Aliases for SLC6A3 Gene
External Ids for SLC6A3 Gene
Previous HGNC Symbols for SLC6A3 Gene
Previous GeneCards Identifiers for SLC6A3 Gene
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]
GeneCards Summary for SLC6A3 Gene
SLC6A3 (Solute Carrier Family 6 (Neurotransmitter Transporter), Member 3) is a Protein Coding gene. Diseases associated with SLC6A3 include parkinsonism-dystonia, infantile and cocaine abuse. Among its related pathways are Alpha-synuclein signaling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include receptor binding and protein N-terminus binding. An important paralog of this gene is SLC6A4.
UniProtKB/Swiss-Prot for SLC6A3 Gene
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Dopamine transporters (DAT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain in areas of dopaminergic activity, including the striatum and substantia nigra. They provide rapid clearance of dopamine.