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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC6A20 Gene

protein-coding GIFtS: 53
GCID: GC03M045796

Solute Carrier Family 6 (Proline IMINO Transporter), Member...

9 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Solute Carrier Family 6 (Proline IMINO Transporter), Member 20¹ ²		Orphan Transporter XT3²
XT3² ³ ⁵		Sodium- And Chloride-Dependent Transporter XTRP3²
Sodium/Imino-Acid Transporter 1² ³		Solute Carrier Family 6 (Neurotransmitter Transporter), Member 20²
Transporter RB21A Homolog² ³		X Transporter Protein 3²
SIT1² ³		XTRP3³
Xtrp3²		Solute Carrier Family 6 Member 20³
Neurotransmitter Transporter RB21A²

External Ids:	HGNC: 30927¹	Entrez Gene: 54716²	Ensembl: ENSG00000163817⁷	OMIM: 605616⁵	UniProtKB: Q9NP91³

Export aliases for SLC6A20 gene to outside databases

Previous GC identifers: GC03M045758 GC03M045771

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC6A20 Gene:

Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins

which have been classified into several families of related genes. The protein encoded by this gene is a member of the

subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family. This gene is

expressed in kidney, and its alternative splicing generates 2 transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLC6A20 Gene:

SLC6A20 (solute carrier family 6 (proline IMINO transporter), member 20) is a protein-coding gene. Diseases associated with SLC6A20 include slc6a20-related hyperglycinuria, and iminoglycinuria, and among its related super-pathways are Amino acid transport across the plasma membrane and Transmembrane transport of small molecules. GO annotations related to this gene include neurotransmitter:sodium symporter activity and amino acid transmembrane transporter activity. An important paralog of this gene is SLC6A15.

UniProtKB/Swiss-Prot: S6A20_HUMAN, Q9NP91

Function: Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as

well as N-methylated amino acids. Involved in the transport of glycine

Gene Wiki entry for SLC6A20 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NT_022517.18 NC_018914.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC6A20 gene promoter:
ATF-2 FOXO3 FOXO3b PPAR-gamma1 E2F-1 E2F FOXO4 FOXO3a PPAR-gamma2 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC6A20 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC6A20

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC6A20

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.6

SLC6A20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC6A20 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M045796: view genomic region (about GC identifiers)

Start:	45,796,941 bp from pter	End:	45,838,035 bp from pter
Size:	41,095 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S6A20_HUMAN, Q9NP91 (See protein sequence)

Recommended Name: Sodium- and chloride-dependent transporter XTRP3

Size: 592 amino acids; 65914 Da

Subcellular location: Apical cell membrane; Multi-pass membrane protein (By similarity). Note=Located in the apical

brush border membrane of kidney proximal tubule cells (By similarity)

Sequence caution: Sequence=AAL75944.1; Type=Erroneous initiation;

Secondary accessions: A1A4F2 O75590 Q8TF10 Q9NPQ2 Q9NQ77

Alternative splicing: 2 isoforms: Q9NP91-1 Q9NP91-2

Explore the universe of human proteins at neXtProt for SLC6A20: NX_Q9NP91

Explore proteomics data for SLC6A20 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9NP91

SLC6A20 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_064593.1 NP_071800.1

ENSEMBL proteins:

ENSP00000296133 ENSP00000346298 ENSP00000395506 ENSP00000404310

Reactome Protein details: Q9NP91
Human Recombinant Protein Products for SLC6A20:

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	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IEA	--
GO:0016021	integral to membrane	--	--
GO:0016324	apical plasma membrane	ISS	--

SLC6A20 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: SIT1

Neutral amino acid transporter subfamily

2 InterPro protein domains:

IPR000175 Na/ntran_symport

IPR002438 Na/ntran_symport_orphan

Graphical View of Domain Structure for InterPro Entry Q9NP91

ProtoNet protein and cluster: Q9NP91

1 Blocks protein domain: IPB002438 Orphan neurotransmitter transporter signature

UniProtKB/Swiss-Prot: S6A20_HUMAN, Q9NP91

Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A20 subfamily

SLC6A20 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: S6A20_HUMAN, Q9NP91

Function: Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as

well as N-methylated amino acids. Involved in the transport of glycine

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005328	neurotransmitter:sodium symporter activity	IEA	--
GO:0015171	amino acid transmembrane transporter activity	IDA	15632147

SLC6A20 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SLC6A20:

Decreased viability of wild-ty

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC6A20

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC6A20

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC6A20

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for SLC6A20 About

See pathways by source

SuperPath

Contained pathways About

Amino acid and oligopeptide SLC transporters

	Amino acid and oligopeptide SLC transporters	0.63			Transport of inorganic cations/anions and amino acids/oligopeptides	0.52
	Amino acid transport across the plasma membrane	0.63

SLC-mediated transmembrane transport

	SLC-mediated transmembrane transport	0.50			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.38
	Transmembrane transport of small molecules	0.50

Amine compound SLC transporters

Amine compound SLC transporters

0.63

Na+/Cl- dependent neurotransmitter transporters

0.63

Pathways by source See SuperPaths
Show all pathways

5/8 Reactome Pathways for SLC6A20 (see all 8)

	Na+/Cl- dependent neurotransmitter transporters
	Amino acid transport across the plasma membrane
	Amine compound SLC transporters
	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules

SLC6A20 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC6A20

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003333	amino acid transmembrane transport	IDA	15632147
GO:0006811	ion transport	TAS	--
GO:0006836	neurotransmitter transport	--	--
GO:0006865	amino acid transport	TAS	--
GO:0015816	glycine transport	IMP	19033659

SLC6A20 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC6A20 (S6A20)

2 HMDB Compounds for SLC6A20 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Sodium	Sodium (see all 2)	7440-23-5	--

Search CenterWatch for drugs/clinical trials and news about SLC6A20 / S6A20

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC6A20 gene (2 alternative transcripts):

NM_020208.3 NM_022405.3

Unigene Cluster for SLC6A20:

Solute carrier family 6 (proline IMINO transporter), member 20

Hs.413095 [show with all ESTs]

Unigene Representative Sequence: NM_020208

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000353278(uc003cow.3) ENST00000358525(uc011bai.2 uc011baj.2)

ENST00000473146 ENST00000493980 ENST00000413781 ENST00000470226 ENST00000456124

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Additional mRNA sequence:

AF075260.1 AJ276207.1 AJ276208.1 AL389979.1 BC036073.1 BC126197.1 BC136431.1 BC144087.1

5 DOTS entries:

DT.101979329 DT.95165442 DT.40201073 DT.100748350 DT.95260371

24/53 AceView cDNA sequences (see all 53):

CA394539 AI269820 NM_022405 AW137313 NM_020208 AI569553 BM707737 AF125107

CD643407 AL389979 AI733761 CB853385 AI364647 CB241149 BQ956246 AI761527

BI544266 AA316835 AJ276208 AW962443 AF075260 AA296916 CA945208 AI732605

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A20 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13a	·	13b
SP1:					-		-										-
SP2:
SP3:

ECgene alternative splicing isoforms for SLC6A20

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC6A20 expression in normal human tissues (normalized intensities) SLC6A20 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

SLC6A20 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/3 selected tissues (see all 3) fully expand


Endothelium (Cardiovascular System) fully expand to see all 2 entries
Endothelial Cells Blood Brain Barrier

Brain (Nervous System) fully expand to see all 2 entries
Endothelial Cells Blood Brain Barrier

Kidney (Urinary System)
Proximal Tubule Cells Proximal Tubule

-- (Gastrointestinal Tract)
colon

See SLC6A20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC6A20

SOURCE GeneReport for Unigene cluster: Hs.413095

UniProtKB/Swiss-Prot: S6A20_HUMAN, Q9NP91

Tissue specificity: Kidney and small intestine. Expressed in the S3 segment of the proximal tubule

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SLC6A20 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Slc6a20a^{1 , 5}	solute carrier family 6 (neurotransmitter transporter), more^{1, 5}	87.84(n)¹ 92.06(a)¹		9 (74.26 cM)⁵ 102680¹ NM_139142.2¹ NP_631881.1¹ 123636122⁵
chicken (Gallus gallus)	Aves	SLC6A20¹	solute carrier family 6 (proline IMINO transporter), more	78.66(n) 83.28(a)		420699 XM_418798.2 XP_418798.2
lizard (Anolis carolinensis)	Reptilia	SLC6A20⁶	solute carrier family 6 (proline IMINO transporter...	80(a)	1 ↔ 1	GL343324.1(221105-246710)
fruit fly (Drosophila melanogaster)	Insecta	CG43066⁶ CG10804⁶	--	35(a) 34(a)	many ↔ many many ↔ many	2R(14402081-14413944) X(3370722-3376355)

ENSEMBL Gene Tree for SLC6A20 (if available)
TreeFam Gene Tree for SLC6A20 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC6A20 gene

SLC6A15² SLC6A17² SLC6A18² SLC6A16² SLC6A19²

18/21 SIMAP similar genes for SLC6A20 using alignment to 3 protein entries: S6A20_HUMAN (see all proteins) (see all similar genes):

DAT1 SLC6A15 SLC6A19 DKFZp761I0921 SLC6A17 SLC6A18

5HTT SLC6A4 SLC6A16 SLC6A6 SLC6A3 SLC6A8

SLC6A1 SLC6A7 SLC6A11 SLC6A12 SLC6A13 SLC6A5

SLC6A20 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SLC6A20
PGOHUM00000259827

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17279437^1,2,4	C,F,H	pathogenic¹	45745015(+)	`ACGCCG/ATGAAA`	3	/T /M	int¹ mis¹ ese³		19		NA NS EA EU	2957
rs188775244^1,2		--	45727415(+)	`CACTCA/CCCCCT`	2	--	ds500¹		0	--	--	--	--
rs144304573^1,2	C	--	45727488(+)	`AGAGAC/TGCTGA`	2	--	ds500¹		0	--	--	--	--
rs180802919^1,2	C	--	45727546(+)	`TGCAGC/TAATTC`	2	--	ds500¹		0	--	--	--	--
rs2251021^1,2	C,F,O,H	--	45727580(-)	`TTGGCC/TGGATT`	2	--	ds500¹		41		EA NS NA CSA WA	5298
rs75471877^1,2	C,F	--	45727617(+)	`TGTGGA/TCTCTA`	2	--	ds500¹		1		WA	118
rs151027568^1,2		--	45727669(+)	`TGGTGC/TGGTCT`	2	--	ds500¹		0	--	--	--	--
rs74410675^1,2	C	--	45727688(+)	`ATATGA/CAGAGG`	2	--	ds500¹		0	--	--	--	--
rs185470677^1,2		--	45727725(+)	`AAAGGA/TTGGAT`	2	--	ds500¹		0	--	--	--	--
rs140924012^1,2	C	--	45727801(+)	`ATCTTA/GTGTTG`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC6A20 (45796941 - 45838035 bp)

Structural Variations
Database of Genomic Variants (DGV) 9 variations for SLC6A20: About this table

Variant ID	Type	Subtype	PubMed ID
esv2192183	CNV	Deletion	18987734
esv2725225	CNV	Deletion	23290073
esv2725226	CNV	Deletion	23290073
esv2670527	CNV	Deletion	23128226
esv1614687	CNV	Deletion	17803354
esv267840	CNV	Insertion	20981092
nsv876735	CNV	Loss	21882294
nsv834678	CNV	Gain	17160897
nsv876734	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): SLC6A20

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC6A20 for disorders           About GeneDecksing

OMIM gene information: 605616
OMIM disorders: 138500  242600
UniProtKB/Swiss-Prot: S6A20_HUMAN, Q9NP91

Hyperglycinuria (HG) [MIM:138500]: A condition characterized by excess of glycine in the urine. In some cases

it is associated with renal colic and renal oxalate stones. Note=The disease is caused by mutations affecting the gene

represented in this entry

Iminoglycinuria (IG) [MIM:242600]: A disorder of renal tubular reabsorption of glycine and imino acids

(proline and hydroxyproline), marked by excessive levels of all three substances in the urine. Note=The disease is

caused by mutations affecting the gene represented in this entry. Haploinsufficiency of SLC6A20 combined with

deficiency of the neutral amino acid transporter SLC6A19 or partially inactivating mutations in SLC36A2, is

responsible for iminoglycinuria. Additional polymorphisms and mutations in SLC6A18 can contribute to the IG phenotype

in some families

9 diseases for SLC6A20: About MalaCards

hyperglycinuria pellagra aminoaciduria smallpox

malignant mesothelioma

1 disease from the University of Copenhagen DISEASES database for SLC6A20:

Hartnup disease

Genetic Association Database (GAD): SLC6A20

Export disorders for SLC6A20 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC6A20 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with SLC6A20)

Utopia: connect your pdf to the dynamic
world of online information

The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3. (PubMed id 11352561)^{1, 2, 3} Kiss H....Dumanski J.P. (2001)
Cloning, gene structure, and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms. (PubMed id 9932288)^{1, 2, 3} Nash S.R.... Caron M.G. (1998)
Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino. (PubMed id 15632147)^{1, 2, 9} Takanaga H.... Hediger M.A. (2005)
A genome-wide association study of metabolic traits i n human urine. (PubMed id 21572414)^{1, 4} Suhre K....Nauck M. (2011)
Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters. (PubMed id 19033659)^{1, 2} Broer S....Rasko J.E. (2008)
Sodium translocation by the iminoglycinuria associate d imino transporter (SLC6A20). (PubMed id 19657969)^{1, 9} BrAPer A....BrAPer S. (2009)
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)¹ Kennedy R.B....Poland G.A. (2012)
Amino acid transport across mammalian intestinal and renal epithelia. (PubMed id 18195088)¹ BrAPer S. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation. (PubMed id 15308626)¹ Kanei-Ishii C....Ishii S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54716	HGNC: 30927	AceView: SLC6A20	Ensembl:ENSG00000163817	euGenes: HUgn54716
ECgene: SLC6A20	H-InvDB: SLC6A20

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC6A20	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC6A20 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC6A20 gene:
Search GeneIP for patents involving SLC6A20

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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