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Aliases for SLC7A6OS Gene

Aliases for SLC7A6OS Gene

  • Solute Carrier Family 7 Member 6 Opposite Strand 2 3 5
  • Solute Carrier Family 7 Member 6 Opposite Strand Transcript 4
  • Solute Carrier Family 7, Member 6 Opposite Strand 2
  • ADAMS Proteinase-Related Protein 4

External Ids for SLC7A6OS Gene

Previous GeneCards Identifiers for SLC7A6OS Gene

  • GC16M066890
  • GC16M068332
  • GC16M054207
  • GC16M068320

Summaries for SLC7A6OS Gene

GeneCards Summary for SLC7A6OS Gene

SLC7A6OS (Solute Carrier Family 7 Member 6 Opposite Strand) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SLC7A6OS Gene

  • Directs RNA polymerase II nuclear import.

Additional gene information for SLC7A6OS Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A6OS Gene

Genomics for SLC7A6OS Gene

GeneHancer (GH) Regulatory Elements for SLC7A6OS Gene

Promoters and enhancers for SLC7A6OS Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I068309 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.1 146 2.7 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PRMT7 SLC7A6OS PIR55231 EDC4 CENPT NFATC3 DUS2 PIR32305
GH16I068312 Enhancer 0.2 Ensembl 550.8 -1.6 -1636 0.4 PRMT7 SLC7A6OS PIR55231 ENSG00000259797
GH16I067479 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.5 +828.9 828913 5 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ATP6V0D1 LOC101927837 AGRP ZDHHC1 ENKD1 NAE1 EDC4 CENPT CTCF SLC7A6OS
GH16I068842 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.3 -532.9 -532932 1.9 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 POLR2B TANGO6 EDC4 CHTF8 CENPT NONOP1 ZFP90 NFAT5 SNTB2 ENSG00000263276 PRMT7
GH16I068077 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 +225.3 225284 16 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC NFATC3 GC16M068083 PRMT7 CTCF EDC4 TRADD ZDHHC1 DPEP2 DUS2 E2F4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC7A6OS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC7A6OS gene promoter:

Genomic Locations for SLC7A6OS Gene

Genomic Locations for SLC7A6OS Gene
26,463 bases
Minus strand

Genomic View for SLC7A6OS Gene

Genes around SLC7A6OS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC7A6OS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC7A6OS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A6OS Gene

Proteins for SLC7A6OS Gene

  • Protein details for SLC7A6OS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable RNA polymerase II nuclear localization protein SLC7A6OS
    Protein Accession:
    Secondary Accessions:
    • Q8TCZ3
    • Q9H8R8

    Protein attributes for SLC7A6OS Gene

    309 amino acids
    Molecular mass:
    35028 Da
    Quaternary structure:
    No Data Available
    • When transfected to S.cerevisiae cells, able to partially restore polymerase II mislocalization and cellular shape in IWR1 mutant cells.
    • Sequence=AAL79958.1; Type=Frameshift; Positions=234; Evidence={ECO:0000305};

neXtProt entry for SLC7A6OS Gene

Post-translational modifications for SLC7A6OS Gene

No Post-translational modifications

Other Protein References for SLC7A6OS Gene

No data available for DME Specific Peptides for SLC7A6OS Gene

Domains & Families for SLC7A6OS Gene

Gene Families for SLC7A6OS Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SLC7A6OS Gene


Suggested Antigen Peptide Sequences for SLC7A6OS Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IWR1/SLC7A6OS family.
  • Belongs to the IWR1/SLC7A6OS family.
genes like me logo Genes that share domains with SLC7A6OS: view

Function for SLC7A6OS Gene

Molecular function for SLC7A6OS Gene

UniProtKB/Swiss-Prot Function:
Directs RNA polymerase II nuclear import.

Phenotypes From GWAS Catalog for SLC7A6OS Gene

genes like me logo Genes that share phenotypes with SLC7A6OS: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC7A6OS Gene

Localization for SLC7A6OS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A6OS Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC7A6OS gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC7A6OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SLC7A6OS: view

Pathways & Interactions for SLC7A6OS Gene

SuperPathways for SLC7A6OS Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC7A6OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SLC7A6OS: view

No data available for Pathways by source and SIGNOR curated interactions for SLC7A6OS Gene

Drugs & Compounds for SLC7A6OS Gene

No Compound Related Data Available

Transcripts for SLC7A6OS Gene

Unigene Clusters for SLC7A6OS Gene

Solute carrier family 7, member 6 opposite strand:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A6OS Gene

No ASD Table

Relevant External Links for SLC7A6OS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC7A6OS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC7A6OS Gene

Protein differential expression in normal tissues from HIPED for SLC7A6OS Gene

This gene is overexpressed in Blymphocyte (25.7), Peripheral blood mononuclear cells (16.0), Retina (12.7), and Colon (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC7A6OS Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC7A6OS Gene:


SOURCE GeneReport for Unigene cluster for SLC7A6OS Gene:


Evidence on tissue expression from TISSUES for SLC7A6OS Gene

  • Adrenal gland(4.2)
  • Liver(4.2)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with SLC7A6OS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC7A6OS Gene

Orthologs for SLC7A6OS Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC7A6OS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC7A6OS 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia SLC7A6OS 33 34
  • 84.31 (n)
(Bos Taurus)
Mammalia SLC7A6OS 33 34
  • 80.72 (n)
(Rattus norvegicus)
Mammalia Slc7a6os 33
  • 80.15 (n)
(Mus musculus)
Mammalia Slc7a6os 33 16 34
  • 79.93 (n)
(Monodelphis domestica)
Mammalia SLC7A6OS 34
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia SLC7A6OS 34
  • 32 (a)
(Gallus gallus)
Aves SLC7A6OS 33 34
  • 63.46 (n)
(Anolis carolinensis)
Reptilia SLC7A6OS 34
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc7a6os 33
  • 55.26 (n)
(Danio rerio)
Actinopterygii slc7a6os 33 34
  • 58.56 (n)
Dr.12894 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2841 34
  • 24 (a)
Species where no ortholog for SLC7A6OS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC7A6OS Gene

Gene Tree for SLC7A6OS (if available)
Gene Tree for SLC7A6OS (if available)

Paralogs for SLC7A6OS Gene

No data available for Paralogs for SLC7A6OS Gene

Variants for SLC7A6OS Gene

Sequence variations from dbSNP and Humsavar for SLC7A6OS Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000156517 -- 68,303,200(-) G/A intron_variant
rs1000160210 -- 68,311,550(-) C/T upstream_transcript_variant
rs1000234417 -- 68,309,252(-) G/A intron_variant
rs1000472065 -- 68,302,112(-) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000581059 -- 68,307,761(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC7A6OS Gene

Variant ID Type Subtype PubMed ID
nsv510691 CNV deletion 20534489
nsv519368 CNV loss 19592680

Variation tolerance for SLC7A6OS Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.64; 65.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC7A6OS Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC7A6OS Gene

Disorders for SLC7A6OS Gene

Additional Disease Information for SLC7A6OS

No disorders were found for SLC7A6OS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC7A6OS Gene

Publications for SLC7A6OS Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58

Products for SLC7A6OS Gene

Sources for SLC7A6OS Gene

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