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SLC6A7 Gene

protein-coding   GIFtS: 56
GCID: GC05P149569

Solute Carrier Family 6 (Neurotransmitter Transporter),...

(Previous names: solute carrier family 6 (neurotransmitter transporter, L-proline),...)
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Aliases
for SLC6A7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 6 (Neurotransmitter Transporter), Member 71 2
PROT2 3 5
Solute Carrier Family 6 (Neurotransmitter Transporter, L-Proline), Member
71 2
Brain-Specific L-Proline Transporter1 2
Sodium-Dependent Proline Transporter1 2
Solute Carrier Family 6 Member 72 3

External Ids:    HGNC: 110541   Entrez Gene: 65342   Ensembl: ENSG000000110837   OMIM: 6062055   UniProtKB: Q998843   

Export aliases for SLC6A7 gene to outside databases

Previous GC identifers: GC05P149640 GC05P150156 GC05P149598 GC05P149549 GC05P144717


Summaries
for SLC6A7 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC6A7 Gene:
This gene is a member of the gamma-aminobutyric acid (GABA) neurotransmitter gene family and encodes a
high-affinity mammalian brain L-proline transporter protein. This transporter protein differs from other
sodium-dependent plasma membrane carriers by its pharmacological specificity, kinetic properties, and ionic
requirements. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLC6A7 Gene:
SLC6A7 (solute carrier family 6 (neurotransmitter transporter), member 7) is a protein-coding gene. GO annotations related to this gene include neurotransmitter:sodium symporter activity. An important paralog of this gene is SLC6A6.

UniProtKB/Swiss-Prot: SC6A7_HUMAN, Q99884
Function: Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic
terminals




Genomic Views
for SLC6A7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC6A7 gene promoter:
         Egr-3   AhR   Max1   AP-1   AML1a   ATF-2   MyoD   Roaz   AREB6   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC6A7 promoter sequence
   Search Chromatin IP Primers for SLC6A7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC6A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

SLC6A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC6A7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P149569:  view genomic region     (about GC identifiers)

Start:
 149,569,520 bp from pter      End:
 149,602,351 bp from pter
Size:
 32,832 bases      Orientation:
 plus strand

Proteins
for SLC6A7 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SC6A7_HUMAN, Q99884 (See protein sequence)
Recommended Name: Sodium-dependent proline transporter  
Size: 636 amino acids; 70911 Da
Secondary accessions: Q0VG81 Q52LU6

Explore the universe of human proteins at neXtProt for SLC6A7: NX_Q99884

Explore proteomics data for SLC6A7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn182
  • Modification sites at PhosphoSitePlus

    • See SLC6A7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055043.2  
    ENSEMBL proteins: 
     ENSP00000230671   ENSP00000428200  
    Reactome Protein details: Q99884

    SLC6A7 Human Recombinant Protein Products:

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    Novus Biologicals SLC6A7 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

         		 Search eBioscience for Proteins for SLC6A7 

         		antibodies-online proteins for SLC6A7 

         		 Search antibodies-online for peptides for SLC6A7

    SLC6A7 Antibody Products:

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    antibodies-online antibodies for SLC6A7 (18 products) 

    SLC6A7 Assay Products:

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    Search eBioscience for ELISAs for SLC6A7 
    antibodies-online kits for SLC6A7 (6 products) 

    Domains /
    Families
    for SLC6A7 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: PROT
    Glycine transporter subfamily

    1 InterPro protein domain:
     IPR000175 Na/ntran_symport

    Graphical View of Domain Structure for InterPro Entry Q99884

    ProtoNet protein and cluster: Q99884

    UniProtKB/Swiss-Prot: SC6A7_HUMAN, Q99884
    Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A7 subfamily


    Find genes that share domains with SLC6A7           About GenesLikeMe


    Function
    for SLC6A7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC6A7_HUMAN, Q99884
    Function: Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic
    terminals

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005328neurotransmitter:sodium symporter activity IEA--
         
    Find genes that share ontologies with SLC6A7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC6A7:
     Increased S DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC6A7

    miRNA
    Products:            		Block miRNA regulation of human, mouse, rat SLC6A7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SLC6A7
    SwitchGear 3'UTR luciferase reporter plasmid: SLC6A7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC6A7

    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Localization
    for SLC6A7 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SC6A7_HUMAN, Q99884: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    mitochondrion2
    nucleus2
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7651355
    GO:0016020membrane TAS7651355
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SLC6A7           About GenesLikeMe


    Pathways & Interactions
    for SLC6A7 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC6A7 About    
    See pathways by source

    		      Powered
    by    		     
    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    		SLC-mediated transmembrane transport0.47
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.47
    		Na+/Cl- dependent neurotransmitter transporters0.00
    2Metabolism of amino acids and derivatives
    		Metabolism of amino acids and derivatives
    		Creatine metabolism0.00
    3Metabolism
    		Metabolism0.38


    Find genes that share SuperPaths with SLC6A7           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways



    2 Reactome Pathways for SLC6A7
        Creatine metabolism
    Na+/Cl- dependent neurotransmitter transporters


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC6A7
    Interactions:

        Search GeneGlobe Interaction Network for SLC6A7

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC6A7 (ENSP000002306714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --ENSP000002938134STRING: ENSP00000293813
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS7651355
    GO:0006836neurotransmitter transport ----
    GO:0015824proline transport TAS7651355
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with SLC6A7           About GenesLikeMe



    Drugs & Compounds
    for SLC6A7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC6A7 (SC6A7)

    2 HMDB Compounds for SLC6A7    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Proline(-)-(S)-Proline (see all 16)147-85-3--
    SodiumSodium (see all 2)7440-23-5--

    1 DrugBank Compound for SLC6A7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3target--17139284 17016423

    1 IUPHAR Ligand for SLC6A7 (PROT)    About this table
    LigandTypeActionAffinityPubmed IDs
    LP-403812
    		InhibitorInhibition719159658

    1 Novoseek inferred chemical compound relationship for SLC6A7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 71.9 9 10414958 (2), 9140969 (1), 19159658 (1), 7797577 (1)



    Find genes that share compounds with SLC6A7           About GenesLikeMe



    Transcripts
    for SLC6A7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC6A7 gene: 
    NM_014228.3  

    Unigene Cluster for SLC6A7:

    Solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
    Hs.241597  [show with all ESTs]
    Unigene Representative Sequence: NM_014228
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000230671(uc003lrr.3) ENST00000524041 ENST00000513403
    miRNA
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    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat SLC6A7

    Additional mRNA sequence: 

    AK096607.1 AK308895.1 AK312309.1 BC069631.1 BC093785.1 BC113425.1 S80071.1 

    1 DOTS entry:

    DT.105705 

    13 AceView cDNA sequences:

    BC069631 NM_014228 AI986397 BI919202 S80071 BM719544 AK096607 AW134521 
    AI673162 H40741 AA323583 AW080843 AA984230 

    GeneLoc Exon Structure


    Expression
    for SLC6A7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC6A7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACACAGCAT
    SLC6A7 Expression
    About this image


    SLC6A7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
    SLC6A7 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    SLC6A7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.241597

    UniProtKB/Swiss-Prot: SC6A7_HUMAN, Q99884
    Tissue specificity: Brain

        Custom PCR Arrays for SLC6A7
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    In Situ
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    Orthologs
    for SLC6A7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC6A7 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Slc6a71 , 5 solute carrier family 6 (neurotransmitter transporter, more1, 5 90.46(n)1
    97.64(a)1    		   18 (34.41 cM)5
    2403321  NM_201353.11  NP_958741.11 
     609953815 
    chicken
    (Gallus gallus)    		 Aves SLC6A71 solute carrier family 6 (neurotransmitter transporter, more 80.42(n)
    86.61(a)    		   416277  XM_004944948.1  XP_004945005.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC6A76
    		 solute carrier family 6 (neurotransmitter transpor...
    		 86(a)
    		 1 ↔ 1
    		 2(139309868-139346188)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia slc6a71 solute carrier family 6 (neurotransmitter transporter, more 74.76(n)
    84.7(a)    		   100487063  XM_002940085.2  XP_002940131.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii SLC6A76
    		 solute carrier family 6 (neurotransmitter transpor...
    		 44(a)
    		 1 ↔ 1
    		 21(29557405-29593955) ENSDARG00000030006
    worm
    (Caenorhabditis elegans)    		 Secernentea snf-43   -- 35(a)
    (best of 7)    		   II(12832809-12835718)   --


    ENSEMBL Gene Tree for SLC6A7 (if available)
    TreeFam Gene Tree for SLC6A7 (if available)

    Paralogs
    for SLC6A7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC6A7 gene
    SLC6A62  SLC6A112  SLC6A122  SLC6A82  SLC6A52  SLC6A142  SLC6A32  SLC6A12  
    SLC6A42  SLC6A132  SLC6A22  SLC6A92  
    Selected SIMAP similar genes for SLC6A7 using alignment to 2 protein entries:     SC6A7_HUMAN (see all proteins) (see all similar genes):
    SLC6A4    SLC6A9    SLC6A1    SLC6A3    SLC6A6    SLC6A12
    SLC6A5    SLC6A11    SLC6A13    SLC6A14    SLC6A2    DAT1
    SLC6A8    5HTT    SLC6A15    SLC6A19    SLC6A18    SLC6A16

    Find genes that share paralogs with SLC6A7           About GenesLikeMe



    Genomic Variants
    for SLC6A7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC6A7 (see all 670)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1438903721,2
    		C--149567591(+) GGCTGC/TGGGGA 1 -- us2k10--------
    rs797258941,2
    		C,F--149567642(+) AGCCTG/TGGTGA 1 -- us2k13Minor allele frequency- T:0.05WA NA EA 358
    rs1472519661,2
    		--149567657(+) AGACTC/TCTAGG 1 -- us2k10--------
    rs1113733891,2
    		F--149567700(+) TGAGTG/AATTTT 1 -- us2k12Minor allele frequency- A:0.03CSA WA 119
    rs774826981,2
    		C,F--149567747(+) TGAAAG/AGCATG 1 -- us2k11Minor allele frequency- A:0.15WA 118
    rs1155347741,2
    		C,F--149567916(+) GAAGGG/ATCATA 1 -- us2k11Minor allele frequency- A:0.15WA 118
    rs37760831,2
    		C,F,H--149567970(+) TGCTCG/ACTGTC 1 -- us2k122Minor allele frequency- A:0.32NS EA NA WA CSA 2226
    rs1406811291,2
    		--149568049(+) CAAGGC/TTGAGC 1 -- us2k10--------
    rs745321141,2
    		C,F--149568072(+) AGATGC/TATTGA 1 -- us2k12Minor allele frequency- T:0.04WA NA 238
    rs37760841,2
    		C,F,H--149568093(+) GTGAGG/AGATGG 1 -- us2k1 tfbs324Minor allele frequency- A:0.38EA NS NA WA CSA 3848

    HapMap Linkage Disequilibrium report for SLC6A7 (149569520 - 149602351 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC6A7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv462487CNV Loss19166990
    nsv883027CNV Loss21882294
    nsv883030CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC6A7
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    Disorders / Diseases
    for SLC6A7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 606205    OMIM disorders: --


    Find genes that share disorders with SLC6A7           About GenesLikeMe

    Genetic Association Database (GAD): SLC6A7
    Human Genome Epidemiology (HuGE) Navigator: SLC6A7 (6 documents)

    Export disorders for SLC6A7 gene to outside databases

    Publications
    for SLC6A7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SLC6A7 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with SLC6A7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes. (PubMed id 7651355)1, 2, 3, 9 Shafqat S.... Fremeau R.T. Jr. (Mol. Pharmacol. 1995)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    4. A new association between polymorphisms of the SLC6A7 gene in the chromosome 5q31-32 region and asthma. (PubMed id 20431603)1, 4 Kim J.H....Shin H.D. (J. Hum. Genet. 2010)
    5. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Mammalian brain-specific L-proline transporter. Neuronal localization of mRNA and enrichment of transporter protein in synaptic plasma membranes. (PubMed id 7797577)1, 9 Velaz-Faircloth M....Fremeau R.T. (J. Biol. Chem. 1995)
    8. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    9. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    External Searches for SLC6A7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
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    Genome Databases showing SLC6A7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6534 HGNC: 11054 AceView: SLC6A7 Ensembl:ENSG00000011083 euGenes: HUgn6534
    ECgene: SLC6A7 H-InvDB: SLC6A7

    Other Databases showing SLC6A7 gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing SLC6A7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC6A7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC6A7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for SLC6A7 gene:
    Search GeneIP for patents involving SLC6A7

    GeneCards and IP:
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