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Aliases for SLC6A9 Gene

Aliases for SLC6A9 Gene

  • Solute Carrier Family 6 Member 9 2 3 4 5
  • Solute Carrier Family 6 (Neurotransmitter Transporter, Glycine), Member 9 2 3
  • GlyT-1 3 4
  • GLYT1 3 4
  • Sodium- And Chloride-Dependent Glycine Transporter 1 3

External Ids for SLC6A9 Gene

Previous GeneCards Identifiers for SLC6A9 Gene

  • GC01M044301
  • GC01M043463
  • GC01M043891
  • GC01M043876
  • GC01M044132
  • GC01M044462
  • GC01M042577

Summaries for SLC6A9 Gene

Entrez Gene Summary for SLC6A9 Gene

  • The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. [provided by RefSeq, Jun 2016]

GeneCards Summary for SLC6A9 Gene

SLC6A9 (Solute Carrier Family 6 Member 9) is a Protein Coding gene. Diseases associated with SLC6A9 include Substance Dependence and Schizophrenia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include neurotransmitter:sodium symporter activity and sodium:amino acid symporter activity. An important paralog of this gene is SLC6A5.

UniProtKB/Swiss-Prot for SLC6A9 Gene

  • Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.

Tocris Summary for SLC6A9 Gene

  • Glycine transporters (GlyTs) belong to a family of high affinity Na+- and Cl--dependent neurotransmitter transporters proteins. There are two subtypes of glycine transporters; GlyT1 and GlyT2. GlyT1s are predominantly located on glia within caudal brain areas.

Gene Wiki entry for SLC6A9 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A9 Gene

Genomics for SLC6A9 Gene

Regulatory Elements for SLC6A9 Gene

Enhancers for SLC6A9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SLC6A9 on UCSC Golden Path with GeneCards custom track

Promoters for SLC6A9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC6A9 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC6A9 Gene

Chromosome:
1
Start:
43,991,500 bp from pter
End:
44,031,492 bp from pter
Size:
39,993 bases
Orientation:
Minus strand

Genomic View for SLC6A9 Gene

Genes around SLC6A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC6A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC6A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A9 Gene

Proteins for SLC6A9 Gene

  • Protein details for SLC6A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48067-SC6A9_HUMAN
    Recommended name:
    Sodium- and chloride-dependent glycine transporter 1
    Protein Accession:
    P48067
    Secondary Accessions:
    • A6NDH1
    • A6NII2
    • A6NNZ8
    • Q5TAB8
    • Q5TAB9
    • Q5TAC0

    Protein attributes for SLC6A9 Gene

    Size:
    706 amino acids
    Molecular mass:
    78260 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB30784.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305}; Sequence=AAB30785.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305}; Sequence=CAI19428.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI19429.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC6A9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC6A9 Gene

Post-translational modifications for SLC6A9 Gene

  • Glycosylation at Asn 256
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC6A9 Gene

Domains & Families for SLC6A9 Gene

Gene Families for SLC6A9 Gene

Suggested Antigen Peptide Sequences for SLC6A9 Gene

Graphical View of Domain Structure for InterPro Entry

P48067

UniProtKB/Swiss-Prot:

SC6A9_HUMAN :
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
Family:
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
genes like me logo Genes that share domains with SLC6A9: view

Function for SLC6A9 Gene

Molecular function for SLC6A9 Gene

GENATLAS Biochemistry:
solute carrier family 6,member A9,neurotransmitter transporter,glycine
UniProtKB/Swiss-Prot Function:
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.

Gene Ontology (GO) - Molecular Function for SLC6A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005328 neurotransmitter:sodium symporter activity IEA --
GO:0005515 protein binding IEA --
GO:0015187 glycine transmembrane transporter activity IEA --
GO:0015375 glycine:sodium symporter activity TAS --
genes like me logo Genes that share ontologies with SLC6A9: view
genes like me logo Genes that share phenotypes with SLC6A9: view

Animal Models for SLC6A9 Gene

MGI Knock Outs for SLC6A9:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC6A9

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC6A9 Gene

Localization for SLC6A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC6A9 Gene COMPARTMENTS Subcellular localization image for SLC6A9 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SLC6A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane TAS 8183239
GO:0098793 presynapse IEA --
genes like me logo Genes that share ontologies with SLC6A9: view

Pathways & Interactions for SLC6A9 Gene

genes like me logo Genes that share pathways with SLC6A9: view

Gene Ontology (GO) - Biological Process for SLC6A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IEA --
GO:0006810 transport TAS 8183239
GO:0015816 glycine transport IEA --
GO:0036233 glycine import IBA --
GO:0060012 synaptic transmission, glycinergic IBA --
genes like me logo Genes that share ontologies with SLC6A9: view

No data available for SIGNOR curated interactions for SLC6A9 Gene

Drugs & Compounds for SLC6A9 Gene

(23) Drugs for SLC6A9 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved, Vet_approved Nutra Full agonist, Agonist, Target 198
NFPS Pharma Inhibition, Inhibitor Selective non-transportable GlyT1 inhibitor 0
Bitopertin Pharma Glycine reuptake inhibitor(GlyT1) 0
ALX 5407 hydrochloride Pharma GlyT1 inhibitor,selective non-transportable, Selective non-transportable GlyT1 inhibitor 0
LY 2365109 hydrochloride Pharma Potent and selective GlyT1 inhibitor 0

(6) Additional Compounds for SLC6A9 Gene - From: IUPHAR, HMDB, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NPTS
Inhibition, Inhibitor
Org 24598
Inhibition, Inhibitor
RG1678
Inhibition, Inhibitor
SB-733993
Inhibition, Inhibitor
sodium
  • Sodium
  • Sodium ion
7440-23-5

(5) Tocris Compounds for SLC6A9 Gene

Compound Action Cas Number
ALX 5407 hydrochloride Selective non-transportable GlyT1 inhibitor 200006-08-2
LY 2365109 hydrochloride Potent and selective GlyT1 inhibitor 868265-28-5
NFPS Selective non-transportable GlyT1 inhibitor 405225-21-0
Org 24598 lithium salt Selective GlyT1 inhibitor 722456-08-8
Org 25543 hydrochloride Potent and selective GlyT2 inhibitor 495076-64-7

(7) ApexBio Compounds for SLC6A9 Gene

Compound Action Cas Number
ALX 5407 hydrochloride GlyT1 inhibitor,selective non-transportable 200006-08-2
Bitopertin Glycine reuptake inhibitor(GlyT1) 845614-11-1
Bitopertin (R enantiomer) Glycine reuptake inhibitor 845614-12-2
LY 2365109 hydrochloride 868265-28-5
NFPS 405225-21-0
Org 24598 lithium salt 722456-08-8
Sarcosine 107-97-1
genes like me logo Genes that share compounds with SLC6A9: view

Transcripts for SLC6A9 Gene

Unigene Clusters for SLC6A9 Gene

Solute carrier family 6 (neurotransmitter transporter, glycine), member 9:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A9 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP2: - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - -
SP7:

Relevant External Links for SLC6A9 Gene

GeneLoc Exon Structure for
SLC6A9
ECgene alternative splicing isoforms for
SLC6A9

Expression for SLC6A9 Gene

mRNA expression in normal human tissues for SLC6A9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC6A9 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.5) and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for SLC6A9 Gene

This gene is overexpressed in Retina (33.6) and Spinal cord (21.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC6A9 Gene



Protein tissue co-expression partners for SLC6A9 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC6A9 Gene:

SLC6A9

SOURCE GeneReport for Unigene cluster for SLC6A9 Gene:

Hs.442590

mRNA Expression by UniProt/SwissProt for SLC6A9 Gene:

P48067-SC6A9_HUMAN
Tissue specificity: Isoform GlyT-1A and isoform GlyT-1B can be found in brain, kidney, pancreas, lung, placenta and liver but isoform GlyT-1C is only found in brain.
genes like me logo Genes that share expression patterns with SLC6A9: view

Primer Products

Orthologs for SLC6A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC6A9 34
  • 91.49 (n)
  • 94.38 (a)
SLC6A9 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC6A9 34
  • 91.24 (n)
  • 95.55 (a)
SLC6A9 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc6a9 34
  • 90.64 (n)
  • 96.95 (a)
Slc6a9 16
Slc6a9 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC6A9 34
  • 99.66 (n)
  • 99.41 (a)
SLC6A9 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc6a9 34
  • 90.48 (n)
  • 96.31 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC6A9 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC6A9 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC6A9 34
  • 82.14 (n)
  • 84.69 (a)
SLC6A9 35
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC6A9 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc6a9 34
  • 72.35 (n)
  • 82.48 (a)
zebrafish
(Danio rerio)
Actinopterygii slc6a9 34
  • 72.9 (n)
  • 78.54 (a)
slc6a9 35
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BG:DS03431.1 36
  • 37 (a)
CG1698 36
  • 36 (a)
CG3252 36
  • 37 (a)
CG4476 36
  • 37 (a)
CG5549 36
  • 48 (a)
CG7075 36
  • 35 (a)
CG8850 36
  • 34 (a)
ine 36
  • 41 (a)
Ntl 34
  • 53.42 (n)
  • 43.85 (a)
CG5549 35
  • 25 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008467 34
  • 52 (n)
  • 43.29 (a)
worm
(Caenorhabditis elegans)
Secernentea snf-1 36
  • 25 (a)
snf-12 36
  • 31 (a)
snf-2 36
  • 30 (a)
snf-3 36
  • 37 (a)
snf-4 36
  • 34 (a)
snf-5 36
  • 31 (a)
snf-6 36
  • 31 (a)
snf-9 36
  • 34 (a)
Species where no ortholog for SLC6A9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC6A9 Gene

ENSEMBL:
Gene Tree for SLC6A9 (if available)
TreeFam:
Gene Tree for SLC6A9 (if available)

Paralogs for SLC6A9 Gene

Pseudogenes.org Pseudogenes for SLC6A9 Gene

genes like me logo Genes that share paralogs with SLC6A9: view

Variants for SLC6A9 Gene

Sequence variations from dbSNP and Humsavar for SLC6A9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs783305 -- 44,016,640(+) TACCA(C/T)GTTCC intron-variant
rs783306 -- 44,028,484(+) ggcgc(A/G)gtggc intron-variant
rs783307 -- 44,028,880(+) GACAA(C/T)AGGGT intron-variant
rs803619 -- 43,999,747(+) AAGTC(C/T)GGTGC intron-variant
rs1296541 -- 44,000,633(+) AGCCT(C/T)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC6A9 Gene

Variant ID Type Subtype PubMed ID
nsv519538 CNV loss 19592680
nsv546142 CNV loss 21841781
nsv546143 CNV loss 21841781
nsv829704 CNV loss 17160897

Variation tolerance for SLC6A9 Gene

Residual Variation Intolerance Score: 8.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC6A9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC6A9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC6A9 Gene

Disorders for SLC6A9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC6A9 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
substance dependence
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC6A9

Genetic Association Database (GAD)
SLC6A9
Human Genome Epidemiology (HuGE) Navigator
SLC6A9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC6A9
genes like me logo Genes that share disorders with SLC6A9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC6A9 Gene

Publications for SLC6A9 Gene

  1. The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder. (PMID: 17582620) Morita Y. … Kuroda S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 22 46 65
  2. Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia. (PMID: 18638388) Deng X. … Fukumaki Y. (BMC Psychiatry 2008) 3 22 46 65
  3. Association study of polymorphisms in glycine transporter with schizophrenia. (PMID: 16604304) Tsai S.J. … Liou Y.J. (J Neural Transm 2006) 3 22 46 65
  4. Polymorphisms in glycine transporter with schizophrenia. (PMID: 16841561) Tsai S.J. … Liou Y.J. (Neuropsychopharmacol Hung 2006) 3 22 46 65
  5. Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes. (PMID: 8183239) Kim K.-M. … Giros B. (Mol. Pharmacol. 1994) 2 3 4 65

Products for SLC6A9 Gene

Sources for SLC6A9 Gene

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