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Aliases for SLC7A13 Gene

Aliases for SLC7A13 Gene

  • Solute Carrier Family 7 Member 13 2 3 5
  • Solute Carrier Family 7 (Anionic Amino Acid Transporter), Member 13 2 3
  • Sodium-Independent Aspartate/Glutamate Transporter 1 3 4
  • X-Amino Acid Transporter 2 3 4
  • AGT1 3 4
  • XAT2 3 4
  • Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 13 3
  • Amino Acid Transporter XAT2 3
  • AGT-1 3

External Ids for SLC7A13 Gene

Previous GeneCards Identifiers for SLC7A13 Gene

  • GC08M086895
  • GC08M087182
  • GC08M087295
  • GC08M082438

Summaries for SLC7A13 Gene

GeneCards Summary for SLC7A13 Gene

SLC7A13 (Solute Carrier Family 7 Member 13) is a Protein Coding gene. GO annotations related to this gene include amino acid transmembrane transporter activity and L-amino acid transmembrane transporter activity. An important paralog of this gene is SLC7A6.

UniProtKB/Swiss-Prot for SLC7A13 Gene

  • Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.

Additional gene information for SLC7A13 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A13 Gene

Genomics for SLC7A13 Gene

Regulatory Elements for SLC7A13 Gene

Enhancers for SLC7A13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H086108 1.2 Ensembl ENCODE 10.6 +212.3 212335 1 PKNOX1 FOXA2 ATF1 INSM2 BMI1 ZNF366 FOS SMARCA5 ZNF362 ELF1 SLC7A13 WWP1 LOC105375624 CA3-AS1 CA2 PSKH2 ENSG00000253675
GH08H086319 1.1 Ensembl ENCODE 0.7 +0.8 833 0 ELF3 FOXA2 JUN MAX CEBPG RAD21 RARA YY1 GATA3 HNF4G RMDN1 SLC7A13 LOC105375623
GH08H086320 0.8 ENCODE 0.7 +0.3 253 0 ELF3 SOX13 FOXA2 RARA YY1 GATA3 HNF4G TCF7L2 SOX5 GATAD2A SLC7A13 LOC105375623
GH08H086305 0.8 ENCODE 0.4 +15.6 15550 0 FOXA2 JUN FEZF1 ZNF664 ZNF366 SCRT2 FOSL2 FOS EZH2 SMARCE1 SLC7A13 LOC105375623
GH08H086289 1 ENCODE 0.3 +30.9 30936 0 FOXA2 ATF1 FEZF1 DMAP1 ZNF2 YY1 FOS MIER2 KAT8 NFIL3 RMDN1 WWP1 SLC7A13 LOC105375623
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC7A13 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC7A13 Gene

Chromosome:
8
Start:
86,201,763 bp from pter
End:
86,321,146 bp from pter
Size:
119,384 bases
Orientation:
Minus strand

Genomic View for SLC7A13 Gene

Genes around SLC7A13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC7A13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC7A13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A13 Gene

Proteins for SLC7A13 Gene

  • Protein details for SLC7A13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCU3-S7A13_HUMAN
    Recommended name:
    Solute carrier family 7 member 13
    Protein Accession:
    Q8TCU3
    Secondary Accessions:
    • Q05C37
    • Q08AH9
    • Q96N84

    Protein attributes for SLC7A13 Gene

    Size:
    470 amino acids
    Molecular mass:
    52114 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC7A13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC7A13 Gene

Post-translational modifications for SLC7A13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC7A13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC7A13 Gene

Domains & Families for SLC7A13 Gene

Gene Families for SLC7A13 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC7A13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC7A13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCU3

UniProtKB/Swiss-Prot:

S7A13_HUMAN :
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily.
Family:
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily.
genes like me logo Genes that share domains with SLC7A13: view

Function for SLC7A13 Gene

Molecular function for SLC7A13 Gene

UniProtKB/Swiss-Prot Function:
Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.

Gene Ontology (GO) - Molecular Function for SLC7A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity IEA --
GO:0015179 L-amino acid transmembrane transporter activity IBA --
GO:0015297 antiporter activity IBA --
genes like me logo Genes that share ontologies with SLC7A13: view
genes like me logo Genes that share phenotypes with SLC7A13: view

Animal Models for SLC7A13 Gene

MGI Knock Outs for SLC7A13:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC7A13

CRISPR Products

miRNA for SLC7A13 Gene

miRTarBase miRNAs that target SLC7A13

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC7A13
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC7A13 Gene

Localization for SLC7A13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC7A13 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC7A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC7A13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC7A13 Gene

Pathways & Interactions for SLC7A13 Gene

SuperPathways for SLC7A13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC7A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006865 amino acid transport IEA --
GO:0015807 L-amino acid transport IEA --
GO:1902475 L-alpha-amino acid transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC7A13: view

No data available for Pathways by source and SIGNOR curated interactions for SLC7A13 Gene

Drugs & Compounds for SLC7A13 Gene

(1) Additional Compounds for SLC7A13 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC7A13: view

Transcripts for SLC7A13 Gene

mRNA/cDNA for SLC7A13 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC7A13 Gene

Solute carrier family 7 (anionic amino acid transporter), member 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC7A13
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A13 Gene

No ASD Table

Relevant External Links for SLC7A13 Gene

GeneLoc Exon Structure for
SLC7A13
ECgene alternative splicing isoforms for
SLC7A13

Expression for SLC7A13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC7A13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC7A13 Gene

This gene is overexpressed in Kidney - Cortex (x38.1) and Testis (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of SLC7A13 Gene:

SLC7A13

SOURCE GeneReport for Unigene cluster for SLC7A13 Gene:

Hs.149095

mRNA Expression by UniProt/SwissProt for SLC7A13 Gene:

Q8TCU3-S7A13_HUMAN
Tissue specificity: Expressed in the kidney.

Evidence on tissue expression from TISSUES for SLC7A13 Gene

  • Kidney(4.2)
genes like me logo Genes that share expression patterns with SLC7A13: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC7A13 Gene

Orthologs for SLC7A13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC7A13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC7A13 33 34
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia SLC7A13 33 34
  • 80.07 (n)
mouse
(Mus musculus)
Mammalia Slc7a13 33 16 34
  • 76.38 (n)
rat
(Rattus norvegicus)
Mammalia Slc7a13 33
  • 75.6 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 51 (a)
OneToMany
-- 34
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC7A13 34
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC7A13 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC7A13 34
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC7A13 34
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01074334.1 34
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea aat-8 34
  • 25 (a)
ManyToMany
aat-4 34
  • 24 (a)
ManyToMany
aat-7 34
  • 24 (a)
ManyToMany
aat-9 34
  • 23 (a)
ManyToMany
aat-5 34
  • 22 (a)
ManyToMany
aat-6 34
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MUP1 34
  • 17 (a)
ManyToMany
MUP3 34
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.158 34
  • 30 (a)
ManyToMany
Species where no ortholog for SLC7A13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC7A13 Gene

ENSEMBL:
Gene Tree for SLC7A13 (if available)
TreeFam:
Gene Tree for SLC7A13 (if available)

Paralogs for SLC7A13 Gene

Paralogs for SLC7A13 Gene

(9) SIMAP similar genes for SLC7A13 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SLC7A13 Gene

genes like me logo Genes that share paralogs with SLC7A13: view

Variants for SLC7A13 Gene

Sequence variations from dbSNP and Humsavar for SLC7A13 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000175342 -- 86,218,610(+) AATGT(G/T)CATGG intron-variant
rs1000187946 -- 86,223,389(+) ACATT(A/T)TGTAG intron-variant
rs1000189834 -- 86,222,920(+) TAGTT(A/T)CGTTG intron-variant
rs1000205591 -- 86,228,792(+) AGTGA(A/G)CTGAA intron-variant
rs1000219270 -- 86,218,925(+) GTTTC(C/G)AGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC7A13 Gene

Variant ID Type Subtype PubMed ID
dgv12228n54 CNV gain 21841781
dgv7263n100 CNV gain 25217958
esv2761445 CNV gain 21179565
esv2762757 CNV gain 21179565
esv3617906 CNV gain 21293372
nsv428204 CNV gain 18775914
nsv465733 CNV gain 19166990
nsv519507 CNV gain+loss 19592680
nsv611674 CNV gain 21841781
nsv6290 CNV deletion 18451855

Variation tolerance for SLC7A13 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.84; 94.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC7A13 Gene

Human Gene Mutation Database (HGMD)
SLC7A13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC7A13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC7A13 Gene

Disorders for SLC7A13 Gene

Relevant External Links for SLC7A13

Genetic Association Database (GAD)
SLC7A13
Human Genome Epidemiology (HuGE) Navigator
SLC7A13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC7A13

No disorders were found for SLC7A13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC7A13 Gene

Publications for SLC7A13 Gene

  1. Homologues of amino acid permeases: cloning and tissue expression of XAT1 and XAT2. (PMID: 11943479) Blondeau JP (Gene 2002) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains. (PMID: 11907033) Matsuo H … Endou H (The Journal of biological chemistry 2002) 2 3 60
  5. Mig-6 controls EGFR trafficking and suppresses gliomagenesis. (PMID: 20351267) Ying H … DePinho RA (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 60

Products for SLC7A13 Gene

Sources for SLC7A13 Gene

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