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Aliases for SLC6A2 Gene

Aliases for SLC6A2 Gene

  • Solute Carrier Family 6 Member 2 2 3 4
  • Solute Carrier Family 6 (Neurotransmitter Transporter), Member 2 2 3 5
  • Norepinephrine Transporter 2 3 4
  • Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2 2 3
  • SLC6A5 3 4
  • NAT1 3 4
  • NET1 3 4
  • NET 3 4
  • Solute Carrier Family 6 Member 5 3
  • Neurotransmitter Transporter 3

External Ids for SLC6A2 Gene

Previous HGNC Symbols for SLC6A2 Gene

  • NET1
  • NAT1
  • SLC6A5

Previous GeneCards Identifiers for SLC6A2 Gene

  • GC16M046129
  • GC16P055745
  • GC16P055428
  • GC16P055469
  • GC16P054247
  • GC16P041576

Summaries for SLC6A2 Gene

Entrez Gene Summary for SLC6A2 Gene

  • This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

GeneCards Summary for SLC6A2 Gene

SLC6A2 (Solute Carrier Family 6 Member 2) is a Protein Coding gene. Diseases associated with SLC6A2 include Orthostatic Intolerance and Syncope. Among its related pathways are Monoamine Transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include beta-tubulin binding and neurotransmitter:sodium symporter activity. An important paralog of this gene is SLC6A4.

UniProtKB/Swiss-Prot for SLC6A2 Gene

  • Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.

Tocris Summary for SLC6A2 Gene

  • Adrenergic transporters (NET) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain within noradrenergic neuronal plasma membranes. They are responsible for re-uptake of adrenalin and noradrenalin.

Gene Wiki entry for SLC6A2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A2 Gene

Genomics for SLC6A2 Gene

Regulatory Elements for SLC6A2 Gene

Enhancers for SLC6A2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC6A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC6A2 Gene

55,655,604 bp from pter
55,706,192 bp from pter
50,589 bases
Plus strand

Genomic View for SLC6A2 Gene

Genes around SLC6A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC6A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC6A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A2 Gene

Proteins for SLC6A2 Gene

  • Protein details for SLC6A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium-dependent noradrenaline transporter
    Protein Accession:
    Secondary Accessions:
    • B2R707
    • B4DX48
    • Q96KH8

    Protein attributes for SLC6A2 Gene

    617 amino acids
    Molecular mass:
    69332 Da
    Quaternary structure:
    • Interacts with PRKCABP.
    • This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

    Alternative splice isoforms for SLC6A2 Gene


neXtProt entry for SLC6A2 Gene

Proteomics data for SLC6A2 Gene at MOPED

Post-translational modifications for SLC6A2 Gene

  • Glycosylation at Asn 184, Asn 192, and Asn 198
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SLC6A2 Gene

Domains & Families for SLC6A2 Gene

Gene Families for SLC6A2 Gene


Suggested Antigen Peptide Sequences for SLC6A2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily.
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily.
genes like me logo Genes that share domains with SLC6A2: view

Function for SLC6A2 Gene

Molecular function for SLC6A2 Gene

GENATLAS Biochemistry:
solute carrier family 6,member 2,neurotransmitter transporter,noradrenalin/morepinephrine
UniProtKB/Swiss-Prot Function:
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.

Gene Ontology (GO) - Molecular Function for SLC6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11343649
genes like me logo Genes that share ontologies with SLC6A2: view
genes like me logo Genes that share phenotypes with SLC6A2: view

Human Phenotype Ontology for SLC6A2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLC6A2 Gene

MGI Knock Outs for SLC6A2:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC6A2 Gene

Localization for SLC6A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC6A2 Gene COMPARTMENTS Subcellular localization image for SLC6A2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SLC6A2 Gene

Pathways & Interactions for SLC6A2 Gene

genes like me logo Genes that share pathways with SLC6A2: view

Gene Ontology (GO) - Biological Process for SLC6A2 Gene


No data available for SIGNOR curated interactions for SLC6A2 Gene

Drugs & Compounds for SLC6A2 Gene

(122) Drugs for SLC6A2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atomoxetine Approved Pharma inhibitor, Target 0
Mazindol Approved Pharma Inhibition, Inhibitor, inhibitor, Target 3
Reboxetine Approved, Investigational Pharma Inhibition, Inhibitor, inhibitor, Target 26
Bupropion Approved Pharma inhibitor, Target 312
Clomipramine Approved Pharma inhibitor, Target 24

(48) Additional Compounds for SLC6A2 Gene - From: Novoseek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
Indatraline hydrochloride
Maprotiline hydrochloride
Nisoxetine hydrochloride

(5) Tocris Compounds for SLC6A2 Gene

Compound Action Cas Number
Indatraline hydrochloride Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake 96850-13-4
Maprotiline hydrochloride Noradrenalin re-uptake inhibitor 10347-81-6
Nisoxetine hydrochloride Noradrenalin re-uptake inhibitor 57754-86-6
Reboxetine mesylate Potent, selective noradrenalin uptake inhibitor; orally active 98769-84-7
Threo-methylphenidate hydrochloride Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant 298-59-9

(2) ApexBio Compounds for SLC6A2 Gene

Compound Action Cas Number
Atomoxetine HCl Noradrenalin re-uptake inhibitor 82248-59-7
Reboxetine mesylate 98769-84-7
genes like me logo Genes that share compounds with SLC6A2: view

Drug Products

Transcripts for SLC6A2 Gene

Unigene Clusters for SLC6A2 Gene

Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP2: - -
SP3: -
SP4: -

Relevant External Links for SLC6A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC6A2 Gene

mRNA expression in normal human tissues for SLC6A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC6A2 Gene

This gene is overexpressed in Testis (x11.5), Skin - Not Sun Exposed (Suprapubic) (x6.3), Cervix - Endocervix (x5.2), and Adrenal Gland (x5.1).

Protein differential expression in normal tissues from HIPED for SLC6A2 Gene

This gene is overexpressed in Esophagus (65.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC6A2 Gene

SOURCE GeneReport for Unigene cluster for SLC6A2 Gene Hs.78036

genes like me logo Genes that share expression patterns with SLC6A2: view

Protein tissue co-expression partners for SLC6A2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC6A2 Gene

Orthologs for SLC6A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC6A2 35
  • 90.19 (n)
  • 93.5 (a)
SLC6A2 36
  • 93 (a)
(Canis familiaris)
Mammalia SLC6A2 35
  • 89.63 (n)
  • 93.03 (a)
SLC6A2 36
  • 92 (a)
(Mus musculus)
Mammalia Slc6a2 35
  • 86.6 (n)
  • 94.33 (a)
Slc6a2 16
Slc6a2 36
  • 94 (a)
(Pan troglodytes)
Mammalia SLC6A2 35
  • 99.73 (n)
  • 99.68 (a)
SLC6A2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc6a2 35
  • 87.19 (n)
  • 93.99 (a)
(Monodelphis domestica)
Mammalia SLC6A2 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia SLC6A2 36
  • 88 (a)
(Gallus gallus)
Aves SLC6A2 35
  • 76.11 (n)
  • 85.67 (a)
SLC6A2 36
  • 82 (a)
(Anolis carolinensis)
Reptilia SLC6A2 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc6a2 35
  • 71.38 (n)
  • 79.81 (a)
(Danio rerio)
Actinopterygii LOC565776 35
  • 69.72 (n)
  • 73.37 (a)
slc6a2 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta BG:DS03431.1 37
  • 33 (a)
CG10804 37
  • 35 (a)
CG1698 37
  • 36 (a)
CG3252 37
  • 37 (a)
CG4476 37
  • 35 (a)
CG7075 37
  • 31 (a)
CG8850 37
  • 35 (a)
DAT 37
  • 55 (a)
ine 37
  • 39 (a)
SerT 37
  • 54 (a)
DAT 35
  • 58.92 (n)
  • 59.1 (a)
DAT 36
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007367 35
  • 62.07 (n)
  • 56.64 (a)
(Caenorhabditis elegans)
Secernentea mod-5 37
  • 46 (a)
snf-12 37
  • 29 (a)
snf-2 37
  • 31 (a)
snf-3 37
  • 38 (a)
snf-4 37
  • 32 (a)
snf-8 37
  • 25 (a)
dat-1 35
  • 53.58 (n)
  • 51.33 (a)
dat-1 36
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10022 36
  • 38 (a)
Species with no ortholog for SLC6A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC6A2 Gene

Gene Tree for SLC6A2 (if available)
Gene Tree for SLC6A2 (if available)

Paralogs for SLC6A2 Gene

genes like me logo Genes that share paralogs with SLC6A2: view

Variants for SLC6A2 Gene

Sequence variations from dbSNP and Humsavar for SLC6A2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_010022 Orthostatic intolerance (OI)
VAR_011756 -
rs1805065 - 55,669,586(+) GTACA(C/T)ACTGT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1805066 - 55,685,231(+) TCGTC(A/G)TCATC nc-transcript-variant, reference, missense
rs5563 - 55,692,009(-) CATCA(A/C/G/T)TGCCT intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC6A2 Gene

Variant ID Type Subtype PubMed ID
nsv906673 CNV Loss 21882294
nsv517827 CNV Loss 19592680
dgv892e1 CNV Complex 17122850
esv9043 CNV Gain 19470904
esv8787 CNV Gain 19470904
esv1621115 CNV Insertion 17803354
nsv103423 CNV Insertion 16902084
nsv906674 CNV Gain 21882294
nsv1813 CNV Insertion 18451855
nsv819933 CNV Gain 19587683

Variation tolerance for SLC6A2 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 49.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC6A2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC6A2 Gene

Disorders for SLC6A2 Gene

MalaCards: The human disease database

(24) MalaCards diseases for SLC6A2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
orthostatic intolerance
  • neurocirculatory asthenia
orthostatic intolerance due to net deficiency
  • familial orthostatic tachycardia due to norepinephrine transporter deficiency
oppositional defiant disorder
ocular hyperemia
  • hyperemia eye
- elite association - COSMIC cancer census association via MalaCards


  • Orthostatic intolerance (OI) [MIM:604715]: Syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high. {ECO:0000269 PubMed:10684912}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLC6A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC6A2: view

No data available for Genatlas for SLC6A2 Gene

Publications for SLC6A2 Gene

  1. Norepinephrine transporter gene variation modulates acute response to D-amphetamine. (PMID: 17239355) Dlugos A. … de Wit H. (Biol. Psychiatry 2007) 3 23 25 26
  2. Chronic depolarization stimulates norepinephrine transporter expression via catecholamines. (PMID: 16573647) Habecker B.A. … Woodward W.R. (J. Neurochem. 2006) 3 23 25 26
  3. Norepinephrine transporter gene (NET) polymorphism in patients with type 2 diabetes. (PMID: 17124432) Ksiazek P. … Buraczynska M. (Kidney Blood Press. Res. 2006) 3 23 25 26
  4. Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. (PMID: 10684912) Shannon J.R. … Robertson D. (N. Engl. J. Med. 2000) 3 4 48 67
  5. The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters. (PMID: 20141432) Cloonan S.M. … Williams D.C. (Leuk. Lymphoma 2010) 23 25 26

Products for SLC6A2 Gene

Sources for SLC6A2 Gene