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SLC7A11 Gene

protein-coding   GIFtS: 62
GCID: GC04M139085

Solute Carrier Family 7 (Anionic Amino Acid Transporter...

  See SLC7A11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 7 (Anionic Amino Acid Transporter Light Chain,
Xc- System), Member 111 2
     xCT2 3
Amino Acid Transport System Xc-2 3     CCBR12
Calcium Channel Blocker Resistance Protein CCBR12 3     Cystine/Glutamate Transporter2
Solute Carrier Family 7 Member 112 3     Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System)
Member 112

External Ids:    HGNC: 110591   Entrez Gene: 236572   Ensembl: ENSG000001510127   OMIM: 6079335   UniProtKB: Q9UPY53   

Export aliases for SLC7A11 gene to outside databases

Previous GC identifers: GC04M140018 GC04M139368 GC04M139551 GC04M139662 GC04M139669 GC04M139442 GC04M139304 GC04M134820


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC7A11 Gene:
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is
highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is
transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi
sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this
gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via
the XCT channels, resulting in neuronal cell death. (provided by RefSeq, Sep 2011)

GeneCards Summary for SLC7A11 Gene:
SLC7A11 (solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11) is a protein-coding gene. Diseases associated with SLC7A11 include dyscalculia, and kaposi's sarcoma. GO annotations related to this gene include cystine:glutamate antiporter activity. An important paralog of this gene is SLC7A7.

UniProtKB/Swiss-Prot: XCT_HUMAN, Q9UPY5
Function: Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form
of cystine and glutamate

Gene Wiki entry for SLC7A11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC7A11 gene promoter:
         STAT5B   AP-1   ATF-2   Evi-1   AREB6   POU2F1   POU2F1a   c-Jun   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC7A11 promoter sequence
   Search Chromatin IP Primers for SLC7A11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC7A11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28-q32   Ensembl cytogenetic band:  4q28.3   HGNC cytogenetic band: 4q28-q32

SLC7A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC7A11 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M139085:  view genomic region     (about GC identifiers)

Start:
139,085,248 bp from pter      End:
139,163,503 bp from pter
Size:
78,256 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: XCT_HUMAN, Q9UPY5 (See protein sequence)
Recommended Name: Cystine/glutamate transporter  
Size: 501 amino acids; 55423 Da
Subunit: Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (By similarity)
Secondary accessions: A8K2U4

Explore the universe of human proteins at neXtProt for SLC7A11: NX_Q9UPY5

Explore proteomics data for SLC7A11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys12
  • Glycosylation2 at Asn314
  • Modification sites at PhosphoSitePlus

  • See SLC7A11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055146.1  
    ENSEMBL proteins: 
     ENSP00000280612   ENSP00000424046  
    Reactome Protein details: Q9UPY5

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    antibodies-online peptides for SLC7A11

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Cystine/glutamate transporter
    SLC7 family

    2 InterPro protein domains:
     IPR004760 L_AA_transporter
     IPR002293 AA/rel_permease1

    Graphical View of Domain Structure for InterPro Entry Q9UPY5

    ProtoNet protein and cluster: Q9UPY5

    UniProtKB/Swiss-Prot: XCT_HUMAN, Q9UPY5
    Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter
    (LAT) (TC 2.A.3.8) family


    Find genes that share domains with SLC7A11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XCT_HUMAN, Q9UPY5
    Function: Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form
    of cystine and glutamate

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0015171amino acid transmembrane transporter activity ----
    GO:0015327cystine:glutamate antiporter activity TAS10206947
         
    Find genes that share ontologies with SLC7A11           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Slc7a11):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  integument 
     pigmentation  tumorigenesis 

    Find genes that share phenotypes with SLC7A11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc7a11tm1Hsat for SLC7A11

       genOway: Develop your customized and physiologically relevant rodent model for SLC7A11

    miRNA
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    miRTarBase miRNAs that target SLC7A11:
    hsa-mir-32-5p (MIRT028377), hsa-mir-122-5p (MIRT003108), hsa-mir-340-5p (MIRT019651), hsa-mir-215-5p (MIRT024370), hsa-mir-192-5p (MIRT026724), hsa-mir-155-5p (MIRT020896), hsa-mir-128-3p (MIRT022074), hsa-mir-181a-5p (MIRT025179), hsa-mir-30a-5p (MIRT005145), hsa-mir-26b-5p (MIRT029918), hsa-mir-148b-3p (MIRT019496)

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    Selected qRT-PCR Assays for microRNAs that regulate SLC7A11 (see all 107):
    hsa-miR-411* hsa-miR-548j hsa-miR-3607-3p hsa-miR-4254 hsa-miR-376b hsa-miR-199a-3p hsa-miR-128 hsa-miR-30d
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XCT_HUMAN, Q9UPY5: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2
    mitochondrion2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005791rough endoplasmic reticulum IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC7A11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC7A11 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Amino acid transport across the plasma membrane0.32
    2Hemostasis
    Hemostasis0.43
    3Glucose / Energy Metabolism
    Glucose / Energy Metabolism
    4Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall
    5Basigin interactions
    Basigin interactions


    Find genes that share SuperPaths with SLC7A11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SLC7A11
        Glucose / Energy Metabolism

    2 Reactome Pathways for SLC7A11
        Amino acid transport across the plasma membrane
    Basigin interactions


        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC7A11: 
              GABA & Glutamate in human mouse rat
              Drug Transporters in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC7A11

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLC7A11 (Q9UPY51, 3 ENSP000002806124) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD44P160701, 3, ENSP000002783854EBI-3843348,EBI-490245 I2D: score=1 STRING: ENSP00000278385
    BAATQ140323, ENSP000002594074I2D: score=1 STRING: ENSP00000259407
    SLC3A2P081953, ENSP000003671244I2D: score=1 STRING: ENSP00000367124
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003333amino acid transmembrane transport ----
    GO:0006810transport ----
    GO:0006811ion transport TAS--
    GO:0006865amino acid transport TAS--
    GO:0006979response to oxidative stress IEA--

    Find genes that share ontologies with SLC7A11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC7A11 (XCT)

    2 HMDB Compounds for SLC7A11    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Cystine(-)-Cystine (see all 31)56-89-3--
    SodiumSodium (see all 2)7440-23-5--

    7 DrugBank Compounds for SLC7A11    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Cystine(-)-Cystine (see all 5)56-89-3target--12898700 12065721 11867597 12498985 16014042
    Riluzole-- 1744-22-5targetinducer20226190 8813989 10899284 12629173 20059984
    SulfasalazineSulfasalazin (see all 2)599-79-1targetinhibitor11587223 11752352
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--16719820
    Rosuvastatin-- 287714-41-4transporter--16697742
    Taurocholic Acid-- 81-24-3transporter--8132774
    Tauroursodeoxycholic acidTauroursodeoxycholate (see all 2)14605-22-2transporter--9486191

    5 Novoseek inferred chemical compound relationships for SLC7A11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cystine 91.3 29 12763038 (4), 18054200 (2), 11133847 (2), 19207949 (2) (see all 16)
    diethylmaleate 64 6 12498985 (4), 11406111 (1)
    glutamate 63.9 21 12763038 (2), 11133847 (2), 19207949 (2), 16771835 (2) (see all 12)
    cysteine 46.5 2 18654882 (2)
    oxygen 4.1 2 11213471 (2)



    Find genes that share compounds with SLC7A11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC7A11 gene: 
    NM_014331.3  

    Unigene Cluster for SLC7A11:

    Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
    Hs.390594  [show with all ESTs]
    Unigene Representative Sequence: NM_014331
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280612(uc021xrw.1) ENST00000509248
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat SLC7A11

    Additional mRNA sequence: 

    AB026891.1 AB040875.1 AF200708.1 AF252872.1 AJ277882.1 AK290359.1 AK314855.1 BC012087.1 
    BC041925.1 BX538293.1 

    2 DOTS entries:

    DT.40213789  DT.95336134 

    Selected AceView cDNA sequences (see all 152):

    BQ000500 AI677965 BC041925 BM668540 CB157913 AA486499 AV715032 BI335326 
    AI206626 BX473996 CB138744 BU172643 BG284503 AW469211 AI423703 BM739316 
    AA639698 BM772075 BQ014898 BF114686 CB135077 AW237145 AA227926 AW961203 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A11    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                        
    SP2:                                            -           -               
    SP3:                                                                        


    ECgene alternative splicing isoforms for SLC7A11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC7A11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTTTGTA
    SLC7A11 Expression
    About this image


    SLC7A11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Eye (Sensory Organs)
             Lens
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
    SLC7A11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC7A11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.390594
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC7A11: 
              GABA & Glutamate in human mouse rat
              Drug Transporters in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SLC7A11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC7A11 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc7a111 , 5 solute carrier family 7 (cationic amino acid transporter, more1, 5 87.33(n)1
    89.4(a)1
      3 (21.72 cM)5
    265701  NM_011990.21  NP_036120.11 
     503649365 
    chicken
    (Gallus gallus)
    Aves SLC7A111 solute carrier family 7 (anionic amino acid transporter more 80.25(n)
    85.34(a)
      428731  XM_426289.4  XP_426289.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC7A116
    solute carrier family 7 (anionic amino acid transp...
    82(a)
    1 ↔ 1
    5(120682280-120751095)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004967261 cystine/glutamate transporter-like 76.5(n)
    83.47(a)
      100496726  XM_002932048.2  XP_002932094.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003312031 cystine/glutamate transporter-like 67.54(n)
    70.08(a)
      100331203  XM_002664447.2  XP_002664493.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F27C8.13 integral membrane protein E16 like 43(a)
    (best of 10)
      IV(9599614-9601874)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MUP16
    MUP36
    High affinity methionine permease, integral membra...
    Low affinity methionine permease, similar to Mup1p...
    20(a)
    19(a)
    many ↔ many
    many ↔ many
    VII(599417-601141) YGR055W
    VIII(26241-27881) YHL036W


    ENSEMBL Gene Tree for SLC7A11 (if available)
    TreeFam Gene Tree for SLC7A11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for SLC7A11 gene
    SLC7A72  SLC7A62  SLC7A82  SLC7A92  SLC7A52  SLC7A132  SLC7A102  
    9 SIMAP similar genes for SLC7A11 using alignment to 3 protein entries:     XCT_HUMAN (see all proteins):
    hxCT    SLC7A6    SLC7A5    SLC7A7    lat1    SLC7A9
    SLC7A10    SLC7A8    SLC7A13

    Find genes that share paralogs with SLC7A11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SLC7A11 (see all 1315)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881376151,2
    --139099833(+) AAAATG/TAAATG 1 -- int10--------
    rs1449102621,2
    --139099900(+) GTTATC/TATAAT 1 -- int10--------
    rs780862741,2
    C,F--139099938(+) GTAGCG/ATACAG 1 -- int11Minor allele frequency- A:0.11WA 118
    rs1490272291,2
    --139099946(+) CAGTCA/GTAATG 1 -- int10--------
    rs1806812151,2
    --139099965(+) ATTTGC/TAGGCC 1 -- int10--------
    rs1422449941,2
    --139099995(+) AATCTC/TGTGTC 1 -- int10--------
    rs1851130401,2
    C--139100123(+) AAAATC/TTCATC 1 -- int10--------
    rs1467530351,2
    --139100248(+) ATGCCA/GTAATG 1 -- int10--------
    rs1899750551,2
    --139100250(+) GCCATA/CATGTT 1 -- int10--------
    rs1813520191,2
    --139100257(+) TGTTCG/TCAAAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SLC7A11 (139085248 - 139163503 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC7A11 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv822746CNV Loss20364138
    nsv526177CNV Loss19592680
    nsv880158CNV Loss21882294
    nsv508317CNV Loss20534489
    nsv880157CNV Loss21882294
    nsv470081CNV Loss18288195
    nsv470082CNV Gain18288195
    nsv880156CNV Gain21882294
    nsv830080CNV Gain17160897
    nsv818280CNV Gain17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC7A11
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC7A11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607933    OMIM disorders: --

    3 diseases for SLC7A11:    
    About MalaCards
    dyscalculia    kaposi's sarcoma    cystinuria

    1 disease from the University of Copenhagen DISEASES database for SLC7A11:
    Dyscalculia

    Find genes that share disorders with SLC7A11           About GenesLikeMe

    1 Novoseek inferred disease relationship for SLC7A11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 3 18054200 (1), 11766986 (1)

    Genetic Association Database (GAD): SLC7A11
    Human Genome Epidemiology (HuGE) Navigator: SLC7A11 (2 documents)

    Export disorders for SLC7A11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC7A11 gene, integrated from 10 sources (see all 79):
    (articles sorted by number of sources associating them with SLC7A11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT. (PubMed id 12763038)1, 3, 9 Wang H....Sato H. (Biochem. Biophys. Res. Commun. 2003)
    2. Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-. (PubMed id 11213471)1, 2, 9 Sato H.... Bannai S. (Antioxid. Redox Signal. 2000)
    3. Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells. (PubMed id 11133847)1, 2, 9 Bridges C.C.... Ganapathy V. (Invest. Ophthalmol. Vis. Sci. 2001)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility. (PubMed id 15151999)1, 2 Gasol E.... Palacin M. (J. Biol. Chem. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. (PubMed id 10206947)1, 3 Sato H....Bannai S. (J. Biol. Chem. 1999)
    8. Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-. (PubMed id 11417227)1, 9 Bassi M.T....PalacA-n M. (Pflugers Arch. 2001)
    9. Decreased expression of the active subunit of the cystine/glutamate antiporter xCT is associated with loss of heterozygosity of 1p in oligodendroglial tumours WHO grade II. (PubMed id 19207949)1, 9 Stockhammer F....van Landeghem F.K. (Histopathology 2009)
    10. xCT expression reduces the early cell cycle requirement for calcium signaling. (PubMed id 18054200)1, 9 Lastro M....Conklin D.S. (Cell. Signal. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23657 HGNC: 11059 AceView: SLC7A11 Ensembl:ENSG00000151012 euGenes: HUgn23657
    ECgene: SLC7A11 H-InvDB: SLC7A11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC7A11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC7A11 gene:
    Search GeneIP for patents involving SLC7A11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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