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Aliases for SLC7A3 Gene

Aliases for SLC7A3 Gene

  • Solute Carrier Family 7 Member 3 2 3 4 5
  • Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 3 2 3
  • ATRC3 3 4
  • CAT-3 3 4
  • CAT3 3 4
  • Cationic Amino Acid Transporter Y+ 4
  • Cationic Amino Acid Transporter 3 3

External Ids for SLC7A3 Gene

Previous GeneCards Identifiers for SLC7A3 Gene

  • GC0XM066323
  • GC0XM067622
  • GC0XM068378
  • GC0XM069012
  • GC0XM069928
  • GC0XM070062
  • GC0XM063965
  • GC0XM070145

Summaries for SLC7A3 Gene

Entrez Gene Summary for SLC7A3 Gene

  • This gene encodes a member of the solute carrier family 7. The encoded protein is a sodium-independent cationic amino acid transporter. Alternate splicing results in multiple transcripts that encoded the same protein.[provided by RefSeq, May 2010]

GeneCards Summary for SLC7A3 Gene

SLC7A3 (Solute Carrier Family 7 Member 3) is a Protein Coding gene. Diseases associated with SLC7A3 include Aphakia, Congenital Primary and Chromophobe Adenoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Amino acid transport across the plasma membrane. GO annotations related to this gene include amino acid transmembrane transporter activity and basic amino acid transmembrane transporter activity. An important paralog of this gene is SLC7A1.

UniProtKB/Swiss-Prot for SLC7A3 Gene

  • Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.

Gene Wiki entry for SLC7A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A3 Gene

Genomics for SLC7A3 Gene

Regulatory Elements for SLC7A3 Gene

Enhancers for SLC7A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF070921 0.2 ENCODE 5.6 +9.0 8987 1.3 SPI1 SP7 SLC7A3 TEX11
GH0XF070930 0.6 ENCODE 0.8 +0.1 110 1.4 L3MBTL2 POLR2A SCRT2 CXorf65 SLC7A3 TEX11
GH0XF070922 0.5 ENCODE 0.4 +8.0 7993 0.5 ZNF316 MAFF MAFG EMSY MAFK SLC7A3 TEX11
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC7A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC7A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001917597 225 1400 L3MBTL2 POLR2A SCRT2

Genomic Location for SLC7A3 Gene

Chromosome:
X
Start:
70,925,579 bp from pter
End:
70,931,125 bp from pter
Size:
5,547 bases
Orientation:
Minus strand

Genomic View for SLC7A3 Gene

Genes around SLC7A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC7A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC7A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A3 Gene

Proteins for SLC7A3 Gene

  • Protein details for SLC7A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY07-CTR3_HUMAN
    Recommended name:
    Cationic amino acid transporter 3
    Protein Accession:
    Q8WY07
    Secondary Accessions:
    • D3DVU7
    • Q5JQR2
    • Q8N185
    • Q8NCA7
    • Q96SZ7

    Protein attributes for SLC7A3 Gene

    Size:
    619 amino acids
    Molecular mass:
    67169 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55118.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC7A3 Gene

Post-translational modifications for SLC7A3 Gene

Other Protein References for SLC7A3 Gene

No data available for DME Specific Peptides for SLC7A3 Gene

Domains & Families for SLC7A3 Gene

Gene Families for SLC7A3 Gene

Protein Domains for SLC7A3 Gene

Suggested Antigen Peptide Sequences for SLC7A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WY07

UniProtKB/Swiss-Prot:

CTR3_HUMAN :
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
Family:
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
genes like me logo Genes that share domains with SLC7A3: view

Function for SLC7A3 Gene

Molecular function for SLC7A3 Gene

UniProtKB/Swiss-Prot Function:
Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.

Gene Ontology (GO) - Molecular Function for SLC7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000064 L-ornithine transmembrane transporter activity IBA --
GO:0015171 amino acid transmembrane transporter activity TAS --
GO:0015174 basic amino acid transmembrane transporter activity IEA --
GO:0015181 arginine transmembrane transporter activity IBA --
GO:0015189 L-lysine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC7A3: view
genes like me logo Genes that share phenotypes with SLC7A3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC7A3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC7A3 Gene

Localization for SLC7A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC7A3 Gene COMPARTMENTS Subcellular localization image for SLC7A3 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC7A3: view

Pathways & Interactions for SLC7A3 Gene

genes like me logo Genes that share pathways with SLC7A3: view

Interacting Proteins for SLC7A3 Gene

Gene Ontology (GO) - Biological Process for SLC7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IEA --
GO:0006810 transport IEA --
GO:0006865 amino acid transport TAS --
GO:0015809 arginine transport IEA --
GO:1902475 L-alpha-amino acid transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC7A3: view

No data available for SIGNOR curated interactions for SLC7A3 Gene

Drugs & Compounds for SLC7A3 Gene

(4) Drugs for SLC7A3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Arginine Approved Nutra Full agonist, Agonist, Target 0
L-Lysine Approved Nutra Full agonist, Agonist, Target 0
L-ornithine Approved Nutra Full agonist, Agonist, Target 0
Ornithine Nutra 69

(1) Additional Compounds for SLC7A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC7A3: view

Transcripts for SLC7A3 Gene

mRNA/cDNA for SLC7A3 Gene

Unigene Clusters for SLC7A3 Gene

Solute carrier family 7 (cationic amino acid transporter, y+ system), member 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3: - - -
SP4:
SP5:

Relevant External Links for SLC7A3 Gene

GeneLoc Exon Structure for
SLC7A3
ECgene alternative splicing isoforms for
SLC7A3

Expression for SLC7A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC7A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC7A3 Gene

This gene is overexpressed in Uterus (x9.4), Brain - Hypothalamus (x7.1), and Stomach (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC7A3 Gene



Protein tissue co-expression partners for SLC7A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC7A3 Gene:

SLC7A3

SOURCE GeneReport for Unigene cluster for SLC7A3 Gene:

Hs.175220

mRNA Expression by UniProt/SwissProt for SLC7A3 Gene:

Q8WY07-CTR3_HUMAN
Tissue specificity: Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala.
genes like me logo Genes that share expression patterns with SLC7A3: view

Primer Products

No data available for Protein differential expression in normal tissues for SLC7A3 Gene

Orthologs for SLC7A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC7A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC7A3 34 35
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 89 (a)
OneToMany
SLC7A3 34
  • 88.49 (n)
-- 35
  • 68 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
-- 35
  • 66 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SLC7A3 34 35
  • 88.37 (n)
rat
(Rattus norvegicus)
Mammalia Slc7a3 34
  • 83.87 (n)
mouse
(Mus musculus)
Mammalia Slc7a3 34 16 35
  • 83.58 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 55 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SLC7A3 34
  • 65.89 (n)
-- 35
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10160 34
African clawed frog
(Xenopus laevis)
Amphibia slc7a3-prov 34
zebrafish
(Danio rerio)
Actinopterygii slc7a3a 34 35
  • 65.25 (n)
CT573152.3 35
  • 60 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11128 36
  • 48 (a)
CG7255 36
  • 45 (a)
CG5535 36
  • 44 (a)
CG13248 36
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea C50D2.2 36
  • 39 (a)
B0454.6 36
  • 37 (a)
F23F1.6 36
  • 36 (a)
rice
(Oryza sativa)
Liliopsida Os10g0437100 34
  • 47.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToMany
Species where no ortholog for SLC7A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC7A3 Gene

ENSEMBL:
Gene Tree for SLC7A3 (if available)
TreeFam:
Gene Tree for SLC7A3 (if available)

Paralogs for SLC7A3 Gene

Paralogs for SLC7A3 Gene

(4) SIMAP similar genes for SLC7A3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SLC7A3 Gene

genes like me logo Genes that share paralogs with SLC7A3: view

Variants for SLC7A3 Gene

Sequence variations from dbSNP and Humsavar for SLC7A3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs11291509 -- 70,929,484(+) CAACA(-/C)CCCCC intron-variant
rs113512004 -- 70,927,809(+) GAAAG(A/G)GCACA reference, synonymous-codon
rs12556893 -- 70,932,454(+) TCCTA(A/G)TCCTA upstream-variant-2KB
rs137991585 -- 70,929,641(+) TAGGA(A/G)AGGAT reference, synonymous-codon
rs138547693 -- 70,928,557(+) ACGAA(C/T)CCAAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SLC7A3 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv33082 CNV loss 17666407
nsv510931 OTHER complex 20534489

Variation tolerance for SLC7A3 Gene

Residual Variation Intolerance Score: 48.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.11; 80.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC7A3 Gene

Human Gene Mutation Database (HGMD)
SLC7A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC7A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC7A3 Gene

Disorders for SLC7A3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC7A3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
aphakia, congenital primary
  • congenital aphakia
chromophobe adenoma
  • chromophobe adenoma of the pituitary gland
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC7A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC7A3
genes like me logo Genes that share disorders with SLC7A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC7A3 Gene

Publications for SLC7A3 Gene

  1. Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues. (PMID: 11591158) Vekony N. … Closs E.I. (Biochemistry 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Hypomorphic variants of cationic amino acid transporter 3 in males with autism spectrum disorders. (PMID: 26215737) Nava C. … Depienne C. (Amino Acids 2015) 3 64

Products for SLC7A3 Gene

Sources for SLC7A3 Gene

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