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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC7A6OS Gene

protein-coding   GIFtS: 42
GCID: GC16M068320

Solute Carrier Family 7, Member 6 Opposite Strand

  Search for SLC7A6OS
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 7, Member 6 Opposite Strand1 2
Solute Carrier Family 7 Member 6 Opposite Strand Transcript2 3
ADAMS Proteinase-Related Protein2 3
Probable RNA Polymerase II Nuclear Localization Protein SLC7A6OS2
Protein SLC7A6OS2

External Ids:    HGNC: 258071   Entrez Gene: 841382   Ensembl: ENSG000001030617   UniProtKB: Q96CW63   

Export aliases for SLC7A6OS gene to outside databases

Previous GC identifers: GC16M066890 GC16M068332 GC16M054207


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC7A6OS Gene: 
SLC7A6OS (solute carrier family 7, member 6 opposite strand) is a protein-coding gene.

UniProtKB/Swiss-Prot: S7A6O_HUMAN, Q96CW6
Function: Directs RNA polymerase II nuclear import (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC7A6OS gene promoter:
         GR   ER-alpha   Pax-5   NCX/Ncx   NF-E2 p45   GATA-2   GATA-1   COMP1   GR-alpha   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC7A6OS promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC7A6OS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC7A6OS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

SLC7A6OS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC7A6OS gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M068320:  view genomic region     (about GC identifiers)

Start:
68,318,406 bp from pter      End:
68,344,868 bp from pter
Size:
26,463 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S7A6O_HUMAN, Q96CW6 (See protein sequence)
Recommended Name: Probable RNA polymerase II nuclear localization protein SLC7A6OS  
Size: 309 amino acids; 35028 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Miscellaneous: When transfected to S.cerevisiae cells, able to partially restore polymerase II mislocalization and
cellular shape in IWR1 mutant cells (PubMed:21504834)
Sequence caution: Sequence=AAL79958.1; Type=Frameshift; Positions=234;
Secondary accessions: Q8TCZ3 Q9H8R8

Explore the universe of human proteins at neXtProt for SLC7A6OS: NX_Q96CW6

Explore proteomics data for SLC7A6OS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96CW6

  • SLC7A6OS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC7A6OS Protein Expression
    REFSEQ proteins: NP_115554.2  
    ENSEMBL proteins: 
     ENSP00000462436   ENSP00000263997   ENSP00000461470  

    Human Recombinant Protein Products for SLC7A6OS: 
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    Novus Biologicals SLC7A6OS Protein
    Novus Biologicals SLC7A6OS Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC7A6OS 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    SLC7A6OS for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for SLC7A6OS 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96CW6

    UniProtKB/Swiss-Prot: S7A6O_HUMAN, Q96CW6
    Similarity: Belongs to the IWR1/SLC7A6OS family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S7A6O_HUMAN, Q96CW6
    Function: Directs RNA polymerase II nuclear import (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for SLC7A6OS:

     Increased cell number in S and 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC7A6OS 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC7A6OS 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSLC7A6OS 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A6OS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC7A6OS

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC7A6OS (ENSP000002639974) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--

    SLC7A6OS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC7A6OS (S7A6O)

    Search CenterWatch for drugs/clinical trials and news about SLC7A6OS / S7A6O

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC7A6OS gene: 
    NM_032178.2  

    Unigene Cluster for SLC7A6OS:

    Solute carrier family 7, member 6 opposite strand
    Hs.729520  [show with all ESTs]
    Unigene Representative Sequence: NM_032178
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000568315 ENST00000263997 ENST00000561933(uc002evw.2) ENST00000561590
    ENST00000568538
    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC7A6OS (see all 9):
    hsa-miR-181c hsa-miR-130a* hsa-miR-23c hsa-miR-181a hsa-miR-181d hsa-miR-23b hsa-miR-23a hsa-miR-4262
    SwitchGear 3'UTR luciferase reporter plasmidSLC7A6OS 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: SLC7A6OS (NM_032178)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC7A6OS
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC7A6OS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC7A6OS

    Additional mRNA sequence: 

    AK023353.1 AK225712.1 AY078070.1 BC013778.1 

    9 DOTS entries:

    DT.40300902  DT.75116670  DT.100781067  DT.217208  DT.95171482  DT.95267260  DT.120723964  DT.433737 
    DT.91767258 

    24/142 AceView cDNA sequences (see all 142):

    BE550669 BC013778 AA677673 CB321817 AI631206 BE075890 BG026213 AA370407 
    BE744736 AI470038 AI422495 BM508191 BU629481 CR591193 N29252 CA442126 
    BU553688 BU620255 BU177982 AA047552 F00475 BQ045236 BE674406 AI088342 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC7A6OS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTAGTAA
    SLC7A6OS Expression
    About this image


    See SLC7A6OS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC7A6OS

    SOURCE GeneReport for Unigene cluster: Hs.729520
        SABiosciences Custom PCR Arrays for SLC7A6OS
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A6OS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC7A6OS gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc7a6os1 , 5 solute carrier family 7, member 6 opposite strand1, 5 79.93(n)1
    76.97(a)1
      8 (53.11 cM)5
    664321  NM_001007567.21  NP_001007568.11 
     1062004385 
    chicken
    (Gallus gallus)
    Aves SLC7A6OS1 solute carrier family 7, member 6 opposite strand 63.46(n)
    55.67(a)
      415621  XM_413987.3  XP_413987.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC7A6OS6
    solute carrier family 7, member 6 opposite strand
    44(a)
    1 ↔ 1
    LGc(6791359-6798329)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.128942 Transcribed sequence with weak similarity to protein more 72.41(n)    57049886 
    worm
    (Caenorhabditis elegans)
    Secernentea W01G7.46
    Protein W01G7.4
    22(a)
    1 ↔ 1
    II(14060739-14062623)


    ENSEMBL Gene Tree for SLC7A6OS (if available)
    TreeFam Gene Tree for SLC7A6OS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/146 SNPs in SLC7A6OS are shown (see all 146)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0325924
    ----see VAR_0325922 G D mis40--------
    VAR_0325934
    ----see VAR_0325932 S A mis40--------
    VAR_0325914
    ----see VAR_0325912 V M mis40--------
    rs1872094901,2
    C--68336263(+) CCTCCC/TGGTCT 1 -- int11Minor allele frequency- T:0.00EU 1323
    rs354158371,2
    C,F--68336312(+) CTGCTC/GTCCTC 2 D E mis13Minor allele frequency- G:0.01NA WA 4742
    rs357369501,2
    C,F--68336360(+) TCGTCA/GTCTTC 2 D syn14Minor allele frequency- G:0.04NA EU 6067
    rs1392260671,2
    C--68336371(+) ATCGTC/TGTAAA 2 N D mis11Minor allele frequency- T:0.00NA 4552
    rs1434201201,2
    C--68336372(+) TCGTCA/GTAAAT 2 Y syn10--------
    rs2003790451,2
    C--68336400(+) CATCAC/TTCACC 2 N S mis10--------
    rs1179489831,2
    C,F--68336449(+) TCTAAG/TGTTAT 1 -- int12Minor allele frequency- T:0.01NA EU 1443

    HapMap Linkage Disequilibrium report for SLC7A6OS (68318406 - 68344868 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC7A6OS:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510691CNV Loss20534489
    nsv519368CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC7A6OS gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with SLC7A6OS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    3. Iwr1 directs RNA polymerase II nuclear import. (PubMed id 21504834)2 Czeko E.... Cramer P. (2011)
    4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    5. Molecular characterization and functional analysis of a protease-related protein in Chang-liver cells. (PubMed id 20510023)1 Wang C....Lin J. (2010)
    6. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84138 HGNC: 25807 AceView: FLJ13291 Ensembl:ENSG00000103061 euGenes: HUgn84138
    ECgene: SLC7A6OS H-InvDB: SLC7A6OS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC7A6OS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC7A6OS gene:
    Search GeneIP for patents involving SLC7A6OS

    GeneCards and IP:
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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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