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SLC7A6OS Gene

protein-coding   GIFtS: 38
GCID: GC16M068320

Solute Carrier Family 7, Member 6 Opposite Strand

  Search for SLC7A6OS
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 7, Member 6 Opposite Strand1 2
Solute Carrier Family 7 Member 6 Opposite Strand Transcript2 3
ADAMS Proteinase-Related Protein2 3
Probable RNA Polymerase II Nuclear Localization Protein SLC7A6OS2
Protein SLC7A6OS2

External Ids:    HGNC: 258071   Entrez Gene: 841382   Ensembl: ENSG000001030617   UniProtKB: Q96CW63   

Export aliases for SLC7A6OS gene to outside databases

Previous GC identifers: GC16M066890 GC16M068332 GC16M054207


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC7A6OS Gene:
SLC7A6OS (solute carrier family 7, member 6 opposite strand) is a protein-coding gene.

UniProtKB/Swiss-Prot: S7A6O_HUMAN, Q96CW6
Function: Directs RNA polymerase II nuclear import (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SLC7A6OS gene promoter:
         GR   ER-alpha   Pax-5   NCX/Ncx   NF-E2 p45   GATA-2   GATA-1   COMP1   GR-alpha   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC7A6OS promoter sequence
   Search Chromatin IP Primers for SLC7A6OS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC7A6OS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

SLC7A6OS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC7A6OS gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M068320:  view genomic region     (about GC identifiers)

Start:
68,318,406 bp from pter      End:
68,344,868 bp from pter
Size:
26,463 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S7A6O_HUMAN, Q96CW6 (See protein sequence)
Recommended Name: Probable RNA polymerase II nuclear localization protein SLC7A6OS  
Size: 309 amino acids; 35028 Da
Miscellaneous: When transfected to S.cerevisiae cells, able to partially restore polymerase II mislocalization and
cellular shape in IWR1 mutant cells (PubMed:21504834)
Sequence caution: Sequence=AAL79958.1; Type=Frameshift; Positions=234;
Secondary accessions: Q8TCZ3 Q9H8R8

Explore the universe of human proteins at neXtProt for SLC7A6OS: NX_Q96CW6

Explore proteomics data for SLC7A6OS at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC7A6OS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115554.2  
    ENSEMBL proteins: 
     ENSP00000462436   ENSP00000263997   ENSP00000461470  

    SLC7A6OS Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SLC7A6OS

     
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    SLC7A6OS Assay Products:

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    Cloud-Clone Corp. ELISAs for SLC7A6OS
    Cloud-Clone Corp. CLIAs for SLC7A6OS
    Search eBioscience for ELISAs for SLC7A6OS 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q96CW6

    UniProtKB/Swiss-Prot: S7A6O_HUMAN, Q96CW6
    Similarity: Belongs to the IWR1/SLC7A6OS family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S7A6O_HUMAN, Q96CW6
    Function: Directs RNA polymerase II nuclear import (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for SLC7A6OS:

     Increased cell number in S and 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC7A6OS
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC7A6OS
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    miRNA
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    Block miRNA regulation of human, mouse, rat SLC7A6OS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC7A6OS (see all 9):
    hsa-miR-181c hsa-miR-130a* hsa-miR-23c hsa-miR-181a hsa-miR-181d hsa-miR-23b hsa-miR-23a hsa-miR-4262
    SwitchGear 3'UTR luciferase reporter plasmidSLC7A6OS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC7A6OS
    Predesigned siRNA for gene silencing in human, mouse, rat SLC7A6OS

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SLC7A6OS (NM_032178)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC7A6OS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC7A6OS

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A6OS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S7A6O_HUMAN, Q96CW6: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    nucleus3
    cytosol1
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with SLC7A6OS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC7A6OS
    Interactions:

        Search GeneGlobe Interaction Network for SLC7A6OS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLC7A6OS (ENSP000002639974) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR2CENSP000002192524STRING: ENSP00000219252
    POLR2EENSP000002155874STRING: ENSP00000215587
    POLR2BENSP000003127354STRING: ENSP00000312735
    POLR2DENSP000002726454STRING: ENSP00000272645
    POLR2GENSP000003017884STRING: ENSP00000301788
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--

    Find genes that share ontologies with SLC7A6OS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC7A6OS (S7A6O)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC7A6OS gene: 
    NM_032178.2  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000568315 ENST00000263997 ENST00000561933(uc002evw.2) ENST00000561590
    ENST00000568538
    miRNA
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    Block miRNA regulation of human, mouse, rat SLC7A6OS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC7A6OS (see all 9):
    hsa-miR-181c hsa-miR-130a* hsa-miR-23c hsa-miR-181a hsa-miR-181d hsa-miR-23b hsa-miR-23a hsa-miR-4262
    SwitchGear 3'UTR luciferase reporter plasmidSLC7A6OS 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC7A6OS
    Predesigned siRNA for gene silencing in human, mouse, rat SLC7A6OS
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC7A6OS
      QuantiTect SYBR Green Assays in human, mouse, rat SLC7A6OS
      QuantiFast Probe-based Assays in human, mouse, rat SLC7A6OS

    Selected AceView cDNA sequences (see all 142):

    CR591193 AI078607 BF432635 BU177982 AI095894 CA442126 BF025896 BE550669 
    BG026213 BC013778 AA677673 BM553652 F00475 AA592950 AA046958 AI631206 
    AA370408 AI422495 BU629481 N29252 BM551808 F00466 AI140747 AA831341 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC7A6OS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTAGTAA
    SLC7A6OS Expression
    About this image

    SLC7A6OS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC7A6OS Protein Expression
        Custom PCR Arrays for SLC7A6OS
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SLC7A6OS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A6OS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC7A6OS gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc7a6os1 , 5 solute carrier family 7, member 6 opposite strand1, 5 79.93(n)1
    76.97(a)1
      8 (53.11 cM)5
    664321  NM_001007567.21  NP_001007568.11 
     1062004385 
    chicken
    (Gallus gallus)
    Aves SLC7A6OS1 solute carrier family 7, member 6 opposite strand 63.46(n)
    55.67(a)
      415621  XM_413987.4  XP_413987.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC7A6OS6
    solute carrier family 7, member 6 opposite strand
    46(a)
    1 ↔ 1
    LGc(6791359-6798329)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc7a6os1 solute carrier family 7, member 6 opposite strand 55.26(n)
    51.15(a)
      733552  NM_001044467.1  NP_001037932.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.128942 Transcribed sequence with weak similarity to protein more 72.41(n)    57049886 


    ENSEMBL Gene Tree for SLC7A6OS (if available)
    TreeFam Gene Tree for SLC7A6OS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC7A6OS (see all 146)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872094901,2
    C--68336263(+) CCTCCC/TGGTCT 1 -- int11Minor allele frequency- T:0.00EU 1323
    rs354158371,2
    C,F--68336312(+) CTGCTC/GTCCTC 2 D E mis13Minor allele frequency- G:0.01NA WA 4742
    rs357369501,2
    C,F--68336360(+) TCGTCA/GTCTTC 2 D syn14Minor allele frequency- G:0.04NA EU 6067
    rs1392260671,2
    C--68336371(+) ATCGTC/TGTAAA 2 N D mis11Minor allele frequency- T:0.00NA 4552
    rs1434201201,2
    C--68336372(+) TCGTCA/GTAAAT 2 Y syn10--------
    rs2003790451,2
    C--68336400(+) CATCAC/TTCACC 2 N S mis10--------
    rs1179489831,2
    C,F--68336449(+) TCTAAG/TGTTAT 1 -- int12Minor allele frequency- T:0.01NA EU 1443
    rs1438497361,2
    --68336613(+) GATAGA/GACATG 1 -- int10--------
    rs1485893741,2
    --68336834(+) TGACCA/GTTAGG 1 -- int10--------
    rs1429593261,2
    --68336870(+) CATTTC/TAGAAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SLC7A6OS (68318406 - 68344868 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC7A6OS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510691CNV Loss20534489
    nsv519368CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC7A6OS
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC7A6OS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC7A6OS gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with SLC7A6OS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    3. Iwr1 directs RNA polymerase II nuclear import. (PubMed id 21504834)2 Czeko E.... Cramer P. (Mol. Cell 2011)
    4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    5. Molecular characterization and functional analysis of a protease-related protein in Chang-liver cells. (PubMed id 20510023)1 Wang C....Lin J. (BMB Rep 2010)
    6. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (Cell 2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84138 HGNC: 25807 AceView: FLJ13291 Ensembl:ENSG00000103061 euGenes: HUgn84138
    ECgene: SLC7A6OS H-InvDB: SLC7A6OS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC7A6OS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC7A6OS gene:
    Search GeneIP for patents involving SLC7A6OS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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