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SLC7A4 Gene

protein-coding   GIFtS: 54
GCID: GC22M021383

Solute Carrier Family 7, Member 4

(Previous names: solute carrier family 7 (cationic amino acid transporter,...)
  See SLC7A4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 7, Member 41 2     HCAT32
CAT42 3 5     VH2
Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System),
Member 41 2
     Cationic Amino Acid Transporter 42
Solute Carrier Family 7 (Orphan Transporter), Member 41 2     Ig Heavy Chain Variable Region2
Solute Carrier Family 7 Member 42 3     VH 3 Family2
CAT-42 3     

External Ids:    HGNC: 110621   Entrez Gene: 65452   Ensembl: ENSG000000999607   OMIM: 6037525   UniProtKB: O432463   

Export aliases for SLC7A4 gene to outside databases

Previous GC identifers: GC22M018081 GC22M019707 GC22M004651


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC7A4 Gene:
SLC7A4 (solute carrier family 7, member 4) is a protein-coding gene. Diseases associated with SLC7A4 include b-cell chronic lymphocytic leukemia, and chronic lymphocytic leukemia. GO annotations related to this gene include basic amino acid transmembrane transporter activity. An important paralog of this gene is LOC284379.

UniProtKB/Swiss-Prot: CTR4_HUMAN, O43246
Function: Involved in the transport of the cationic amino acids (arginine, lysine and ornithine)

Gene Wiki entry for SLC7A4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC7A4 gene promoter:
         ER-alpha   AP-2gamma   HNF-1A   HEN1   POU2F1   POU2F1a   HSF2   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC7A4 promoter sequence
   Search Chromatin IP Primers for SLC7A4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC7A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

SLC7A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC7A4 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M021383:  view genomic region     (about GC identifiers)

Start:
21,383,007 bp from pter      End:
21,387,129 bp from pter
Size:
4,123 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTR4_HUMAN, O43246 (See protein sequence)
Recommended Name: Cationic amino acid transporter 4  
Size: 635 amino acids; 68268 Da
Secondary accessions: Q0P5U2 Q3KNQ6 Q4VC45 Q6IBY8 Q96H88

Explore the universe of human proteins at neXtProt for SLC7A4: NX_O43246

Explore proteomics data for SLC7A4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn151, Asn195, Asn221, Asn500, Asn601
  • Modification sites at PhosphoSitePlus

  • See SLC7A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004164.2  
    ENSEMBL proteins: 
     ENSP00000384278   ENSP00000372390   ENSP00000408727  

    SLC7A4 Human Recombinant Protein Products:

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    Novus Biologicals SLC7A4 Protein
    Novus Biologicals SLC7A4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC7A4 

    SLC7A4 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for SLC7A4

    SLC7A4 Assay Products:

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    Search eBioscience for ELISAs for SLC7A4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Cationic amino acid transporter 4
    SLC7 family

    1 InterPro protein domain:
     IPR002293 AA/rel_permease1

    Graphical View of Domain Structure for InterPro Entry O43246

    ProtoNet protein and cluster: O43246

    UniProtKB/Swiss-Prot: CTR4_HUMAN, O43246
    Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter
    (CAT) (TC 2.A.3.3) family


    Find genes that share domains with SLC7A4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTR4_HUMAN, O43246
    Function: Involved in the transport of the cationic amino acids (arginine, lysine and ornithine)

         Genatlas biochemistry entry for SLC7A4:
    solute carrier family 7,member A4,high affinity sodium independent,cationic amino-acid transporter,y+ type

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015171amino acid transmembrane transporter activity ----
    GO:0015174basic amino acid transmembrane transporter activity TAS9598310
         
    Find genes that share ontologies with SLC7A4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC7A4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC7A4
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    miRNA
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    Block miRNA regulation of human, mouse, rat SLC7A4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SLC7A4:
    hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidSLC7A4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC7A4
    Predesigned siRNA for gene silencing in human, mouse, rat SLC7A4

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SLC7A4 (NM_004173)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTR4_HUMAN, O43246: Membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum1
    extracellular1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC7A4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC7A4
    Interactions:

        Search GeneGlobe Interaction Network for SLC7A4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for SLC7A4 (O432463 ENSP000003723904) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAR1BQ9Y6B63I2D: score=1 
    SEC23AQ154363I2D: score=1 
    OTCENSP000000390074STRING: ENSP00000039007
    CLN3ENSP000003530734STRING: ENSP00000353073
    ASLENSP000003071884STRING: ENSP00000307188
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003333amino acid transmembrane transport ----
    GO:0006520cellular amino acid metabolic process TAS9598310
    GO:0006810transport TAS9598310
    GO:0015802basic amino acid transport TAS9598310
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with SLC7A4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC7A4 (CTR4)

    3 DrugBank Compounds for SLC7A4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Lysine(S)-2,6-diaminohexanoic acid (see all 6)56-87-1target--17139284 17016423 15746185
    L-Ornithine(S)-2,5-Diaminopentanoate (see all 4)70-26-8target--17139284 17016423
    L-Arginine(S)-2-Amino-5-guanidinovaleric acid (see all 4)74-79-3target--17329401



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC7A4 gene: 
    NM_004173.2  

    Unigene Cluster for SLC7A4:

    Solute carrier family 7 (orphan transporter), member 4
    Hs.197116  [show with all ESTs]
    Unigene Representative Sequence: BC062565
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403586 ENST00000382932(uc002zud.3 uc002zue.3) ENST00000426145

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC7A4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SLC7A4:
    hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidSLC7A4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC7A4
    Predesigned siRNA for gene silencing in human, mouse, rat SLC7A4
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    GenScript: all cDNA clones in your preferred vector: SLC7A4 (NM_004173)
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    Primer
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    OriGene qPCR primer pairs and template standards for SLC7A4
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC7A4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC7A4
      QuantiTect SYBR Green Assays in human, mouse, rat SLC7A4
      QuantiFast Probe-based Assays in human, mouse, rat SLC7A4

    Additional mRNA sequence: 

    AJ000730.1 BC008814.2 BC062565.1 BC107160.1 BC107161.1 CR456580.1 

    5 DOTS entries:

    DT.204083  DT.75101186  DT.100008827  DT.91680576  DT.91841464 

    Selected AceView cDNA sequences (see all 46):

    BU751855 BC008814 BC062565 BF057801 AI990519 NM_004173 BG704842 CR456580 
    BX279813 BE208542 N31854 BU751854 BI918999 AI341590 BE732966 AA324265 
    AW172291 AJ000730 CD385180 AA604864 AW275082 AI969785 AW197462 AW057532 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC7A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCCTGCTG
    SLC7A4 Expression
    About this image


    SLC7A4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Brain (Nervous System)
             Mature Choroid Plexus Cells Choroid Plexus
     
     Testis (Reproductive System)
    SLC7A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC7A4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.197116
        Custom PCR Arrays for SLC7A4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC7A4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc7a41 , 5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 4 less1, 5 81.63(n)1
    81.42(a)1
      16 (10.89 cM)5
    2240221  NM_144852.31  NP_659101.21 
     175720185 
    chicken
    (Gallus gallus)
    Aves SLC7A41 solute carrier family 7 (orphan transporter), member 4 less 73.11(n)
    71.95(a)
      427062  XM_424658.4  XP_424658.4 
    lizard
    (Anolis carolinensis)
    Reptilia SLC7A46
    solute carrier family 7, member 4
    64(a)
    1 ↔ 1
    GL343417.1(785376-794908)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc7a41 solute carrier family 7, member 4 67.58(n)
    76.76(a)
      780281  NM_001079352.2  NP_001072820.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc7a42 solute carrier family 7 (cationic amino acid transporter, y+ system), member 4 less 74.55(n)   378481  NM_194427.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG132481 , 3 cationic amino acid transporter3
    CG132481
    41(a)3
    54.38(n)1
    45.16(a)1
      402541  NM_140962.21  NP_649219.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C50D2.23 amino acid permease 40(a)
    (best of 3)
      II(109203-111230)   --


    ENSEMBL Gene Tree for SLC7A4 (if available)
    TreeFam Gene Tree for SLC7A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC7A4 gene
    LOC2843792  SLC7A22  SLC7A12  SLC7A142  SLC7A32  
    4 SIMAP similar genes for SLC7A4 using alignment to 2 protein entries:     CTR4_HUMAN (see all proteins):
    SLC7A1    SLC7A2    SLC7A3    SLC7A14

    Find genes that share paralogs with SLC7A4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC7A4 (see all 229)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs8808811,2
    C--21382864(+) AGGCCC/TACCTG 1 -- int12Minor allele frequency- T:0.28NA 122
    rs8808821,2
    C,F,A,H--21382896(+) CCAGGC/ACTGGC 1 -- int115Minor allele frequency- A:0.42MN NS EA WA NA CSA 2638
    rs1483299671,2
    --21382992(+) ACAAAC/GAATGC 1 -- int10--------
    rs1839787911,2
    --21383080(+) ATCCAC/TCCCAC 1 -- ut310--------
    rs20752781,2
    C,F,A,H--21383282(+) CGGCTT/CGTCTG 1 -- ut31 ese314Minor allele frequency- C:0.31NS EA NA WA CSA 918
    rs20752791,2
    C,F--21383312(+) CAGGTG/ATGGGA 1 -- ut31 ese39Minor allele frequency- A:0.45EA MN WA CSA NA 1670
    rs2002338411,2
    --21383322(+) AGGGCA/GGGGCA 1 -- ut310--------
    rs1408094961,2
    C--21383341(+) CTGATC/TAGCTA 1 -- ut310--------
    rs1996535791,2
    C--21383420(+) GGCTGC/TCCCTG 2 D G mis10--------
    rs557003501,2,,4
    C,F--21383429(+) TGGGGA/TATACC 2 Y F mis11Minor allele frequency- T:0.00NA 4546

    HapMap Linkage Disequilibrium report for SLC7A4 (21383007 - 21387129 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC7A4 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678175CNV Deletion23128226
    nsv436864CNV Insertion17901297
    nsv834141CNV Loss17160897
    nsv3563CNV Loss18451855
    nsv523162CNV Loss19592680
    nsv828960CNV Loss20364138
    nsv471185CNV Loss18288195
    nsv914423CNV Gain21882294
    nsv914429CNV Gain21882294
    nsv834142CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC7A4
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC7A4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603752    OMIM disorders: --

    2 diseases for SLC7A4:    
    About MalaCards
    b-cell chronic lymphocytic leukemia    chronic lymphocytic leukemia


    Find genes that share disorders with SLC7A4           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: SLC7A4 (3 documents)

    Export disorders for SLC7A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC7A4 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with SLC7A4)
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    1. The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome. (PubMed id 9598310)1, 2, 3, 9 Sperandeo M.P.... Sebastio G. (Genomics 1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    4. Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4. (PubMed id 11665818)1, 3 Hammermann R....RackAc K. (Amino Acids 2001)
    5. Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia. (PubMed id 20685009)1 Proitsi P....Powell J.F. (Neurobiol. Aging 2012)
    6. Influence of serotonin transporter gene polymorphisms on clozapine response in Brazilian schizophrenics. (PubMed id 20452607)1 Kohlrausch F.B....Hutz M.H. (J Psychiatr Res 2010)
    7. The role of clinical variables, neuropsychological performance and SLC6A4 and COMT gene polymorphisms on the prediction of early response to fluoxetine in major depressive disorder. (PubMed id 20584552)1 Gudayol-FerrAc E....GuA rdia-Olmos J. (J Affect Disord 2010)
    8. Characterization of de novo diffuse large B-cell lymphoma with a translocation of c-myc and immunoglobulin genes. (PubMed id 18460403)1 Kikuchi A....Ando K. (Leuk. Res. 2008)
    9. Activation of classical protein kinase C decreases transport via systems y+ and y+L. (PubMed id 17329401)7 Rotmann A.... Closs E.I. (Am. J. Physiol. 2007)
    10. Comparative analysis of ZAP-70 expression and Ig VH mutational status in B-cell chronic lymphocytic leukemia. (PubMed id 17051526)1 MuA+oz L....NomdedAcu J.F. (Cytometry B Clin Cytom 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6545 HGNC: 11062 AceView: SLC7A4 Ensembl:ENSG00000099960 euGenes: HUgn6545
    ECgene: SLC7A4 H-InvDB: SLC7A4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC7A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC7A4 gene:
    Search GeneIP for patents involving SLC7A4

    GeneCards and IP:
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