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Aliases for SLC7A13 Gene

Aliases for SLC7A13 Gene

  • Solute Carrier Family 7 Member 13 2 3 5
  • Solute Carrier Family 7 (Anionic Amino Acid Transporter), Member 13 2 3
  • Sodium-Independent Aspartate/Glutamate Transporter 1 3 4
  • X-Amino Acid Transporter 2 3 4
  • AGT1 3 4
  • XAT2 3 4
  • Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 13 3
  • Amino Acid Transporter XAT2 3
  • AGT-1 3

External Ids for SLC7A13 Gene

Previous GeneCards Identifiers for SLC7A13 Gene

  • GC08M086895
  • GC08M087182
  • GC08M087295
  • GC08M082438

Summaries for SLC7A13 Gene

GeneCards Summary for SLC7A13 Gene

SLC7A13 (Solute Carrier Family 7 Member 13) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include amino acid transmembrane transporter activity and L-amino acid transmembrane transporter activity. An important paralog of this gene is SLC7A6.

UniProtKB/Swiss-Prot for SLC7A13 Gene

  • Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.

Additional gene information for SLC7A13 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A13 Gene

Genomics for SLC7A13 Gene

GeneHancer (GH) Regulatory Elements for SLC7A13 Gene

Promoters and enhancers for SLC7A13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I086319 Enhancer 1 Ensembl ENCODE 550.8 +0.8 833 0.8 ELF3 FOXA2 RAD21 RARA YY1 RXRA NR2F2 ZNF148 NFIL3 ATF4 SLC7A13 RMDN1 LOC105375623
GH08I086320 Enhancer 0.7 ENCODE 550.8 +0.3 252 0.1 ELF3 SOX13 FOXA2 RARA YY1 GATA3 HNF4G TCF7L2 GATAD2A SOX5 SLC7A13 LOC105375623
GH08I086230 Promoter 0.5 EPDnew 550.2 +90.7 90745 0.1 SLC7A13 LOC105375623
GH08I086108 Enhancer 1.1 Ensembl ENCODE 10.6 +212.3 212335 1.2 PKNOX1 ATF1 FOXA2 NEUROD1 FOS TSHZ1 MEF2D SMARCA4 PRDM4 WT1 SLC7A13 WWP1 LOC105375624 CA2 CA3-AS1 PSKH2 ENSG00000253675 ATP6V0D2
GH08I086305 Enhancer 0.8 ENCODE 0.4 +15.5 15549 0.2 FOXA2 JUN FEZF1 ZNF664 ZNF366 SCRT2 FOSL2 FOS EZH2 SMARCE1 SLC7A13 LOC105375623
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC7A13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC7A13 gene promoter:

Genomic Locations for SLC7A13 Gene

Genomic Locations for SLC7A13 Gene
119,384 bases
Minus strand

Genomic View for SLC7A13 Gene

Genes around SLC7A13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC7A13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC7A13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A13 Gene

Proteins for SLC7A13 Gene

  • Protein details for SLC7A13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 7 member 13
    Protein Accession:
    Secondary Accessions:
    • Q05C37
    • Q08AH9
    • Q96N84

    Protein attributes for SLC7A13 Gene

    470 amino acids
    Molecular mass:
    52114 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC7A13 Gene


neXtProt entry for SLC7A13 Gene

Post-translational modifications for SLC7A13 Gene

No Post-translational modifications

Other Protein References for SLC7A13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC7A13 Gene

Domains & Families for SLC7A13 Gene

Gene Families for SLC7A13 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC7A13 Gene


Suggested Antigen Peptide Sequences for SLC7A13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the amino acid-polyamine-organocation (APC) superfamily.
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily.
genes like me logo Genes that share domains with SLC7A13: view

Function for SLC7A13 Gene

Molecular function for SLC7A13 Gene

UniProtKB/Swiss-Prot Function:
Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.

Phenotypes From GWAS Catalog for SLC7A13 Gene

Gene Ontology (GO) - Molecular Function for SLC7A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity IEA --
GO:0015179 L-amino acid transmembrane transporter activity IBA --
GO:0015297 antiporter activity IBA --
genes like me logo Genes that share ontologies with SLC7A13: view
genes like me logo Genes that share phenotypes with SLC7A13: view

Animal Models for SLC7A13 Gene

MGI Knock Outs for SLC7A13:

Animal Model Products

CRISPR Products

miRNA for SLC7A13 Gene

miRTarBase miRNAs that target SLC7A13

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC7A13 Gene

Localization for SLC7A13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC7A13 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC7A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC7A13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC7A13 Gene

Pathways & Interactions for SLC7A13 Gene

SuperPathways for SLC7A13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC7A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006865 amino acid transport IEA --
GO:1902475 L-alpha-amino acid transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC7A13: view

No data available for Pathways by source and SIGNOR curated interactions for SLC7A13 Gene

Drugs & Compounds for SLC7A13 Gene

(1) Additional Compounds for SLC7A13 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC7A13: view

Transcripts for SLC7A13 Gene

mRNA/cDNA for SLC7A13 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC7A13 Gene

Solute carrier family 7 (anionic amino acid transporter), member 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A13 Gene

No ASD Table

Relevant External Links for SLC7A13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC7A13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC7A13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC7A13 Gene

This gene is overexpressed in Kidney - Cortex (x38.1) and Testis (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of SLC7A13 Gene:


SOURCE GeneReport for Unigene cluster for SLC7A13 Gene:


mRNA Expression by UniProt/SwissProt for SLC7A13 Gene:

Tissue specificity: Expressed in the kidney.

Evidence on tissue expression from TISSUES for SLC7A13 Gene

  • Kidney(4.2)
genes like me logo Genes that share expression patterns with SLC7A13: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC7A13 Gene

Orthologs for SLC7A13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC7A13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC7A13 33 34
  • 99.29 (n)
(Canis familiaris)
Mammalia SLC7A13 33 34
  • 80.07 (n)
(Mus musculus)
Mammalia Slc7a13 33 16 34
  • 76.38 (n)
(Rattus norvegicus)
Mammalia Slc7a13 33
  • 75.6 (n)
(Bos Taurus)
Mammalia -- 34
  • 51 (a)
-- 34
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia SLC7A13 34
  • 51 (a)
(Monodelphis domestica)
Mammalia SLC7A13 34
  • 50 (a)
(Gallus gallus)
Aves SLC7A13 34
  • 44 (a)
(Anolis carolinensis)
Reptilia SLC7A13 34
  • 44 (a)
(Danio rerio)
Actinopterygii CABZ01074334.1 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea aat-8 34
  • 25 (a)
aat-4 34
  • 24 (a)
aat-7 34
  • 24 (a)
aat-9 34
  • 23 (a)
aat-5 34
  • 22 (a)
aat-6 34
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MUP1 34
  • 17 (a)
MUP3 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.158 34
  • 30 (a)
Species where no ortholog for SLC7A13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC7A13 Gene

Gene Tree for SLC7A13 (if available)
Gene Tree for SLC7A13 (if available)

Paralogs for SLC7A13 Gene

Paralogs for SLC7A13 Gene

(9) SIMAP similar genes for SLC7A13 Gene using alignment to 1 proteins: Pseudogenes for SLC7A13 Gene

genes like me logo Genes that share paralogs with SLC7A13: view

Variants for SLC7A13 Gene

Sequence variations from dbSNP and Humsavar for SLC7A13 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000175342 -- 86,218,610(-) T/G intron_variant
rs1000187946 -- 86,223,389(-) T/A intron_variant
rs1000189834 -- 86,222,920(-) A/C/T intron_variant
rs1000205591 -- 86,228,792(-) G/A intron_variant
rs1000219270 -- 86,218,925(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC7A13 Gene

Variant ID Type Subtype PubMed ID
dgv12228n54 CNV gain 21841781
dgv7263n100 CNV gain 25217958
esv2761445 CNV gain 21179565
esv2762757 CNV gain 21179565
esv3617906 CNV gain 21293372
nsv428204 CNV gain 18775914
nsv465733 CNV gain 19166990
nsv519507 CNV gain+loss 19592680
nsv611674 CNV gain 21841781
nsv6290 CNV deletion 18451855

Variation tolerance for SLC7A13 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.84; 94.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC7A13 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC7A13 Gene

Disorders for SLC7A13 Gene

Additional Disease Information for SLC7A13

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC7A13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC7A13 Gene

Publications for SLC7A13 Gene

  1. Homologues of amino acid permeases: cloning and tissue expression of XAT1 and XAT2. (PMID: 11943479) Blondeau JP (Gene 2002) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains. (PMID: 11907033) Matsuo H … Endou H (The Journal of biological chemistry 2002) 2 3 58
  5. Mig-6 controls EGFR trafficking and suppresses gliomagenesis. (PMID: 20351267) Ying H … DePinho RA (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 58

Products for SLC7A13 Gene

Sources for SLC7A13 Gene

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