Aliases for SLC6A4 Gene
Aliases for SLC6A4 Gene
- Solute Carrier Family 6 Member 4 2 3 4 5
- Solute Carrier Family 6 (Neurotransmitter Transporter, Serotonin), Member 4 2 3
- Solute Carrier Family 6 (Neurotransmitter Transporter), Member 4 2 3
- 5-Hydroxytryptamine (Serotonin) Transporter 2 3
- Serotonin Transporter 1 2 3
- 5HT Transporter 3 4
- 5HTT 3 4
- SERT 3 4
- HTT 3 4
External Ids for SLC6A4 Gene
- HGNC: 11050
- Entrez Gene: 6532
- Ensembl: ENSG00000108576
- OMIM: 182138
- UniProtKB: P31645
Previous HGNC Symbols for SLC6A4 Gene
- HTT
- OCD1
Previous GeneCards Identifiers for SLC6A4 Gene
- GC17M028278
- GC17M030431
- GC17M028670
- GC17M025549
- GC17M028521
- GC17M024733
Summaries for SLC6A4 Gene
-
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC6A4 Gene
SLC6A4 (Solute Carrier Family 6 Member 4) is a Protein Coding gene. Diseases associated with SLC6A4 include Obsessive-Compulsive Disorder and Slc6a4-Related Altered Drug Metabolism. Among its related pathways are Serotonergic synapse and Circadian rythm related genes. GO annotations related to this gene include protein homodimerization activity and Rab GTPase binding. An important paralog of this gene is SLC6A2.
UniProtKB/Swiss-Prot for SLC6A4 Gene
-
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
-
5-HT transporters (serotonin transporters, SERT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) found widely distributed throughout the brain. They are responsible for re-uptake of 5-HT and undergo a conformational change to move molecules.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A4 Gene
Genomics for SLC6A4 Gene
Regulatory Elements for SLC6A4 Gene
Enhancers for SLC6A4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SLC6A4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SLC6A4 gene promoter:
Regulatory Element Products
Genomic Location for SLC6A4 Gene
- Chromosome:
- 17
- Start:
- 30,194,319 bp from pter
- End:
- 30,236,002 bp from pter
- Size:
- 41,684 bases
- Orientation:
- Minus strand
Genomic View for SLC6A4 Gene
Genes around SLC6A4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q11.2 by Ensembl
- 17q11.2 by Entrez Gene
- 17q11.2 by HGNC
SLC6A4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC6A4 Gene
Proteins for SLC6A4 Gene
-
Protein details for SLC6A4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31645-SC6A4_HUMAN
- Recommended name:
- Sodium-dependent serotonin transporter
- Protein Accession:
- P31645
- Q5EE02
Protein attributes for SLC6A4 Gene
- Size:
- 630 amino acids
- Molecular mass:
- 70325 Da
- Quaternary structure:
-
- Monomer or homooligomer (By similarity). Interacts with TGFB1I1. Interacts (via sialylated form) with MYH9. Interacts with SEC23A, SEC24C and PATJ. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake. Interacts with filamentous actin and STX1A (By similarity). Interacts (via C-terminus) with VIM. Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly. Interacts with RAB4 (GTP-bound form); the interaction retains transporter molecules intracellularly.
- Miscellaneous:
-
- This protein is the target of psychomotor stimulants such as amphetamines or cocaine.
Three dimensional structures from OCA and Proteopedia for SLC6A4 Gene
Protein Expression for SLC6A4 Gene
Post-translational modifications for SLC6A4 Gene
- Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms.
- Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation. Phosphorylation upon PKC stimulation modifies the SERT distribution and density in the membrane, and diminishes the uptake capacity.
- Glycosylation at isoforms=2208 and isoforms=2217
- Modification sites at PhosphoSitePlus
Other Protein References for SLC6A4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top SLC6A4 Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for SLC6A4
-
Custom Antibody ServicesOriGene Antibodies for SLC6A4
- Novus Biologicals Antibodies for SLC6A4
-
Cloud-Clone Corp. Antibodies for SLC6A4
- Invitrogen Antibodies for SLC6A4
- antibodies-online Antibodies for SLC6A4: See all 98
- GeneTex SLC6A4 antibody for SLC6A4
-
Santa Cruz Biotechnology (SCBT) Antibodies for SLC6A4
Protein Products
-
OriGene Purified Proteins for SLC6A4
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC6A4
- Origene Custom Protein Services for SLC6A4
-
Cloud-Clone Corp. Proteins for SLC6A4
- antibodies-online Proteins for SLC6A4: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SLC6A4
No data available for DME Specific Peptides for SLC6A4 Gene
Domains & Families for SLC6A4 Gene
Gene Families for SLC6A4 Gene
- HGNC:
- IUPHAR :
Protein Domains for SLC6A4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC6A4 Gene
Graphical View of Domain Structure for InterPro Entry
P31645UniProtKB/Swiss-Prot:
SC6A4_HUMAN :- Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
- Family:
-
- Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
Function for SLC6A4 Gene
Molecular function for SLC6A4 Gene
- GENATLAS Biochemistry:
- solute carrier family 6,member A4,neurotransmitter transporter,serotonin
- UniProtKB/Swiss-Prot Function:
- Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated when plasma serotonin is elevated.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005328 | neurotransmitter:sodium symporter activity | IEA | -- |
| GO:0005330 | dopamine:sodium symporter activity | IBA | -- |
| GO:0005335 | serotonin:sodium symporter activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 11343649 |
| GO:0008504 | monoamine transmembrane transporter activity | IDA | 16024787 |
Phenotypes for SLC6A4 Gene
- MGI mutant phenotypes for SLC6A4:
- inferred from 10 alleles
- GenomeRNAi human phenotypes for SLC6A4:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased IL-8 secretion
- Increased cell number in S
- Weakly decreased NFAT1-GFP nuclear translocation
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
Animal Models for SLC6A4 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for SLC6A4
- Cyagen custom Knockout/knockin (KOKI) mouse models for SLC6A4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SLC6A4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC6A4 gene
- Search ViGene Biosciences for SLC6A4
CRISPR Products
-
OriGene CRISPR knockouts for SLC6A4
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC6A4
- GenScript: Design CRISPR guide RNA sequences for SLC6A4
miRNA for SLC6A4 Gene
- miRTarBase miRNAs that target SLC6A4
-
- hsa-mir-335-5p (MIRT018862)
- hsa-mir-16-5p (MIRT053620)
- hsa-mir-135a-5p (MIRT438132)
- hsa-mir-544a (MIRT639473)
- hsa-mir-3678-3p (MIRT639474)
- hsa-mir-6749-3p (MIRT639475)
- hsa-mir-6792-3p (MIRT639476)
- hsa-mir-4691-5p (MIRT639477)
- hsa-mir-2467-3p (MIRT639478)
- hsa-mir-17-3p (MIRT639479)
- hsa-mir-1205 (MIRT639480)
- hsa-mir-1184 (MIRT639481)
- hsa-mir-3158-5p (MIRT639482)
- hsa-mir-4685-3p (MIRT639483)
- hsa-mir-4287 (MIRT639484)
- hsa-mir-1237-3p (MIRT639485)
- hsa-mir-5088-3p (MIRT639486)
- hsa-mir-5590-3p (MIRT639487)
- hsa-mir-142-5p (MIRT639488)
- hsa-mir-1264 (MIRT639489)
- hsa-mir-6507-3p (MIRT639490)
- hsa-mir-5089-5p (MIRT699251)
- hsa-mir-7156-3p (MIRT699252)
- hsa-mir-937-5p (MIRT699253)
- hsa-mir-7151-3p (MIRT699254)
- hsa-mir-5095 (MIRT699255)
- hsa-mir-5589-5p (MIRT699256)
- hsa-mir-4731-5p (MIRT699257)
- hsa-mir-5702 (MIRT699258)
- hsa-mir-6506-5p (MIRT699259)
- hsa-mir-619-5p (MIRT699260)
- hsa-mir-3130-3p (MIRT699261)
- hsa-mir-150-5p (MIRT699262)
- hsa-mir-186-3p (MIRT699263)
- hsa-mir-3934-5p (MIRT699264)
- hsa-mir-6890-3p (MIRT699265)
- hsa-mir-520h (MIRT699266)
- hsa-mir-520g-3p (MIRT699267)
- hsa-mir-6504-3p (MIRT699268)
- hsa-mir-512-3p (MIRT699269)
- hsa-mir-509-5p (MIRT699270)
- hsa-mir-509-3-5p (MIRT699271)
- hsa-mir-4418 (MIRT699272)
- hsa-mir-552-3p (MIRT699273)
- hsa-mir-520e (MIRT699274)
- hsa-mir-520d-3p (MIRT699275)
- hsa-mir-520c-3p (MIRT699276)
- hsa-mir-520b (MIRT699277)
- hsa-mir-520a-3p (MIRT699278)
- hsa-mir-373-3p (MIRT699279)
- hsa-mir-372-3p (MIRT699280)
- hsa-mir-302e (MIRT699281)
- hsa-mir-302d-3p (MIRT699282)
- hsa-mir-302c-3p (MIRT699283)
- hsa-mir-302b-3p (MIRT699284)
- hsa-mir-302a-3p (MIRT699285)
- hsa-mir-93-5p (MIRT699286)
- hsa-mir-526b-3p (MIRT699287)
- hsa-mir-519d-3p (MIRT699288)
- hsa-mir-20b-5p (MIRT699289)
- hsa-mir-20a-5p (MIRT699290)
- hsa-mir-17-5p (MIRT699291)
- hsa-mir-106b-5p (MIRT699292)
- hsa-mir-106a-5p (MIRT699293)
miRNA Products
- Search ViGene Biosciences for SLC6A4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for SLC6A4
- Browse OriGene Inhibitory RNA Products For SLC6A4
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC6A4 gene
Clone Products
-
OriGene ORF clones in human for SLC6A4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SLC6A4
- VectorBuilder custom plasmid, inducible vectors for SLC6A4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC6A4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for SLC6A4 (SLC6A4/5-HTTLPR)
Cell Line Products
-
Horizon Cell Lines for SLC6A4
-
ViGene Biosciences adenoviral particle packaged cDNA for SLC6A4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SLC6A4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC6A4 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC6A4 Gene
Localization for SLC6A4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC6A4 Gene
- Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Could be part of recycling endosomes (PubMed:18227069, PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858) (PubMed:18227069). {ECO:0000250 UniProtKB:P31652, ECO:0000269 PubMed:16870614, ECO:0000269 PubMed:17506858, ECO:0000269 PubMed:18227069}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| extracellular | 3 |
| endosome | 3 |
| nucleus | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005768 | endosome | IEA | -- |
| GO:0005829 | cytosol | IDA | 19270731 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IC | 19270731 |
| GO:0010008 | endosome membrane | IEA | -- |
Pathways & Interactions for SLC6A4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transmission across Chemical Synapses |
.62
|
|
| 2 | Neurotransmitter Clearance In The Synaptic Cleft | ||
| 3 | Monoamine Transport | ||
| 4 | Serotonergic synapse | ||
| 5 | Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics | ||
Pathways by source for SLC6A4 Gene
6 BioSystems pathways for SLC6A4 Gene
4 Reactome pathways for SLC6A4 Gene
2 PharmGKB pathways for SLC6A4 Gene
1 KEGG pathway for SLC6A4 Gene
Interacting Proteins for SLC6A4 Gene
Selected Interacting proteins:
ENSP00000261707
P31645-SC6A4_HUMAN
for SLC6A4 Gene via
STRING
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0006810 | transport | IEA | -- |
| GO:0006836 | neurotransmitter transport | IEA | -- |
| GO:0006837 | serotonin transport | IDA | 19270731 |
| GO:0007420 | brain development | IEA | -- |
Drugs & Compounds for SLC6A4 Gene
(150) Drugs for SLC6A4 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Paroxetine | Approved, Investigational | Pharma | Inhibition, Inhibitor, inhibitor, Target | 228 | ||
| Sertraline | Approved | Pharma | Inhibition, Inhibitor, inhibitor, Target | 299 | ||
| Citalopram | Approved | Pharma | inhibitor, Target, Transporter, substrate | 512 | ||
| Clomipramine | Approved, Vet_approved | Pharma | inhibitor, Target | 24 | ||
| Escitalopram | Approved, Investigational | Pharma | inhibitor, Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| N-Desmethylcitalopram |
|
|||||
| O-Desmethylverapamil (D-702) |
|
|
||||
| sodium |
|
7440-23-5 |
|
|||
| Fluoxetine hydrochloride |
|
56296-78-7 |
|
|
(5) Tocris Compounds for SLC6A4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Citalopram hydrobromide | Highly potent and selective 5-HT uptake inhibitor | 59729-32-7 |
| Dexfenfluramine hydrochloride | 5-HT re-uptake inhibitor. Also stimulates 5-HT release | 3239-45-0 |
| Fluoxetine hydrochloride | 5-HT re-uptake inhibitor | 56296-78-7 |
| Fluvoxamine maleate | 5-HT re-uptake inhibitor | 61718-82-9 |
| Indatraline hydrochloride | Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake | 96850-13-4 |
(9) ApexBio Compounds for SLC6A4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| (±)-McN 5652 | 5-HT uptake inhibitor | 96795-89-0 |
| Atomoxetine HCl | Noradrenalin re-uptake inhibitor | 82248-59-7 |
| Bicifadine hydrochloride | 66504-75-4 | |
| Desipramine hydrochloride | 58-28-6 | |
| Escitalopram Oxalate | Serotonin(5-HT) reuptake (SSRI) inhibitor | 219861-08-2 |
| Indatraline hydrochloride | 96850-13-4 | |
| Nisoxetine hydrochloride | 57754-86-6 | |
| Sertraline HCl | 79559-97-0 | |
| Zimelidine dihydrochloride | 60525-15-7 |
Transcripts for SLC6A4 Gene
mRNA/cDNA for SLC6A4 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (15) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SLC6A4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SLC6A4
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC6A4
- GenScript: Design CRISPR guide RNA sequences for SLC6A4
miRNA Products
- Search ViGene Biosciences for SLC6A4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for SLC6A4
- Browse OriGene Inhibitory RNA Products For SLC6A4
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC6A4 gene
Clone Products
-
OriGene ORF clones in human for SLC6A4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SLC6A4
- VectorBuilder custom plasmid, inducible vectors for SLC6A4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC6A4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for SLC6A4 (SLC6A4/5-HTTLPR)
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for SLC6A4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Liver (Hepatobiliary System)
-
Placenta (Extraembryonic Tissues)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for SLC6A4 Gene
This gene is overexpressed in Lung (x32.4) and Small Intestine - Terminal Ileum (x5.7).
This gene is overexpressed in Peripheral blood mononuclear cells (22.0), Lung (15.0), Placenta (11.4), Platelet (9.7), and Pancreatic juice (9.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC6A4 Gene
NURSA nuclear receptor signaling pathways regulating expression of SLC6A4 Gene:
SLC6A4SOURCE GeneReport for Unigene cluster for SLC6A4 Gene:
Hs.29792mRNA Expression by UniProt/SwissProt for SLC6A4 Gene:
P31645-SC6A4_HUMAN
Tissue specificity:
Expressed in platelets (at protein level).
Evidence on tissue expression from TISSUES for SLC6A4 Gene
- Nervous system(4.7)
- Blood(4.5)
- Lung(4.4)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs for SLC6A4
-
OriGene qPCR primer pairs and template standards for SLC6A4
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC6A4 Gene
Orthologs for SLC6A4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLC6A4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | SLC6A4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | SLC6A4 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Slc6a4 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Slc6a4 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SLC6A4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SLC6A4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SLC6A4 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SLC6A4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100493853 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | slc6a4a 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | SerT 36 35 |
|
||
| DAT 36 |
|
|
|||
| CG8850 36 |
|
|
|||
| CG10804 36 |
|
|
|||
| CG1698 36 |
|
|
|||
| CG7075 36 |
|
|
|||
| CG4476 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | mod-5 36 35 |
|
||
| snf-3 36 |
|
|
|||
| snf-12 36 |
|
|
|||
| snf-6 36 |
|
|
|||
| snf-9 36 |
|
|
|||
| snf-8 36 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for SLC6A4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SLC6A4 Gene
Paralogs for SLC6A4 Gene
(21) SIMAP similar genes for SLC6A4 Gene using alignment to 15 proteins:
Variants for SLC6A4 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for SLC6A4 Gene
- SC6A4_HUMAN-P31645
- A polymorphism in the promoter region (5-HTT gene-linked polymorphic region, 5-HTTLPR) is located approximately 1 kb upstream of the transcription initiation site and is composed of 16 repeat elements. The polymorphism consists of a 44-bp insertion or deletion involving repeat elements 6 to 8. The short allele is associated with lower transcriptional efficiency of the promoter compared with the long allele. Over half of the Caucasian population has a short allele. Individuals with one or two copies of the short allele exhibit more depressive symptoms, diagnosable depression and suicidality in relation to stressful life events than individuals homozygous for the long allele.
- SC6A4_HUMAN-P31645
- Genetic variations in SLC6A4 determine the genetic susceptibility to alcoholism [MIM:103780].
- SC6A4_HUMAN-P31645
- The polymorphism Val-425 seems to be linked to a susceptibility to obsessive-compulsive disorder (OCD) [MIM:164230].
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1042173 | Likely benign | 30,197,993(-) | ATATA(G/T)AATTT | utr-variant-3-prime | |
| rs25533 | Likely benign | 30,235,874(-) | CTCCC(C/T)GGCGA | upstream-variant-2KB, utr-variant-5-prime | |
| rs28914831 | Likely benign | 30,222,844(-) | AGTTG(A/C/G)TGGCA | utr-variant-5-prime | |
| rs3813034 | Likely benign | 30,197,786(+) | TGTTA(A/C)TGTAA | utr-variant-3-prime | |
| rs45541837 | Likely benign | 30,222,868(-) | AATAA(C/G)AAGGG | utr-variant-5-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2715808 | CNV | deletion | 23290073 |
| nsv1120113 | OTHER | inversion | 24896259 |
Residual Variation Intolerance Score:
12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.34;
41.64% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SLC6A4 Gene
Disorders for SLC6A4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| obsessive-compulsive disorder |
|
|
| slc6a4-related altered drug metabolism |
|
|
| slc6a4-related behavior disorders |
|
|
| mood disorder |
|
|
| anxiety disorder |
|
Search SLC6A4 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for SLC6A4
No data available for UniProtKB/Swiss-Prot and Genatlas for SLC6A4 Gene
Publications for SLC6A4 Gene
- Alteration of gastric functions and candidate genes associated with weight reduction in response to sibutramine. (PMID: 17544870) Vazquez Roque M.I. … Zinsmeister A.R. (Clin. Gastroenterol. Hepatol. 2007) 3 22 25 46 64
- Age-dependent antidepressant pharmacogenomics: polymorphisms of the serotonin transporter and G protein beta3 subunit as predictors of response to fluoxetine and nortriptyline. (PMID: 14604448) Joyce P.R. … Kennedy M.A. (Int. J. Neuropsychopharmacol. 2003) 3 22 25 46 64
- Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients. (PMID: 11817517) Yoshida K. … Otani K. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2002) 3 22 25 46 64
- Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. (PMID: 11027924) Pollock B.G. … Kupfer D.J. (Neuropsychopharmacology 2000) 3 22 25 46 64
- Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. (PMID: 7681602) Ramamoorthy S. … Blakely R.D. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 22 64
Products for SLC6A4 Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore top SLC6A4 Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for SLC6A4
- Browse Purified and Recombinant Proteins at EMD Millipore
- Browse Kits and Assays available from EMD Millipore
- EMD Millipore genomic analysis products
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for SLC6A4 (SLC6A4/5-HTTLPR)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for SLC6A4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SLC6A4
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC6A4
- Origene Custom Protein Services for SLC6A4
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for SLC6A4
- Browse OriGene Inhibitory RNA Products For SLC6A4
- OriGene qPCR primer pairs and template standards for SLC6A4
- OriGene qPCR primer pairs for SLC6A4
- OriGene CRISPR knockouts for SLC6A4
- OriGene ORF clones in human for SLC6A4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SLC6A4
- GenScript: Next-day shipping cDNA ORF clone for SLC6A4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for SLC6A4
- GenScript Custom Assay Services for SLC6A4
- GenScript Custom overexpressing Cell Line Services for SLC6A4
- GenScript: Design CRISPR guide RNA sequences for SLC6A4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SLC6A4
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for SLC6A4
- Novus Biologicals proteins and lysates for SLC6A4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for SLC6A4
- Cloud-Clone Corp. Proteins for SLC6A4
- Cloud-Clone Corp Assay Kits for SLC6A4
- Taconic Biosciences Mouse Models for SLC6A4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for SLC6A4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for SLC6A4
- Addgene plasmids for SLC6A4
- antibodies-online Antibodies for SLC6A4: See all 98
- antibodies-online Kits for SLC6A4: See all 40
- antibodies-online Proteins for SLC6A4: See all 5
- Search antibodies-online for peptides
- GeneTex SLC6A4 antibody for SLC6A4
- Search GeneTex for Proteins for SLC6A4
- ViGene Biosciences adenoviral particle packaged cDNA for SLC6A4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SLC6A4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SLC6A4 gene
- Search ViGene Biosciences for SLC6A4
- Santa Cruz Biotechnology (SCBT) Antibodies for SLC6A4
- Search Santa Cruz Biotechnology (SCBT) for SLC6A4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SLC6A4
- Horizon Cell Lines for SLC6A4
- Cyagen custom Knockout/knockin (KOKI) mouse models for SLC6A4
- VectorBuilder custom plasmid, inducible vectors for SLC6A4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC6A4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SLC6A4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer