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Aliases for SLC7A6OS Gene

Aliases for SLC7A6OS Gene

  • Solute Carrier Family 7 Member 6 Opposite Strand 2 3 5
  • Solute Carrier Family 7 Member 6 Opposite Strand Transcript 4
  • Solute Carrier Family 7, Member 6 Opposite Strand 2
  • ADAMS Proteinase-Related Protein 4

External Ids for SLC7A6OS Gene

Previous GeneCards Identifiers for SLC7A6OS Gene

  • GC16M066890
  • GC16M068332
  • GC16M054207
  • GC16M068320

Summaries for SLC7A6OS Gene

GeneCards Summary for SLC7A6OS Gene

SLC7A6OS (Solute Carrier Family 7 Member 6 Opposite Strand) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SLC7A6OS Gene

  • Directs RNA polymerase II nuclear import.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A6OS Gene

Genomics for SLC7A6OS Gene

Regulatory Elements for SLC7A6OS Gene

Promoters for SLC7A6OS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC7A6OS on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC7A6OS Gene

68,284,503 bp from pter
68,310,965 bp from pter
26,463 bases
Minus strand

Genomic View for SLC7A6OS Gene

Genes around SLC7A6OS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC7A6OS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC7A6OS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A6OS Gene

Proteins for SLC7A6OS Gene

  • Protein details for SLC7A6OS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable RNA polymerase II nuclear localization protein SLC7A6OS
    Protein Accession:
    Secondary Accessions:
    • Q8TCZ3
    • Q9H8R8

    Protein attributes for SLC7A6OS Gene

    309 amino acids
    Molecular mass:
    35028 Da
    Quaternary structure:
    No Data Available
    • When transfected to S.cerevisiae cells, able to partially restore polymerase II mislocalization and cellular shape in IWR1 mutant cells.
    • Sequence=AAL79958.1; Type=Frameshift; Positions=234; Evidence={ECO:0000305};

neXtProt entry for SLC7A6OS Gene

Proteomics data for SLC7A6OS Gene at MOPED

Post-translational modifications for SLC7A6OS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC7A6OS Gene

No data available for DME Specific Peptides for SLC7A6OS Gene

Domains & Families for SLC7A6OS Gene

Protein Domains for SLC7A6OS Gene


Suggested Antigen Peptide Sequences for SLC7A6OS Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IWR1/SLC7A6OS family.
  • Belongs to the IWR1/SLC7A6OS family.
genes like me logo Genes that share domains with SLC7A6OS: view

No data available for Gene Families for SLC7A6OS Gene

Function for SLC7A6OS Gene

Molecular function for SLC7A6OS Gene

UniProtKB/Swiss-Prot Function:
Directs RNA polymerase II nuclear import.
genes like me logo Genes that share phenotypes with SLC7A6OS: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC7A6OS Gene

Localization for SLC7A6OS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A6OS Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for SLC7A6OS Gene COMPARTMENTS Subcellular localization image for SLC7A6OS gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for SLC7A6OS Gene

Pathways & Interactions for SLC7A6OS Gene

SuperPathways for SLC7A6OS Gene

No Data Available

Interacting Proteins for SLC7A6OS Gene

Gene Ontology (GO) - Biological Process for SLC7A6OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SLC7A6OS: view

No data available for Pathways by source and SIGNOR curated interactions for SLC7A6OS Gene

Drugs & Compounds for SLC7A6OS Gene

No Compound Related Data Available

Transcripts for SLC7A6OS Gene

Unigene Clusters for SLC7A6OS Gene

Solute carrier family 7, member 6 opposite strand:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A6OS Gene

No ASD Table

Relevant External Links for SLC7A6OS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC7A6OS Gene

mRNA expression in normal human tissues for SLC7A6OS Gene

Protein differential expression in normal tissues from HIPED for SLC7A6OS Gene

This gene is overexpressed in Blymphocyte (25.7), Peripheral blood mononuclear cells (16.0), Retina (12.7), and Colon (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC7A6OS Gene

SOURCE GeneReport for Unigene cluster for SLC7A6OS Gene Hs.729520

genes like me logo Genes that share expression patterns with SLC7A6OS: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC7A6OS Gene

Orthologs for SLC7A6OS Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC7A6OS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC7A6OS 35
  • 80.72 (n)
  • 77.45 (a)
  • 77 (a)
(Canis familiaris)
Mammalia SLC7A6OS 35
  • 84.31 (n)
  • 81.17 (a)
  • 64 (a)
(Mus musculus)
Mammalia Slc7a6os 35
  • 79.93 (n)
  • 76.97 (a)
Slc7a6os 16
Slc7a6os 36
  • 76 (a)
(Pan troglodytes)
Mammalia SLC7A6OS 35
  • 99.46 (n)
  • 99.35 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc7a6os 35
  • 80.15 (n)
  • 77.63 (a)
(Monodelphis domestica)
Mammalia SLC7A6OS 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia SLC7A6OS 36
  • 32 (a)
(Gallus gallus)
Aves SLC7A6OS 35
  • 63.46 (n)
  • 55.67 (a)
  • 48 (a)
(Anolis carolinensis)
Reptilia SLC7A6OS 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc7a6os 35
  • 55.26 (n)
  • 51.15 (a)
(Danio rerio)
Actinopterygii Dr.12894 35
slc7a6os 35
  • 58.56 (n)
  • 55.98 (a)
slc7a6os 36
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2841 36
  • 24 (a)
Species with no ortholog for SLC7A6OS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC7A6OS Gene

Gene Tree for SLC7A6OS (if available)
Gene Tree for SLC7A6OS (if available)

Paralogs for SLC7A6OS Gene

No data available for Paralogs for SLC7A6OS Gene

Variants for SLC7A6OS Gene

Sequence variations from dbSNP and Humsavar for SLC7A6OS Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_032591 -
VAR_032592 -
VAR_032593 -
rs11548855 - 68,304,045(-) GCCCT(A/G)CAGCC reference, missense
rs3068658 -- 68,306,827(-) gaatg(-/AATG)aATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC7A6OS Gene

Variant ID Type Subtype PubMed ID
nsv510691 CNV Loss 20534489
nsv519368 CNV Loss 19592680

Variation tolerance for SLC7A6OS Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.64; 65.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC7A6OS Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC7A6OS Gene

Disorders for SLC7A6OS Gene

Relevant External Links for SLC7A6OS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC7A6OS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC7A6OS Gene

Publications for SLC7A6OS Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  4. Molecular characterization and functional analysis of a protease-related protein in Chang-liver cells. (PMID: 20510023) Wang C. … Lin J. (BMB Rep 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for SLC7A6OS Gene

Sources for SLC7A6OS Gene

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