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Aliases for SLC7A3 Gene

Aliases for SLC7A3 Gene

  • Solute Carrier Family 7 Member 3 2 3 4
  • Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 3 2 3 5
  • ATRC3 3 4
  • CAT-3 3 4
  • CAT3 3 4
  • Cationic Amino Acid Transporter Y+ 4

External Ids for SLC7A3 Gene

Previous GeneCards Identifiers for SLC7A3 Gene

  • GC0XM066323
  • GC0XM067622
  • GC0XM068378
  • GC0XM069012
  • GC0XM069928
  • GC0XM070062
  • GC0XM063965
  • GC0XM070145

Summaries for SLC7A3 Gene

Entrez Gene Summary for SLC7A3 Gene

  • This gene encodes a member of the solute carrier family 7. The encoded protein is a sodium-independent cationic amino acid transporter. Alternate splicing results in multiple transcripts that encoded the same protein.[provided by RefSeq, May 2010]

GeneCards Summary for SLC7A3 Gene

SLC7A3 (Solute Carrier Family 7 Member 3) is a Protein Coding gene. Diseases associated with SLC7A3 include congenital aphakia and chromophobe adenoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include amino acid transmembrane transporter activity and basic amino acid transmembrane transporter activity. An important paralog of this gene is SLC7A2.

UniProtKB/Swiss-Prot for SLC7A3 Gene

  • Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.

Gene Wiki entry for SLC7A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A3 Gene

Genomics for SLC7A3 Gene

Regulatory Elements for SLC7A3 Gene

Enhancers for SLC7A3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC7A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC7A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC7A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC7A3 Gene

Chromosome:
X
Start:
70,925,579 bp from pter
End:
70,931,125 bp from pter
Size:
5,547 bases
Orientation:
Minus strand

Genomic View for SLC7A3 Gene

Genes around SLC7A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC7A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC7A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A3 Gene

Proteins for SLC7A3 Gene

  • Protein details for SLC7A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY07-CTR3_HUMAN
    Recommended name:
    Cationic amino acid transporter 3
    Protein Accession:
    Q8WY07
    Secondary Accessions:
    • D3DVU7
    • Q5JQR2
    • Q8N185
    • Q8NCA7
    • Q96SZ7

    Protein attributes for SLC7A3 Gene

    Size:
    619 amino acids
    Molecular mass:
    67169 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55118.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC7A3 Gene

Proteomics data for SLC7A3 Gene at MOPED

Post-translational modifications for SLC7A3 Gene

Other Protein References for SLC7A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC7A3 Gene

Domains & Families for SLC7A3 Gene

Gene Families for SLC7A3 Gene

Protein Domains for SLC7A3 Gene

Suggested Antigen Peptide Sequences for SLC7A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WY07

UniProtKB/Swiss-Prot:

CTR3_HUMAN :
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
Family:
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
genes like me logo Genes that share domains with SLC7A3: view

Function for SLC7A3 Gene

Molecular function for SLC7A3 Gene

UniProtKB/Swiss-Prot Function:
Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.

Phenotypes for SLC7A3 Gene

genes like me logo Genes that share phenotypes with SLC7A3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC7A3

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC7A3 Gene

Localization for SLC7A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC7A3 Gene COMPARTMENTS Subcellular localization image for SLC7A3 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for SLC7A3 Gene

Pathways & Interactions for SLC7A3 Gene

genes like me logo Genes that share pathways with SLC7A3: view

Interacting Proteins for SLC7A3 Gene

Gene Ontology (GO) - Biological Process for SLC7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015822 ornithine transport IEA --
GO:0055085 transmembrane transport TAS --
GO:1903352 L-ornithine transmembrane transport IBA --
GO:1903401 L-lysine transmembrane transport IEA --
GO:1903826 arginine transmembrane transport IEA,IBA --
genes like me logo Genes that share ontologies with SLC7A3: view

No data available for SIGNOR curated interactions for SLC7A3 Gene

Drugs & Compounds for SLC7A3 Gene

(3) Drugs for SLC7A3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ornithine Approved Nutra Full agonist, Agonist, Target 67
L-Arginine Approved Nutra Full agonist, Agonist, Target 0
L-Lysine Approved Nutra Full agonist, Agonist, Target 0

(1) Additional Compounds for SLC7A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC7A3: view

Transcripts for SLC7A3 Gene

mRNA/cDNA for SLC7A3 Gene

Unigene Clusters for SLC7A3 Gene

Solute carrier family 7 (cationic amino acid transporter, y+ system), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3: - - -
SP4:
SP5:

Relevant External Links for SLC7A3 Gene

GeneLoc Exon Structure for
SLC7A3
ECgene alternative splicing isoforms for
SLC7A3

Expression for SLC7A3 Gene

mRNA expression in normal human tissues for SLC7A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC7A3 Gene

This gene is overexpressed in Uterus (x9.4), Brain - Hypothalamus (x7.1), and Stomach (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC7A3 Gene



SOURCE GeneReport for Unigene cluster for SLC7A3 Gene Hs.175220

mRNA Expression by UniProt/SwissProt for SLC7A3 Gene

Q8WY07-CTR3_HUMAN
Tissue specificity: Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala.
genes like me logo Genes that share expression patterns with SLC7A3: view

Protein tissue co-expression partners for SLC7A3 Gene

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues for SLC7A3 Gene

Orthologs for SLC7A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC7A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC7A3 35
  • 88.37 (n)
  • 87.4 (a)
SLC7A3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC7A3 35
  • 88.49 (n)
  • 87.84 (a)
-- 36
  • 67 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slc7a3 35
  • 83.58 (n)
  • 82.17 (a)
Slc7a3 16
Slc7a3 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC7A3 35
  • 99.35 (n)
  • 98.87 (a)
SLC7A3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc7a3 35
  • 83.87 (n)
  • 83.66 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SLC7A3 35
  • 65.89 (n)
  • 66.28 (a)
-- 36
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10160 35
African clawed frog
(Xenopus laevis)
Amphibia slc7a3-prov 35
zebrafish
(Danio rerio)
Actinopterygii slc7a3a 35
  • 65.25 (n)
  • 68.64 (a)
CT573152.3 36
  • 60 (a)
ManyToMany
slc7a3a 36
  • 62 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11128 37
  • 48 (a)
CG13248 37
  • 40 (a)
CG5535 37
  • 44 (a)
CG7255 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea B0454.6 37
  • 37 (a)
C50D2.2 37
  • 39 (a)
F23F1.6 37
  • 36 (a)
rice
(Oryza sativa)
Liliopsida Os10g0437100 35
  • 47.36 (n)
  • 38.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for SLC7A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC7A3 Gene

ENSEMBL:
Gene Tree for SLC7A3 (if available)
TreeFam:
Gene Tree for SLC7A3 (if available)

Paralogs for SLC7A3 Gene

Paralogs for SLC7A3 Gene

(4) SIMAP similar genes for SLC7A3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SLC7A3 Gene

genes like me logo Genes that share paralogs with SLC7A3: view

Variants for SLC7A3 Gene

Sequence variations from dbSNP and Humsavar for SLC7A3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_048154 -
VAR_064754 -
rs747729341 -- 70,925,819(+) CAAAC(C/T)GAGTG reference, synonymous-codon
rs748911893 -- 70,925,165(+) TGCCA(A/C)ACACC downstream-variant-500B
rs749790512 -- 70,925,982(+) TAAAG(G/T)CTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC7A3 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
esv33082 CNV Loss 17666407
nsv510931 CNV Complex 20534489

Variation tolerance for SLC7A3 Gene

Residual Variation Intolerance Score: 48.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.11; 80.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC7A3 Gene

HapMap Linkage Disequilibrium report
SLC7A3
Human Gene Mutation Database (HGMD)
SLC7A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC7A3 Gene

Disorders for SLC7A3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC7A3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
congenital aphakia
  • aphakia, congenital primary
chromophobe adenoma
  • chromophobe adenoma of the pituitary gland
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC7A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC7A3
genes like me logo Genes that share disorders with SLC7A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC7A3 Gene

Publications for SLC7A3 Gene

  1. Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues. (PMID: 11591158) Vekony N. … Closs E.I. (Biochemistry 2001) 2 3 4 67
  2. Activation of classical protein kinase C decreases transport via systems y+ and y+L. (PMID: 17329401) Rotmann A. … Closs E.I. (Am. J. Physiol. 2007) 23 25
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. Cloning and characterization of a brain-specific cationic amino acid transporter. (PMID: 9079705) Hosokawa H. … Masaki T. (J. Biol. Chem. 1997) 25 26

Products for SLC7A3 Gene

Sources for SLC7A3 Gene

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