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SLC7A10 Gene

protein-coding   GIFtS: 57
GCID: GC19M033699

Solute Carrier Family 7 (Neutral Amino Acid Transporter...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 7 (Neutral Amino Acid Transporter Light Chain,
Asc System), Member 101 2
     Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System)
Member 102
Solute Carrier Family 7 Member 102 3     Solute Carrier Family 7, (Neutral Amino Acid Transporter, Y+ System)
Member 102
HASC-12     ASC13
asc-12     Asc-13
Asc-Type Amino Acid Transporter 12     

External Ids:    HGNC: 110581   Entrez Gene: 563012   Ensembl: ENSG000001308767   OMIM: 6079595   UniProtKB: Q9NS823   

Export aliases for SLC7A10 gene to outside databases

Previous GC identifers: GC19M034317 GC19M034148 GC19M038375 GC19M038391 GC19M030201


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC7A10 Gene:
SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several
other neutral amino acids (Nakauchi et al., 2000 (PubMed 10863037)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC7A10 Gene:
SLC7A10 (solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10) is a protein-coding gene. Diseases associated with SLC7A10 include cystinuria, and choroiditis. GO annotations related to this gene include neutral amino acid transmembrane transporter activity and L-serine transmembrane transporter activity. An important paralog of this gene is SLC7A7.

UniProtKB/Swiss-Prot: AAA1_HUMAN, Q9NS82
Function: Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in
the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse

Gene Wiki entry for SLC7A10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC7A10 gene promoter:
         c-Fos   SRF   AP-1   SRF (504 AA)   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC7A10 promoter sequence
   Search Chromatin IP Primers for SLC7A10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC7A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.11

SLC7A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC7A10 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M033699:  view genomic region     (about GC identifiers)

Start:
33,699,570 bp from pter      End:
33,716,756 bp from pter
Size:
17,187 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AAA1_HUMAN, Q9NS82 (See protein sequence)
Recommended Name: Asc-type amino acid transporter 1  
Size: 523 amino acids; 56798 Da
Subunit: Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (By similarity)
Secondary accessions: B2RE84

Explore the universe of human proteins at neXtProt for SLC7A10: NX_Q9NS82

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_062823.1  
    ENSEMBL proteins: 
     ENSP00000253188   ENSP00000465421   ENSP00000466876   ENSP00000466410  
    Reactome Protein details: Q9NS82

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Asc-type amino acid transporter 1
    SLC7 family

    1 InterPro protein domain:
     IPR002293 AA/rel_permease1

    Graphical View of Domain Structure for InterPro Entry Q9NS82

    ProtoNet protein and cluster: Q9NS82

    UniProtKB/Swiss-Prot: AAA1_HUMAN, Q9NS82
    Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily


    SLC7A10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AAA1_HUMAN, Q9NS82
    Function: Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in
    the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0015171amino acid transmembrane transporter activity ----
    GO:0015175neutral amino acid transmembrane transporter activity IDA10863037
    GO:0015194L-serine transmembrane transporter activity TAS10863037
         
    SLC7A10 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc7a10):
     behavior/neurological  growth/size/body  homeostasis/metabolism  mortality/aging  muscle 
     nervous system 

    SLC7A10 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC7A10
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC7A10
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    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate SLC7A10:
    hsa-miR-30c hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-621 hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidSLC7A10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC7A10

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AAA1_HUMAN, Q9NS82: Membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS10863037
    GO:0016020membrane TAS10734121
    GO:0016021integral component of membrane ----

    SLC7A10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC7A10 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Amino acid transport across the plasma membrane0.32
    2Hemostasis
    Hemostasis0.43
    3Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall
    4Basigin interactions
    Basigin interactions

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for SLC7A10
        Amino acid transport across the plasma membrane
    Basigin interactions



    SLC7A10 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC7A10
    Interactions:

        GeneGlobe Interaction Network for SLC7A10

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SLC7A10 (Q9NS823 ENSP000002531884) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC3A2P081953, ENSP000003671244I2D: score=1 STRING: ENSP00000367124
    SLC3A1ENSP000002606494STRING: ENSP00000260649
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003333amino acid transmembrane transport ----
    GO:0006810transport ----
    GO:0006811ion transport TAS--
    GO:0006865amino acid transport TAS--
    GO:0007596blood coagulation TAS--

    SLC7A10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC7A10 (AAA1)

    2 HMDB Compounds for SLC7A10    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Serine(2R)-2-amino-3-hydroxypropanoate (see all 8)312-84-5--
    SodiumSodium (see all 2)7440-23-5--

    1 Novoseek inferred chemical compound relationship for SLC7A10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 48.2 22 19382234 (3), 18805436 (2), 10863037 (2), 14622183 (1) (see all 5)



    SLC7A10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC7A10 gene: 
    NM_019849.2  

    Unigene Cluster for SLC7A10:

    Solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10
    Hs.58679  [show with all ESTs]
    Unigene Representative Sequence: NM_019849
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253188(uc002nul.2 uc002num.2 uc010xrq.2) ENST00000590490
    ENST00000590036 ENST00000587064 ENST00000592596
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate SLC7A10:
    hsa-miR-30c hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-621 hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidSLC7A10 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC7A10
      QuantiFast Probe-based Assays in human, mouse, rat SLC7A10

    Additional mRNA sequence: 

    AB037670.1 AJ277731.1 AK307527.1 AK316594.1 BC022457.1 BC035627.1 

    2 DOTS entries:

    DT.406649  DT.95367393 

    17 AceView cDNA sequences:

    AB037670 BI754386 BI912797 AJ277731 BC035627 CD245113 NM_019849 BI756372 
    BP382521 AK000846 BC022457 CB270168 BI522792 AI123040 AA026793 BG709630 
    BF949108 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A10    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                -                                       
    SP2:                                                                        


    ECgene alternative splicing isoforms for SLC7A10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC7A10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTTATTG
    SLC7A10 Expression
    About this image


    SLC7A10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
    SLC7A10 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.58679

    UniProtKB/Swiss-Prot: AAA1_HUMAN, Q9NS82
    Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC7A10 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc7a101 , 5 solute carrier family 7 (cationic amino acid transporter, more1, 5 88.34(n)1
    92.93(a)1
      7 (21.13 cM)5
    538961  NM_017394.41  NP_059090.31 
     351863855 
    chicken
    (Gallus gallus)
    Aves SLC7A101 solute carrier family 7, (neutral amino acid transporter, more 77.26(n)
    85.34(a)
      415774  XM_414136.4  XP_414136.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC7A106
    solute carrier family 7 (neutral amino acid transp...
    78(a)
    1 ↔ 1
    GL343295.1(1333213-1412875)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc7a101 solute carrier family 7 (neutral amino acid transporter more 68.9(n)
    77.82(a)
      100494333  XM_002935793.2  XP_002935839.2 
    zebrafish
    (Danio rerio)
    Actinopterygii slc7a10b1 solute carrier family 7 (neutral amino acid transporter more 73.14(n)
    75.95(a)
      559395  XM_682733.4  XP_687825.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta mnd3 amino acid transporter 49(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea F27C8.13 integral membrane protein E16 like 42(a)
    (best of 7)
      IV(9599614-9601874)   --


    ENSEMBL Gene Tree for SLC7A10 (if available)
    TreeFam Gene Tree for SLC7A10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC7A10 gene
    SLC7A72  SLC7A62  SLC7A112  SLC7A82  SLC7A92  SLC7A52  SLC7A132  
    13 SIMAP similar genes for SLC7A10 using alignment to 3 protein entries:     AAA1_HUMAN (see all proteins):
    xCT    SLC7A8    SLC7A7    SLC7A5    SLC7A5P1    lat1
    SLC7A5P2    SLC7A6    DKFZp686K14185    SLC7A9    hxCT    SLC7A11
    SLC7A13

    SLC7A10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC7A10 (see all 468)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs362164741,2
    C--30219090(+) CACGA-/TGTG  
      TGTGTG
    TGTGT
    1 -- int10--------
    rs23030941,2
    C,F--33700281(-) CTTACG/TGGGGT 2 T syn1 ese37Minor allele frequency- T:0.06EA NA NS EU 7491
    rs2001610311,2
    C--33700298(+) GATGAC/TGCCGA 2 I V mis11Minor allele frequency- T:0.00EU 1265
    rs23030931,2
    C,F,A--33700445(-) CGGGGG/ATACAG 1 -- int18Minor allele frequency- A:0.29NA WA EA 368
    rs786860001,2
    F--33700449(+) ACCCCC/TGACCC 1 -- int11Minor allele frequency- T:0.07WA 118
    rs1902130731,2
    --33700524(+) CTACAA/CCCCCT 1 -- int10--------
    rs1496248501,2
    --33700535(+) CTTGGC/TGACAG 1 -- int10--------
    rs1443287101,2
    C--33700576(+) AGGCCA/GTTGGC 1 -- int10--------
    rs794497731,2
    C,F--33700610(+) AGTCTC/TAGCGG 1 -- int12Minor allele frequency- T:0.07NA EA 240
    rs81070021,2
    C,F--33700615(+) CAGCGG/ACACCG 1 -- int11Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for SLC7A10 (33699570 - 33716756 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SLC7A10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1069310CNV Insertion17803354
    dgv3841n71CNV Loss21882294
    dgv3840n71CNV Loss21882294
    dgv3842n71CNV Loss21882294
    nsv911579CNV Loss21882294
    dgv3843n71CNV Loss21882294
    nsv833808CNV Loss17160897
    dgv3839n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): SLC7A10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC7A10
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC7A10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607959    OMIM disorders: --

    6 diseases for SLC7A10:    
    About MalaCards
    cystinuria    choroiditis    schizophrenia    inflammatory bowel disease
    crohn's disease    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SLC7A10:
    Cystinuria

    SLC7A10 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SLC7A10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cystinuria 86.8 14 15458438 (5), 11509015 (3), 16225397 (1)

    Genetic Association Database (GAD): SLC7A10

    Export disorders for SLC7A10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC7A10 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with SLC7A10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a human brain Na+-independent transporter for small neutral amino acids that transports D-serine with high affinity. (PubMed id 10863037)1, 2, 3, 9 Nakauchi J.... Kanai Y. (Neurosci. Lett. 2000)
    2. Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria? (PubMed id 11509015)1, 2, 9 Leclerc D.... Rozen R. (Mol. Genet. Metab. 2001)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids. (PubMed id 10734121)1, 3 Fukasawa Y....Kanai Y. (J. Biol. Chem. 2000)
    5. The amino acid transporter asc-1 is not involved in cystinuria. (PubMed id 15458438)1, 9 Pineda M....PalacA-n M. (Kidney Int. 2004)
    6. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    7. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)4 Franke A....Parkes M. (Nat. Genet. 2010)
    8. Common variants at five new loci associated with early-onset inflammatory bowel disease. (PubMed id 19915574)4 Imielinski M....Hakonarson H. (Nat. Genet. 2009)
    9. Amino acid transport across mammalian intestinal and renal epithelia. (PubMed id 18195088)1 BrAPer S. (Physiol. Rev. 2008)
    10. Metabolic activation-related CD147-CD98 complex. (PubMed id 15901826)1 Xu D. and Hemler M.E. (amp 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56301 HGNC: 11058 AceView: SLC7A10 Ensembl:ENSG00000130876 euGenes: HUgn56301
    ECgene: SLC7A10 H-InvDB: SLC7A10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC7A10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC7A10 gene:
    Search GeneIP for patents involving SLC7A10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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