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Aliases for SLC7A10 Gene

Aliases for SLC7A10 Gene

  • Solute Carrier Family 7 Member 10 2 3 4
  • Solute Carrier Family 7 (Neutral Amino Acid Transporter Light Chain, Asc System), Member 10 2 3 5
  • ASC-1 3 4
  • ASC1 3 4
  • Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 10 3
  • Solute Carrier Family 7, (Neutral Amino Acid Transporter, Y+ System) Member 10 3
  • HASC-1 3

External Ids for SLC7A10 Gene

Previous GeneCards Identifiers for SLC7A10 Gene

  • GC19M034317
  • GC19M034148
  • GC19M038375
  • GC19M038391
  • GC19M033699
  • GC19M030201

Summaries for SLC7A10 Gene

Entrez Gene Summary for SLC7A10 Gene

  • SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several other neutral amino acids (Nakauchi et al., 2000 [PubMed 10863037]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC7A10 Gene

SLC7A10 (Solute Carrier Family 7 Member 10) is a Protein Coding gene. Diseases associated with SLC7A10 include cystinuria. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Basigin interactions. GO annotations related to this gene include amino acid transmembrane transporter activity and neutral amino acid transmembrane transporter activity. An important paralog of this gene is SLC7A7.

UniProtKB/Swiss-Prot for SLC7A10 Gene

  • Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.

Gene Wiki entry for SLC7A10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A10 Gene

Genomics for SLC7A10 Gene

Regulatory Elements for SLC7A10 Gene

Enhancers for SLC7A10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC7A10 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC7A10 Gene

Chromosome:
19
Start:
33,208,664 bp from pter
End:
33,225,850 bp from pter
Size:
17,187 bases
Orientation:
Minus strand

Genomic View for SLC7A10 Gene

Genes around SLC7A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC7A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC7A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A10 Gene

Proteins for SLC7A10 Gene

  • Protein details for SLC7A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS82-AAA1_HUMAN
    Recommended name:
    Asc-type amino acid transporter 1
    Protein Accession:
    Q9NS82
    Secondary Accessions:
    • B2RE84

    Protein attributes for SLC7A10 Gene

    Size:
    523 amino acids
    Molecular mass:
    56798 Da
    Quaternary structure:
    • Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

neXtProt entry for SLC7A10 Gene

Proteomics data for SLC7A10 Gene at MOPED

Post-translational modifications for SLC7A10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC7A10 Gene

Antibody Products

No data available for DME Specific Peptides for SLC7A10 Gene

Domains & Families for SLC7A10 Gene

Gene Families for SLC7A10 Gene

Protein Domains for SLC7A10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC7A10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS82

UniProtKB/Swiss-Prot:

AAA1_HUMAN :
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily.
Family:
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily.
genes like me logo Genes that share domains with SLC7A10: view

Function for SLC7A10 Gene

Molecular function for SLC7A10 Gene

UniProtKB/Swiss-Prot Function:
Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.

Gene Ontology (GO) - Molecular Function for SLC7A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity IEA --
GO:0015297 antiporter activity IBA --
genes like me logo Genes that share ontologies with SLC7A10: view
genes like me logo Genes that share phenotypes with SLC7A10: view

Animal Models for SLC7A10 Gene

MGI Knock Outs for SLC7A10:

Animal Model Products

CRISPR Products

miRNA for SLC7A10 Gene

miRTarBase miRNAs that target SLC7A10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC7A10 Gene

Localization for SLC7A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC7A10 Gene COMPARTMENTS Subcellular localization image for SLC7A10 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for SLC7A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,TAS 10734121
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with SLC7A10: view

Pathways & Interactions for SLC7A10 Gene

genes like me logo Genes that share pathways with SLC7A10: view

Gene Ontology (GO) - Biological Process for SLC7A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IEA --
GO:0006811 ion transport TAS --
GO:0042942 D-serine transport IEA,IBA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC7A10: view

No data available for SIGNOR curated interactions for SLC7A10 Gene

Drugs & Compounds for SLC7A10 Gene

(2) Drugs for SLC7A10 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-serine Experimental Pharma Agonist 0

(1) Additional Compounds for SLC7A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC7A10: view

Transcripts for SLC7A10 Gene

Unigene Clusters for SLC7A10 Gene

Solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:

Relevant External Links for SLC7A10 Gene

GeneLoc Exon Structure for
SLC7A10
ECgene alternative splicing isoforms for
SLC7A10

Expression for SLC7A10 Gene

mRNA expression in normal human tissues for SLC7A10 Gene

mRNA differential expression in normal tissues according to GTEx for SLC7A10 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x10.0), Adipose - Subcutaneous (x4.6), and Brain - Caudate (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for SLC7A10 Gene

This gene is overexpressed in Testis (49.0), Frontal cortex (11.1), and Fetal Brain (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC7A10 Gene



SOURCE GeneReport for Unigene cluster for SLC7A10 Gene Hs.58679

mRNA Expression by UniProt/SwissProt for SLC7A10 Gene

Q9NS82-AAA1_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.
genes like me logo Genes that share expression patterns with SLC7A10: view

Protein tissue co-expression partners for SLC7A10 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC7A10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC7A10 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SLC7A10 35
  • 91.91 (n)
  • 94.41 (a)
SLC7A10 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc7a10 35
  • 88.34 (n)
  • 92.93 (a)
Slc7a10 16
Slc7a10 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC7A10 35
  • 99.11 (n)
  • 98.47 (a)
SLC7A10 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc7a10 35
  • 88.66 (n)
  • 92.93 (a)
cow
(Bos Taurus)
Mammalia SLC7A10 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC7A10 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC7A10 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC7A10 35
  • 77.26 (n)
  • 85.34 (a)
SLC7A10 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC7A10 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc7a10 35
  • 68.9 (n)
  • 77.82 (a)
zebrafish
(Danio rerio)
Actinopterygii slc7a10b 35
  • 73.14 (n)
  • 75.95 (a)
slc7a10a 36
  • 70 (a)
OneToMany
slc7a10b 36
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6070 37
  • 42 (a)
JhI-21 37
  • 43 (a)
mnd 37
  • 49 (a)
gb 36
  • 41 (a)
ManyToMany
JhI-21 36
  • 41 (a)
ManyToMany
mnd 36
  • 45 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C55C2.5a 37
  • 30 (a)
C55C2.5b 37
  • 30 (a)
F07C3.7 37
  • 42 (a)
F27C8.1 37
  • 42 (a)
F52H2.2 37
  • 38 (a)
T13A10.10 37
  • 32 (a)
Y53H1C.1 37
  • 33 (a)
aat-2 36
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for SLC7A10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC7A10 Gene

ENSEMBL:
Gene Tree for SLC7A10 (if available)
TreeFam:
Gene Tree for SLC7A10 (if available)

Paralogs for SLC7A10 Gene

Paralogs for SLC7A10 Gene

(13) SIMAP similar genes for SLC7A10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC7A10: view

Variants for SLC7A10 Gene

Sequence variations from dbSNP and Humsavar for SLC7A10 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs79717007 - 33,215,789(+) AAGAT(C/G)TCTGT intron-variant, nc-transcript-variant, reference, missense
rs34663170 - 33,210,492(-) GAGGC(A/C/G)GCCTG intron-variant, nc-transcript-variant, reference, missense
rs7258412 -- 33,219,244(+) CTGAG(A/C)CTTCG intron-variant
rs7508758 -- 33,216,800(+) gtctc(A/G)aactc intron-variant
rs8101891 -- 33,219,789(+) GCTCT(C/T)CCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC7A10 Gene

Variant ID Type Subtype PubMed ID
nsv833808 CNV Loss 17160897
nsv911579 CNV Loss 21882294
dgv3839n71 CNV Loss 21882294
dgv3840n71 CNV Loss 21882294
dgv3841n71 CNV Loss 21882294
dgv3842n71 CNV Loss 21882294
esv1069310 CNV Insertion 17803354
dgv3843n71 CNV Loss 21882294

Variation tolerance for SLC7A10 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC7A10 Gene

HapMap Linkage Disequilibrium report
SLC7A10
Human Gene Mutation Database (HGMD)
SLC7A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC7A10 Gene

Disorders for SLC7A10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC7A10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cystinuria
  • csnu
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC7A10

Genetic Association Database (GAD)
SLC7A10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC7A10
genes like me logo Genes that share disorders with SLC7A10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC7A10 Gene

Publications for SLC7A10 Gene

  1. Cloning and characterization of a human brain Na+-independent transporter for small neutral amino acids that transports D-serine with high affinity. (PMID: 10863037) Nakauchi J. … Kanai Y. (Neurosci. Lett. 2000) 2 3 4 23 67
  2. The amino acid transporter asc-1 is not involved in cystinuria. (PMID: 15458438) Pineda M. … PalacA-n M. (Kidney Int. 2004) 3 23
  3. Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria? (PMID: 11509015) Leclerc D. … Rozen R. (Mol. Genet. Metab. 2001) 3 23
  4. Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids. (PMID: 10734121) Fukasawa Y. … Kanai Y. (J. Biol. Chem. 2000) 2 3
  5. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. (PMID: 25080478) Ussar S. … Kahn C.R. (Sci Transl Med 2014) 3

Products for SLC7A10 Gene

Sources for SLC7A10 Gene

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