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Aliases for SLC6A3 Gene

Aliases for SLC6A3 Gene

  • Solute Carrier Family 6 (Neurotransmitter Transporter), Member 3 2 3
  • DAT1 3 4 6
  • Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 2 3
  • Dopamine Transporter 1 2 3
  • DA Transporter 3 4
  • PKDYS 3 6
  • DAT 3 4
  • Sodium-Dependent Dopamine Transporter 3
  • Solute Carrier Family 6 Member 3 4
  • Dopamine Transporter 2

External Ids for SLC6A3 Gene

Previous HGNC Symbols for SLC6A3 Gene

  • DAT1

Previous GeneCards Identifiers for SLC6A3 Gene

  • GC05P001491
  • GC05M001531
  • GC05M001425
  • GC05M001445
  • GC05M001423
  • GC05M001374

Summaries for SLC6A3 Gene

Entrez Gene Summary for SLC6A3 Gene

  • This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]

GeneCards Summary for SLC6A3 Gene

SLC6A3 (Solute Carrier Family 6 (Neurotransmitter Transporter), Member 3) is a Protein Coding gene. Diseases associated with SLC6A3 include parkinsonism-dystonia, infantile and nicotine dependence, protection against. Among its related pathways are Alpha-synuclein signaling and RNA Polymerase I Promoter Opening. GO annotations related to this gene include receptor binding and protein N-terminus binding. An important paralog of this gene is SLC6A4.

UniProtKB/Swiss-Prot for SLC6A3 Gene

  • Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.

Tocris Summary for SLC6A3 Gene

  • Dopamine transporters (DAT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain in areas of dopaminergic activity, including the striatum and substantia nigra. They provide rapid clearance of dopamine, adrenalin and noradrenalin from the synaptic cleft, terminating the neurotransmitter signal. Dopamine transporters can also mediate an outward efflux and it has been suggested that inward and outward transport are independently regulated. Structural motifs include 12-TM domains, extracellular loops, cytoplasmic C- and N-termini and putative phosphorylation sites. There is evidence to support the role of dopamine transporters in attention deficit disorder, bipolar disorder, clinical depression and alcoholism.

Gene Wiki entry for SLC6A3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A3 Gene

Genomics for SLC6A3 Gene

Regulatory Elements for SLC6A3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC6A3 Gene

1,392,790 bp from pter
1,445,430 bp from pter
52,641 bases
Minus strand

Genomic View for SLC6A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC6A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A3 Gene

Proteins for SLC6A3 Gene

  • Protein details for SLC6A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium-dependent dopamine transporter
    Protein Accession:
    Secondary Accessions:
    • A2RUN4
    • Q14996

    Protein attributes for SLC6A3 Gene

    620 amino acids
    Molecular mass:
    68495 Da
    Quaternary structure:
    • Homooligomer; disulfide-linked. Interacts with PRKCABP and TGFB1I1. Interacts (via N-terminus) with SYNGR3 (via N-terminus). Interacts with SLC18A2. Interacts with TOR1A (ATP-bound); TOR1A regulates SLC6A3 subcellular location.
    • This protein is the target of psychomotor stimulants such as amphetamines or cocaine

neXtProt entry for SLC6A3 Gene

Proteomics data for SLC6A3 Gene at MOPED

Post-translational modifications for SLC6A3 Gene

  • Glycosylation at Asn181, Asn188, and Asn205
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC6A3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC6A3 Gene

Domains for SLC6A3 Gene

Gene Families for SLC6A3 Gene


Protein Domains for SLC6A3 Gene

Suggested Antigen Peptide Sequences for SLC6A3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
genes like me logo Genes that share domains with SLC6A3: view

Function for SLC6A3 Gene

Molecular function for SLC6A3 Gene

GENATLAS Biochemistry:
solute carrier family 6,member A3,neurotransmitter transporter,dopamine,unlikely involved in Gilles de la Tourette syndrome,inconsistent evidence for involvement in bipolar effective disorder
UniProtKB/Swiss-Prot Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.

Gene Ontology (GO) - Molecular Function for SLC6A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0005102 receptor binding IEA --
GO:0005328 neurotransmitter:sodium symporter activity --
GO:0005329 dopamine transmembrane transporter activity IDA 15505207
GO:0005330 dopamine:sodium symporter activity IEA --
genes like me logo Genes that share ontologies with SLC6A3: view
genes like me logo Genes that share phenotypes with SLC6A3: view

Animal Models for SLC6A3 Gene

MGI Knock Outs for SLC6A3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC6A3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for SLC6A3 Gene

Localization for SLC6A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC6A3 Gene COMPARTMENTS Subcellular localization image for SLC6A3 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
endosome 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SLC6A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 10823899
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016021 integral component of membrane TAS 8628395
GO:0030424 axon IDA 12958153
genes like me logo Genes that share ontologies with SLC6A3: view

Pathways for SLC6A3 Gene

genes like me logo Genes that share pathways with SLC6A3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SLC6A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006836 neurotransmitter transport IEA --
GO:0007268 synaptic transmission TAS --
GO:0007568 aging IEA --
GO:0007595 lactation IEA --
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with SLC6A3: view

Drugs for SLC6A3 Gene

(45) Drugbank Compounds for SLC6A3 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • Butramin
106650-56-0 5210 Target inhibitor approved, illicit, investigational, withdrawn
  • Fencamfamin
1209-98-9 14584 Target inhibitor approved, illicit, withdrawn
  • 1-phenyl-2-aminopropane
300-62-9 Target negative modulator approved, illicit
  • (+)-benzphetamine
156-08-1 Target inhibitor approved, illicit
  • (-)-Cocaine
50-36-2 Target inhibitor approved, illicit

(5) Tocris Compounds for SLC6A3 Gene

Compound Action Cas Number
Bupropion hydrochloride Non-selective inhibitor of dopamine and noradrenalin transporters [31677-93-7]
Cocaine hydrochloride Inhibitor of monoamine transporters [53-21-4]
GBR 12909 dihydrochloride Selective DA uptake inhibitor. Also sigma ligand [67469-78-7]
Reserpine Inhibitor of vesicular monoamine transport [50-55-5]
Tetrabenazine Potent inhibitor of vesicular monoamine transport [58-46-8]

(1) ApexBio Compounds for SLC6A3 Gene

Compound Action Cas Number
Atomoxetine HCl Noradrenalin re-uptake inhibitor [82248-59-7]

(25) HMDB Compounds for SLC6A3 Gene

Compound Synonyms Cas Number PubMed IDs
  • (+/-)-Benzedrine
  • Benzatropina [INN-Spanish]
  • Benzfetamine
  • (+-)-Bupropion
  • Chloroprocain

(5) IUPHAR Ligand for SLC6A3 Gene

Ligand Type Action Affinity Pubmed IDs
mazindol Inhibitor Inhibition 8.9
[3H]GBR12935 None None 8.5
[3H]WIN35428 None None 8
WIN35428 Inhibitor Inhibition 7.9
GBR12935 Inhibitor Inhibition 7.6

(117) Novoseek inferred chemical compound relationships for SLC6A3 Gene

Compound -log(P) Hits PubMed IDs
dopamine 96.5 533
(123i)fp-cit 92.6 32
(123i)-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 90.6 16
spec-t 87.4 157
cocaine 87 293

(1) PharmGKB related drug/compound annotations for SLC6A3 Gene

Drug/compound Annotation
levodopa Clinical Annotation
genes like me logo Genes that share compounds with SLC6A3: view

Compound Products

Transcripts for SLC6A3 Gene

mRNA/cDNA for SLC6A3 Gene

(9) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC6A3 Gene

Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC6A3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A3 Gene

No ASD Table

Relevant External Links for SLC6A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC6A3 Gene

mRNA expression in normal human tissues for SLC6A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC6A3 Gene

This gene is overexpressed in Brain - Substantia nigra (47.0).

Protein differential expression in normal tissues for SLC6A3 Gene

This gene is overexpressed in Heart (52.2) and Frontal cortex (16.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC6A3 Gene

SOURCE GeneReport for Unigene cluster for SLC6A3 Gene Hs.406

mRNA Expression by UniProt/SwissProt for SLC6A3 Gene

Tissue specificity: Highly expressed in substantia nigra.
genes like me logo Genes that share expressions with SLC6A3: view

Expression partners for SLC6A3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC6A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SLC6A3 35
  • 87.9 (n)
  • 91.07 (a)
SLC6A3 36
  • 86 (a)
(Mus musculus)
Mammalia Slc6a3 35
  • 87.56 (n)
  • 93.7 (a)
Slc6a3 16
Slc6a3 36
  • 94 (a)
(Pan troglodytes)
Mammalia SLC6A3 35
  • 95.28 (n)
  • 94.47 (a)
SLC6A3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Slc6a3 35
  • 87.95 (n)
  • 93.68 (a)
(Bos Taurus)
Mammalia SLC6A3 36
  • 66 (a)
(Monodelphis domestica)
Mammalia SLC6A3 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia SLC6A3 36
  • 75 (a)
(Gallus gallus)
Aves -- 36
  • 39 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc6a3 35
  • 73.06 (n)
  • 83.71 (a)
(Danio rerio)
Actinopterygii slc6a3 35
  • 77.33 (n)
  • 82 (a)
SLC6A3 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta BG:DS03431.1 37
  • 33 (a)
CG10804 37
  • 37 (a)
CG1698 37
  • 36 (a)
CG3252 37
  • 35 (a)
CG4476 37
  • 35 (a)
CG7075 37
  • 34 (a)
DAT 37
  • 52 (a)
ine 37
  • 41 (a)
SerT 37
  • 52 (a)
DAT 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea mod-5 37
  • 45 (a)
snf-12 37
  • 30 (a)
snf-2 37
  • 32 (a)
snf-4 37
  • 33 (a)
snf-8 37
  • 24 (a)
snf-9 37
  • 31 (a)
dat-1 36
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for SLC6A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC6A3 Gene

Gene Tree for SLC6A3 (if available)
Gene Tree for SLC6A3 (if available)

Paralogs for SLC6A3 Gene

Paralogs for SLC6A3 Gene Pseudogenes for SLC6A3 Gene

genes like me logo Genes that share paralogs with SLC6A3: view

Variants for SLC6A3 Gene

Sequence variations from dbSNP and Humsavar for SLC6A3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs2735911 -- 1,429,433(-) GAAGG(G/T)TGCCC intron-variant
rs2735910 -- 1,431,666(-) gccag(C/G)cccct intron-variant
rs2735909 -- 1,431,724(-) GCCAG(G/T)CACAA intron-variant
rs2735908 -- 1,436,396(-) GACAG(A/T)CTCCC intron-variant
rs2735859 -- 1,444,026(-) TTTTG(C/T)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC6A3 Gene

Variant ID Type Subtype PubMed ID
nsv880847 CNV Loss 21882294
nsv509045 CNV Insertion 20534489
nsv880418 CNV Loss 21882294
nsv830187 CNV Loss 17160897
nsv461908 CNV Loss 19166990
dgv5917n71 CNV Loss 21882294
nsv881664 CNV Loss 21882294
nsv880402 CNV Loss 21882294
esv2729483 CNV Deletion 23290073
esv1433047 CNV Insertion 17803354
nsv4680 CNV Insertion 18451855
esv2729484 CNV Deletion 23290073
esv23210 CNV Loss 19812545
esv1707642 CNV Insertion 17803354
esv2729486 CNV Deletion 23290073
esv2729487 CNV Deletion 23290073
esv2729488 CNV Deletion 23290073
nsv328158 CNV Insertion 16902084
nsv461910 CNV Loss 19166990
esv2729489 CNV Deletion 23290073
nsv881100 CNV Loss 21882294
esv21833 CNV Loss 19812545

Relevant External Links for SLC6A3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC6A3 Gene

Disorders for SLC6A3 Gene

(2) OMIM Diseases for SLC6A3 Gene (126455)


  • Parkinsonism-dystonia infantile (PKDYS) [MIM:613135]: A neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradykinesia and pyramidal tract signs. {ECO:0000269 PubMed:19478460}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(87) Novoseek inferred disease relationships for SLC6A3 Gene

Disease -log(P) Hits PubMed IDs
parkinson disease 87.5 148
attention-deficit hyperactivity disorder 87.4 113
parkinsonism 81.8 79
cocaine abuse 71.4 16
cocaine addiction 71 11

Relevant External Links for SLC6A3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC6A3: view

No data available for Genatlas for SLC6A3 Gene

Publications for SLC6A3 Gene

  1. Dopamine transporter gene associated with diminished subjective response to amphetamine. (PMID: 15602501) Lott D.C. … de Wit H. (Neuropsychopharmacology 2005) 3 23 25 26 48
  2. Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. (PMID: 1406597) Giros B. … Caron M.G. (Mol. Pharmacol. 1992) 2 3 4 23
  3. Polymorphisms in dopamine transporter (SLC6A3) are associated with stimulant effects of D-amphetamine: an exploratory pharmacogenetic study using healthy volunteers. (PMID: 20091113) Hamidovic A. … de Wit H. (Behav. Genet. 2010) 3 23 25 26
  4. Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. (PMID: 10823899) Saunders C. … Galli A. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 23 25 26
  5. Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations. (PMID: 10889531) Vandenbergh D.J. … Uhl G.R. (Mol. Psychiatry 2000) 3 4 23

Products for SLC6A3 Gene

Sources for SLC6A3 Gene

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