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SLC7A3 Gene

protein-coding   GIFtS: 56
GCID: GC0XM070145

Solute Carrier Family 7 (Cationic Amino Acid Transporter,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System),
Member 31 2
     Cationic Amino Acid Transporter 32
CAT32 3 5     Cationic Amino Acid Transporter Y+3
ATRC32 3     Solute Carrier Family 7 Member 33
CAT-32 3     

External Ids:    HGNC: 110611   Entrez Gene: 848892   Ensembl: ENSG000001653497   OMIM: 3004435   UniProtKB: Q8WY073   

Export aliases for SLC7A3 gene to outside databases

Previous GC identifers: GC0XM066323 GC0XM067622 GC0XM068378 GC0XM069012 GC0XM069928 GC0XM070062 GC0XM063965


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC7A3 Gene:
This gene encodes a member of the solute carrier family 7. The encoded protein is a sodium-independent cationic
amino acid transporter. Alternate splicing results in multiple transcripts that encoded the same
protein.(provided by RefSeq, May 2010)

GeneCards Summary for SLC7A3 Gene:
SLC7A3 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 3) is a protein-coding gene. Diseases associated with SLC7A3 include allan-herndon-dudley syndrome, and pneumonia. GO annotations related to this gene include arginine transmembrane transporter activity and cationic amino acid transmembrane transporter activity. An important paralog of this gene is LOC284379.

UniProtKB/Swiss-Prot: CTR3_HUMAN, Q8WY07
Function: Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent
manner

Gene Wiki entry for SLC7A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC7A3 gene promoter:
         Max1   RFX1   AML1a   FOXD3   AREB6   POU2F1   FOXC1   POU2F1a   FOXJ2 (long isoform)   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC7A3 promoter sequence
   Search Chromatin IP Primers for SLC7A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC7A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq12

SLC7A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC7A3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM070145:  view genomic region     (about GC identifiers)

Start:
70,145,429 bp from pter      End:
70,150,975 bp from pter
Size:
5,547 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTR3_HUMAN, Q8WY07 (See protein sequence)
Recommended Name: Cationic amino acid transporter 3  
Size: 619 amino acids; 67169 Da
Sequence caution: Sequence=BAB55118.1; Type=Erroneous initiation;
Secondary accessions: D3DVU7 Q5JQR2 Q8N185 Q8NCA7 Q96SZ7

Explore the universe of human proteins at neXtProt for SLC7A3: NX_Q8WY07

Explore proteomics data for SLC7A3 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn232
  • Modification sites at PhosphoSitePlus

  • See SLC7A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001041629.1  NP_116192.4  

    ENSEMBL proteins: 
     ENSP00000363417   ENSP00000298085  
    Reactome Protein details: Q8WY07

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    Browse Proteins at Cloud-Clone Corp.

    SLC7A3 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Cationic amino acid transporter 3
    SLC7 family

    2 InterPro protein domains:
     IPR004755 Cat_AA_permease
     IPR002293 AA/rel_permease1

    Graphical View of Domain Structure for InterPro Entry Q8WY07

    ProtoNet protein and cluster: Q8WY07

    UniProtKB/Swiss-Prot: CTR3_HUMAN, Q8WY07
    Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter
    (CAT) (TC 2.A.3.3) family


    SLC7A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTR3_HUMAN, Q8WY07
    Function: Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent
    manner

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015171amino acid transmembrane transporter activity ----
    GO:0015181arginine transmembrane transporter activity IEA--
    GO:0015189L-lysine transmembrane transporter activity IEA--
    GO:0015326cationic amino acid transmembrane transporter activity IEA--
         
    SLC7A3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC7A3:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Slc7a3 (no phenotypes)

    SLC7A3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC7A3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC7A3
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    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SLC7A3:
    hsa-miR-136 hsa-miR-885-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC7A3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTR3_HUMAN, Q8WY07: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    SLC7A3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC7A3 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Amino acid transport across the plasma membrane0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC7A3
        Amino acid transport across the plasma membrane



    SLC7A3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC7A3
    Interactions:

        Search GeneGlobe Interaction Network for SLC7A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for SLC7A3 (ENSP000002980854) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRT1ENSP000002120154STRING: ENSP00000212015
    OTCENSP000000390074STRING: ENSP00000039007
    CLN3ENSP000003530734STRING: ENSP00000353073
    ASLENSP000003071884STRING: ENSP00000307188
    ASS1ENSP000002530044STRING: ENSP00000253004
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003333amino acid transmembrane transport ----
    GO:0006810transport ----
    GO:0006811ion transport TAS--
    GO:0006865amino acid transport TAS--
    GO:0015809arginine transport ----

    SLC7A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC7A3 (CTR3)

    1 HMDB Compound for SLC7A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    3 DrugBank Compounds for SLC7A3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Lysine(S)-2,6-diaminohexanoic acid (see all 6)56-87-1target--9079705 17139284 17016423 16406639
    L-Ornithine(S)-2,5-Diaminopentanoate (see all 4)70-26-8target--9079705 17139284 17016423
    L-Arginine(S)-2-Amino-5-guanidinovaleric acid (see all 4)74-79-3target--17329401 17234578



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC7A3 gene (2 alternative transcripts): 
    NM_001048164.2  NM_032803.5  

    Unigene Cluster for SLC7A3:

    Solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
    Hs.175220  [show with all ESTs]
    Unigene Representative Sequence: NM_032803
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374299(uc004dyn.3) ENST00000298085(uc004dyo.3)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SLC7A3:
    hsa-miR-136 hsa-miR-885-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC7A3 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC7A3
      QuantiFast Probe-based Assays in human, mouse, rat SLC7A3

    Additional mRNA sequence: 

    AF320612.1 AK027447.1 AK074865.1 AK075014.1 BC033816.1 

    4 DOTS entries:

    DT.100019061  DT.104128  DT.121317508  DT.121317516 

    Selected AceView cDNA sequences (see all 32):

    AW134952 CR601875 BX393864 BX089821 AI656849 AK075014 AK074865 AF320612 
    BX385441 AI963203 BX364256 BX349355 NM_032803 BC033816 AA205485 BX374615 
    BX364257 BG503185 AK027447 AI962329 AA232266 AI436660 BE562324 BM907132 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:              -                 -                       -                 -                                 
    SP2:                                -                       -                 -                                 
    SP3:                                                        -                 -           -                     
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for SLC7A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC7A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCATTCCTCT
    SLC7A3 Expression
    About this image


    SLC7A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
             Inner Cell Mass Cells Inner Cell Mass
             Human embryonic stem cells (family)
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
     
     Ovary (Reproductive System)
             Oviduct
    SLC7A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC7A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.175220

    UniProtKB/Swiss-Prot: CTR3_HUMAN, Q8WY07
    Tissue specificity: Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary
    gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and
    amygdala

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC7A3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc7a31 , 5 solute carrier family 7 (cationic amino acid transporter, more1, 5 83.58(n)1
    82.17(a)1
      X (43.72 cM)5
    119891  NM_007515.21  NP_031541.11 
     1010792105 
    chicken
    (Gallus gallus)
    Aves SLC7A31 solute carrier family 7 (cationic amino acid transporter, more 65.89(n)
    66.28(a)
      422213  XM_420204.4  XP_420204.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    64(a)
    1 → many
    GL343758.1(81749-129256)
    African clawed frog
    (Xenopus laevis)
    Amphibia slc7a3-prov2 solute carrier family 7 (cationic amino acid transporter, more 74.9(n)    BC042222.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc7a3a1 solute carrier family 7 (cationic amino acid transporter, more 65.25(n)
    68.64(a)
      492363  NM_001007329.2  NP_001007330.2 
    rice
    (Oryza sativa)
    Liliopsida Os10g04371001 Os10g0437100 47.36(n)
    38.55(a)
      4348708  NM_001071210.1  NP_001064675.1 


    ENSEMBL Gene Tree for SLC7A3 (if available)
    TreeFam Gene Tree for SLC7A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC7A3 gene
    LOC2843792  SLC7A22  SLC7A42  SLC7A12  SLC7A142  
    4 SIMAP similar genes for SLC7A3 using alignment to 1 protein entry:     CTR3_HUMAN:
    SLC7A1    SLC7A2    SLC7A4    SLC7A14

    SLC7A3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SLC7A3
    PGOHUM00000234417 PGOHUM00000234418


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC7A3 (see all 192)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112915091,2
    C--70149334(+) CAACA-/C/CC  
            
    CCCCC
    2 -- int11CSA 2
    rs39346181,2
    A--70151080(-) GTTGTG/TTGTGT 2 -- us2k10--------
    rs49930781,2
    C--70151082(+) ACACAA/CAACAC 2 -- us2k14Minor allele frequency- C:0.17WA NA CSA 6
    rs2005749491,2
    C--70151082(+) ACACA-/CAACAC 2 -- us2k10--------
    rs1915089151,2
    --70152902(+) AACACA/CGCAGC 2 -- ds50010--------
    rs735524281,2
    C--70152903(+) ACACCA/GCAGCC 2 -- ds50012Minor allele frequency- G:0.33WA CSA 3
    rs1447161551,2
    --70152989(+) TTTCAC/GTGTAG 2 -- ds50010--------
    rs1825322991,2
    --70153133(+) TGACTA/GGACTG 2 -- ds50010--------
    rs726288821,2
    C--70153159(+) ACACCA/TCCCTC 2 -- ds50010--------
    rs1882534541,2
    --70153444(+) ATTAGC/TATCCA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC7A3 (70145429 - 70150975 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC7A3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33082CNV Loss17666407
    nsv510931CNV Complex20534489
    esv1584074OTHER Inversion17803354

    Locus Specific Mutation Databases (LSDB): SLC7A3

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC7A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC7A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 300443    OMIM disorders: --

    8 diseases for SLC7A3:    
    About MalaCards
    allan-herndon-dudley syndrome    pneumonia    tonsillitis    tuberculosis
    neuronitis    prostatitis    leukemia    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for SLC7A3:
    Allan-Herndon-Dudley syndrome

    SLC7A3 for disorders           About GeneDecksing


    Export disorders for SLC7A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC7A3 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with SLC7A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues. (PubMed id 11591158)1, 2, 3 Vekony N.... Closs E.I. (Biochemistry 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Activation of classical protein kinase C decreases transport via systems y+ and y+L. (PubMed id 17329401)7, 9 Rotmann A.... Closs E.I. (Am. J. Physiol. 2007)
    5. Differential topochemistry of three cationic amino acid transporter proteins, hCAT1, hCAT2 and hCAT3, in the adult human brain. (PubMed id 22870827)1 JAoger K....Bernstein H.G. (Amino Acids 2013)
    6. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (Nature 2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. Amino acid transport across mammalian intestinal and renal epithelia. (PubMed id 18195088)1 BrAPer S. (Physiol. Rev. 2008)
    10. The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. (PubMed id 17234578)7 Huang Y....Snyder S.H. (J. Neurosci. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84889 HGNC: 11061 AceView: SLC7A3 Ensembl:ENSG00000165349 euGenes: HUgn84889
    ECgene: SLC7A3 H-InvDB: SLC7A3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC7A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC7A3 gene:
    Search GeneIP for patents involving SLC7A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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