Aliases for SLC6A9 Gene
External Ids for SLC6A9 Gene
Previous GeneCards Identifiers for SLC6A9 Gene
The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. [provided by RefSeq, Jun 2016]
GeneCards Summary for SLC6A9 Gene
SLC6A9 (Solute Carrier Family 6 Member 9) is a Protein Coding gene. Diseases associated with SLC6A9 include Substance Dependence and Schizophrenia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include neurotransmitter:sodium symporter activity and sodium:amino acid symporter activity. An important paralog of this gene is SLC6A5.
UniProtKB/Swiss-Prot for SLC6A9 Gene
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.
Glycine transporters (GlyTs) belong to a family of high affinity Na+- and Cl--dependent neurotransmitter transporters proteins. There are two subtypes of glycine transporters; GlyT1 and GlyT2. GlyT1s are predominantly located on glia within caudal brain areas.