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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC7A6 Gene

protein-coding GIFtS: 59
GCID: GC16P068298

solute carrier family 7 (amino acid transporter light chain,...

Explore 6 diseases affiliated with
SLC7A6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 7 (Amino Acid Transporter Light Chain, Y+L System), Member 6¹ ²		Y(+)L-Type Amino Acid Transporter 2² ³
Y+LAT-2¹		Amino Acid Permease²
LAT-2¹ ²		Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 6²
LAT3¹ ²		Y+LAT2³
KIAA0245¹ ³		Y+L Amino Acid Transporter 2²
Cationic Amino Acid Transporter, Y+ System² ³		Y+LAT2³
Solute Carrier Family 7 Member 6² ³

External Ids:	HGNC: 11064¹	Entrez Gene: 9057²	Ensembl: ENSG00000103064⁷	OMIM: 605641⁵	UniProtKB: Q92536³

Export aliases for SLC7A6 gene to outside databases

Previous GC identifers: GC16P058995 GC16P068678 GC16P068033 GC16P068076 GC16P068074 GC16P066855 GC16U900049 GC16P054171

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: YLAT2_HUMAN, Q92536

Function: Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral

amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also

acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing

arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical

vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.

Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells

Gene Wiki entry for SLC7A6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC7A6 gene promoter:
USF1 NF-1 SREBP-1c USF2 USF-1:USF-2 C/EBPalpha IRF-2 USF-1 Zic3 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC7A6 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC7A6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC7A6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1

SLC7A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC7A6 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P068298: view genomic region (about GC identifiers)

Start:	68,298,423 bp from pter	End:	68,335,722 bp from pter
Size:	37,300 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: YLAT2_HUMAN, Q92536 (See protein sequence)

Recommended Name: Y+L amino acid transporter 2

Size: 515 amino acids; 56828 Da

Subunit: Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc

Subcellular location: Basolateral cell membrane; Multi-pass membrane protein

Sequence caution: Sequence=BAA13376.2; Type=Erroneous initiation;

Secondary accessions: Q68DS4 Q7L1N3

Explore the universe of human proteins at neXtProt for SLC7A6: NX_Q92536

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92536

SLC7A6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001070253.1 NP_003974.3

ENSEMBL proteins:

ENSP00000219343 ENSP00000368448 ENSP00000457758 ENSP00000455064 ENSP00000455357

ENSP00000456629 ENSP00000456896 ENSP00000454824 ENSP00000455487 ENSP00000457550

ENSP00000456474 ENSP00000463394

Reactome Protein details: Q92536
Human Recombinant Protein Products:

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	Novus Biologicals SLC7A6 Lysates
	Browse Sino Biological Recombinant Proteins
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	Uscn Proteins for SLC7A6

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9829974
GO:0016021	integral to membrane	--	--
GO:0016323	basolateral plasma membrane	IEA	--

SLC7A6 for ontologies About GeneDecksing

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	Uscn Antibodies for SLC7A6
	ThermoFisher Antibodies for SLC7A6

Assay Products for SLC7A6:

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	Uscn ELISAs and CLIAs for SLC7A6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC7A6 for domains About GeneDecksing

1 InterPro domain/family:

IPR002293 AA/rel_permease1

Graphical View of Domain Structure for InterPro Entry Q92536

ProtoNet protein and cluster: Q92536

UniProtKB/Swiss-Prot: YLAT2_HUMAN, Q92536

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC

2.A.3.8) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: YLAT2_HUMAN, Q92536

Function: Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral

amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also

acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing

arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical

vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.

Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells

Enzyme regulation: Arginine transport is strongly inhibited by lysine, glutamate, leucine, glutamine, methionine and

histidine, in the presence of Na(+). Also inhibited by protein kinase C (PKC) and treatment with

phorbol-12-myristate-13-acetate (PMA). Mutual inhibition is observed when leucine or glutamine is used as substrate.

Inhibition of arginine and leucine uptake also occurs when SLC3A2/4F2hc is either truncated at its C-terminus or

mutated at critical residues within the terminal 15 amino acids

Biophysicochemical properties: Kinetic parameters: KM=295 uM for glutamine (in the presence of NaCl); KM=236 uM for

leucine (in the presence of NaCl); KM=120 uM for arginine (in the presence of NaCl); KM=138 uM for arginine (in the

absence of NaCl);

Genatlas biochemistry entry for SLC7A6:

solute carrier family 7,member A6,heterodimerizing with the cell surface glycoprotein to form a complex mediating y+L

-type transporter exchanging cationic aminoacids and/or neutral aminoacids together with sodium,glycoprotein

associated aminoacid transporter family

miRNA Products:		miRTarBase miRNAs that target SLC7A6: hsa-mir-125b (MIRT004987), hsa-mir-30a (MIRT001761)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC7A6
		8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC7A6 (see all 56):
		hsa-miR-549 hsa-miR-345 hsa-miR-3194-5p hsa-miR-328 hsa-miR-605 hsa-miR-134 hsa-miR-29a hsa-miR-624*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLC7A6
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A6

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015171	amino acid transmembrane transporter activity	IEA	--
GO:0015297	antiporter activity	IEA	--

SLC7A6 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for SLC7A6:

Increased cell number in G1, a

Upregulation of Wnt/beta-caten

Animal Models:
1 MGI phenotypic allele

for Slc7a6 (no phenotypes)

SLC7A6 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Amino acid and oligopeptide SLC transporters

	Amino acid and oligopeptide SLC transporters	1.00			Transport of inorganic cations/anions and amino acids/oligopeptides	0.52
	Amino acid transport across the plasma membrane	0.63

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Basigin interactions

Basigin interactions

1.00

Sodium-coupled transporters and pumps

Sodium-coupled transporters and pumps

1.00

Cell surface interactions at the vascular wall

Cell surface interactions at the vascular wall

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SLC7A6

Sodium-coupled transporters and pumps

5/8 Reactome Pathways for SLC7A6 (see all 8)

	Hemostasis
	Transmembrane transport of small molecules
	SLC-mediated transmembrane transport
	Amino acid and oligopeptide SLC transporters
	Transport of inorganic cations/anions and amino acids/oligopeptides

SLC7A6 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SLC7A6

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for SLC7A6 (Q92536³ ENSP00000219343⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ESR2	Q92731³, ENSP00000343925⁴	I2D: score=1 STRING: ENSP00000343925
SLC3A2	P08195³, ENSP00000367124⁴	I2D: score=1 STRING: ENSP00000367124
ITGB1	P05556³	I2D: score=1

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003333	amino acid transmembrane transport	--	--
GO:0006461	protein complex assembly	TAS	9829974
GO:0006520	cellular amino acid metabolic process	TAS	9829974
GO:0006810	transport	TAS	9829974
GO:0006811	ion transport	TAS	--

SLC7A6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC7A6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC7A6

3 HMDB Compounds for SLC7A6 About this table

Compound	Synonyms	CAS #	PubMed Ids
L-Arginine	(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)	74-79-3	--
Ornithine	(+)-S-Ornithine (see all 9)	70-26-8	--
Sodium	Sodium (see all 2)	7440-23-5	--

3 Novoseek chemical compound relationships for SLC7A6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	35.9	1	19562367 (1)
arginine	33.5	2	19562367 (2)
glucose	0	2	17430988 (1)

Search CenterWatch for drugs/clinical trials and news about SLC7A6 / YLAT2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC7A6 gene (2 alternative transcripts):

NM_001076785.2 NM_003983.5

Unigene Cluster for SLC7A6:

Solute carrier family 7 (amino acid transporter light chain, y+L system), member 6

Hs.679580 [show with all ESTs]

Unigene Representative Sequence: NM_001076785

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000219343(uc002evv.2 uc002evu.2) ENST00000379152(uc010cfc.1)

ENST00000566834 ENST00000566454(uc002evt.2) ENST00000568088 ENST00000564708

ENST00000562727 ENST00000563080(uc010cfb.2) ENST00000563146 ENST00000568024

ENST00000566579 ENST00000567346 ENST00000563208 ENST00000562863 ENST00000567325

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SLC7A6 Browse OriGene MicroRNA Expression Plasmids
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		8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC7A6 (see all 56):
		hsa-miR-549 hsa-miR-345 hsa-miR-3194-5p hsa-miR-328 hsa-miR-605 hsa-miR-134 hsa-miR-29a hsa-miR-624*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Additional cDNA sequence:

AK057593.1 AK310602.1 AK310866.1 AK311610.1 BC028216.1 BC113100.1 CR749291.1 CR749475.1

D87432.1

13 DOTS entries:

DT.75116670 DT.91767258 DT.95171482 DT.217208 DT.40300902 DT.435093 DT.120724074 DT.95357556

DT.100712956 DT.120723969 DT.120724020 DT.102843183 DT.120724028

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A6 (see all 13) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14	^
SP1:
SP2:																																																	-
SP3:					-						-		-		-
SP4:
SP5:																																			-		-

ExUns:	15	^	16
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SLC7A6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC7A6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACATCACAA

About this image

SLC7A6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Mature Choroid Plexus Cells

Selective marker (cell-identifying gene)

Choroid Plexus

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

See SLC7A6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC7A6

SOURCE GeneReport for Unigene cluster: Hs.679580

UniProtKB/Swiss-Prot: YLAT2_HUMAN, Q92536

Tissue specificity: Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes,

RPE cells, and various carcinoma cell lines

SABiosciences Expression via Pathway-Focused PCR Array including SLC7A6:

Drug Transporters in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SLC7A6 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC7A6¹	solute carrier family 7 (amino acid transporter light more	72.26(n) 80.37(a)		415622 XM_001231336.2 XP_001231337.1
lizard (Anolis carolinensis)	Reptilia	SLC7A6⁶	--	78(a)	1 ↔ 1	LGc(6807612-6825824)
zebrafish (Danio rerio)	Actinopterygii	Dr.18441²	Transcribed sequence with moderate similarity to protein more	78.32(n)		CD284768.1
fruit fly (Drosophila melanogaster)	Insecta	mnd³	amino acid transporter	54(a) (best of 3)		--
worm (Caenorhabditis elegans)	Secernentea	F52H2.2³	amino acid permease	46(a) (best of 10)		X(2589541-2592778) --
E. coli (Escherichia coli)	Gamma proteobacteria	frlA⁶	predicted fructoselysine transporter	21(a)	1 → many	Chromosome(3497932-3499269)

ENSEMBL Gene Tree for SLC7A6 (if available)
TreeFam Gene Tree for SLC7A6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC7A6 gene

SLC7A4² SLC7A9² SLC7A14² SLC7A3² SLC7A10² SLC7A13² SLC7A7² SLC7A11²

SLC7A2² SLC7A8² SLC7A1² SLC7A5²

14 SIMAP similar genes for SLC7A6 using alignment to 12 protein entries: YLAT2_HUMAN (see all proteins):

DKFZp686K14185 xCT SLC7A7 SLC7A5P1 SLC7A5P2 SLC7A5

lat1 SLC7A8 SLC7A11 hxCT SLC7A10 SLC7A9

SLC7A13 SLC7A1

SLC7A6 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SLC7A6
PGOHUM00000240591

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1075851^1,2	C,A,	--	68296529(-)	`GCCTCA/GAACTC`	2	--	us2k¹		6		NA WA EA	364
rs189944171^1,2		--	68296668(+)	`CTGATA/GGTGTT`	2	--	us2k¹		0	--	--	--	--
rs71145990^1,2	C	--	68296776(+)	`TTTTTTT/-TTTTT`	2	--	us2k¹		1		NA	2
rs182891934^1,2		--	68296868(+)	`TGCCTC/TCTGGG`	2	--	us2k¹		0	--	--	--	--
rs139752724^1,2		--	68296934(+)	`CACCAC/TACTCG`	2	--	us2k¹		0	--	--	--	--
rs187280674^1,2		--	68297024(+)	`CTGCCC/TGCCTC`	2	--	us2k¹		0	--	--	--	--
rs9930908^1,2	C,F,A,H,	--	68297058(+)	`CAGGCT/GTGAGC`	2	--	us2k¹		12		NA WA CSA EA	374
rs192570772^1,2		--	68297082(+)	`TGAGCA/CGGCAT`	2	--	us2k¹		0	--	--	--	--
rs9930792^1,2	C,F,A,H,	--	68297115(+)	`GGACAA/CGTGGG`	2	--	us2k¹ tfbs³		16		NA EA WA CSA	736
rs9888986^1,2	C,F,H,	--	68297228(+)	`TATACG/ATCCAC`	2	--	us2k¹		17		NS EA NA WA	2338

HapMap Linkage Disequilibrium report for SLC7A6 (68298423 - 68335722 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC7A6: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SLC7A6 for disorders           About GeneDecksing

OMIM gene information: 605641    OMIM disorders: --

6 diseases for SLC7A6:    About MalaCards

lysinuric protein intolerance nonspecific interstitial pneumonia colon carcinoma pneumonia

retinitis carcinoma

1 Novoseek disease relationship for SLC7A6 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lysinuric protein intolerance	86.6	1	15756301 (1)

Export disorders for SLC7A6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLC7A6 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with SLC7A6)

Utopia: connect your pdf to the dynamic
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The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine. (PubMed id 10903140)^{1, 2} Broeer A.... Broeer S. (2000)
Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family. (PubMed id 9878049)^{1, 3} Pfeiffer R.... Verrey F. (1999)
Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance. (PubMed id 9829974)^{1, 2} Torrents D.... Palacin M. (1998)
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)^{1, 2} Nagase T....Nomura N. (1996)
A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance. (PubMed id 15756301)^{2, 9} Sperandeo M.P.... Sebastio G. (2005)
Activation of classical protein kinase C decreases transport via systems y+ and y+L. (PubMed id 17329401)^{2, 9} Rotmann A.... Closs E.I. (2007)
Arginine transport through system y(+)L in cultured human fibroblasts: normal phenotype of cells from LPI subjects. (PubMed id 11078698)^{2, 9} Dall'Asta V....Gazzola G.C. (2000)
Androgen receptor and nutrient signaling pathways coor dinate the demand for increased amino acid transport during prostate cancer prog ression. (PubMed id 22007000)¹ Wang Q....Holst J. (2011)
Human metabolic individuality in biomedical and pharma ceutical research. (PubMed id 21886157)¹ Suhre K....Gieger C. (2011)
Amino acid transporter LAT3 is required for podocyte development and function. (PubMed id 19443642)¹ Sekine Y....Yan K. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9057	HGNC: 11064	Ensembl:ENSG00000103064	euGenes: HUgn9057	ECgene: SLC7A6
H-InvDB: SLC7A6

(According to HUGE)
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HUGE: KIAA0245

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SLC7A6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC7A6 gene
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Patent Information for SLC7A6 gene:
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