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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC7A3 Gene

protein-coding GIFtS: 56
GCID: GC0XM070145

solute carrier family 7 (cationic amino acid transporter,...

Explore 6 diseases affiliated with
SLC7A3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 3¹ ²		FLJ14541¹
ATRC3¹ ² ³		Cationic Amino Acid Transporter 3²
CAT-3¹ ² ³		Cationic Amino Acid Transporter Y+³
CAT3² ³		Solute Carrier Family 7 Member 3³

External Ids:	HGNC: 11061¹	Entrez Gene: 84889²	Ensembl: ENSG00000165349⁷	OMIM: 300443⁵	UniProtKB: Q8WY07³

Export aliases for SLC7A3 gene to outside databases

Previous GC identifers: GC0XM066323 GC0XM067622 GC0XM068378 GC0XM069012 GC0XM069928 GC0XM070062 GC0XM063965

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC7A3:

This gene encodes a member of the solute carrier family 7. The encoded protein is a sodium-independent cationic amino

acid transporter. Alternate splicing results in multiple transcripts that encoded the same protein.(provided by

RefSeq, May 2010)

UniProtKB/Swiss-Prot: CTR3_HUMAN, Q8WY07

Function: Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner

Gene Wiki entry for SLC7A3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011669.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC7A3 gene promoter:
Max1 RFX1 AML1a FOXD3 AREB6 POU2F1 FOXC1 POU2F1a FOXJ2 (long isoform) c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC7A3 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC7A3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC7A3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq12

SLC7A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC7A3 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM070145: view genomic region (about GC identifiers)

Start:	70,145,429 bp from pter	End:	70,150,975 bp from pter
Size:	5,547 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CTR3_HUMAN, Q8WY07 (See protein sequence)

Recommended Name: Cationic amino acid transporter 3

Size: 619 amino acids; 67169 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Sequence caution: Sequence=BAB55118.1; Type=Erroneous initiation;

Secondary accessions: D3DVU7 Q5JQR2 Q8N185 Q8NCA7 Q96SZ7

Explore the universe of human proteins at neXtProt for SLC7A3: NX_Q8WY07

Post-translational modifications:

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WY07

SLC7A3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001041629.1 NP_116192.4

ENSEMBL proteins:

ENSP00000363417 ENSP00000298085

Reactome Protein details: Q8WY07
Human Recombinant Protein Products for SLC7A3:

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	Novus Biologicals SLC7A3 Lysates
	Browse Sino Biological Recombinant Proteins
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	Uscn Proteins for SLC7A3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

SLC7A3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SLC7A3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC7A3 for domains About GeneDecksing

3 InterPro domains/families:

IPR004755 Cat_AA_permease

IPR015606 Cat-AATrans

IPR002293 AA/rel_permease1

Graphical View of Domain Structure for InterPro Entry Q8WY07

ProtoNet protein and cluster: Q8WY07

UniProtKB/Swiss-Prot: CTR3_HUMAN, Q8WY07

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT)

(TC 2.A.3.3) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CTR3_HUMAN, Q8WY07

Function: Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000064	L-ornithine transmembrane transporter activity	--	--
GO:0015181	arginine transmembrane transporter activity	IEA	--
GO:0015189	L-lysine transmembrane transporter activity	IEA	--
GO:0015326	cationic amino acid transmembrane transporter activity	IEA	--

SLC7A3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SLC7A3:

Synthetic lethal with Ras

1 MGI phenotypic allele

for Slc7a3 (no phenotypes)

SLC7A3 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC7A3

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC7A3
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		hsa-miR-136 hsa-miR-885-5p
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Amino acid and oligopeptide SLC transporters

	Amino acid and oligopeptide SLC transporters	1.00			Transport of inorganic cations/anions and amino acids/oligopeptides	0.52
	Amino acid transport across the plasma membrane	0.63

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for SLC7A3

	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Amino acid and oligopeptide SLC transporters
	Amino acid transport across the plasma membrane
	Transport of inorganic cations/anions and amino acids/oligopeptides

SLC7A3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC7A3

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for SLC7A3 (ENSP00000298085⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SIRT1	ENSP00000212015⁴	STRING: ENSP00000212015

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	TAS	--
GO:0006865	amino acid transport	TAS	--
GO:0015809	arginine transport	--	--
GO:0015819	lysine transport	--	--
GO:0015822	ornithine transport	--	--

SLC7A3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC7A3

1 HMDB Compound for SLC7A3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Sodium	Sodium (see all 2)	7440-23-5	--

3 DrugBank Compounds for SLC7A3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Lysine	(S)-2,6-diaminohexanoic acid (see all 6)	56-87-1	target	--	9079705 17139284 17016423 16406639
L-Ornithine	(S)-2,5-Diaminopentanoate (see all 4)	70-26-8	target	--	9079705 17139284 17016423
L-Arginine	(S)-2-Amino-5-guanidinovaleric acid (see all 4)	74-79-3	target	--	17329401 17234578

Search CenterWatch for drugs/clinical trials and news about SLC7A3 / CTR3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC7A3 gene (2 alternative transcripts):

NM_001048164.2 NM_032803.5

Unigene Cluster for SLC7A3:

Solute carrier family 7 (cationic amino acid transporter, y+ system), member 3

Hs.175220 [show with all ESTs]

Unigene Representative Sequence: NM_032803

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000374299(uc004dyn.3) ENST00000298085(uc004dyo.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC7A3
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC7A3:
		hsa-miR-136 hsa-miR-885-5p
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC7A3

Additional cDNA sequence:

AF320612.1 AK027447.1 AK074865.1 AK075014.1 BC033816.1

4 DOTS entries:

DT.100019061 DT.104128 DT.121317508 DT.121317516

24/32 AceView cDNA sequences (see all 32):

BX089821 AF320612 AK075014 AW134952 CR601875 AI656849 BX393864 AK074865

BC033816 BP362211 AI963203 AI962329 AA205485 BE562324 AA232266 BX349355

BX374615 BM544911 BE396977 BM907132 NM_032803 BX385441 BI766806 AK027447

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A3 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13
SP1:					-						-								-						-
SP2:											-								-						-
SP3:																			-						-				-
SP4:
SP5:

ECgene alternative splicing isoforms for SLC7A3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC7A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCATTCCTCT

About this image

SLC7A3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)

Matrigel embedded cells (Derivation of cardio...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC7A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC7A3

SOURCE GeneReport for Unigene cluster: Hs.175220

UniProtKB/Swiss-Prot: CTR3_HUMAN, Q8WY07

Tissue specificity: Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland,

prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala

SABiosciences Custom PCR Arrays for SLC7A3

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SLC7A3 gene from 8/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC7A3¹	solute carrier family 7 (cationic amino acid transporter, more	65.4(n) 66(a)		422213 XM_420204.3 XP_420204.3
lizard (Anolis carolinensis)	Reptilia	SLC7A3⁶	--	64(a)	1 ↔ 1	GL343758.1(116204-129238)
African clawed frog (Xenopus laevis)	Amphibia	slc7a3-prov²	solute carrier family 7 (cationic amino acid transporter, more	74.9(n)		BC042222.1
zebrafish (Danio rerio)	Actinopterygii	slc7a3a¹	solute carrier family 7 (cationic amino acid transporter, more	65.58(n) 69.42(a)		492363 NM_001007329.2 NP_001007330.2
fruit fly (Drosophila melanogaster)	Insecta	CG11128³ slif¹	cationic amino acid transporter³ slimfast¹	48(a) (best of 4)³ 56.24(n)¹ 51.18(a)¹		80B2³ 40510¹ NM_141171.2¹ NP_649428.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	CAT2⁶ CAT3⁶ (see all 9)	cationic amino acid transporter 3 (see all 9)	31(a) 31(a) (see all 9)	many ↔ many many ↔ many (see all 9)	1(21464001-21468420) 5(14590166-14594384)
rice (Oryza sativa)	Liliopsida	-- -- (see all 11)	amino acid permease, putative, expressed (see all 11)	32(a) 31(a) (see all 11)	many ↔ many many ↔ many (see all 11)	12(26587454-26592524) 10(15558083-15564670)
E. coli (Escherichia coli)	Gamma proteobacteria	puuP⁶ plaP⁶ (see all 3)	putrescine importer, low affinity (see all 3)	20(a) 18(a) (see all 3)	possible ortholog possible ortholog (see all 3)	Chromosome(1355826-1357211) Chromosome(2083728-2085086)

ENSEMBL Gene Tree for SLC7A3 (if available)
TreeFam Gene Tree for SLC7A3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC7A3 gene

SLC7A6² SLC7A4² SLC7A9² SLC7A14² SLC7A10² SLC7A13² SLC7A7² SLC7A11²

SLC7A2² SLC7A8² SLC7A1² SLC7A5²

4 SIMAP similar genes for SLC7A3 using alignment to 1 protein entry: CTR3_HUMAN:

SLC7A1 SLC7A2 SLC7A4 SLC7A14

SLC7A3 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for SLC7A3
PGOHUM00000234417 PGOHUM00000234418

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191508915^1,2		--	70145020(+)	`AACACA/CGCAGC`	2	--	ds500¹		0	--	--	--	--
rs73552428^1,2	C	--	70145021(+)	`ACACCA/GCAGCC`	2	--	ds500¹		2		WA CSA	3
rs144716155^1,2		--	70145107(+)	`TTTCAC/GTGTAG`	2	--	ds500¹		0	--	--	--	--
rs182532299^1,2		--	70145251(+)	`TGACTA/GGACTG`	2	--	ds500¹		0	--	--	--	--
rs72628882^1,2	C	--	70145277(+)	`ACACCA/TCCCTC`	2	--	ds500¹		0	--	--	--	--
rs188253454^1,2		--	70145562(+)	`ATTAGC/TATCCA`	2	--	ut3¹		0	--	--	--	--
rs193167949^1,2		--	70145585(+)	`CAGGGA/GAGGGC`	2	--	ut3¹		0	--	--	--	--
rs147665669^1,2	C,F	--	70145724(+)	`ACTTGC/TGTGAG`	4	H R	mis¹		1		NA	4550
rs138954830^1,2	C	--	70145725(+)	`CTTGCG/ATGAGG`	4	/R /C	mis¹		1		NA	4550
rs185505099^1,2	C	--	70145739(+)	`GGTTAC/GTCTTA`	4	T S	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC7A3 (70145429 - 70150975 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC7A3
1 CNV: 7797
Locus Specific Mutation Databases (LSDB): SLC7A3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SLC7A3 for disorders           About GeneDecksing

OMIM gene information: 300443    OMIM disorders: --

6 diseases for SLC7A3:    About MalaCards

allan-herndon-dudley syndrome pneumonia tuberculosis prostatitis

neuronitis mycobacterium tuberculosis

1 disease from the University of Copenhagen DISEASES database for SLC7A3:

Allan-Herndon-Dudley syndrome

Export disorders for SLC7A3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC7A3 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with SLC7A3)

Utopia: connect your pdf to the dynamic
world of online information

Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues. (PubMed id 11591158)^{1, 2, 3} Vekony N.... Closs E.I. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Activation of classical protein kinase C decreases transport via systems y+ and y+L. (PubMed id 17329401)^{7, 9} Rotmann A.... Closs E.I. (2007)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)² Varela I....Futreal P.A. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Amino acid transport across mammalian intestinal and renal epithelia. (PubMed id 18195088)¹ BrAPer S. (2008)
The cationic amino acid transporters CAT1 and CAT3 me diate NMDA receptor activation-dependent changes in elaboration of neuronal pro cesses via the mammalian target of rapamycin mTOR pathway. (PubMed id 17234578)⁷ Huang Y....Snyder S.H. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84889	HGNC: 11061	AceView: SLC7A3	Ensembl:ENSG00000165349	euGenes: HUgn84889
ECgene: SLC7A3	H-InvDB: SLC7A3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC7A3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC7A3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC7A3 gene:
Search GeneIP for patents involving SLC7A3

GeneCards and IP:
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