Aliases for SLC7A6 Gene
- Solute Carrier Family 7 Member 6 2 3 4 5
- Solute Carrier Family 7 (Amino Acid Transporter Light Chain, Y+L System), Member 6 2 3
- Cationic Amino Acid Transporter, Y+ System 3 4
- Y(+)L-Type Amino Acid Transporter 2 3 4
- Y+LAT-2 3 4
- Y+LAT2 3 4
- Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 6 3
External Ids for SLC7A6 Gene
Previous GeneCards Identifiers for SLC7A6 Gene
GeneCards Summary for SLC7A6 Gene
SLC7A6 (Solute Carrier Family 7 Member 6) is a Protein Coding gene. Diseases associated with SLC7A6 include Lysinuric Protein Intolerance. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include amino acid transmembrane transporter activity and L-amino acid transmembrane transporter activity. An important paralog of this gene is SLC7A7.
UniProtKB/Swiss-Prot for SLC7A6 Gene
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.