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SLC6A20 Gene

protein-coding   GIFtS: 53
GCID: GC03M045796

Solute Carrier Family 6 (Proline IMINO Transporter), Member...

  See SLC6A20-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 6 (Proline IMINO Transporter), Member 201 2     Orphan Transporter XT32
XT32 3 5     Sodium- And Chloride-Dependent Transporter XTRP32
Sodium/Imino-Acid Transporter 12 3     Solute Carrier Family 6 (Neurotransmitter Transporter), Member 202
Transporter RB21A Homolog2 3     X Transporter Protein 32
SIT12 3     XTRP33
Xtrp32     Solute Carrier Family 6 Member 203
Neurotransmitter Transporter RB21A2     

External Ids:    HGNC: 309271   Entrez Gene: 547162   Ensembl: ENSG000001638177   OMIM: 6056165   UniProtKB: Q9NP913   

Export aliases for SLC6A20 gene to outside databases

Previous GC identifers: GC03M045758 GC03M045771


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC6A20 Gene:
Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter
proteins which have been classified into several families of related genes. The protein encoded by this gene is a
member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter
family. This gene is expressed in kidney, and its alternative splicing generates 2 transcript variants. (provided
by RefSeq, Jul 2008)

GeneCards Summary for SLC6A20 Gene:
SLC6A20 (solute carrier family 6 (proline IMINO transporter), member 20) is a protein-coding gene. Diseases associated with SLC6A20 include slc6a20-related hyperglycinuria, and iminoglycinuria. GO annotations related to this gene include neurotransmitter:sodium symporter activity and amino acid transmembrane transporter activity. An important paralog of this gene is SLC6A15.

UniProtKB/Swiss-Prot: S6A20_HUMAN, Q9NP91
Function: Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and
pipecolate as well as N-methylated amino acids. Involved in the transport of glycine

Gene Wiki entry for SLC6A20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC6A20 gene promoter:
         ATF-2   FOXO3   FOXO3b   PPAR-gamma1   E2F-1   E2F   FOXO4   FOXO3a   PPAR-gamma2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC6A20 promoter sequence
   Search Chromatin IP Primers for SLC6A20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC6A20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.6

SLC6A20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC6A20 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M045796:  view genomic region     (about GC identifiers)

Start:
45,796,941 bp from pter      End:
45,838,035 bp from pter
Size:
41,095 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S6A20_HUMAN, Q9NP91 (See protein sequence)
Recommended Name: Sodium- and chloride-dependent transporter XTRP3  
Size: 592 amino acids; 65914 Da
Sequence caution: Sequence=AAL75944.1; Type=Erroneous initiation;
Secondary accessions: A1A4F2 O75590 Q8TF10 Q9NPQ2 Q9NQ77
Alternative splicing: 2 isoforms:  Q9NP91-1   Q9NP91-2   

Explore the universe of human proteins at neXtProt for SLC6A20: NX_Q9NP91

Explore proteomics data for SLC6A20 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn131, Asn357
  • Modification sites at PhosphoSitePlus

  • See SLC6A20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_064593.1  NP_071800.1  

    ENSEMBL proteins: 
     ENSP00000296133   ENSP00000346298   ENSP00000395506   ENSP00000404310  
    Reactome Protein details: Q9NP91

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SIT1
    Neutral amino acid transporter subfamily

    2 InterPro protein domains:
     IPR000175 Na/ntran_symport
     IPR002438 Na/ntran_symport_orphan

    Graphical View of Domain Structure for InterPro Entry Q9NP91

    ProtoNet protein and cluster: Q9NP91

    1 Blocks protein domain: IPB002438 Orphan neurotransmitter transporter signature

    UniProtKB/Swiss-Prot: S6A20_HUMAN, Q9NP91
    Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A20 subfamily


    Find genes that share domains with SLC6A20           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S6A20_HUMAN, Q9NP91
    Function: Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and
    pipecolate as well as N-methylated amino acids. Involved in the transport of glycine

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005328neurotransmitter:sodium symporter activity IEA--
    GO:0015171amino acid transmembrane transporter activity IDA15632147
         
    Find genes that share ontologies with SLC6A20           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC6A20:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC6A20
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    hsa-miR-183* hsa-miR-610 hsa-miR-571 hsa-let-7g* hsa-miR-3674 hsa-let-7a-2*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S6A20_HUMAN, Q9NP91: Apical cell membrane; Multi-pass membrane protein (By similarity). Note=Located in the
    apical brush border membrane of kidney proximal tubule cells (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016021integral component of membrane ----
    GO:0016324apical plasma membrane ISS--

    Find genes that share ontologies with SLC6A20           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC6A20 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Amino acid transport across the plasma membrane0.32
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Na+/Cl- dependent neurotransmitter transporters0.00


    Find genes that share SuperPaths with SLC6A20           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for SLC6A20
        Na+/Cl- dependent neurotransmitter transporters
    Amino acid transport across the plasma membrane


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC6A20
    Interactions:

        Search GeneGlobe Interaction Network for SLC6A20

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003333amino acid transmembrane transport ----
    GO:0006811ion transport TAS--
    GO:0006836neurotransmitter transport ----
    GO:0006865amino acid transport TAS--
    GO:0015816glycine transport IMP19033659

    Find genes that share ontologies with SLC6A20           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLC6A20 (S6A20)

    2 HMDB Compounds for SLC6A20    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    SodiumSodium (see all 2)7440-23-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC6A20 gene (2 alternative transcripts): 
    NM_020208.3  NM_022405.3  

    Unigene Cluster for SLC6A20:

    Solute carrier family 6 (proline IMINO transporter), member 20
    Hs.413095  [show with all ESTs]
    Unigene Representative Sequence: NM_020208
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000353278(uc003cow.3) ENST00000358525(uc011bai.2 uc011baj.2)
    ENST00000473146 ENST00000493980 ENST00000413781 ENST00000470226 ENST00000456124

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    hsa-miR-183* hsa-miR-610 hsa-miR-571 hsa-let-7g* hsa-miR-3674 hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidSLC6A20 3' UTR sequence
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    Additional mRNA sequence: 

    AF075260.1 AJ276207.1 AJ276208.1 AL389979.1 BC036073.1 BC126197.1 BC136431.1 BC144087.1 

    5 DOTS entries:

    DT.101979329  DT.95165442  DT.40201073  DT.100748350  DT.95260371 

    Selected AceView cDNA sequences (see all 53):

    NM_022405 BM707737 AW137313 AI733761 NM_020208 CA394539 CB241149 CD643407 
    AI569553 AF125107 AL389979 AI269820 AI364647 CB853385 AA296916 AI761527 
    AJ276208 BI544266 AF075260 AI732605 BQ956246 BC036073 AJ276207 BF724647 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A20    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:              -     -                             -                                             
    SP2:                                                                                                
    SP3:                                                                                                


    ECgene alternative splicing isoforms for SLC6A20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC6A20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC6A20 Expression
    About this image


    SLC6A20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Epithelial Cells
             Proximal Tubule Cells Proximal Tubule
     
     Kidney (Urinary System)
             Proximal Tubule Cells Proximal Tubule
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Colon (Gastrointestinal Tract)
    SLC6A20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC6A20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.413095

    UniProtKB/Swiss-Prot: S6A20_HUMAN, Q9NP91
    Tissue specificity: Kidney and small intestine. Expressed in the S3 segment of the proximal tubule

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC6A20 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc6a20a1 , 5 solute carrier family 6 (neurotransmitter transporter), more1, 5 87.84(n)1
    92.06(a)1
      9 (74.26 cM)5
    1026801  NM_139142.21  NP_631881.11 
     1236361225 
    chicken
    (Gallus gallus)
    Aves SLC6A201 solute carrier family 6 (proline IMINO transporter), more 78.66(n)
    83.28(a)
      420699  XM_418798.3  XP_418798.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC6A206
    solute carrier family 6 (proline IMINO transporter...
    80(a)
    1 ↔ 1
    GL343324.1(221105-246710)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004970791 sodium- and chloride-dependent transporter XTRP3A-like 67.35(n)
    74.74(a)
      100497079  XM_002942525.2  XP_002942571.1 
    zebrafish
    (Danio rerio)
    Actinopterygii SLC6A206
    solute carrier family 6 (proline IMINO transporter...
    33(a)
    1 → many
    5(22570100-22597916) ENSDARG00000002405
    fruit fly
    (Drosophila melanogaster)
    Insecta ine6
    inebriated
    22(a)
    1 ↔ 1
    2L(4468000-4477024)
    worm
    (Caenorhabditis elegans)
    Secernentea snf-106
    Protein SNF-10 (snf-10) mRNA, complete cds
    16(a)
    1 ↔ 1
    V(10438366-10440795) WBGene00004909


    ENSEMBL Gene Tree for SLC6A20 (if available)
    TreeFam Gene Tree for SLC6A20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC6A20 gene
    SLC6A152  SLC6A172  SLC6A182  SLC6A162  SLC6A192  
    Selected SIMAP similar genes for SLC6A20 using alignment to 3 protein entries:     S6A20_HUMAN (see all proteins) (see all similar genes):
    DAT1    SLC6A15    SLC6A19    DKFZp761I0921    SLC6A17    SLC6A18
    5HTT    SLC6A4    SLC6A16    SLC6A6    SLC6A3    SLC6A8
    SLC6A1    SLC6A7    SLC6A11    SLC6A12    SLC6A13    SLC6A5

    Find genes that share paralogs with SLC6A20           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SLC6A20
    PGOHUM00000259827


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC6A20 (see all 961)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs172794371,2,,4
    C,F,Hpathogenic145745015(+) ACGCCG/ATGAAA 3 /T /M int1 mis1 ese319Minor allele frequency- A:0.06NA NS EA EU 2957
    rs1887752441,2
    --45727415(+) CACTCA/CCCCCT 2 -- ds50010--------
    rs1443045731,2
    C--45727488(+) AGAGAC/TGCTGA 2 -- ds50010--------
    rs1808029191,2
    C--45727546(+) TGCAGC/TAATTC 2 -- ds50010--------
    rs22510211,2
    C,F,O,H--45727580(-) TTGGCC/TGGATT 2 -- ds500141Minor allele frequency- T:0.29EA NS NA CSA WA 5298
    rs754718771,2
    C,F--45727617(+) TGTGGA/TCTCTA 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1510275681,2
    --45727669(+) TGGTGC/TGGTCT 2 -- ds50010--------
    rs744106751,2
    C--45727688(+) ATATGA/CAGAGG 2 -- ds50010--------
    rs1854706771,2
    --45727725(+) AAAGGA/TTGGAT 2 -- ds50010--------
    rs1409240121,2
    C--45727801(+) ATCTTA/GTGTTG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC6A20 (45796941 - 45838035 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SLC6A20:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2192183CNV Deletion18987734
    esv2725225CNV Deletion23290073
    esv2725226CNV Deletion23290073
    esv2670527CNV Deletion23128226
    esv1614687CNV Deletion17803354
    esv267840CNV Insertion20981092
    nsv876735CNV Loss21882294
    nsv834678CNV Gain17160897
    nsv876734CNV Gain21882294

    Human Gene Mutation Database (HGMD): SLC6A20
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC6A20
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC6A20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 605616   
    OMIM disorders: 138500  242600  
    UniProtKB/Swiss-Prot: S6A20_HUMAN, Q9NP91
  • Hyperglycinuria (HG) [MIM:138500]: A condition characterized by excess of glycine in the urine. In some
    cases it is associated with renal colic and renal oxalate stones. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Iminoglycinuria (IG) [MIM:242600]: A disorder of renal tubular reabsorption of glycine and imino acids
    (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. Note=The disease
    is caused by mutations affecting the gene represented in this entry. Haploinsufficiency of SLC6A20 combined with
    deficiency of the neutral amino acid transporter SLC6A19 or partially inactivating mutations in SLC36A2, is
    responsible for iminoglycinuria. Additional polymorphisms and mutations in SLC6A18 can contribute to the IG
    phenotype in some families

  • 5 diseases for SLC6A20:    
    About MalaCards
    slc6a20-related hyperglycinuria    iminoglycinuria    hyperglycinuria    hartnup disease
    iminoglycinuria, digenic

    1 disease from the University of Copenhagen DISEASES database for SLC6A20:
    Hartnup disease

    Find genes that share disorders with SLC6A20           About GenesLikeMe

    Genetic Association Database (GAD): SLC6A20

    Export disorders for SLC6A20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SLC6A20 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with SLC6A20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3. (PubMed id 11352561)1, 2, 3 Kiss H.... Dumanski J.P. (Genomics 2001)
    2. Cloning, gene structure, and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms. (PubMed id 9932288)1, 2, 3 Nash S.R.... Caron M.G. (Recept. Channels 1998)
    3. Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino. (PubMed id 15632147)1, 2, 9 Takanaga H.... Hediger M.A. (J. Biol. Chem. 2005)
    4. A genome-wide association study of metabolic traits in human urine. (PubMed id 21572414)1, 4 Suhre K....Nauck M. (Nat. Genet. 2011)
    5. Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters. (PubMed id 19033659)1, 2 Broer S.... Rasko J.E. (J. Clin. Invest. 2008)
    6. Sodium translocation by the iminoglycinuria associated imino transporter (SLC6A20). (PubMed id 19657969)1, 9 BrAPer A....BrAPer S. (Mol. Membr. Biol. 2009)
    7. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (Hum. Genet. 2012)
    8. Amino acid transport across mammalian intestinal and renal epithelia. (PubMed id 18195088)1 BrAPer S. (Physiol. Rev. 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation. (PubMed id 15308626)1 Kanei-Ishii C....Ishii S. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 54716 HGNC: 30927 AceView: SLC6A20 Ensembl:ENSG00000163817 euGenes: HUgn54716
    ECgene: SLC6A20 H-InvDB: SLC6A20

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC6A20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC6A20 gene:
    Search GeneIP for patents involving SLC6A20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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