Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC6A9 Gene

Aliases for SLC6A9 Gene

  • Solute Carrier Family 6 (Neurotransmitter Transporter, Glycine), Member 9 2 3
  • GLYT1 3 4 6
  • Solute Carrier Family 6 Member 9 3 4
  • GlyT-1 3 4
  • Sodium- And Chloride-Dependent Glycine Transporter 1 3

External Ids for SLC6A9 Gene

Summaries for SLC6A9 Gene

GeneCards Summary for SLC6A9 Gene

SLC6A9 (Solute Carrier Family 6 (Neurotransmitter Transporter, Glycine), Member 9) is a Protein Coding gene. Diseases associated with SLC6A9 include schizophrenia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include neurotransmitter:sodium symporter activity and glycine:sodium symporter activity. An important paralog of this gene is SLC6A4.

UniProtKB/Swiss-Prot for SLC6A9 Gene

  • Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission

Tocris Summary for SLC6A9 Gene

  • Glycine transporters (GlyTs) belong to a family of high affinity Na+- and Cl--dependent neurotransmitter transporters proteins. There are two subtypes of glycine transporters; GlyT1 and GlyT2. GlyT1s are predominantly located on glia within caudal brain areas, the diencephalon and olfactory bulb. They regulate synaptic glycine concentration, influencing NMDA receptor-mediated neurotransmission and are important in neonatal life for regulating glycine concentrations at inhibitory glycinergic synapses. GlyT2s are predominantly located on neurons within caudal brain areas, the spinal cord, brainstem and cerebellum. They are crucial for efficient transmitter loading of synaptic vesicles and lack-of-function mutations are fatal in the early neonatal period. Both GlyT1 and GlyT2 are unevenly distributed across the cell surface, which is thought to optimize the removal of glycine from the extracellular compartment. Transport of glycine involves co-transport of Na+ and Cl- ions. The Na+ concentration gradient is maintained by the plasma membrane Na+,K+-ATPase and allows the accumulation of glycine against its concentration gradient. GlyTs are glycosylated and this is necessary for the protein trafficking to the plasma membrane. Further regulatory mechanisms of GlyTs include the presence of PKC, PKA and CaMK consensus sites, pH and syntaxin1 levels. Pharmacologically, glycine transporter inhibitors may have applications in the treatment of muscle tone defects, epilepsy, schizophrenia, pain and neurodegenerative disorders.

Gene Wiki entry for SLC6A9 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A9 Gene

Genomics for SLC6A9 Gene

Genomic Location for SLC6A9 Gene

Start:
43,991,500 bp from pter
End:
44,031,492 bp from pter
Size:
39,993 bases
Orientation:
Minus strand

Genomic View for SLC6A9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC6A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A9 Gene

Regulatory Elements for SLC6A9 Gene

Proteins for SLC6A9 Gene

  • Protein details for SLC6A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48067-SC6A9_HUMAN
    Recommended name:
    Sodium- and chloride-dependent glycine transporter 1
    Protein Accession:
    P48067
    Secondary Accessions:
    • A6NDH1
    • A6NII2
    • A6NNZ8
    • Q5TAB8
    • Q5TAB9
    • Q5TAC0

    Protein attributes for SLC6A9 Gene

    Size:
    706 amino acids
    Molecular mass:
    78260 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB30784.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305}; Sequence=AAB30785.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305}; Sequence=CAI19428.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI19429.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC6A9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC6A9 Gene

Proteomics data for SLC6A9 Gene at MOPED

Post-translational modifications for SLC6A9 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn250 and Asn256

No data available for DME Specific Peptides for SLC6A9 Gene

Domains for SLC6A9 Gene

Gene Families for SLC6A9 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

UniProtKB/Swiss-Prot:

SC6A9_HUMAN
Family:
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.:
    • P48067
genes like me logo Genes that share domains with SLC6A9: view

Function for SLC6A9 Gene

Molecular function for SLC6A9 Gene

GENATLAS Biochemistry: solute carrier family 6,member A9,neurotransmitter transporter,glycine
UniProtKB/Swiss-Prot Function: Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission

Gene Ontology (GO) - Molecular Function for SLC6A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005283 sodium:amino acid symporter activity --
GO:0005328 neurotransmitter:sodium symporter activity IEA --
GO:0005515 protein binding --
GO:0015187 glycine transmembrane transporter activity --
GO:0015375 glycine:sodium symporter activity TAS 8183239
genes like me logo Genes that share ontologies with SLC6A9: view
genes like me logo Genes that share phenotypes with SLC6A9: view

Animal Models for SLC6A9 Gene

MGI Knock Outs for SLC6A9:

miRNA for SLC6A9 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC6A9 Gene

Localization for SLC6A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC6A9 Gene COMPARTMENTS Subcellular localization image for SLC6A9 gene
Compartment Confidence
plasma membrane 4
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC6A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane TAS 8183239
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC6A9: view

Pathways for SLC6A9 Gene

genes like me logo Genes that share pathways with SLC6A9: view

Interacting Proteins for SLC6A9 Gene

Gene Ontology (GO) - Biological Process for SLC6A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IEA --
GO:0006810 transport TAS 8183239
GO:0006836 neurotransmitter transport IEA --
GO:0015816 glycine transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC6A9: view

Compounds for SLC6A9 Gene

(5) Tocris Compounds for SLC6A9 Gene

Compound Action Cas Number
ALX 5407 hydrochloride Selective non-transportable GlyT1 inhibitor [571147-18-7]
LY 2365109 hydrochloride Potent and selective GlyT1 inhibitor [868265-28-5]
NFPS Selective non-transportable GlyT1 inhibitor [405225-21-0]
Org 24598 lithium salt Selective GlyT1 inhibitor [722456-08-8]
Org 25543 hydrochloride Potent and selective GlyT2 inhibitor [495076-64-7]

(2) HMDB Compounds for SLC6A9 Gene

Compound Synonyms Cas Number PubMed IDs
Glycine
  • 2-Aminoacetate
56-40-6
Sodium
  • Sodium
7440-23-5

(1) Drugbank Compounds for SLC6A9 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glycine
  • 2-Aminoacetic acid
56-40-6 target

(17) IUPHAR Ligand for SLC6A9 Gene

Ligand Type Action Affinity Pubmed IDs
(R)-NFPS Inhibitor Inhibition 9.1
[3H](R)-NPTS None None 9
[3H]GSK931145 None None 8.8
[3H]SB-733993 None None 8.7
SSR-103800 Inhibitor Inhibition 8.7
[35S]ACPPB None None 8.7
N-methyl-SSR504734 Inhibitor Inhibition 8.6
[3H]N-methyl-SSR504734 None None 8.5
NFPS Inhibitor Inhibition 8.5
[3H]NFPS None None 8.2
LY2365109 Inhibitor Inhibition 7.8
SSR-504734 Inhibitor Inhibition 7.7
GSK931145 Inhibitor Inhibition 7.6
SB-733993 Inhibitor Inhibition 7.5
RG1678 Inhibitor Inhibition 7.5
NPTS Inhibitor Inhibition 7.4
Org 24598 Inhibitor Inhibition

(4) Novoseek inferred chemical compound relationships for SLC6A9 Gene

Compound -log(P) Hits PubMed IDs
sarcosine 91.3 7
nmda 70.1 22
strychnine 69.6 2
glutamate 44.1 1
genes like me logo Genes that share compounds with SLC6A9: view

Transcripts for SLC6A9 Gene

Unigene Clusters for SLC6A9 Gene

Solute carrier family 6 (neurotransmitter transporter, glycine), member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A9 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP2: - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - -
SP7:

Relevant External Links for SLC6A9 Gene

GeneLoc Exon Structure for
SLC6A9
ECgene alternative splicing isoforms for
SLC6A9

Expression for SLC6A9 Gene

mRNA expression in normal human tissues for SLC6A9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC6A9 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (6.5) and Skin - Sun Exposed (Lower leg) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC6A9 Gene

SOURCE GeneReport for Unigene cluster for SLC6A9 Gene Hs.442590

mRNA Expression by UniProt/SwissProt for SLC6A9 Gene

P48067-SC6A9_HUMAN
Tissue specificity: Isoform GlyT-1A and isoform GlyT-1B can be found in brain, kidney, pancreas, lung, placenta and liver but isoform GlyT-1C is only found in brain
genes like me logo Genes that share expressions with SLC6A9: view

Orthologs for SLC6A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC6A9 36
  • 99.66 (n)
  • 99.41 (a)
SLC6A9 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC6A9 36
  • 91.49 (n)
  • 94.38 (a)
SLC6A9 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC6A9 36
  • 91.24 (n)
  • 95.55 (a)
SLC6A9 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc6a9 36
  • 90.64 (n)
  • 96.95 (a)
Slc6a9 16
Slc6a9 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC6A9 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC6A9 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc6a9 36
  • 90.48 (n)
  • 96.31 (a)
chicken
(Gallus gallus)
Aves SLC6A9 36
  • 82.14 (n)
  • 84.69 (a)
SLC6A9 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC6A9 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc6a9 36
  • 72.35 (n)
  • 82.48 (a)
zebrafish
(Danio rerio)
Actinopterygii slc6a9 36
  • 72.9 (n)
  • 78.54 (a)
slc6a9 37
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008467 36
  • 52 (n)
  • 43.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5549 37
  • 25 (a)
OneToMany
Ntl 36
  • 53.42 (n)
  • 43.85 (a)
ine 38
  • 41 (a)
BG:DS03431.1 38
  • 37 (a)
CG7075 38
  • 35 (a)
CG4476 38
  • 37 (a)
CG5549 38
  • 48 (a)
CG3252 38
  • 37 (a)
CG1698 38
  • 36 (a)
CG8850 38
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea snf-4 38
  • 34 (a)
snf-3 38
  • 37 (a)
snf-5 38
  • 31 (a)
snf-9 38
  • 34 (a)
snf-12 38
  • 31 (a)
snf-6 38
  • 31 (a)
snf-1 38
  • 25 (a)
snf-2 38
  • 30 (a)
Species with no ortholog for SLC6A9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC6A9 Gene

ENSEMBL:
Gene Tree for SLC6A9 (if available)
TreeFam:
Gene Tree for SLC6A9 (if available)

Paralogs for SLC6A9 Gene

Paralogs for SLC6A9 Gene

Pseudogenes.org Pseudogenes for SLC6A9 Gene

genes like me logo Genes that share paralogs with SLC6A9: view

Variants for SLC6A9 Gene

Sequence variations from dbSNP and Humsavar for SLC6A9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs783305 -- 44,016,640(+) TACCA(C/T)GTTCC intron-variant
rs783306 -- 44,028,484(+) ggcgc(A/G)gtggc intron-variant
rs783307 -- 44,028,880(+) GACAA(C/T)AGGGT intron-variant
rs803619 -- 43,999,747(+) AAGTC(C/T)GGTGC intron-variant
rs1296541 -- 44,000,633(+) AGCCT(C/T)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC6A9 Gene

Variant ID Type Subtype PubMed ID
nsv870606 CNV Loss 21882294
nsv519538 CNV Loss 19592680
nsv829704 CNV Loss 17160897

Relevant External Links for SLC6A9 Gene

HapMap Linkage Disequilibrium report
SLC6A9

Disorders for SLC6A9 Gene

(1) MalaCards Diseases for SLC6A9 Gene

Search for SLC6A9 Gene in MalaCards »

(3) Novoseek inferred disease relationships for SLC6A9 Gene

Disease -log(P) Hits PubMed IDs
hypofunction 75.4 6
schizophrenia 61.4 21
psychotic 24.3 2

Relevant External Links for SLC6A9

Genetic Association Database (GAD)
SLC6A9
Human Genome Epidemiology (HuGE) Navigator
SLC6A9
genes like me logo Genes that share disorders with SLC6A9: view

No data available for UniProtKB/Swiss-Prot for SLC6A9 Gene

Publications for SLC6A9 Gene

  1. Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia. (PMID: 18638388) Deng X. … Fukumaki Y. (BMC Psychiatry 2008) 3 23 49
  2. Polymorphisms in glycine transporter with schizophrenia. (PMID: 16841561) Tsai S.J. … Liou Y.J. (Neuropsychopharmacol Hung 2006) 3 23 49
  3. Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes. (PMID: 8183239) Kim K.-M. … Giros B. (Mol. Pharmacol. 1994) 2 3 4
  4. Association study of polymorphisms in glycine transporter with schizophrenia. (PMID: 16604304) Tsai S.J. … Liou Y.J. (J Neural Transm 2006) 3 23 49
  5. The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder. (PMID: 17582620) Morita Y. … Kuroda S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23 49

Products for SLC6A9 Gene

Sources for SLC6A9 Gene

Back to Top

Content