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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC7A2 Gene

protein-coding GIFtS: 59
GCID: GC08P017354

solute carrier family 7 (cationic amino acid transporter,...

(Previous symbol: ATRC2)

Explore 11 diseases affiliated with
SLC7A2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 2¹ ²		CAT2² ³
ATRC2¹ ² ³ ⁵		Low Affinity Cationic Amino Acid Transporter 2²
HCAT2¹ ² ⁵		Solute Carrier Family 7 Member 2³
CAT-2¹ ³

External Ids:	HGNC: 11060¹	Entrez Gene: 6542²	Ensembl: ENSG00000003989⁷	OMIM: 601872⁵	UniProtKB: P52569³

Export aliases for SLC7A2 gene to outside databases

Previous GC identifers: GC08P017289 GC08P017475 GC08P017406 GC08P017440 GC08P015899

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC7A2:

The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino

acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular

uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for

this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: CTR2_HUMAN, P52569

Function: Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine

and ornithine). Plays a regulatory role in classical or alternative activation of macrophages (By similarity)

Gene Wiki entry for SLC7A2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC7A2 gene promoter:
E2F-3a E2F-1 E2F Chx10 Nkx2-5 E2F-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC7A2 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC7A2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC7A2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22 Ensembl cytogenetic band: 8p22 HGNC cytogenetic band: 8p22

SLC7A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC7A2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P017354: view genomic region (about GC identifiers)

Start:	17,354,597 bp from pter	End:	17,428,082 bp from pter
Size:	73,486 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CTR2_HUMAN, P52569 (See protein sequence)

Recommended Name: Low affinity cationic amino acid transporter 2

Size: 658 amino acids; 71673 Da

Subcellular location: Membrane; Multi-pass membrane protein

Sequence caution: Sequence=AAH69648.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAI04906.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI13662.1;

Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI43584.1; Type=Erroneous initiation;

Note=Translation N-terminally extended;

Secondary accessions: B7ZL54 O15291 O15292 Q14CQ6 Q6NSZ7 Q86TC6

Alternative splicing: 3 isoforms: P52569-1 P52569-2 P52569-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC7A2: NX_P52569

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P52569

SLC7A2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001008539.3 NP_001158243.1 NP_003037.4

ENSEMBL proteins:

ENSP00000419140 ENSP00000430464 ENSP00000419873 ENSP00000004531 ENSP00000381164

Reactome Protein details: P52569
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	Uscn Proteins for SLC7A2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8954799
GO:0016020	membrane	TAS	8954799

SLC7A2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC7A2 for domains About GeneDecksing

3 InterPro domains/families:

IPR004755 Cat_AA_permease

IPR015606 Cat-AATrans

IPR002293 AA/rel_permease1

Graphical View of Domain Structure for InterPro Entry P52569

ProtoNet protein and cluster: P52569

UniProtKB/Swiss-Prot: CTR2_HUMAN, P52569

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT)

(TC 2.A.3.3) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CTR2_HUMAN, P52569

Function: Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine

and ornithine). Plays a regulatory role in classical or alternative activation of macrophages (By similarity)

Genatlas biochemistry entry for SLC7A2:

solute carrier family 7,member A2,high affinity sodium independent,cationic amino-acid transporter,expressed in stomach

liver,skeletal muscle,skin,brain and lung,y+ type

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000064	L-ornithine transmembrane transporter activity	IEA	--
GO:0005289	high affinity arginine transmembrane transporter activity	IEA	--
GO:0015174	basic amino acid transmembrane transporter activity	TAS	8954799
GO:0015179	L-amino acid transmembrane transporter activity	--	--
GO:0015181	arginine transmembrane transporter activity	--	--

SLC7A2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SLC7A2:

Decreased nuclei size in G2M

Animal Models:
Mouse knock-out Slc7a2^tm1Clm for SLC7A2
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Slc7a2):

immune system

no phenotypic analysis

SLC7A2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Amino acid and oligopeptide SLC transporters

	Amino acid and oligopeptide SLC transporters	1.00			Transport of inorganic cations/anions and amino acids/oligopeptides	0.52
	Amino acid transport across the plasma membrane	0.63

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for SLC7A2

	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Amino acid and oligopeptide SLC transporters
	Amino acid transport across the plasma membrane
	Transport of inorganic cations/anions and amino acids/oligopeptides

SLC7A2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC7A2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for SLC7A2 (P52569³ ENSP00000381164⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PSMA1	P25786³	I2D: score=1
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002537	nitric oxide production involved in inflammatory response	IEA	--
GO:0006520	cellular amino acid metabolic process	TAS	8954799
GO:0006809	nitric oxide biosynthetic process	IEA	--
GO:0006810	transport	TAS	8954799
GO:0006811	ion transport	TAS	--

SLC7A2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC7A2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC7A2

2 DrugBank Compounds for SLC7A2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Lysine	(S)-2,6-diaminohexanoic acid (see all 6)	56-87-1	target	--	17139284 17016423 7499219 15746185 12475743
L-Ornithine	(S)-2,5-Diaminopentanoate (see all 4)	70-26-8	target	--	17065601 12679322 16703566

2 Novoseek chemical compound relationships for SLC7A2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
arginine	65.1	7	16344361 (2), 15976236 (2), 10973927 (1), 12675924 (1)
nitric oxide	48.9	14	11829538 (2), 12675924 (2), 15044352 (1), 12787129 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about SLC7A2 / CTR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC7A2 gene (3 alternative transcripts):

NM_001008539.3 NM_001164771.1 NM_003046.5

Unigene Cluster for SLC7A2:

Solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

Hs.448520 [show with all ESTs]

Unigene Representative Sequence: NM_001008539

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000494857(uc011kyc.2) ENST00000522656 ENST00000470360(uc011kyd.2)

ENST00000004531(uc011kye.2) ENST00000398090

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		8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC7A2 (see all 45):
		hsa-miR-21* hsa-miR-15a hsa-miR-106a hsa-miR-449a hsa-miR-424 hsa-miR-133a hsa-miR-629 hsa-miR-93

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Additional cDNA sequence:

AK314287.1 AL512749.1 AL832016.2 BC069648.1 BC104905.1 BC113661.1 BC143583.1 D29990.1

U76368.1 U76369.1

15 DOTS entries:

DT.92433903 DT.120635360 DT.120635388 DT.447966 DT.444106 DT.92433895 DT.92433900 DT.100826603

DT.100826600 DT.91668896 DT.92419283 DT.97791781 DT.75103048 DT.86847529 DT.91907334

24/240 AceView cDNA sequences (see all 240):

AI160069 CK904222 CD672552 AA845419 AI051929 CD359908 AI167788 CA389756

AA456311 AA890052 W56680 BI258150 BM023392 AA776479 AA456301 BM694074

CA449960 CB216962 AA699705 AA772024 AI339730 BM704629 CB156037 F31413

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13
SP1:															-
SP2:																	-

ECgene alternative splicing isoforms for SLC7A2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC7A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACTGACAGC

About this image

SLC7A2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Myocardium

Mature Cardiac Fibroblasts

Epicardium

Testis

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

Nkx2-1 GFP+ cells (Efficient derivation...)

HyStem+BMP4-induced SK11 cells (HyStem+BMP4 inductio...)

Bone, Cartilage

See SLC7A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC7A2

SOURCE GeneReport for Unigene cluster: Hs.448520

UniProtKB/Swiss-Prot: CTR2_HUMAN, P52569

Tissue specificity: Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate

levels in the liver and pancreas and at low levels in the kidney and heart

SABiosciences Custom PCR Arrays for SLC7A2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC7A2

In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SLC7A2 gene from 9/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC7A2¹	solute carrier family 7 (cationic amino acid transporter, more	74.64(n) 77.76(a)		422730 NM_001199102.1 NP_001186031.1
lizard (Anolis carolinensis)	Reptilia	SLC7A2⁶	--	70(a)	1 ↔ 1	5(108915629-108940231)
African clawed frog (Xenopus laevis)	Amphibia	BC063720.1²	--	77.04(n)		BC063720.1
zebrafish (Danio rerio)	Actinopterygii	slc7a2¹	solute carrier family 7 (cationic amino acid transporter, more	65.19(n) 69.94(a)		494041 NM_001008584.1 NP_001008584.1
fruit fly (Drosophila melanogaster)	Insecta	CG7255³ CG5535¹	cationic amino acid transporter³ CG5535¹	47(a) (best of 4)³ 53.94(n)¹ 47.4(a)¹		71C2³ 39990¹ NM_140762.1¹ NP_649019.2¹
worm (Caenorhabditis elegans)	Secernentea	C50D2.2^{1 , 3}	amino acid permease³ Protein C50D2.2¹	39(a) (best of 3)³ 52.94(n)¹ 44.78(a)¹		II(109203-111230)³ 183650¹ NM_061261.3¹ NP_493662.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	CAT4¹	cationic amino acid transporter 4	47.73(n) 37.99(a)		821176 NM_111243.7 NP_187022.5
rice (Oryza sativa)	Liliopsida	-- -- (see all 11)	amino acid permease, putative, expressed (see all 11)	32(a) 31(a) (see all 11)	many ↔ many many ↔ many (see all 11)	12(26587454-26592524) 10(15558083-15564670)
E. coli (Escherichia coli)	Gamma proteobacteria	plaP⁶ puuP⁶ (see all 3)	putrescine importer (see all 3)	20(a) 19(a) (see all 3)	possible ortholog possible ortholog (see all 3)	Chromosome(2083728-2085086) Chromosome(1355826-1357211)

ENSEMBL Gene Tree for SLC7A2 (if available)
TreeFam Gene Tree for SLC7A2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC7A2 gene

SLC7A6² SLC7A4² SLC7A9² SLC7A14² SLC7A3² SLC7A10² SLC7A13² SLC7A7²

SLC7A11² SLC7A8² SLC7A1² SLC7A5²

4 SIMAP similar genes for SLC7A2 using alignment to 1 protein entry: CTR2_HUMAN:

SLC7A1 SLC7A3 SLC7A4 SLC7A14

SLC7A2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78042572^1,2	F,	--	15897189(+)	`TTGCTT/CAAGTT`	1	--	us2k¹		1		WA	118
rs77150961^1,2	F,	--	15897433(+)	`CTCCTA/TGCCGT`	1	--	us2k¹		1		EA	120
rs74720879^1,2	C,F,	--	15897480(+)	`GCATCA/GTTTCC`	1	--	us2k¹		1		NA	120
rs2517153^1,2	C,A,	--	15899039(+)	`ATTGGT/CCAGCG`	1	--	us2k¹		2		NA	4
rs2517161^1,2	C,	--	15899209(+)	`TCTTCG/CCGGGA`	1	--	ut5¹		4		NA	126
rs7819360^1,2	A	--	15899576(+)	`CCCGGA/GATGCG`	1	--	int¹		0	--	--	--	--
rs7819361^1,2	A	--	15899577(+)	`CCGGAA/GTGCGC`	1	--	int¹		0	--	--	--	--
rs7836145^1,2	A	--	15899614(+)	`CGGCTC/GTGCCC`	1	--	int¹		0	--	--	--	--
rs7819393^1,2	A	--	15899624(+)	`CGGGGA/GCTTCG`	1	--	int¹		0	--	--	--	--
rs11782172^1,2	H	--	15899793(+)	`TTCGGG/TTCTTG`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC7A2 (17354597 - 17428082 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SLC7A2
4 CNVs: 52458 2743 3724 9089
1 Indel: 33871
Human Gene Mutation Database (HGMD): SLC7A2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SLC7A2 for disorders           About GeneDecksing

OMIM gene information: 601872    OMIM disorders: --

11 diseases for SLC7A2:    About MalaCards

lysinuric protein intolerance nonspecific interstitial pneumonia velocardiofacial syndrome asthma

pneumonia lung carcinoma psoriasis tuberculosis

carcinoma neuronitis mycobacterium tuberculosis

1 Novoseek disease relationship for SLC7A2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
asthma	13.4	1	12813022 (1)

Human Genome Epidemiology (HuGE) Navigator: SLC7A2 (1 document)

Export disorders for SLC7A2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLC7A2 gene, integrated from 9 sources (see all 53):
(articles sorted by number of sources associating them with SLC7A2)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning, tissue distribution, and chromosomal localization of human cationic amino acid transporter 2 (HCAT2). (PubMed id 8954799)^{1, 2, 3, 9} Hoshide R.... Matsuda I. (1996)
Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties. (PubMed id 9174363)^{1, 2, 9} Closs E.I.... Foerstermann U. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4. (PubMed id 11665818)^{1, 9} Hammermann R....Racke K. (2001)
The importance of cationic amino acid transporter expression in human skin. (PubMed id 12787129)^{1, 9} Schnorr O....Kolb-Bachofen V. (2003)
A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine tr ansport. (PubMed id 22787143)¹ Jaenecke I....Closs E.I. (2012)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)¹ Shi Y....Qin J. (2011)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6542	HGNC: 11060	AceView: SLC7A2	Ensembl:ENSG00000003989	euGenes: HUgn6542
ECgene: SLC7A2	H-InvDB: SLC7A2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SLC7A2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC7A2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC7A2 gene:
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GeneCards and IP:
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