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Aliases for SLC6A7 Gene

Aliases for SLC6A7 Gene

  • Solute Carrier Family 6 (Neurotransmitter Transporter), Member 7 2 3
  • PROT 3 4 6
  • Solute Carrier Family 6 (Neurotransmitter Transporter, L-Proline), Member 7 2 3
  • Brain-Specific L-Proline Transporter 2 3
  • Sodium-Dependent Proline Transporter 2 3
  • Solute Carrier Family 6 Member 7 3 4

External Ids for SLC6A7 Gene

Previous GeneCards Identifiers for SLC6A7 Gene

  • GC05P149640
  • GC05P149598
  • GC05P149549
  • GC05P144717
  • GC05P149569

Summaries for SLC6A7 Gene

Entrez Gene Summary for SLC6A7 Gene

  • This gene is a member of the gamma-aminobutyric acid (GABA) neurotransmitter gene family and encodes a high-affinity mammalian brain L-proline transporter protein. This transporter protein differs from other sodium-dependent plasma membrane carriers by its pharmacological specificity, kinetic properties, and ionic requirements. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC6A7 Gene

SLC6A7 (Solute Carrier Family 6 (Neurotransmitter Transporter), Member 7) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of amino acids and derivatives. GO annotations related to this gene include neurotransmitter:sodium symporter activity. An important paralog of this gene is SLC6A4.

UniProtKB/Swiss-Prot for SLC6A7 Gene

  • Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A7 Gene

Genomics for SLC6A7 Gene

Regulatory Elements for SLC6A7 Gene

Genomic Location for SLC6A7 Gene

150,189,957 bp from pter
150,222,788 bp from pter
32,832 bases
Plus strand

Genomic View for SLC6A7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC6A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A7 Gene

Proteins for SLC6A7 Gene

  • Protein details for SLC6A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium-dependent proline transporter
    Protein Accession:
    Secondary Accessions:
    • Q0VG81
    • Q52LU6

    Protein attributes for SLC6A7 Gene

    636 amino acids
    Molecular mass:
    70911 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC6A7 Gene

Proteomics data for SLC6A7 Gene at MOPED

Post-translational modifications for SLC6A7 Gene

  • Glycosylation at Asn182
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC6A7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC6A7 Gene

Domains for SLC6A7 Gene

Gene Families for SLC6A7 Gene

  • SLC :Solute carriers

Protein Domains for SLC6A7 Gene


Suggested Antigen Peptide Sequences for SLC6A7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q99884
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A7 subfamily.
genes like me logo Genes that share domains with SLC6A7: view

Function for SLC6A7 Gene

Molecular function for SLC6A7 Gene

UniProtKB/Swiss-Prot Function: Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals

Gene Ontology (GO) - Molecular Function for SLC6A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005328 neurotransmitter:sodium symporter activity IEA --
genes like me logo Genes that share ontologies with SLC6A7: view

Phenotypes for SLC6A7 Gene

GenomeRNAi human phenotypes for SLC6A7:
genes like me logo Genes that share phenotypes with SLC6A7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC6A7 Gene

Localization for SLC6A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC6A7 Gene COMPARTMENTS Subcellular localization image for SLC6A7 gene
Compartment Confidence
plasma membrane 4
cytosol 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC6A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7651355
GO:0016020 membrane TAS 7651355
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC6A7: view

Pathways for SLC6A7 Gene

genes like me logo Genes that share pathways with SLC6A7: view

Interacting Proteins for SLC6A7 Gene

Gene Ontology (GO) - Biological Process for SLC6A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 7651355
GO:0006836 neurotransmitter transport IEA --
GO:0015824 proline transport TAS 7651355
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC6A7: view

Compounds for SLC6A7 Gene

(2) HMDB Compounds for SLC6A7 Gene

Compound Synonyms Cas Number PubMed IDs
  • (-)-(S)-Proline
  • Sodium

(1) Drugbank Compounds for SLC6A7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • (-)-2-Pyrrolidinecarboxylic acid
147-85-3 target

(1) IUPHAR Ligand for SLC6A7 Gene

Ligand Type Action Affinity Pubmed IDs
LP-403812 Inhibitor Inhibition 7

(1) Novoseek inferred chemical compound relationships for SLC6A7 Gene

Compound -log(P) Hits PubMed IDs
proline 71.9 5
genes like me logo Genes that share compounds with SLC6A7: view

Transcripts for SLC6A7 Gene

mRNA/cDNA for SLC6A7 Gene

(13) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC6A7 Gene

Solute carrier family 6 (neurotransmitter transporter, L-proline), member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A7 Gene

No ASD Table

Relevant External Links for SLC6A7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC6A7 Gene

mRNA expression in normal human tissues for SLC6A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC6A7 Gene

This gene is overexpressed in Brain - Cerebellum (12.9), Brain - Cerebellar Hemisphere (11.7), Brain - Cortex (7.7), Brain - Frontal Cortex (BA9) (6.4), and Brain - Anterior cingulate cortex (BA24) (4.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC6A7 Gene

SOURCE GeneReport for Unigene cluster for SLC6A7 Gene Hs.241597

mRNA Expression by UniProt/SwissProt for SLC6A7 Gene

Tissue specificity: Brain
genes like me logo Genes that share expressions with SLC6A7: view

Orthologs for SLC6A7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC6A7 35
  • 99.32 (n)
  • 99.53 (a)
SLC6A7 36
  • 92 (a)
(Bos Taurus)
Mammalia SLC6A7 35
  • 93.87 (n)
  • 98.43 (a)
SLC6A7 36
  • 98 (a)
(Canis familiaris)
Mammalia SLC6A7 35
  • 91.69 (n)
  • 96.21 (a)
SLC6A7 36
  • 96 (a)
(Mus musculus)
Mammalia Slc6a7 35
  • 90.46 (n)
  • 97.64 (a)
Slc6a7 16
Slc6a7 36
  • 98 (a)
(Monodelphis domestica)
Mammalia SLC6A7 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia SLC6A7 36
  • 78 (a)
(Gallus gallus)
Aves SLC6A7 35
  • 80.42 (n)
  • 86.61 (a)
SLC6A7 36
  • 87 (a)
(Anolis carolinensis)
Reptilia SLC6A7 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc6a7 35
  • 74.76 (n)
  • 84.7 (a)
(Danio rerio)
Actinopterygii SLC6A7 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta ine 37
  • 42 (a)
BG:DS03431.1 37
  • 38 (a)
CG7075 37
  • 34 (a)
CG4476 37
  • 40 (a)
CG10804 37
  • 36 (a)
CG5549 37
  • 45 (a)
CG3252 37
  • 39 (a)
CG1698 37
  • 36 (a)
CG8850 37
  • 37 (a)
(Caenorhabditis elegans)
Secernentea snf-3 36
  • 34 (a)
snf-8 37
  • 25 (a)
snf-4 37
  • 35 (a)
snf-5 37
  • 31 (a)
snf-9 37
  • 32 (a)
snf-12 37
  • 32 (a)
snf-6 37
  • 32 (a)
snf-2 37
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
CSA.4092 36
  • 48 (a)
CSA.62 36
  • 46 (a)
Species with no ortholog for SLC6A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC6A7 Gene

Gene Tree for SLC6A7 (if available)
Gene Tree for SLC6A7 (if available)

Paralogs for SLC6A7 Gene

Paralogs for SLC6A7 Gene

genes like me logo Genes that share paralogs with SLC6A7: view

Variants for SLC6A7 Gene

Sequence variations from dbSNP and Humsavar for SLC6A7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs729817 -- 150,197,799(+) TAAGG(C/G)CAGGA intron-variant
rs731375 -- 150,199,182(-) CCAGG(C/T)TCCAC intron-variant
rs731376 -- 150,199,436(+) AGGGC(A/T)TGGAC intron-variant
rs758590 -- 150,190,984(+) GTGGC(C/T)GTGGG intron-variant
rs758591 -- 150,198,106(+) AAGAA(A/G)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC6A7 Gene

Variant ID Type Subtype PubMed ID
nsv883027 CNV Loss 21882294
nsv883030 CNV Loss 21882294
nsv462487 CNV Loss 19166990

Relevant External Links for SLC6A7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC6A7 Gene

Disorders for SLC6A7 Gene

Relevant External Links for SLC6A7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC6A7: view

No data available for UniProtKB/Swiss-Prot for SLC6A7 Gene

Publications for SLC6A7 Gene

  1. Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes. (PMID: 7651355) Shafqat S. … Fremeau R.T. Jr. (Mol. Pharmacol. 1995) 2 3 4 23
  2. Mammalian brain-specific L-proline transporter. Neuronal localization of mRNA and enrichment of transporter protein in synaptic plasma membranes. (PMID: 7797577) Velaz-Faircloth M. … Fremeau R.T. (J. Biol. Chem. 1995) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B. … Hoffman P.L. (BMC Biol. 2009) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for SLC6A7 Gene

  • antibodies-online proteins for SLC6A7
  • antibodies-online antibodies for SLC6A7
  • antibodies-online kits for SLC6A7

Sources for SLC6A7 Gene

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