Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC6A7 Gene

Aliases for SLC6A7 Gene

  • Solute Carrier Family 6 Member 7 2 3 4
  • Solute Carrier Family 6 (Neurotransmitter Transporter, L-Proline), Member 7 2 3
  • Solute Carrier Family 6 (Neurotransmitter Transporter), Member 7 2 5
  • Brain-Specific L-Proline Transporter 2 3
  • PROT 3 4
  • Sodium-Dependent Proline Transporter 2

External Ids for SLC6A7 Gene

Previous GeneCards Identifiers for SLC6A7 Gene

  • GC05P149640
  • GC05P149598
  • GC05P149549
  • GC05P144717
  • GC05P149569

Summaries for SLC6A7 Gene

Entrez Gene Summary for SLC6A7 Gene

  • This gene is a member of the gamma-aminobutyric acid (GABA) neurotransmitter gene family and encodes a high-affinity mammalian brain L-proline transporter protein. This transporter protein differs from other sodium-dependent plasma membrane carriers by its pharmacological specificity, kinetic properties, and ionic requirements. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC6A7 Gene

SLC6A7 (Solute Carrier Family 6 Member 7) is a Protein Coding gene. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include neurotransmitter:sodium symporter activity. An important paralog of this gene is SLC6A4.

UniProtKB/Swiss-Prot for SLC6A7 Gene

  • Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A7 Gene

Genomics for SLC6A7 Gene

Regulatory Elements for SLC6A7 Gene

Genomic Location for SLC6A7 Gene

Chromosome:
5
Start:
150,189,957 bp from pter
End:
150,222,788 bp from pter
Size:
32,832 bases
Orientation:
Plus strand

Genomic View for SLC6A7 Gene

Genes around SLC6A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC6A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC6A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A7 Gene

Proteins for SLC6A7 Gene

  • Protein details for SLC6A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99884-SC6A7_HUMAN
    Recommended name:
    Sodium-dependent proline transporter
    Protein Accession:
    Q99884
    Secondary Accessions:
    • Q0VG81
    • Q52LU6

    Protein attributes for SLC6A7 Gene

    Size:
    636 amino acids
    Molecular mass:
    70911 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC6A7 Gene

Proteomics data for SLC6A7 Gene at MOPED

Post-translational modifications for SLC6A7 Gene

  • Glycosylation at Asn 182
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC6A7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC6A7 Gene

Domains & Families for SLC6A7 Gene

Gene Families for SLC6A7 Gene

HGNC:
IUPHAR :

Protein Domains for SLC6A7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC6A7 Gene

Graphical View of Domain Structure for InterPro Entry

Q99884

UniProtKB/Swiss-Prot:

SC6A7_HUMAN :
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A7 subfamily.
Family:
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A7 subfamily.
genes like me logo Genes that share domains with SLC6A7: view

Function for SLC6A7 Gene

Molecular function for SLC6A7 Gene

UniProtKB/Swiss-Prot Function:
Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals.

Gene Ontology (GO) - Molecular Function for SLC6A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005298 proline:sodium symporter activity TAS --
GO:0015193 L-proline transmembrane transporter activity IEA,IBA --
genes like me logo Genes that share ontologies with SLC6A7: view
genes like me logo Genes that share phenotypes with SLC6A7: view

Animal Model Products

CRISPR Products

miRNA for SLC6A7 Gene

miRTarBase miRNAs that target SLC6A7

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC6A7 Gene

Localization for SLC6A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC6A7 Gene COMPARTMENTS Subcellular localization image for SLC6A7 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC6A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 7651355
genes like me logo Genes that share ontologies with SLC6A7: view

Pathways & Interactions for SLC6A7 Gene

genes like me logo Genes that share pathways with SLC6A7: view

Interacting Proteins for SLC6A7 Gene

Gene Ontology (GO) - Biological Process for SLC6A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC6A7: view

No data available for SIGNOR curated interactions for SLC6A7 Gene

Drugs & Compounds for SLC6A7 Gene

(3) Drugs for SLC6A7 Gene - From: IUPHAR, DGIdb, DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Proline Approved Nutra Target 0
LP-403812 Pharma Inhibition, Inhibitor 0

(1) Additional Compounds for SLC6A7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC6A7: view

Transcripts for SLC6A7 Gene

mRNA/cDNA for SLC6A7 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC6A7 Gene

Solute carrier family 6 (neurotransmitter transporter, L-proline), member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A7 Gene

No ASD Table

Relevant External Links for SLC6A7 Gene

GeneLoc Exon Structure for
SLC6A7
ECgene alternative splicing isoforms for
SLC6A7

Expression for SLC6A7 Gene

mRNA expression in normal human tissues for SLC6A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC6A7 Gene

This gene is overexpressed in Brain - Cerebellum (x12.9), Brain - Cerebellar Hemisphere (x11.7), Brain - Cortex (x7.7), Brain - Frontal Cortex (BA9) (x6.4), and Brain - Anterior cingulate cortex (BA24) (x4.9).

Protein differential expression in normal tissues from HIPED for SLC6A7 Gene

This gene is overexpressed in Frontal cortex (52.5) and Fetal Brain (16.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC6A7 Gene



SOURCE GeneReport for Unigene cluster for SLC6A7 Gene Hs.241597

mRNA Expression by UniProt/SwissProt for SLC6A7 Gene

Q99884-SC6A7_HUMAN
Tissue specificity: Brain.
genes like me logo Genes that share expression patterns with SLC6A7: view

Protein tissue co-expression partners for SLC6A7 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC6A7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC6A7 35
  • 93.87 (n)
  • 98.43 (a)
SLC6A7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC6A7 35
  • 91.69 (n)
  • 96.21 (a)
SLC6A7 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc6a7 35
  • 90.46 (n)
  • 97.64 (a)
Slc6a7 16
Slc6a7 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC6A7 35
  • 99.32 (n)
  • 99.53 (a)
SLC6A7 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC6A7 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC6A7 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC6A7 35
  • 80.42 (n)
  • 86.61 (a)
SLC6A7 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC6A7 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc6a7 35
  • 74.76 (n)
  • 84.7 (a)
zebrafish
(Danio rerio)
Actinopterygii SLC6A7 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BG:DS03431.1 37
  • 38 (a)
CG10804 37
  • 36 (a)
CG1698 37
  • 36 (a)
CG3252 37
  • 39 (a)
CG5549 37
  • 45 (a)
CG7075 37
  • 34 (a)
CG8850 37
  • 37 (a)
ine 37
  • 42 (a)
CG4476 37
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea snf-12 37
  • 32 (a)
snf-2 37
  • 29 (a)
snf-4 37
  • 35 (a)
snf-5 37
  • 31 (a)
snf-6 37
  • 32 (a)
snf-8 37
  • 25 (a)
snf-9 37
  • 32 (a)
snf-3 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
CSA.4092 36
  • 48 (a)
OneToMany
CSA.62 36
  • 46 (a)
OneToMany
Species with no ortholog for SLC6A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC6A7 Gene

ENSEMBL:
Gene Tree for SLC6A7 (if available)
TreeFam:
Gene Tree for SLC6A7 (if available)

Paralogs for SLC6A7 Gene

genes like me logo Genes that share paralogs with SLC6A7: view

Variants for SLC6A7 Gene

Sequence variations from dbSNP and Humsavar for SLC6A7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1468564 - 150,202,649(-) CCGTG(C/G)TGGGC reference, missense
rs729817 -- 150,197,799(+) TAAGG(C/G)CAGGA intron-variant
rs731376 -- 150,199,436(+) AGGGC(A/T)TGGAC intron-variant
rs758590 -- 150,190,984(+) GTGGC(C/T)GTGGG intron-variant
rs758591 -- 150,198,106(+) AAGAA(A/G)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC6A7 Gene

Variant ID Type Subtype PubMed ID
nsv883027 CNV Loss 21882294
nsv883030 CNV Loss 21882294
nsv462487 CNV Loss 19166990

Variation tolerance for SLC6A7 Gene

Residual Variation Intolerance Score: 19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC6A7 Gene

HapMap Linkage Disequilibrium report
SLC6A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC6A7 Gene

Disorders for SLC6A7 Gene

Relevant External Links for SLC6A7

Genetic Association Database (GAD)
SLC6A7
Human Genome Epidemiology (HuGE) Navigator
SLC6A7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC6A7

No disorders were found for SLC6A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC6A7 Gene

Publications for SLC6A7 Gene

  1. Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes. (PMID: 7651355) Shafqat S. … Fremeau R.T. Jr. (Mol. Pharmacol. 1995) 2 3 4 23 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Mammalian brain-specific L-proline transporter. Neuronal localization of mRNA and enrichment of transporter protein in synaptic plasma membranes. (PMID: 7797577) Velaz-Faircloth M. … Fremeau R.T. (J. Biol. Chem. 1995) 3 23
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for SLC6A7 Gene

Sources for SLC6A7 Gene

Back to Top

Content