SLC7A13 Gene
protein-coding GIFtS: 41
GCID: GC08M087295
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solute carrier family 7 (anionic amino acid transporter),...
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Aliases
for SLC7A13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 7 (Anionic Amino Acid Transporter), Member 131 2 | | X-Amino Acid Transporter 22 3 | | XAT21 2 3 | | Amino Acid Transporter XAT22 | | AGT-11 2 | | Solute Carrier Family 7 Member 132 | | Sodium-Independent Aspartate/Glutamate Transporter 12 3 | | Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 132 | | AGT12 3 | | |
Export aliases for SLC7A13 gene to outside databasesPrevious GC identifers: GC08M086895 GC08M087182 GC08M082438 |
Summaries
for SLC7A13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: S7A13_HUMAN, Q8TCU3Function: Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner (By similarity)
|
Genomic Views
for SLC7A13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC7A13 gene promoter:
C/EBPbeta HTF Ik-3 HNF-1A HEN1 POU2F1 POU2F1b POU2F1a HNF-1 POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC7A13
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC7A13 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q21.3 Ensembl cytogenetic band: 8q21.3 HGNC cytogenetic band: 8q21.2SLC7A13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M087295: view genomic region
(about GC identifiers)
Start:
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87,226,281 bp from pter |
End:
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87,333,375 bp from pter |
Size:
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107,095 bases |
Orientation:
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minus strand |
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Proteins
for SLC7A13 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S7A13_HUMAN, Q8TCU3 (See
protein sequence)Recommended Name: Solute carrier family 7 member 13 Size: 470 amino acids; 52114 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q05C37 Q08AH9 Q96N84Alternative splicing: 2 isoforms: Q8TCU3-1 Q8TCU3-2 Explore the universe of human proteins at neXtProt for SLC7A13: NX_Q8TCU3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TCU3
SLC7A13 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_620172.2
ENSEMBL proteins: ENSP00000297524 ENSP00000410982
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLC7A13 for ontologies About GeneDecksing
SLC7A13 Antibody Products:
Assay Products for SLC7A13: |
Protein
Domains /
Families
for SLC7A13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC7A13 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TCU3ProtoNet protein and cluster: Q8TCU3 UniProtKB/Swiss-Prot: S7A13_HUMAN, Q8TCU3Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily |
Function
for SLC7A13 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S7A13_HUMAN, Q8TCU3Function: Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC7A13
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for SLC7A13 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC7A13 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A13 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015171 | amino acid transmembrane transporter activity |
IEA | -- |
SLC7A13 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SLC7A13:
|
Pathways & Interactions
for SLC7A13 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC7A13
|
Drugs & Compounds
for SLC7A13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC7A13
1 HMDB Compound for SLC7A13 About this table
Search CenterWatch for drugs/clinical trials and news about SLC7A13 / S7A13
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Transcripts
for SLC7A13 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC7A13 gene: NM_138817.2 Unigene Cluster for SLC7A13: Solute carrier family 7 (anionic amino acid transporter), member 13 Hs.149095 [show with all ESTs]Unigene Representative Sequence: AK0558153 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000297524(uc003ydq.1 uc003ydr.1) ENST00000419776 ENST00000520624
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC7A13 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC7A13
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC7A13 (NM_138817) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC7A13 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC7A13 |
Additional cDNA sequence: AJ417661.1 AK055815.1 BC029436.1 BC125165.1 BC125166.1 3 DOTS entries: DT.70104635 DT.95356123 DT.121476821 11 AceView cDNA sequences: AI471866 AK055815 BE048439 NM_138817 AJ417661 BC029436 BF740025 AW243234 AI244085 AW614273 BG401198
GeneLoc Exon Structure
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Expression
for SLC7A13 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC7A13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGAAATTCC
About this image
See SLC7A13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC7A13
SOURCE GeneReport for Unigene cluster: Hs.149095
UniProtKB/Swiss-Prot: S7A13_HUMAN, Q8TCU3Tissue specificity: Expressed in the kidney
SABiosciences Custom PCR Arrays for SLC7A13
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC7A13
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC7A13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC7A13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC7A13 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A13 |
Orthologs
for SLC7A13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SLC7A13 gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for SLC7A13 (if available)
TreeFam Gene Tree for SLC7A13 (if available) |
Paralogs
for SLC7A13 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC7A13 gene
- SLC7A62 SLC7A42 SLC7A92 SLC7A142 SLC7A32 SLC7A102 SLC7A72 SLC7A112
- SLC7A22 SLC7A82 SLC7A12 SLC7A52
9 SIMAP similar genes for SLC7A13 using alignment to 1 protein entry: S7A13_HUMAN:SLC7A6 SLC7A10 SLC7A9 SLC7A11 SLC7A5 SLC7A8
hxCT lat1 SLC7A7
SLC7A13 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SLC7A13
PGOHUM00000249732
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Genomic Variants
for SLC7A13 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC7A13 (87226281 - 87333375 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC7A13: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC7A13 |
|
Disorders
/ Diseases
for SLC7A13 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SLC7A13 for disorders About MalaCards
SLC7A13 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SLC7A13 (1 document)
Export disorders for SLC7A13 gene to outside databases
|
Publications
for SLC7A13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC7A13 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC7A13) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Homologues of amino acid permeases: cloning and tissue expression of XAT1 and XAT2. (PubMed id 11943479)1, 2, 3 Blondeau J.P. (2002)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains. (PubMed id 11907033)1, 3 Matsuo H....Endou H. (2002)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLC7A13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC7A13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC7A13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC7A13 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC7A13 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLC7A13 gene:
Search GeneIP for patents involving SLC7A13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC7A13 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC7A13 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC7A13 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC7A13 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC7A13 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC7A13 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC7A13 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for SLC7A13 |
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 | | | SLC7A13 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A13 |
|  |  |  | | | | ThermoFisher Antibodies for SLC7A13 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC7A13 |
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