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Aliases for SLC7A13 Gene

Aliases for SLC7A13 Gene

  • Solute Carrier Family 7 Member 13 2 3
  • Solute Carrier Family 7 (Anionic Amino Acid Transporter), Member 13 2 3 5
  • Sodium-Independent Aspartate/Glutamate Transporter 1 3 4
  • X-Amino Acid Transporter 2 3 4
  • AGT1 3 4
  • XAT2 3 4
  • Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 13 3
  • Amino Acid Transporter XAT2 3
  • AGT-1 3

External Ids for SLC7A13 Gene

Previous GeneCards Identifiers for SLC7A13 Gene

  • GC08M086895
  • GC08M087182
  • GC08M087295
  • GC08M082438

Summaries for SLC7A13 Gene

GeneCards Summary for SLC7A13 Gene

SLC7A13 (Solute Carrier Family 7 Member 13) is a Protein Coding gene. GO annotations related to this gene include amino acid transmembrane transporter activity and L-amino acid transmembrane transporter activity. An important paralog of this gene is SLC7A10.

UniProtKB/Swiss-Prot for SLC7A13 Gene

  • Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A13 Gene

Genomics for SLC7A13 Gene

Regulatory Elements for SLC7A13 Gene

Enhancers for SLC7A13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC7A13 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC7A13 Gene

86,201,763 bp from pter
86,321,146 bp from pter
119,384 bases
Minus strand

Genomic View for SLC7A13 Gene

Genes around SLC7A13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC7A13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC7A13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A13 Gene

Proteins for SLC7A13 Gene

  • Protein details for SLC7A13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 7 member 13
    Protein Accession:
    Secondary Accessions:
    • Q05C37
    • Q08AH9
    • Q96N84

    Protein attributes for SLC7A13 Gene

    470 amino acids
    Molecular mass:
    52114 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC7A13 Gene


neXtProt entry for SLC7A13 Gene

Proteomics data for SLC7A13 Gene at MOPED

Post-translational modifications for SLC7A13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC7A13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC7A13 Gene

Domains & Families for SLC7A13 Gene

Gene Families for SLC7A13 Gene


Protein Domains for SLC7A13 Gene


Suggested Antigen Peptide Sequences for SLC7A13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the amino acid-polyamine-organocation (APC) superfamily.
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily.
genes like me logo Genes that share domains with SLC7A13: view

Function for SLC7A13 Gene

Molecular function for SLC7A13 Gene

UniProtKB/Swiss-Prot Function:
Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.

Gene Ontology (GO) - Molecular Function for SLC7A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015175 neutral amino acid transmembrane transporter activity IBA --
GO:0015297 antiporter activity IBA --
genes like me logo Genes that share ontologies with SLC7A13: view
genes like me logo Genes that share phenotypes with SLC7A13: view

Animal Models for SLC7A13 Gene

MGI Knock Outs for SLC7A13:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC7A13

CRISPR Products

miRNA for SLC7A13 Gene

miRTarBase miRNAs that target SLC7A13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC7A13 Gene

Localization for SLC7A13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC7A13 Gene COMPARTMENTS Subcellular localization image for SLC7A13 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC7A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC7A13: view

Pathways & Interactions for SLC7A13 Gene

SuperPathways for SLC7A13 Gene

No Data Available

Interacting Proteins for SLC7A13 Gene

Gene Ontology (GO) - Biological Process for SLC7A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015807 L-amino acid transport IBA --
genes like me logo Genes that share ontologies with SLC7A13: view

No data available for Pathways by source and SIGNOR curated interactions for SLC7A13 Gene

Drugs & Compounds for SLC7A13 Gene

(1) Additional Compounds for SLC7A13 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC7A13: view

Transcripts for SLC7A13 Gene

mRNA/cDNA for SLC7A13 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC7A13 Gene

Solute carrier family 7 (anionic amino acid transporter), member 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A13 Gene

No ASD Table

Relevant External Links for SLC7A13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC7A13 Gene

mRNA expression in normal human tissues for SLC7A13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC7A13 Gene

This gene is overexpressed in Kidney - Cortex (x38.1) and Testis (x5.7).

SOURCE GeneReport for Unigene cluster for SLC7A13 Gene Hs.149095

mRNA Expression by UniProt/SwissProt for SLC7A13 Gene

Tissue specificity: Expressed in the kidney.
genes like me logo Genes that share expression patterns with SLC7A13: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SLC7A13 Gene

Orthologs for SLC7A13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC7A13 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SLC7A13 35
  • 80.07 (n)
  • 67.68 (a)
SLC7A13 36
  • 47 (a)
(Mus musculus)
Mammalia Slc7a13 35
  • 76.38 (n)
  • 69.79 (a)
Slc7a13 16
Slc7a13 36
  • 69 (a)
(Pan troglodytes)
Mammalia SLC7A13 35
  • 99.29 (n)
  • 98.94 (a)
SLC7A13 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc7a13 35
  • 75.6 (n)
  • 69.79 (a)
(Bos Taurus)
Mammalia -- 36
  • 51 (a)
-- 36
  • 49 (a)
(Monodelphis domestica)
Mammalia SLC7A13 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia SLC7A13 36
  • 51 (a)
(Gallus gallus)
Aves SLC7A13 36
  • 44 (a)
(Anolis carolinensis)
Reptilia SLC7A13 36
  • 44 (a)
(Danio rerio)
Actinopterygii CABZ01074334.1 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea aat-4 36
  • 24 (a)
aat-5 36
  • 22 (a)
aat-6 36
  • 21 (a)
aat-7 36
  • 24 (a)
aat-8 36
  • 25 (a)
aat-9 36
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MUP1 36
  • 17 (a)
MUP3 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.158 36
  • 30 (a)
Species with no ortholog for SLC7A13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC7A13 Gene

Gene Tree for SLC7A13 (if available)
Gene Tree for SLC7A13 (if available)

Paralogs for SLC7A13 Gene

Paralogs for SLC7A13 Gene

(9) SIMAP similar genes for SLC7A13 Gene using alignment to 1 proteins: Pseudogenes for SLC7A13 Gene

genes like me logo Genes that share paralogs with SLC7A13: view

Variants for SLC7A13 Gene

Sequence variations from dbSNP and Humsavar for SLC7A13 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2976189 - 86,223,044(-) CTCTG(A/G)TGACT reference, missense
rs4419794 - 86,217,510(+) TCCGC(C/T)TTAGT intron-variant, reference, missense
rs9656982 - 86,214,471(+) AAGTC(A/G)TCTTC intron-variant, reference, missense
rs9693999 - 86,214,418(+) CTATT(C/T)CTCAG intron-variant, reference, missense
rs9656983 -- 86,216,264(+) GCAGA(C/T)GTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC7A13 Gene

Variant ID Type Subtype PubMed ID
nsv428204 CNV Gain 18775914
nsv891147 CNV Gain 21882294
nsv6290 CNV Loss 18451855
nsv465733 CNV Gain 19166990
nsv519507 CNV Gain+Loss 19592680

Variation tolerance for SLC7A13 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.84; 94.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC7A13 Gene

Disorders for SLC7A13 Gene

Relevant External Links for SLC7A13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC7A13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC7A13 Gene

Publications for SLC7A13 Gene

  1. Homologues of amino acid permeases: cloning and tissue expression of XAT1 and XAT2. (PMID: 11943479) Blondeau J.-P. (Gene 2002) 2 3 4 67
  2. Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains. (PMID: 11907033) Matsuo H. … Endou H. (J. Biol. Chem. 2002) 2 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC7A13 Gene

Sources for SLC7A13 Gene