Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC7A1 Gene

protein-coding   GIFtS: 60
GCID: GC13M030083

Solute Carrier Family 7 (Cationic Amino Acid Transporter,...


(Previous symbols: ERR, ATRC1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System),
Member 11 2
     CAT-12 3
ATRC11 2 3 5     CAT12 3
ERR1 2 3     REC1L2 3
Ecotropic Retroviral Receptor1 2     Amino Acid Transporter1
Ecotropic Retroviral Leukemia Receptor Homolog2 3     Cationic 11
Ecotropic Retrovirus Receptor Homolog2 3     HCAT12
Solute Carrier Family 7 Member 12 3     Amino Acid Transporter, Cationic 12
System Y+ Basic Amino Acid Transporter2 3     High Affinity Cationic Amino Acid Transporter 12

External Ids:    HGNC: 110571   Entrez Gene: 65412   Ensembl: ENSG000001395147   OMIM: 1046155   UniProtKB: P308253   

Export aliases for SLC7A1 gene to outside databases

Previous GC identifers: GC13M028068 GC13M024068 GC13M029016 GC13M027886 GC13M027884 GC13M028984 GC13M010903


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SLC7A1 Gene:
SLC7A1 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 1) is a protein-coding gene. Diseases associated with SLC7A1 include tinea capitis, and nonspecific interstitial pneumonia. GO annotations related to this gene include arginine transmembrane transporter activity. An important paralog of this gene is LOC284379.

UniProtKB/Swiss-Prot: CTR1_HUMAN, P30825
Function: High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine,
lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor

Gene Wiki entry for SLC7A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000013.11  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC7A1 gene promoter:
         CREB   PPAR-gamma1   deltaCREB   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC7A1 promoter sequence
   Search Chromatin IP Primers for SLC7A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC7A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.3   Ensembl cytogenetic band:  13q12.3   HGNC cytogenetic band: 13q12.3

SLC7A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC7A1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M030083:  view genomic region     (about GC identifiers)

Start:
30,083,547 bp from pter      End:
30,169,825 bp from pter
Size:
86,279 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CTR1_HUMAN, P30825 (See protein sequence)
Recommended Name: High affinity cationic amino acid transporter 1  
Size: 629 amino acids; 67638 Da
Secondary accessions: Q5JR50

Explore the universe of human proteins at neXtProt for SLC7A1: NX_P30825

Explore proteomics data for SLC7A1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys4, Lys484
  • Glycosylation2 at Asn216, Asn226, Asn235
  • Modification sites at PhosphoSitePlus

  • See SLC7A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003036.1  
    ENSEMBL proteins: 
     ENSP00000370128   ENSP00000390092  
    Reactome Protein details: P30825

    SLC7A1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SLC7A1
    OriGene Protein Over-expression Lysate for SLC7A1
    OriGene MassSpec for SLC7A1
    OriGene Custom Protein Services for SLC7A1
    GenScript Custom Purified and Recombinant Proteins Services for SLC7A1
    Novus Biologicals SLC7A1 Proteins
    Novus Biologicals SLC7A1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SLC7A1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC7A1
    Novus Biologicals SLC7A1 Antibodies
    Search for Antibodies for SLC7A1 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SLC7A1
    LSBio Antibodies in human, mouse, rat for SLC7A1

    SLC7A1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC7A1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC7A1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: High affinity cationic amino acid transporter 1
    SLC7 family

    2 InterPro protein domains:
     IPR004755 Cat_AA_permease
     IPR002293 AA/rel_permease1

    Graphical View of Domain Structure for InterPro Entry P30825

    ProtoNet protein and cluster: P30825

    UniProtKB/Swiss-Prot: CTR1_HUMAN, P30825
    Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter
    (CAT) (TC 2.A.3.3) family


    SLC7A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTR1_HUMAN, P30825
    Function: High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine,
    lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor

         Genatlas biochemistry entry for SLC7A1:
    solute carrier family 7,member A1,high affinity sodium independent,cationic amino-acid transporter,y+ type

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015171amino acid transmembrane transporter activity ----
    GO:0015181arginine transmembrane transporter activity IEA--
         
    SLC7A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC7A1:
     Lamellipodia and high actin ra 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc7a1):
     cellular  growth/size/body  hematopoietic system  mortality/aging 

    SLC7A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc7a1tm1Rbmn for SLC7A1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC7A1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC7A1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC7A1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC7A1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC7A1:
    hsa-mir-124-3p (MIRT022770), hsa-mir-652-3p (MIRT016141), hsa-mir-16-5p (MIRT001412), hsa-mir-92a-3p (MIRT049642), hsa-mir-155-5p (MIRT020810), hsa-mir-671-5p (MIRT039279), hsa-mir-125b-5p (MIRT005000), hsa-mir-1260b (MIRT052697), hsa-mir-24-3p (MIRT030524), hsa-mir-122-5p (MIRT003105), hsa-mir-328-3p (MIRT043746)

    Block miRNA regulation of human, mouse, rat SLC7A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC7A1 (see all 78):
    hsa-miR-3194-5p hsa-miR-300 hsa-miR-199a-3p hsa-miR-15a hsa-miR-371-5p hsa-miR-3161 hsa-miR-298 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC7A1
    Predesigned siRNA for gene silencing in human, mouse, rat SLC7A1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC7A1

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC7A1 (see all 6)
    OriGene ORF clones in mouse, rat for SLC7A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC7A1 (NM_003045)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC7A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC7A1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC7A1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC7A1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CTR1_HUMAN, P30825: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1718082
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    SLC7A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC7A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Amino acid transport across the plasma membrane0.32
    2Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    3MicroRNAs in cancer
    MicroRNAs in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SLC7A1
        eNOS Signaling

    1 Reactome Pathway for SLC7A1
        Amino acid transport across the plasma membrane


    1 Kegg Pathway  (Kegg details for SLC7A1):
        MicroRNAs in cancer


    SLC7A1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC7A1: 
              Hypertension in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC7A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for SLC7A1 (P308253 ENSP000003701284) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLN3Q132863, ENSP000003530734I2D: score=1 STRING: ENSP00000353073
    CSF1P096033I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    NOS3ENSP000002974944STRING: ENSP00000297494
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003333amino acid transmembrane transport ----
    GO:0006810transport NAS1348489
    GO:0006811ion transport TAS--
    GO:0006865amino acid transport TAS--
    GO:0015809arginine transport ----

    SLC7A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC7A1 (CTR1)

    1 HMDB Compound for SLC7A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--

    3 DrugBank Compounds for SLC7A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Arginine(S)-2-Amino-5-guanidinovaleric acid (see all 4)74-79-3target--17065601 17329401 17325243 17427197 17363779
    L-Lysine(S)-2,6-diaminohexanoic acid (see all 6)56-87-1target--9614060 14523001 17139284 17016423 17042743
    L-Ornithine(S)-2,5-Diaminopentanoate (see all 4)70-26-8target--17065601 16703566 15491978

    Selected Novoseek inferred chemical compound relationships for SLC7A1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 77.5 83 19501907 (4), 16210335 (3), 15064952 (3), 18574322 (3) (see all 36)
    adma 69.2 3 19605523 (2), 15569830 (1)
    citrulline 66 1 18069040 (1)
    ornithine 60.4 19 17197568 (4), 17494634 (4), 16210335 (1), 18069040 (1) (see all 6)
    lysine 58.7 14 14523001 (2), 15086470 (1), 8523543 (1), 12196519 (1) (see all 10)
    nitric oxide 55.9 8 12142345 (2), 11742806 (1), 12787129 (1), 15976236 (1) (see all 5)
    n-ethylmaleimide 51.8 1 16210335 (1)
    dfmo 40.9 3 17494634 (2)
    peroxynitrite 39.6 3 12058042 (2)
    leucine 14.5 1 19562367 (1)



    SLC7A1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC7A1 gene: 
    NM_003045.4  

    Unigene Cluster for SLC7A1:

    Solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
    Hs.14846  [show with all ESTs]
    Unigene Representative Sequence: NM_003045
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380752(uc001uso.3) ENST00000473577 ENST00000450494
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC7A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC7A1 (see all 78):
    hsa-miR-3194-5p hsa-miR-300 hsa-miR-199a-3p hsa-miR-15a hsa-miR-371-5p hsa-miR-3161 hsa-miR-298 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC7A1
    Predesigned siRNA for gene silencing in human, mouse, rat SLC7A1
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC7A1 (see all 6)
    OriGene ORF clones in mouse, rat for SLC7A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC7A1 (NM_003045)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC7A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC7A1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC7A1
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC7A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC7A1
      QuantiTect SYBR Green Assays in human, mouse, rat SLC7A1
      QuantiFast Probe-based Assays in human, mouse, rat SLC7A1

    Additional mRNA sequence: 

    AF078107.1 AK022999.1 AK124591.1 AK312818.1 AL050021.1 BC012895.1 BC033200.1 BC063303.1 
    BC069358.1 BC115407.1 X57303.1 X59155.1 

    12 DOTS entries:

    DT.101972895  DT.302600  DT.97768825  DT.97788455  DT.91755294  DT.100790726  DT.91849104  DT.95247666 
    DT.95365695  DT.100790729  DT.91694928  DT.91902353 

    Selected AceView cDNA sequences (see all 279):

    AL707645 AI369213 AI332885 CN483622 BE221619 X59155 BQ439206 BE669897 
    AA527433 AA482278 AA282548 AI280901 AF078107 BM806705 AA114934 AI422785 
    AI347511 CB137403 BQ775088 AI680860 H20618 BE891654 AW002805 BE857495 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC7A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC7A1 Expression
    About this image


    SLC7A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Adult Endothelial Cells Blood Brain Barrier
             Medulla Oblongata
             brain/midbrain/lateral wall   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
             brain/midbrain/lateral wall   
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
    SLC7A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC7A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.14846

    UniProtKB/Swiss-Prot: CTR1_HUMAN, P30825
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC7A1: 
              Hypertension in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC7A1
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC7A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC7A1
    QuantiTect SYBR Green Assays in human, mouse, rat SLC7A1
    QuantiFast Probe-based Assays in human, mouse, rat SLC7A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC7A1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc7a11 , 5 solute carrier family 7 (cationic amino acid transporter, more1, 5 84.46(n)1
    87.62(a)1
      5 (88.48 cM)5
    119871  NM_007513.41  NP_031539.31 
     1483274105 
    chicken
    (Gallus gallus)
    Aves SLC7A11 solute carrier family 7 (cationic amino acid transporter, more 72.2(n)
    77.26(a)
      418922  NM_001145490.1  NP_001138962.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC7A16
    solute carrier family 7 (cationic amino acid trans...
    80(a)
    1 ↔ 1
    3(184999068-185044514)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc7a11 solute carrier family 7 (cationic amino acid transporter, more 68.3(n)
    74.18(a)
      100492323  XM_002934028.2  XP_002934074.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.265832 Danio rerio cDNA clone MGC63694 IMAGE5916426, complete more 76.39(n)    BC055209.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111283
    slif1
    cationic amino acid transporter3
    slimfast1
    45(a)
    (best of 4)3
    56.16(n)1
    49.12(a)1
      80B23
    405101  NM_141171.31  NP_649428.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CAT41 CAT4 47.54(n)
    39.61(a)
      821176  NM_111243.7  NP_187022.5 
    rice
    (Oryza sativa)
    Liliopsida AK066436.12   -- 68.48(n)    AK066436.1 


    ENSEMBL Gene Tree for SLC7A1 (if available)
    TreeFam Gene Tree for SLC7A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC7A1 gene
    LOC2843792  SLC7A22  SLC7A42  SLC7A142  SLC7A32  
    7 SIMAP similar genes for SLC7A1 using alignment to 2 protein entries:     CTR1_HUMAN (see all proteins):
    SLC7A2    SLC7A3    SLC7A14    SLC7A4    SLC7A6    SLC7A7
    SLC7A8

    SLC7A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC7A1 (see all 1983)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs673051741,2
    C--11099560(-) CCATC-/T/TT  
            
    TTTTT
    1 -- int12NA 4
    rs1996758421,2
    C--30083107(+) TACACC/TCCCCG 1 -- int10--------
    rs1869080361,2
    --30083130(+) CCCTGC/TATGCA 1 -- int10--------
    rs10057191,2
    C,F,A--30083131(+) CCTGCG/ATGCAC 1 -- int111Minor allele frequency- A:0.48NA WA CSA EA 376
    rs40022181,2
    C--30083145(+) GCTCC-/CTCT  
            
    AACAG
    1 -- int11Minor allele frequency- CTCT:0.00NA 2
    rs10057201,2
    C,F,A,H--30083187(+) TGGGGC/TGGCAA 1 -- int123Minor allele frequency- T:0.31NS EA NA WA CSA 2518
    rs586784691,2
    C,F--30083207(+) GCGTTT/GTGTTG 1 -- int13Minor allele frequency- G:0.05WA CSA 122
    rs1178035131,2
    C,F--30083239(+) AAATGC/ACTGAC 1 -- int11Minor allele frequency- A:0.05EA 120
    rs1903684051,2
    C--30083432(+) GAAGAC/TAGGAC 1 -- int10--------
    rs8794271,2
    C,H--30083439(+) GGACTA/GAAGTC 1 -- int14Minor allele frequency- G:0.00NS EA 410

    HapMap Linkage Disequilibrium report for SLC7A1 (30083547 - 30169825 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SLC7A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747210CNV Deletion23290073
    esv2661963CNV Deletion23128226
    esv1006674CNV Deletion20482838
    esv1071553CNV Deletion17803354
    esv2747211CNV Deletion23290073
    esv2671622CNV Deletion23128226
    nsv979CNV Loss18451855
    nsv899960CNV Gain21882294

    Human Gene Mutation Database (HGMD): SLC7A1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC7A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC7A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 104615    OMIM disorders: --

    Selected diseases for SLC7A1 (see all 22):    
    About MalaCards
    tinea capitis    nonspecific interstitial pneumonia    root resorption    congestive heart failure
    leukemia    gestational diabetes    duchenne muscular dystrophy    pneumonia
    pertussis    meningitis    endotheliitis    muscular dystrophy
    psoriasis    hypertension    parkinson's disease    asthma
    retinitis    hypoxia    tuberculosis    breast cancer


    SLC7A1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for SLC7A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 22.1 6 8382989 (1), 8523543 (1), 10482615 (1), 15527836 (1)
    glioblastoma 12.3 1 15491978 (1)
    tumors 0 1 1318407 (1)

    Genetic Association Database (GAD): SLC7A1
    Human Genome Epidemiology (HuGE) Navigator: SLC7A1 (1 document)

    Export disorders for SLC7A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC7A1 gene, integrated from 10 sources (see all 128):
    (articles sorted by number of sources associating them with SLC7A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14. (PubMed id 1348489)1, 2, 3, 9 Albritton L.M.... Cunningham J.M. (Genomics 1992)
    2. Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction. (PubMed id 17325243)1, 4, 7 Yang Z....Kaye D.M. (Circulation 2007)
    3. Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity. (PubMed id 15491978)1, 7, 9 Rotmann A....Closs E.I. (J. Biol. Chem. 2004)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1. (PubMed id 10485994)1, 2 Kamath S.G.... Smith C.H. (J. Membr. Biol. 1999)
    7. Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor. (PubMed id 1718082)1, 2 Yoshimoto T.... Meruelo D. (Virology 1991)
    8. Changes of differentiation and proliferation in k562 cells with various levels of knockdown of cationic amino acid transporter 1. (PubMed id 18574322)1, 9 Maeda T....Tamai I. (Drug Metab. Pharmacokinet. 2008)
    9. Transcriptional control of the arginine/lysine transporter, cat-1, by physiological stress. (PubMed id 14523001)7, 9 Fernandez J....Hatzolgou M. (J. Biol. Chem. 2003)
    10. Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells. (PubMed id 17494634)1, 9 Kaneko S....Ito S. (Am. J. Physiol., Cell Physiol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6541 HGNC: 11057 AceView: SLC7A1 Ensembl:ENSG00000139514 euGenes: HUgn6541
    ECgene: SLC7A1 Kegg: 6541 H-InvDB: SLC7A1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC7A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC7A1 gene:
    Search GeneIP for patents involving SLC7A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC7A1  
     OriGene qPCR primer pairs and template standards for SLC7A1   OriGene Protein Over-expression Lysate for SLC7A1  
     OriGene MassSpec something-or-other for SLC7A1   OriGene clones in human, mouse for SLC7A1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC7A1   OriGene Purified Protein for SLC7A1  
     OriGene ORF clones in mouse, rat for SLC7A1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC7A1   OriGene Custom Protein Services for SLC7A1  

     
     
     Block miRNA regulation of human, mouse, rat SLC7A1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC7A1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC7A1 Predesigned siRNA for gene silencing in human, mouse, rat SLC7A1
     QuantiFast Probe-based Assays in human, mouse, rat SLC7A1 QuantiTect SYBR Green Assays in human, mouse, rat SLC7A1
     PCR Arrays including human, mouse, rat SLC7A1 Search Chromatin IP Primers for SLC7A1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC7A1  Search GeneGlobe Interaction Network for SLC7A1
     Regulatory tfbs in SLC7A1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC7A1 GenScript cDNA clones with any tag delivered in your preferred vector for SLC7A1
     GenScript Custom Assay Services for SLC7A1 GenScript Custom overexpressing Cell Line Services for SLC7A1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC7A1 (CTR1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC7A1 antibodies
     SLC7A1 proteins
     SLC7A1 lysates
     Search for Antibodies for SLC7A1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SLC7A1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC7A1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SLC7A1
     SwitchGear Promoter luciferase reporter plasmids for SLC7A1
     Search ThermoFisher Antibodies for SLC7A1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC7A1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC7A1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC7A1
     LSBio Antibodies in human, mouse, rat for SLC7A1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC7A1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4