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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC7A11 Gene

protein-coding GIFtS: 60
GCID: GC04M139085

solute carrier family 7 (anionic amino acid transporter...

Explore 18 diseases affiliated with
SLC7A11 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 7 (Anionic Amino Acid Transporter Light Chain, Xc- System), Member 11¹ ²		Solute Carrier Family 7 Member 11² ³
XCT¹		CCBR1²
Amino Acid Transport System Xc-² ³		Cystine/Glutamate Transporter²
Calcium Channel Blocker Resistance Protein CCBR1² ³		Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11²

External Ids:	HGNC: 11059¹	Entrez Gene: 23657²	Ensembl: ENSG00000151012⁷	OMIM: 607933⁵	UniProtKB: Q9UPY5³

Export aliases for SLC7A11 gene to outside databases

Previous GC identifers: GC04M140018 GC04M139368 GC04M139551 GC04M139662 GC04M139669 GC04M139442 GC04M139304 GC04M134820

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC7A11:

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly

specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in

exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated

herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas

(compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in

neuronal cell death. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: XCT_HUMAN, Q9UPY5

Function: Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of

cystine and glutamate

Gene Wiki entry for SLC7A11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC7A11 gene promoter:
STAT5B AP-1 ATF-2 Evi-1 AREB6 POU2F1 POU2F1a c-Jun Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC7A11 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC7A11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC7A11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28-q32 Ensembl cytogenetic band: 4q28.3 HGNC cytogenetic band: 4q28-q32

SLC7A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC7A11 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M139085: view genomic region (about GC identifiers)

Start:	139,085,248 bp from pter	End:	139,163,503 bp from pter
Size:	78,256 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: XCT_HUMAN, Q9UPY5 (See protein sequence)

Recommended Name: Cystine/glutamate transporter

Size: 501 amino acids; 55423 Da

Subunit: Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: A8K2U4

Explore the universe of human proteins at neXtProt for SLC7A11: NX_Q9UPY5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UPY5

SLC7A11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055146.1

ENSEMBL proteins:

ENSP00000280612 ENSP00000424046

Reactome Protein details: Q9UPY5
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLC7A11

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005791	rough endoplasmic reticulum	IEA	--
GO:0005792	microsome	--	--
GO:0005856	cytoskeleton	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

SLC7A11 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC7A11 for domains About GeneDecksing

2 InterPro domains/families:

IPR002293 AA/rel_permease1

IPR004760 L_AA_transporter

Graphical View of Domain Structure for InterPro Entry Q9UPY5

ProtoNet protein and cluster: Q9UPY5

UniProtKB/Swiss-Prot: XCT_HUMAN, Q9UPY5

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC

2.A.3.8) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: XCT_HUMAN, Q9UPY5

Function: Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of

cystine and glutamate

miRNA Products:		miRTarBase miRNAs that target SLC7A11: hsa-mir-122 (MIRT003108), hsa-mir-30a (MIRT005145)

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A11

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0015171	amino acid transmembrane transporter activity	--	--
GO:0015327	cystine:glutamate antiporter activity	TAS	10206947

SLC7A11 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Slc7a11^tm1Hsat for SLC7A11
     7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Slc7a11):

cellular	hematopoietic system	homeostasis/metabolism	immune system	integument
pigmentation	tumorigenesis

SLC7A11 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Amino acid and oligopeptide SLC transporters

	Amino acid and oligopeptide SLC transporters	1.00			Transport of inorganic cations/anions and amino acids/oligopeptides	0.52
	Amino acid transport across the plasma membrane	0.63

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Basigin interactions

Basigin interactions

1.00

Cell surface interactions at the vascular wall

Cell surface interactions at the vascular wall

1.00

Platelet activation, signaling and aggregation

Hemostasis

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 Reactome Pathways for SLC7A11 (see all 8)

	Hemostasis
	Transmembrane transport of small molecules
	SLC-mediated transmembrane transport
	Amino acid and oligopeptide SLC transporters
	Transport of inorganic cations/anions and amino acids/oligopeptides

SLC7A11 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SLC7A11

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for SLC7A11 (Q9UPY5^{1, 3} ENSP00000280612⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD44	P16070¹^,³, ENSP00000278385⁴	EBI-3843348,EBI-490245 I2D: score=1 STRING: ENSP00000278385
BAAT	Q14032³, ENSP00000259407⁴	I2D: score=1 STRING: ENSP00000259407
SLC3A2	P08195³, ENSP00000367124⁴	I2D: score=1 STRING: ENSP00000367124
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	TAS	--
GO:0006865	amino acid transport	TAS	--
GO:0006979	response to oxidative stress	IEA	--
GO:0007420	brain development	IEA	--
GO:0007596	blood coagulation	TAS	--

SLC7A11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC7A11 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC7A11

2 HMDB Compounds for SLC7A11 About this table

Compound	Synonyms	CAS #	PubMed Ids
L-Cystine	(-)-Cystine (see all 31)	56-89-3	--
Sodium	Sodium (see all 2)	7440-23-5	--

4 DrugBank Compounds for SLC7A11 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Cystine	(-)-Cystine (see all 5)	56-89-3	target	--	12898700 12065721 11867597 12498985 16014042
Riluzole	--	1744-22-5	target	inducer	20226190 8813989 10899284 12629173 20059984
Sulfasalazine	Sulfasalazin (see all 2)	599-79-1	target	inhibitor	11587223 11752352
L-Glutamic Acid	(2S)-2-Aminopentanedioic acid (see all 15)	56-86-0	target	--	16719820

5 Novoseek chemical compound relationships for SLC7A11 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cystine	91.3	29	12763038 (4), 18054200 (2), 11133847 (2), 19207949 (2) (see all 16)
diethylmaleate	64	6	12498985 (4), 11406111 (1)
glutamate	63.9	21	12763038 (2), 11133847 (2), 19207949 (2), 16771835 (2) (see all 12)
cysteine	46.5	2	18654882 (2)
oxygen	4.1	2	11213471 (2)

Search CenterWatch for drugs/clinical trials and news about SLC7A11 / XCT

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC7A11 gene:

NM_014331.3

Unigene Cluster for SLC7A11:

Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11

Hs.390594 [show with all ESTs]

Unigene Representative Sequence: NM_014331

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000280612(uc021xrw.1) ENST00000509248

miRNA Products:		OriGene 3'-UTR Clone: SLC7A11 Browse OriGene MicroRNA Expression Plasmids
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		8/107 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC7A11 (see all 107):
		hsa-miR-411* hsa-miR-548j hsa-miR-3607-3p hsa-miR-4254 hsa-miR-376b hsa-miR-199a-3p hsa-miR-128 hsa-miR-30d

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Additional cDNA sequence:

AB026891.1 AB040875.1 AF200708.1 AF252872.1 AJ277882.1 AK290359.1 AK314855.1 BC012087.1

BC041925.1 BX538293.1

2 DOTS entries:

DT.40213789 DT.95336134

24/152 AceView cDNA sequences (see all 152):

BC041925 AA375957 CD677372 BQ000500 CB135077 BF114686 AA486499 BQ014898

AI619649 CB138744 BX538293 CB157913 BU172643 BX473996 BU678642 T16595

BM668540 AW237145 BF796780 BM772075 AA488687 AA227926 AW197113 AA639698

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A11 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12
SP1:
SP2:															-				-
SP3:

ECgene alternative splicing isoforms for SLC7A11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC7A11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTTTTGTA

About this image

SLC7A11 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Epicardium

Respiratory Bronchioles

Lung

Ovary

Testis

Eye

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

See SLC7A11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC7A11

SOURCE GeneReport for Unigene cluster: Hs.390594

SABiosciences Expression via Pathway-Focused PCR Arrays including SLC7A11:

GABA & Glutamate in human mouse rat

Drug Transporters in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SLC7A11 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC7A11¹	solute carrier family 7 (anionic amino acid transporter more	80.21(n) 85.11(a)		428731 XM_426289.3 XP_426289.3
lizard (Anolis carolinensis)	Reptilia	-- --	--	83(a) 82(a)	1 ↔ many 1 ↔ many	5(120738574-120751089) 5(120682569-120709094)
zebrafish (Danio rerio)	Actinopterygii	LOC100331203¹	cystine/glutamate transporter-like	67.61(n) 70.22(a)		100331203 XM_002664447.1 XP_002664493.1
honey bee (Apis mellifera)	Insecta	--	--	39(a)	possible ortholog	GroupUn.631(55-1174)
E. coli (Escherichia coli)	Gamma proteobacteria	frlA⁶	predicted fructoselysine transporter	24(a)	1 → many	Chromosome(3497932-3499269)

ENSEMBL Gene Tree for SLC7A11 (if available)
TreeFam Gene Tree for SLC7A11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC7A11 gene

SLC7A6² SLC7A4² SLC7A9² SLC7A14² SLC7A3² SLC7A10² SLC7A13² SLC7A7²

SLC7A2² SLC7A8² SLC7A1² SLC7A5²

9 SIMAP similar genes for SLC7A11 using alignment to 3 protein entries: XCT_HUMAN (see all proteins):

hxCT SLC7A6 SLC7A5 SLC7A7 lat1 SLC7A9

SLC7A10 SLC7A8 SLC7A13

SLC7A11 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SLC7A11
2 CNVs: 9495 3517

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC7A11

DNA2.0 Custom Variant and Variant Library Synthesis for SLC7A11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC7A11 for disorders           About GeneDecksing

OMIM gene information: 607933    OMIM disorders: --

18 diseases for SLC7A11:    About MalaCards

kaposi's sarcoma cleft lip/palate sarcoma cleft lip

dyscalculia brain edema cystinuria multiple sclerosis

gout cholera neurodegeneration ovarian cancer

pancreatic cancer breast cancer pancreatitis neuronitis

retinitis immunodeficiency

1 disease from the University of Copenhagen DISEASES database for SLC7A11:

Dyscalculia

1 Novoseek disease relationship for SLC7A11 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0	3	18054200 (1), 11766986 (1)

Human Genome Epidemiology (HuGE) Navigator: SLC7A11 (2 documents)

Export disorders for SLC7A11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLC7A11 gene, integrated from 9 sources (see all 69):
(articles sorted by number of sources associating them with SLC7A11)

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Expression of the activity of cystine/glutamate excha nge transporter, system x(c)(-), by xCT and rBAT. (PubMed id 12763038)^{1, 3, 9} Wang H....Sato H. (2003)
Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-. (PubMed id 11213471)^{1, 2, 9} Sato H.... Bannai S. (2000)
Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells. (PubMed id 11133847)^{1, 2, 9} Bridges C.C....Ganapathy V. (2001)
Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility. (PubMed id 15151999)^{1, 2} Gasol E.... Palacin M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. (PubMed id 10206947)^{1, 3} Sato H....Bannai S. (1999)
Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-. (PubMed id 11417227)^{1, 9} Bassi M.T....Palacin M. (2001)
Decreased expression of the active subunit of the cystine/glutamate antiporter xCT is associated with loss of heterozygosity of 1p in oligodendroglial tumours WHO grade II. (PubMed id 19207949)^{1, 9} Stockhammer F....van Landeghem F.K. (2009)
xCT expression reduces the early cell cycle requirement for calcium signaling. (PubMed id 18054200)^{1, 9} Lastro M....Conklin D.S. (2008)
Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression. (PubMed id 19017641)^{1, 9} Lewerenz J. and Maher P. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23657	HGNC: 11059	AceView: SLC7A11	Ensembl:ENSG00000151012	euGenes: HUgn23657
ECgene: SLC7A11	H-InvDB: SLC7A11

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SLC7A11	Pharmacogenomics, SNPs, Pathways

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Patent Information for SLC7A11 gene:
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