Aliases for SLC7A6 Gene
External Ids for SLC7A6 Gene
Previous GeneCards Identifiers for SLC7A6 Gene
GeneCards Summary for SLC7A6 Gene
SLC7A6 (Solute Carrier Family 7 Member 6) is a Protein Coding gene. Diseases associated with SLC7A6 include lysinuric protein intolerance. Among its related pathways are Platelet activation, signaling and aggregation and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include amino acid transmembrane transporter activity and L-amino acid transmembrane transporter activity. An important paralog of this gene is SLC7A10.
UniProtKB/Swiss-Prot for SLC7A6 Gene
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.