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Aliases for SLC7A13 Gene

Aliases for SLC7A13 Gene

  • Solute Carrier Family 7 (Anionic Amino Acid Transporter), Member 13 2 3
  • Sodium-Independent Aspartate/Glutamate Transporter 1 3 4
  • X-Amino Acid Transporter 2 3 4
  • AGT1 3 4
  • XAT2 3 4
  • Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 13 3
  • Solute Carrier Family 7 Member 13 3
  • Amino Acid Transporter XAT2 3
  • AGT-1 3

External Ids for SLC7A13 Gene

Previous GeneCards Identifiers for SLC7A13 Gene

  • GC08M086895
  • GC08M087182
  • GC08M087295
  • GC08M082438

Summaries for SLC7A13 Gene

GeneCards Summary for SLC7A13 Gene

SLC7A13 (Solute Carrier Family 7 (Anionic Amino Acid Transporter), Member 13) is a Protein Coding gene. GO annotations related to this gene include amino acid transmembrane transporter activity. An important paralog of this gene is SLC7A7.

UniProtKB/Swiss-Prot for SLC7A13 Gene

  • Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A13 Gene

Genomics for SLC7A13 Gene

Regulatory Elements for SLC7A13 Gene

Genomic Location for SLC7A13 Gene

Start:
86,214,052 bp from pter
End:
86,321,146 bp from pter
Size:
107,095 bases
Orientation:
Minus strand

Genomic View for SLC7A13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC7A13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A13 Gene

Proteins for SLC7A13 Gene

  • Protein details for SLC7A13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCU3-S7A13_HUMAN
    Recommended name:
    Solute carrier family 7 member 13
    Protein Accession:
    Q8TCU3
    Secondary Accessions:
    • Q05C37
    • Q08AH9
    • Q96N84

    Protein attributes for SLC7A13 Gene

    Size:
    470 amino acids
    Molecular mass:
    52114 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC7A13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC7A13 Gene

Proteomics data for SLC7A13 Gene at MOPED

Post-translational modifications for SLC7A13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC7A13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC7A13 Gene

Domains for SLC7A13 Gene

Gene Families for SLC7A13 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC7A13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC7A13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCU3

UniProtKB/Swiss-Prot:

S7A13_HUMAN :
  • Q8TCU3
Family:
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily.
genes like me logo Genes that share domains with SLC7A13: view

Function for SLC7A13 Gene

Molecular function for SLC7A13 Gene

UniProtKB/Swiss-Prot Function: Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.

Gene Ontology (GO) - Molecular Function for SLC7A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity --
GO:0015179 L-amino acid transmembrane transporter activity IBA --
GO:0015297 antiporter activity IBA --
genes like me logo Genes that share ontologies with SLC7A13: view

Phenotypes for SLC7A13 Gene

GenomeRNAi human phenotypes for SLC7A13:
genes like me logo Genes that share phenotypes with SLC7A13: view

Animal Model Products

CRISPR Products

miRNA for SLC7A13 Gene

miRTarBase miRNAs that target SLC7A13

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC7A13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC7A13 Gene

Localization for SLC7A13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC7A13 Gene COMPARTMENTS Subcellular localization image for SLC7A13 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC7A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC7A13: view

Pathways for SLC7A13 Gene

SuperPathways for SLC7A13 Gene

No Data Available

Interacting Proteins for SLC7A13 Gene

Gene Ontology (GO) - Biological Process for SLC7A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0006810 transport --
GO:0015807 L-amino acid transport IBA --
GO:0055085 transmembrane transport --
GO:1902475 L-alpha-amino acid transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC7A13: view

No data available for Pathways by source for SLC7A13 Gene

Compounds for SLC7A13 Gene

(1) HMDB Compounds for SLC7A13 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
genes like me logo Genes that share compounds with SLC7A13: view

Transcripts for SLC7A13 Gene

mRNA/cDNA for SLC7A13 Gene

(11) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC7A13 Gene

Solute carrier family 7 (anionic amino acid transporter), member 13:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC7A13

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC7A13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A13 Gene

No ASD Table

Relevant External Links for SLC7A13 Gene

GeneLoc Exon Structure for
SLC7A13
ECgene alternative splicing isoforms for
SLC7A13

Expression for SLC7A13 Gene

mRNA expression in normal human tissues for SLC7A13 Gene

mRNA differential expression in normal tissues according to GTEx for SLC7A13 Gene

This gene is overexpressed in Kidney - Cortex (38.1) and Testis (5.7).

SOURCE GeneReport for Unigene cluster for SLC7A13 Gene Hs.149095

mRNA Expression by UniProt/SwissProt for SLC7A13 Gene

Q8TCU3-S7A13_HUMAN
Tissue specificity: Expressed in the kidney.
genes like me logo Genes that share expressions with SLC7A13: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for SLC7A13 Gene

Orthologs for SLC7A13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC7A13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC7A13 35
  • 99.29 (n)
  • 98.94 (a)
SLC7A13 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 51 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLC7A13 35
  • 80.07 (n)
  • 67.68 (a)
SLC7A13 36
  • 47 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc7a13 35
  • 76.38 (n)
  • 69.79 (a)
Slc7a13 16
Slc7a13 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC7A13 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC7A13 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc7a13 35
  • 75.6 (n)
  • 69.79 (a)
chicken
(Gallus gallus)
Aves SLC7A13 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC7A13 36
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01074334.1 36
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea aat-4 36
  • 24 (a)
ManyToMany
aat-5 36
  • 22 (a)
ManyToMany
aat-6 36
  • 21 (a)
ManyToMany
aat-7 36
  • 24 (a)
ManyToMany
aat-8 36
  • 25 (a)
ManyToMany
aat-9 36
  • 23 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MUP1 36
  • 17 (a)
ManyToMany
MUP3 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.158 36
  • 30 (a)
ManyToMany
Species with no ortholog for SLC7A13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC7A13 Gene

ENSEMBL:
Gene Tree for SLC7A13 (if available)
TreeFam:
Gene Tree for SLC7A13 (if available)

Paralogs for SLC7A13 Gene

Paralogs for SLC7A13 Gene

Selected SIMAP similar genes for SLC7A13 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SLC7A13 Gene

genes like me logo Genes that share paralogs with SLC7A13: view

Variants for SLC7A13 Gene

Sequence variations from dbSNP and Humsavar for SLC7A13 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2954343 -- 86,224,018(+) TTGAG(A/T)TTGGA intron-variant
rs2954344 -- 86,226,265(+) AACAA(G/T)GAGAT intron-variant
rs2954345 -- 86,227,337(+) TTGAA(A/G)GTGAG intron-variant
rs2954346 -- 86,227,716(+) TTTTT(A/T)AAAAA intron-variant
rs2954347 -- 86,229,486(+) AGAAG(A/G)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC7A13 Gene

Variant ID Type Subtype PubMed ID
nsv428204 CNV Gain 18775914
nsv891147 CNV Gain 21882294
nsv6290 CNV Loss 18451855
nsv465733 CNV Gain 19166990
nsv519507 CNV Gain+Loss 19592680

Relevant External Links for SLC7A13 Gene

HapMap Linkage Disequilibrium report
SLC7A13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC7A13 Gene

Disorders for SLC7A13 Gene

Relevant External Links for SLC7A13

Genetic Association Database (GAD)
SLC7A13
Human Genome Epidemiology (HuGE) Navigator
SLC7A13
genes like me logo Genes that share disorders with SLC7A13: view

No data available for UniProtKB/Swiss-Prot for SLC7A13 Gene

Publications for SLC7A13 Gene

  1. Homologues of amino acid permeases: cloning and tissue expression of XAT1 and XAT2. (PMID: 11943479) Blondeau J.-P. (Gene 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains. (PMID: 11907033) Matsuo H. … Endou H. (J. Biol. Chem. 2002) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SLC7A13 Gene

Sources for SLC7A13 Gene

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