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GIFtS

SLC6A7 Gene

protein-coding   GIFtS: 55
GCID: GC05P149569

Solute Carrier Family 6 (Neurotransmitter Transporter),...

(Previous names: solute carrier family 6 (neurotransmitter transporter, L-proline),...)
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Aliases
for SLC6A7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Solute Carrier Family 6 (Neurotransmitter Transporter), Member 71 2
PROT2 3 5
Solute Carrier Family 6 (Neurotransmitter Transporter, L-Proline), Member
71 2
Brain-Specific L-Proline Transporter1 2
Sodium-Dependent Proline Transporter1 2
Solute Carrier Family 6 Member 72 3

External Ids:    HGNC: 110541   Entrez Gene: 65342   Ensembl: ENSG000000110837   OMIM: 6062055   UniProtKB: Q998843   

Export aliases for SLC6A7 gene to outside databases

Previous GC identifers: GC05P149640 GC05P150156 GC05P149598 GC05P149549 GC05P144717


Summaries
for SLC6A7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC6A7 Gene:
This gene is a member of the gamma-aminobutyric acid (GABA) neurotransmitter gene family and encodes a
high-affinity mammalian brain L-proline transporter protein. This transporter protein differs from other
sodium-dependent plasma membrane carriers by its pharmacological specificity, kinetic properties, and ionic
requirements. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLC6A7 Gene: 
SLC6A7 (solute carrier family 6 (neurotransmitter transporter), member 7) is a protein-coding gene. Diseases associated with SLC6A7 include hyperparathyroidism, and pneumonia, and among its related super-pathways are Transmembrane transport of small molecules and Na+/Cl- dependent neurotransmitter transporters. GO annotations related to this gene include neurotransmitter:sodium symporter activity. An important paralog of this gene is SLC6A6.

UniProtKB/Swiss-Prot: SC6A7_HUMAN, Q99884
Function: Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic
terminals




Genomic Views
for SLC6A7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC6A7 gene promoter:
         Egr-3   AhR   Max1   AP-1   AML1a   ATF-2   MyoD   Roaz   AREB6   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC6A7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC6A7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC6A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

SLC6A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC6A7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P149569:  view genomic region     (about GC identifiers)

Start:
 149,569,520 bp from pter      End:
 149,602,351 bp from pter
Size:
 32,832 bases      Orientation:
 plus strand

Proteins
for SLC6A7 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: SC6A7_HUMAN, Q99884 (See protein sequence)
Recommended Name: Sodium-dependent proline transporter  
Size: 636 amino acids; 70911 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q0VG81 Q52LU6

Explore the universe of human proteins at neXtProt for SLC6A7: NX_Q99884

Explore proteomics data for SLC6A7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99884

    • SLC6A7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC6A7 Protein Expression
    REFSEQ proteins: NP_055043.2  
    ENSEMBL proteins: 
     ENSP00000230671   ENSP00000428200  
    Reactome Protein details: Q99884
    Human Recombinant Protein Products for SLC6A7: 
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    Novus Biologicals SLC6A7 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7651355
    GO:0016020membrane TAS7651355
    GO:0016021integral to membrane ----

    SLC6A7 for ontologies           About GeneDecksing



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    Abcam antibodies for SLC6A7
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    Protein Domains /
    Families
    for SLC6A7 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: PROT 
    Glycine transporter subfamily

    1 InterPro protein domain:
     IPR000175 Na/ntran_symport

    Graphical View of Domain Structure for InterPro Entry Q99884

    ProtoNet protein and cluster: Q99884

    UniProtKB/Swiss-Prot: SC6A7_HUMAN, Q99884
    Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A7 subfamily


    SLC6A7 for domains           About GeneDecksing


    Function
    for SLC6A7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC6A7_HUMAN, Q99884
    Function: Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic
    terminals

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005328neurotransmitter:sodium symporter activity IEA--
         
    SLC6A7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC6A7:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC6A7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC6A7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC6A7 
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    miRNA
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    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SLC6A7

    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for SLC6A7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC6A7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport0.50
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    2Amine compound SLC transporters
    		Amine compound SLC transporters0.63
    		Na+/Cl- dependent neurotransmitter transporters0.63

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for SLC6A7
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Na+/Cl- dependent neurotransmitter transporters
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Amine compound SLC transporters



    SLC6A7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC6A7

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS7651355
    GO:0006836neurotransmitter transport ----
    GO:0015824proline transport TAS7651355
    GO:0055085transmembrane transport TAS--

    SLC6A7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC6A7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC6A7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC6A7 (SC6A7)

    2 HMDB Compounds for SLC6A7    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Proline(-)-(S)-Proline (see all 16)147-85-3--
    SodiumSodium (see all 2)7440-23-5--

    1 DrugBank Compound for SLC6A7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3target--17139284 17016423

    1 IUPHAR Ligand for SLC6A7 (PROT)    About this table 
    LigandTypeActionAffinityPubmed IDs
    LP-403812
    		InhibitorInhibition719159658

    1 Novoseek inferred chemical compound relationship for SLC6A7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 71.9 9 10414958 (2), 9140969 (1), 19159658 (1), 7797577 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC6A7 / SC6A7

    Transcripts
    for SLC6A7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC6A7 gene: 
    NM_014228.3  

    Unigene Cluster for SLC6A7:

    Solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
    Hs.241597  [show with all ESTs]
    Unigene Representative Sequence: NM_014228
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000230671(uc003lrr.3) ENST00000524041 ENST00000513403
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SLC6A7
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SLC6A7 (NM_014228)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC6A7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC6A7
    Sirion Biotech Customized lentivirus for stable overexpression of SLC6A7 
                         Customized lentivirus expression plasmids for stable overexpression of SLC6A7 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC6A7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC6A7

    Additional mRNA sequence: 

    AK096607.1 AK308895.1 AK312309.1 BC069631.1 BC093785.1 BC113425.1 S80071.1 

    1 DOTS entry:

    DT.105705 

    13 AceView cDNA sequences:

    NM_014228 BC069631 BI919202 BM719544 AK096607 S80071 AI986397 AW134521 
    AA323583 H40741 AI673162 AW080843 AA984230 

    GeneLoc Exon Structure


    Expression
    for SLC6A7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC6A7 expression in normal human tissues (normalized intensities)      SLC6A7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACACAGCAT
    SLC6A7 Expression
    About this image


    SLC6A7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Brain (Nervous System)

    See SLC6A7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC6A7

    SOURCE GeneReport for Unigene cluster: Hs.241597

    UniProtKB/Swiss-Prot: SC6A7_HUMAN, Q99884
    Tissue specificity: Brain

        SABiosciences Custom PCR Arrays for SLC6A7
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    In Situ
    Assay Products:     
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    Orthologs
    for SLC6A7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SLC6A7 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Slc6a71 , 5 solute carrier family 6 (neurotransmitter transporter, more1, 5 90.46(n)1
    97.64(a)1    		   18 (34.41 cM)5
    2403321  NM_201353.11  NP_958741.11 
     609953815 
    chicken
    (Gallus gallus)    		 Aves SLC6A71 solute carrier family 6 (neurotransmitter transporter, more 80.42(n)
    86.61(a)    		   416277  XM_414596.2  XP_414596.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC6A76
    --
    		 --
    		 86(a)
    46(a)
    		 1 ↔ 1
    possible ortholog
    		 2(139309868-139346188)
    GL343693.1(101564-147072)
    zebrafish
    (Danio rerio)    		 Actinopterygii SLC6A76
    		 solute carrier family 6 (neurotransmitter transpor...
    		 43(a)
    		 1 ↔ 1
    		 21(29557405-29593955)


    ENSEMBL Gene Tree for SLC6A7 (if available)
    TreeFam Gene Tree for SLC6A7 (if available)

    Paralogs
    for SLC6A7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC6A7 gene
    SLC6A62  SLC6A112  SLC6A122  SLC6A82  SLC6A52  SLC6A142  SLC6A32  SLC6A12  
    SLC6A42  SLC6A132  SLC6A22  SLC6A92  
    18/21 SIMAP similar genes for SLC6A7 using alignment to 2 protein entries:     SC6A7_HUMAN (see all proteins) (see all similar genes):
    SLC6A4    SLC6A9    SLC6A1    SLC6A3    SLC6A6    SLC6A12
    SLC6A5    SLC6A11    SLC6A13    SLC6A14    SLC6A2    DAT1
    SLC6A8    5HTT    SLC6A19    SLC6A18    SLC6A15    SLC6A16

    SLC6A7 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC6A7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/670 SNPs in SLC6A7 are shown (see all 670)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1438903721,2
    		C--149567591(+) GGCTGC/TGGGGA 1 -- us2k10--------
    rs797258941,2
    		C,F--149567642(+) AGCCTG/TGGTGA 1 -- us2k13Minor allele frequency- T:0.05WA NA EA 358
    rs1472519661,2
    		--149567657(+) AGACTC/TCTAGG 1 -- us2k10--------
    rs1113733891,2
    		F--149567700(+) TGAGTG/AATTTT 1 -- us2k12Minor allele frequency- A:0.03CSA WA 119
    rs774826981,2
    		C,F--149567747(+) TGAAAG/AGCATG 1 -- us2k11Minor allele frequency- A:0.15WA 118
    rs1155347741,2
    		C,F--149567916(+) GAAGGG/ATCATA 1 -- us2k11Minor allele frequency- A:0.15WA 118
    rs37760831,2
    		C,F,H--149567970(+) TGCTCG/ACTGTC 1 -- us2k122Minor allele frequency- A:0.32NS EA NA WA CSA 2226
    rs1406811291,2
    		--149568049(+) CAAGGC/TTGAGC 1 -- us2k10--------
    rs745321141,2
    		C,F--149568072(+) AGATGC/TATTGA 1 -- us2k12Minor allele frequency- T:0.04WA NA 238
    rs37760841,2
    		C,F,H--149568093(+) GTGAGG/AGATGG 1 -- us2k1 tfbs324Minor allele frequency- A:0.38EA NS NA WA CSA 3848

    HapMap Linkage Disequilibrium report for SLC6A7 (149569520 - 149602351 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC6A7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv462487CNV Loss19166990
    nsv883027CNV Loss21882294
    nsv883030CNV Loss21882294

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    Disorders / Diseases
    for SLC6A7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 606205    OMIM disorders: --

    5 diseases for SLC6A7:    About MalaCards
    hyperparathyroidism    pneumonia    asthma    alcoholism
    neuronitis


    SLC6A7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC6A7
    Human Genome Epidemiology (HuGE) Navigator: SLC6A7 (6 documents)

    Export disorders for SLC6A7 gene to outside databases

    Publications
    for SLC6A7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC6A7 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with SLC6A7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes. (PubMed id 7651355)1, 2, 3, 9 Shafqat S.... Fremeau R.T. Jr. (1995)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    4. A new association between polymorphisms of the SLC6A7 gene in the chromosome 5q31-32 region and asthma. (PubMed id 20431603)1, 4 Kim J.H....Shin H.D. (2010)
    5. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Mammalian brain-specific L-proline transporter. Neuronal localization of mRNA and enrichment of transporter protein in synaptic plasma membranes. (PubMed id 7797577)1, 9 Velaz-Faircloth M....Fremeau R.T. (1995)
    8. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    9. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    External Searches for SLC6A7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing SLC6A7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6534 HGNC: 11054 AceView: SLC6A7 Ensembl:ENSG00000011083 euGenes: HUgn6534
    ECgene: SLC6A7 H-InvDB: SLC6A7

    Other Databases showing SLC6A7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC6A7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC6A7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC6A7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC6A7 gene:
    Search GeneIP for patents involving SLC6A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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