
Transcripts
for SLC7A6OS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC7A6OS gene: NM_032178.2 Unigene Cluster for SLC7A6OS: Solute carrier family 7, member 6 opposite strand Hs.729520 [show with all ESTs]Unigene Representative Sequence: NM_0321785 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000568315 ENST00000263997 ENST00000561933(uc002evw.2) ENST00000561590
ENST00000568538
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC7A6OS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC7A6OS (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC7A6OS (NM_032178) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC7A6OS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC7A6OS |
Additional cDNA sequence: AK023353.1 AK225712.1 AY078070.1 BC013778.1 7 DOTS entries: DT.40300902 DT.100781067 DT.217208 DT.95267260 DT.120723964 DT.433737 DT.95171482 24/142 AceView cDNA sequences (see all 142): CB321817 AI088342 AI470038 AI141420 BE744736 BM551808 AA677673 BF025896 AI078607 AI422495 AA047552 BM553652 BE550669 BE891086 AA046958 BU177982 AA592950 AI631206 AI095894 AA370408 BU553688 BE674406 F00475 F00466
GeneLoc Exon Structure
|
Expression
for SLC7A6OS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC7A6OS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTTAGTAA
About this image
See SLC7A6OS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC7A6OS
SOURCE GeneReport for Unigene cluster: Hs.729520
SABiosciences Custom PCR Arrays for SLC7A6OS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC7A6OS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC7A6OS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC7A6OS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC7A6OS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A6OS |
Orthologs
for SLC7A6OS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SLC7A6OS gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Slc7a6os1 , 5 |
solute carrier family 7, member 6 opposite strand1, 5 |
79.93(n)1
76.97(a)1 |
|
8 (53.11 cM)5
664321 NM_001007567.21 NP_001007568.11
1062004385 |
chicken
(Gallus gallus) |
Aves |
SLC7A6OS1 |
solute carrier family 7, member 6 opposite strand |
63.46(n)
55.67(a) |
|
415621 XM_413987.3 XP_413987.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SLC7A6OS6 |
-- |
46(a) |
1 ↔ 1 |
LGc(6791692-6797841) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.128942 |
Transcribed sequence with weak similarity to protein more |
72.41(n) |
|
57049886 |
worm
(Caenorhabditis elegans) |
Secernentea |
W01G7.46 |
Protein W01G7.4 |
26(a) |
1 ↔ 1 |
II(14060664-14062548) |
ENSEMBL Gene Tree for SLC7A6OS (if available)
TreeFam Gene Tree for SLC7A6OS (if available) |
Paralogs
for SLC7A6OS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SLC7A6OS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC7A6OS (68318406 - 68344868 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC7A6OS: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC7A6OS |
|
Disorders
/ Diseases
for SLC7A6OS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SLC7A6OS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC7A6OS gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with SLC7A6OS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Iwr1 directs RNA polymerase II nuclear import. (PubMed id 21504834)2 Czeko E.... Cramer P. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Molecular characterization and functional analysis of a protease-related protein in Chang-liver cells. (PubMed id 20510023)1 Wang C....Lin J. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Construction of Chang liver cDNA library and immunoscreening of ADAMS related genes. (PubMed id 15640104)2 Lin J.T.... Xu C.Q. (2004)
|
External Searches for SLC7A6OS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC7A6OS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC7A6OS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC7A6OS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC7A6OS | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC7A6OS gene:
Search GeneIP for patents involving SLC7A6OS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC7A6OS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC7A6OS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC7A6OS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC7A6OS | | | OriGene Protein Over-expression Lysate for SLC7A6OS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC7A6OS | | OriGene 3'-UTR Clone for SLC7A6OS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC7A6OS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC7A6OS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLC7A6OS | | OriGene Custom Protein Services for SLC7A6OS | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC7A6OS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC7A6OS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC7A6OS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC7A6OS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC7A6OS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC7A6OS |
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 | | | SLC7A6OS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A6OS |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC7A6OS |
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