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Aliases for SLC7A6OS Gene

Aliases for SLC7A6OS Gene

  • Solute Carrier Family 7 Member 6 Opposite Strand 2 3 5
  • Solute Carrier Family 7 Member 6 Opposite Strand Transcript 4
  • Solute Carrier Family 7, Member 6 Opposite Strand 2
  • ADAMS Proteinase-Related Protein 4

External Ids for SLC7A6OS Gene

Previous GeneCards Identifiers for SLC7A6OS Gene

  • GC16M066890
  • GC16M068332
  • GC16M054207
  • GC16M068320

Summaries for SLC7A6OS Gene

GeneCards Summary for SLC7A6OS Gene

SLC7A6OS (Solute Carrier Family 7 Member 6 Opposite Strand) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SLC7A6OS Gene

  • Directs RNA polymerase II nuclear import.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A6OS Gene

Genomics for SLC7A6OS Gene

Regulatory Elements for SLC7A6OS Gene

Enhancers for SLC7A6OS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F068279 1.7 FANTOM5 Ensembl ENCODE 16.2 +24.5 24505 13.5 HDGF PKNOX1 MLX WRNIP1 ARID4B DMAP1 SLC30A9 FOS SP5 JUNB PRMT7 SLC7A6 NFATC3 DPEP2 SLC7A6OS RNU4-30P DUS2 RANBP10 PSMB10 LRRC36
GH16F068842 1.1 ENCODE 20.3 -532.9 -532932 1.9 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 NONOP1 PSKH1 CHTF8 SLC7A6OS ENSG00000263276 CENPT TANGO6 GC16P068850
GH16F068414 1.6 FANTOM5 Ensembl ENCODE 12.1 -106.3 -106277 4.6 PKNOX1 ATF1 MLX ARID4B YY1 SLC30A9 ZNF766 GATA2 ZNF143 KLF7 SLC7A6OS SMPD3 ZFP90 PRMT7 RNU4-36P UTP4 CDH1 NFATC3 PSMB10 DPEP2
GH16F068233 1.6 FANTOM5 ENCODE 11.2 +75.1 75090 5.2 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ACD DUS2 PRMT7 SLC7A6OS ENSG00000259797 SLC12A4 ESRP2 TSNAXIP1 ENSG00000261469 ENSG00000262160
GH16F068077 1.5 FANTOM5 ENCODE 11.2 +225.3 225284 16.0 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PRMT7 PSKH1 DPEP2 DUS2 E2F4 ZDHHC1 SLC7A6OS ENSG00000212445 PLEKHG4 B3GNT9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC7A6OS on UCSC Golden Path with GeneCards custom track

Promoters for SLC7A6OS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001506073 -135 2201 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for SLC7A6OS Gene

Chromosome:
16
Start:
68,284,503 bp from pter
End:
68,310,965 bp from pter
Size:
26,463 bases
Orientation:
Minus strand

Genomic View for SLC7A6OS Gene

Genes around SLC7A6OS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC7A6OS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC7A6OS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A6OS Gene

Proteins for SLC7A6OS Gene

  • Protein details for SLC7A6OS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CW6-S7A6O_HUMAN
    Recommended name:
    Probable RNA polymerase II nuclear localization protein SLC7A6OS
    Protein Accession:
    Q96CW6
    Secondary Accessions:
    • Q8TCZ3
    • Q9H8R8

    Protein attributes for SLC7A6OS Gene

    Size:
    309 amino acids
    Molecular mass:
    35028 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • When transfected to S.cerevisiae cells, able to partially restore polymerase II mislocalization and cellular shape in IWR1 mutant cells.
    SequenceCaution:
    • Sequence=AAL79958.1; Type=Frameshift; Positions=234; Evidence={ECO:0000305};

neXtProt entry for SLC7A6OS Gene

Post-translational modifications for SLC7A6OS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC7A6OS Gene

No data available for DME Specific Peptides for SLC7A6OS Gene

Domains & Families for SLC7A6OS Gene

Protein Domains for SLC7A6OS Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC7A6OS Gene

Graphical View of Domain Structure for InterPro Entry

Q96CW6

UniProtKB/Swiss-Prot:

S7A6O_HUMAN :
  • Belongs to the IWR1/SLC7A6OS family.
Family:
  • Belongs to the IWR1/SLC7A6OS family.
genes like me logo Genes that share domains with SLC7A6OS: view

No data available for Gene Families for SLC7A6OS Gene

Function for SLC7A6OS Gene

Molecular function for SLC7A6OS Gene

UniProtKB/Swiss-Prot Function:
Directs RNA polymerase II nuclear import.
genes like me logo Genes that share phenotypes with SLC7A6OS: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC7A6OS Gene

Localization for SLC7A6OS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A6OS Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC7A6OS gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC7A6OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SLC7A6OS: view

Pathways & Interactions for SLC7A6OS Gene

SuperPathways for SLC7A6OS Gene

No Data Available

Interacting Proteins for SLC7A6OS Gene

Gene Ontology (GO) - Biological Process for SLC7A6OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SLC7A6OS: view

No data available for Pathways by source and SIGNOR curated interactions for SLC7A6OS Gene

Transcripts for SLC7A6OS Gene

Unigene Clusters for SLC7A6OS Gene

Solute carrier family 7, member 6 opposite strand:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A6OS Gene

No ASD Table

Relevant External Links for SLC7A6OS Gene

GeneLoc Exon Structure for
SLC7A6OS
ECgene alternative splicing isoforms for
SLC7A6OS

Expression for SLC7A6OS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC7A6OS Gene

Protein differential expression in normal tissues from HIPED for SLC7A6OS Gene

This gene is overexpressed in Blymphocyte (25.7), Peripheral blood mononuclear cells (16.0), Retina (12.7), and Colon (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC7A6OS Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC7A6OS Gene:

SLC7A6OS

SOURCE GeneReport for Unigene cluster for SLC7A6OS Gene:

Hs.729520
genes like me logo Genes that share expression patterns with SLC7A6OS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SLC7A6OS Gene

Orthologs for SLC7A6OS Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC7A6OS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC7A6OS 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia SLC7A6OS 34 35
  • 84.31 (n)
cow
(Bos Taurus)
Mammalia SLC7A6OS 34 35
  • 80.72 (n)
rat
(Rattus norvegicus)
Mammalia Slc7a6os 34
  • 80.15 (n)
mouse
(Mus musculus)
Mammalia Slc7a6os 34 16 35
  • 79.93 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC7A6OS 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC7A6OS 35
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC7A6OS 34 35
  • 63.46 (n)
lizard
(Anolis carolinensis)
Reptilia SLC7A6OS 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc7a6os 34
  • 55.26 (n)
zebrafish
(Danio rerio)
Actinopterygii slc7a6os 34 35
  • 58.56 (n)
Dr.12894 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2841 35
  • 24 (a)
OneToOne
Species where no ortholog for SLC7A6OS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC7A6OS Gene

ENSEMBL:
Gene Tree for SLC7A6OS (if available)
TreeFam:
Gene Tree for SLC7A6OS (if available)

Paralogs for SLC7A6OS Gene

No data available for Paralogs for SLC7A6OS Gene

Variants for SLC7A6OS Gene

Sequence variations from dbSNP and Humsavar for SLC7A6OS Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111252202 -- 68,305,887(+) AAACC(A/G)TCTCT intron-variant
rs111334023 -- 68,310,145(+) AATCT(-/A)AAAAA intron-variant, upstream-variant-2KB
rs111356153 -- 68,307,704(+) TTGCT(A/G)TCAAC intron-variant
rs111377999 -- 68,305,825(+) GAAGC(C/T)AAGGT intron-variant
rs111621809 -- 68,306,745(+) CCTTA(A/G)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC7A6OS Gene

Variant ID Type Subtype PubMed ID
nsv519368 CNV loss 19592680
nsv510691 CNV deletion 20534489

Variation tolerance for SLC7A6OS Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.64; 65.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC7A6OS Gene

Human Gene Mutation Database (HGMD)
SLC7A6OS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC7A6OS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC7A6OS Gene

Disorders for SLC7A6OS Gene

Relevant External Links for SLC7A6OS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC7A6OS

No disorders were found for SLC7A6OS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC7A6OS Gene

Publications for SLC7A6OS Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for SLC7A6OS Gene

Sources for SLC7A6OS Gene

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