SLC7A5 Gene
protein-coding GIFtS : 62 GCID: GC16 M087863
solute carrier family 7 (amino acid transporter light chain,...
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Aliasesfor SLC7A5 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Solute Carrier Family 7 (Amino Acid Transporter Light Chain, L System),Member 5 1 2 4F2 Light Chain2 3 MPE161 2 3 5 CD98 Light Chain2 3 LAT11 2 3 HLAT11 D16S469E1 2 5 L-Type Amino Acid Transporter 12 3 CD981 2 Y+ System Cationic Amino Acid Transporter2 3 E161 2 Large Neutral Amino Acids Transporter 12 Integral Membrane Protein E162 3 Large Neutral Amino Acids Transporter Small Subunit 12 Solute Carrier Family 7 Member 52 3 Sodium-Independent Neutral Amino Acid Transporter LAT12 4F2LC2 3 Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 52 4F2 LC2 3 CD98LC3
Export aliases for SLC7A5 gene to outside databases Previous GC identifers: GC16M079198 GC16M088894 GC16M087604 GC16M087645 GC16M086421
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Summariesfor SLC7A5 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: LAT1_HUMAN, Q01650 Function : Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine,leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts Gene Wiki entry for SLC7A5
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Genomic Viewsfor SLC7A5 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000016.9 NC_018927.1 NT_010498.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SLC7A5 gene promoter:NF-1 NF-1/L Pax-5 FOXO3 FOXO3b PPAR-gamma1 CP2 FOXO3a PPAR-gamma2 Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for SLC7A5 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16q24.3 Ensembl cytogenetic band: 16q24.2 HGNC cytogenetic band: 16q24.3 SLC7A5 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16M087863: view genomic region
(about GC identifiers )
Start: 87,863,629 bp from pter End:
87,903,100 bp from pter
Size: 39,472 bases Orientation:
minus strand
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Proteinsfor SLC7A5 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: LAT1_HUMAN, Q01650 See
protein sequence )Recommended Name: Size : 507 amino acids; 55010 DaSubunit : Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hcSubcellular location : Cytoplasm, cytosol. Apical cell membrane; Multi-pass membrane protein. Note=Located to the plasmamembrane by SLC3A2/4F2hc. Localized to the apical membrane of placental syncytiophoblastic cells. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity)
Miscellaneous : The uptake of leucine, tyrosine and tryptophan is inhibited by the different iodothyronines, inparticular T3. Leucine transport is also inhibited by small zwitterionic amino acids (i.e. glycine, alanine, serine, threonine and cysteine) and by glutamine and asparginine. The uptake of T3 is almost completely blocked by coincubation with leucine, tryptophan, tyrosine, and phenylalanine, or 2-amino-bicyclo-(2,2,1)-heptane-2-carboxylate (BCH). Methionine uptake was inhibited by the L-system substrates L-leucine, BCH, L-cysteine and by the MeHg-L-cysteine complex and structurally related S-ethyl-L-cysteine. MeHg-L-cysteine uptake is inhibited by L-methionine, L-leucine, BCH and S-ethyl-L-cysteine. L-leucine uptake was inhibited by L-CNSO. Tyrosine uptake in fibroblasts was inhibited by D-methionine, and methyl-aminoisobutyric acid (MeAIB)
Secondary accessions : Q9UBN8 Q9UP15 Q9UQC0Explore the universe of human proteins at neXtProt for SLC7A5: NX_Q01650 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q01650 SLC7A5 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_003477.4 ENSEMBL proteins: ENSP00000454323 ENSP00000261622 Reactome Protein details: Q01650 Human Recombinant Protein Products for SLC7A5: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing SLC7A5 Antibody Products: Assay Products for SLC7A5:
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Protein
Domains /for SLC7A5 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q01650 ProtoNet protein and cluster: Q01650
UniProtKB/Swiss-Prot: LAT1_HUMAN, Q01650 Similarity : Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC2.A.3.8) family
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Functionfor SLC7A5 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: LAT1_HUMAN, Q01650 Function : Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine,leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts Biophysicochemical properties : Kinetic parameters: KM=7.9 uM for T4 (in the presence of choline chloride); KM=0.8 uMfor T3 (in the presence of choline chloride); KM=12.5 uM for reverse triiodothyronine (rT3) (in the presence of choline chloride); KM=7.9 uM for 3,3'-diiodothyronine (in the presence of choline chloride); KM=46 uM for leucine (in the presence of choline chloride); KM=19 uM for tryptophan (in the presence of choline chloride); KM=32 uM for L-leucine; KM=10 mM for L-alanine; KM=2.2 mM for L-glutamine; KM=35 uM for L-histidine; KM=740 uM for L-phenylalanine; KM=98 uM for MeHg-L-cysteine; KM=99 uM for methionine; KM=55.2 uM for phenylalanine (in T24 human bladder carcinoma cells); KM=60.4 uM for tyrosine (in T24 human bladder carcinoma cells); KM=16.4 uM for tyrosine (in human fibroblasts); KM=138 uM for Dopa (in T24 human bladder carcinoma cells); KM=96.5 uM for 3-O-methyldopa (in T24 human bladder carcinoma cells); KM=153 uM for alpha-methyltyrosine (in T24 human bladder carcinoma cells); KM=216 uM for alpha-methyldopa (in T24 human bladder carcinoma cells); KM=191 uM for gabapentin (in T24 human bladder carcinoma cells); KM=7.3 uM for triiodothyronine (in T24 human bladder carcinoma cells); KM=162 uM for thyroxine (in T24 human bladder carcinoma cells); KM=75.3 uM for melphanan (in T24 human bladder carcinoma cells); KM=156 uM for BCH (in T24 human bladder carcinoma cells); Induction : Expression induced in quiescent peripheral blood lymphocytes after treatment with phorbol myristate acetate(PMA) and phytohemagglutinin (PHA). Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore
Genatlas biochemistry entry for SLC7A5 solute carrier family 7,member 5,40kDa,human cell surface glycoprotein 4F2 light chain,heterodimerizing with the cell surface glycoprotein 4F2 heavy chain (CD98) to form a complex mediating L-type (sodium independent exchange) of large neutral amino acids transport,not expressed in the intestine Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0015171 amino acid transmembrane transporter activity
ISS -- GO:0015175 neutral amino acid transmembrane transporter activity
TAS 9751058 GO:0015179 L-amino acid transmembrane transporter activity
IEA -- GO:0042605 peptide antigen binding
ISS --
About GeneDecksing Phenotypes: 3 GenomeRNAi human phenotypes for SLC7A5 :1 MGI mutant phenotype (inferred from 1 allele(MGI details for Slc7a5) :About GeneDecksing Animal Models: Slc7a5 tm1Lex for SLC7A5Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SLC7A5 (NM_003486 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC7A5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC7A5
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A5
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Pathways & Interactionsfor SLC7A5 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/6 super-pathways (see all 6 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Amino acid and oligopeptide SLC transporters 2 SLC-mediated transmembrane transport 3 Glucose / Energy Metabolism 4 Basigin interactions 5 Cell surface interactions at the vascular wall
Pathway sources See GeneCards unified pathways Show all pathways 1 5/8 (see all 8 )About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC7A5 STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)5/8 Interacting proteins for SLC7A5 (Q01650 3 ENSP00000261622 4 via UniProtKB, MINT, STRING , and/or I2D (see all 8 )About this table Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12 ): About this table
About GeneDecksing
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Drugs & Compoundsfor SLC7A5 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for SLC7A5 2 HMDB Compounds for SLC7A5 About this table 10/17 Novoseek chemical compound relationships for SLC7A5 gene (see all 17 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
2-aminobicyclo(2,2,1)heptane-2-carboxylic acid
93.8
3
12933350 (1), 18382329 (1)
l-amino acid
72.6
17
11278397 (2), 19244126 (2), 10673541 (1), 12009310 (1) (see all 7 )
leucine
68.8
21
14977877 (2), 11557028 (2), 19890975 (2), 15980244 (2) (see all 11 )
phenylalanine
57
11
15589117 (4), 16972176 (1), 11557028 (1), 12614332 (1) (see all 6 )
melphalan
53
8
17558306 (3), 20466543 (2), 11557028 (1), 19075510 (1)
glutamine
35.8
9
11557028 (2), 20061171 (2), 15980244 (1)
l-tryptophan
31.4
2
11230513 (1)
alanine
30.2
9
18262359 (2), 20061171 (2), 11557028 (1), 15980244 (1)
vegf
25.3
19
19171406 (2), 19347882 (2), 19018776 (2), 19141127 (2) (see all 6 )
cysteine
14.2
8
18793329 (2), 16125134 (2), 18294274 (1)
SLC7A5 / LAT1
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Transcriptsfor SLC7A5 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SLC7A5 gene: NM_003486.5 Unigene Cluster for SLC7A5:
Solute carrier family 7 (amino acid transporter light chain, L system), member 5 Hs.513797 [show with all ESTs ] Unigene Representative Sequence: AF104032 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000565644 ENST00000261622 (uc002fkm.3 ) ENST00000563489 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SLC7A5 (NM_003486 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC7A5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC7A5
Additional cDNA sequence: AB017908.1 AB018009.1 AB018542.1 AF077866.1 AF104032.1 BC014177.2 BC039692.2 BC042600.1 BC114608.1 M80244.1
18 DOTS entries : DT.100792298 DT.451978
DT.100792297 DT.95095029 DT.100792301 DT.95095027 DT.97775348 DT.97809808 DT.91953771 DT.92057720 DT.100045046 DT.100792299 DT.120661759 DT.120661809 DT.92028719 DT.120661834 DT.40263744 DT.95095026 24/684 AceView cDNA sequences (see all 684 ):
AA419177 BM727517 BU185312 BQ961900 BU943925 CR601601 BU169263 AA302268 BU182444 AA311292 BQ707760 BG030930 BF766184 BM708328 BQ221168 AI268756 BQ683707 BU195082 CR625513 BQ682351 BE891693 BI333982 BQ279084 BQ711580 GeneLoc Exon Structure
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Expression for SLC7A5 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SLC7A5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCTGCTCCCTAbout this image SLC7A5 expression in embryonic tissues and stem cells About this table
See SLC7A5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SLC7A5 SOURCE GeneReport for Unigene cluster: Hs.513797 UniProtKB/Swiss-Prot: LAT1_HUMAN, Q01650 Tissue specificity : Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis,resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2 SABiosciences Expression via Pathway-Focused PCR Array including SLC7A5 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A5
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Orthologsfor SLC7A5 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for SLC7A5 gene from 6/22 species (see all 22 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves SLC7A51
solute carrier family 7 (amino acid transporter light more
80.21(n) 84.02(a)
415832 NM_001030579.1 NP_001025750.1
African clawed frog Amphibia MGC689752
hypothetical protein MGC68975
77.94(n)
Y12716.1
zebrafish Actinopterygii LOC7972501
novel protein similar to H.sapiens solute carrier family more
72.62(n) 79.76(a)
797250 NM_001128358.1 NP_001121830.1
fruit fly Insecta mnd3 1
amino acid transporter3 1
52(a) 3 59.28(n) 1 52.85(a) 1
34624 1 NM_164988.3 1 NP_723717.2 1
worm Secernentea F27C8.13
integral membrane protein E16 like
48(a)
IV(9599614-9601874) --
E. coli Gamma proteobacteria frlA6
predicted fructoselysine transporter
24(a)
1 → many
Chromosome(3497932-3499269)
ENSEMBL Gene Tree for SLC7A5 (if available)TreeFam Gene Tree for SLC7A5 (if available)
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Paralogsfor SLC7A5 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SLC7A5 gene SLC7A6 2 SLC7A4 2 SLC7A9 2 SLC7A14 2 SLC7A3 2 SLC7A10 2 SLC7A13 2 SLC7A7 2 SLC7A11 2 SLC7A2 2 SLC7A8 2 SLC7A1 2 12 SIMAP similar genes for SLC7A5 using alignment to 3 protein entries: LAT1_HUMAN (see all proteins ):lat1 SLC7A5P1 SLC7A5P2 SLC7A6 SLC7A7 SLC7A8 DKFZp686K14185 SLC7A10 hxCT SLC7A11 SLC7A9 SLC7A13 About GeneDecksing 2 Pseudogenes.org Pseudogenes for SLC7A5 PGOHUM00000259021 PGOHUM00000259042
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Genomic Variantsfor SLC7A5 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 16 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for SLC7A5 (87863629 - 87903100 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for SLC7A5 2 CNVs 4972 72670 Human Gene Mutation Database (HGMD) : SLC7A5 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor SLC7A5 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 600182
OMIM disorders : --20/40 (see all 40 ): About MalaCards lysinuric protein intolerance maple syrup urine disease non-small cell lung carcinoma gingival overgrowth phenylketonuria oral squamous cell carcinoma squamous cell carcinoma cystinuria transitional cell carcinoma tuberous sclerosis thymic carcinoma bladder carcinoma malignant glioma oral cancer neuroendocrine tumor keratoconjunctivitis choriocarcinoma gingivitis carcinoma lung carcinoma 9 Novoseek disease relationships for SLC7A5 gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
lysinuric protein intolerance
67
2
11766986 (1)
phenylketonurias
42.6
4
16972176 (2), 15589117 (1), 16125134 (1)
glioma
41.7
26
18382329 (6), 18095110 (5), 16496379 (3), 11557028 (1) (see all 5 )
carcinoma squamous cell
41.3
17
15906366 (6), 15274339 (2), 16886618 (2), 19635099 (1) (see all 7 )
oral cancer
39.9
4
15274339 (1), 15036654 (1), 15863273 (1)
bladder carcinoma
35.6
3
11557028 (1), 12225859 (1), 17489360 (1)
tumors
33.6
71
18440724 (5), 18382329 (5), 11557028 (3), 17622555 (3) (see all 25 )
cancer
31.7
32
19018776 (3), 18520037 (2), 16886618 (2), 15916903 (2) (see all 14 )
choriocarcinoma
25.8
1
11742812 (1)
Human Genome Epidemiology (HuGE) Navigator: SLC7A5 (4 documents) Export disorders for SLC7A5 gene to outside databases
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Publicationsfor SLC7A5 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SLC7A5 gene, integrated from 9 sources (see all 164 ):(articles sorted by number of sources associating them with SLC7A5) Utopia : connect your pdf to the dynamic
Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. (PubMed id 9751058) 1 , 2 , 3(1998) Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. (PubMed id 11557028) 1 , 2 , 9(2001) L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors. (PubMed id 16496379) 1 , 2 , 9(2006) Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells. (PubMed id 12225859) 1 , 2 , 9(2002) Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols. (PubMed id 15769744) 1 , 2 , 9(2005) Identification and functional characterization of a Na+-independent large neutral amino acid transporter, LAT1, in human and rabbit cornea. (PubMed id 12824232) 1 , 2 , 9(2003) Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains. (PubMed id 11311135) 1 , 2 , 9(2001) Functional characterization of tyrosine transport in fibroblast cells from healthy controls. (PubMed id 18262359) 1 , 2 , 9(2008) Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function. (PubMed id 10049700) 1 , 2 , 9(1999) The gene for membrane protein E16 (D16S469E) maps to human chromosome 16q24.3 and is expressed in human brain, thymus, and retina. (PubMed id 7829099) 1 , 3, 9(1994)
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External Searches for SLC7A5 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SLC7A5 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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(According to HUGE )
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Specialized Databases showing SLC7A5 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for SLC7A5 gene: SLC7A5 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SLC7A5 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
OriGene Antibodies for SLC7A5 OriGene shRNA RFP for SLC7A5 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for SLC7A5 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SLC7A5 OriGene 3'-UTR Clone for SLC7A5 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SLC7A5 OriGene Custom Protein Services for SLC7A5 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC7A5 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for SLC7A5
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A5
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC7A5
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Expression by the Database of Embryonic development, Stem cell research, and
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Anatomical Compartment 
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