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Aliases for SLC6A17 Gene

Aliases for SLC6A17 Gene

  • Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 17 2 3
  • NTT4 3 4 6
  • Solute Carrier Family 6 (Neurotransmitter Transporter), Member 17 2 3
  • Sodium-Dependent Neurotransmitter Transporter NTT4 3 4
  • Solute Carrier Family 6, Member 17 2 3
  • Orphan Sodium- And Chloride-Dependent Neurotransmitter Transporter NTT4 3
  • Sodium-Dependent Neutral Amino Acid Transporter SLC6A17 3
  • Solute Carrier Family 6 Member 17 4
  • MRT48 3

External Ids for SLC6A17 Gene

Summaries for SLC6A17 Gene

Entrez Gene Summary for SLC6A17 Gene

  • The SLC6 family of proteins, which includes SLC6A17, acts as specific transporters for neurotransmitters, amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 [PubMed 16125675]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC6A17 Gene

SLC6A17 (Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 17) is a Protein Coding gene. GO annotations related to this gene include neurotransmitter:sodium symporter activity. An important paralog of this gene is SLC6A18.

UniProtKB/Swiss-Prot for SLC6A17 Gene

  • Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A17 Gene

Genomics for SLC6A17 Gene

Genomic Location for SLC6A17 Gene

Start:
110,150,486 bp from pter
End:
110,202,202 bp from pter
Size:
51,717 bases
Orientation:
Plus strand

Genomic View for SLC6A17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC6A17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A17 Gene

Regulatory Elements for SLC6A17 Gene

Proteins for SLC6A17 Gene

  • Protein details for SLC6A17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1V8-S6A17_HUMAN
    Recommended name:
    Sodium-dependent neutral amino acid transporter SLC6A17
    Protein Accession:
    Q9H1V8
    Secondary Accessions:
    • A6NEA8
    • A8K1R7
    • B9EIR5
    • Q5T5Q9

    Protein attributes for SLC6A17 Gene

    Size:
    727 amino acids
    Molecular mass:
    81001 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC6A17 Gene

Proteomics data for SLC6A17 Gene at MOPED

Post-translational modifications for SLC6A17 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn186 and Asn393

Other Protein References for SLC6A17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC6A17 Gene

Domains for SLC6A17 Gene

Gene Families for SLC6A17 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC6A17 Gene

UniProtKB/Swiss-Prot:

S6A17_HUMAN
Family:
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A17 subfamily.:
    • Q9H1V8
genes like me logo Genes that share domains with SLC6A17: view

Function for SLC6A17 Gene

Molecular function for SLC6A17 Gene

UniProtKB/Swiss-Prot Function: Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).

Gene Ontology (GO) - Molecular Function for SLC6A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005328 neurotransmitter:sodium symporter activity IEA --
genes like me logo Genes that share ontologies with SLC6A17: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC6A17 Gene

Localization for SLC6A17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A17 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC6A17 Gene COMPARTMENTS Subcellular localization image for SLC6A17 gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC6A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
GO:0008021 synaptic vesicle ISS --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with SLC6A17: view

Pathways for SLC6A17 Gene

SuperPathways for SLC6A17 Gene

No Data Available

Interacting Proteins for SLC6A17 Gene

Gene Ontology (GO) - Biological Process for SLC6A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006836 neurotransmitter transport IEA --
GO:0015804 neutral amino acid transport ISS --
GO:0015816 glycine transport ISS --
GO:0015820 leucine transport ISS --
GO:0015824 proline transport ISS --
genes like me logo Genes that share ontologies with SLC6A17: view

No data available for Pathways by source for SLC6A17 Gene

Compounds for SLC6A17 Gene

(1) HMDB Compounds for SLC6A17 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
genes like me logo Genes that share compounds with SLC6A17: view

Transcripts for SLC6A17 Gene

mRNA/cDNA for SLC6A17 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC6A17 Gene

Solute carrier family 6, member 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A17 Gene

No ASD Table

Relevant External Links for SLC6A17 Gene

GeneLoc Exon Structure for
SLC6A17
ECgene alternative splicing isoforms for
SLC6A17

Expression for SLC6A17 Gene

mRNA expression in normal human tissues for SLC6A17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC6A17 Gene

This gene is overexpressed in Brain - Cortex (8.4), Brain - Frontal Cortex (BA9) (7.6), Brain - Anterior cingulate cortex (BA24) (6.9), and Brain - Cerebellum (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC6A17 Gene

SOURCE GeneReport for Unigene cluster for SLC6A17 Gene Hs.128382

genes like me logo Genes that share expressions with SLC6A17: view

Orthologs for SLC6A17 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC6A17 36
  • 99.63 (n)
  • 99.86 (a)
SLC6A17 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC6A17 36
  • 92.62 (n)
  • 96.97 (a)
SLC6A17 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC6A17 36
  • 92.76 (n)
  • 96.42 (a)
SLC6A17 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc6a17 36
  • 91.8 (n)
  • 96.55 (a)
Slc6a17 16
Slc6a17 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC6A17 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC6A17 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc6a17 36
  • 92.02 (n)
  • 96.97 (a)
chicken
(Gallus gallus)
Aves SLC6A17 36
  • 84.23 (n)
  • 89.41 (a)
SLC6A17 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC6A17 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc6a17 36
  • 71.95 (n)
  • 81.52 (a)
zebrafish
(Danio rerio)
Actinopterygii slc6a17 36
  • 73.31 (n)
  • 76.07 (a)
slc6a17 37
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011279 36
  • 54.51 (n)
  • 46.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10804 37
  • 37 (a)
ManyToMany
CG43066 36
  • 57.14 (n)
  • 45.62 (a)
CG43066 37
  • 40 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
ManyToMany
-- 37
  • 47 (a)
ManyToMany
CSA.3644 37
  • 46 (a)
ManyToMany
Species with no ortholog for SLC6A17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC6A17 Gene

ENSEMBL:
Gene Tree for SLC6A17 (if available)
TreeFam:
Gene Tree for SLC6A17 (if available)

Paralogs for SLC6A17 Gene

Paralogs for SLC6A17 Gene

genes like me logo Genes that share paralogs with SLC6A17: view

Variants for SLC6A17 Gene

Sequence variations from dbSNP and Humsavar for SLC6A17 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs495959 -- 110,189,511(+) TTCCT(C/T)GAAGG intron-variant
rs499435 -- 110,165,593(-) CACAT(A/G)TAATG intron-variant
rs534276 -- 110,193,187(+) TCTCA(C/T)AACTA intron-variant
rs535930 -- 110,181,866(+) gggaa(A/G)gaggt intron-variant
rs545849 -- 110,202,393(-) AATTC(A/C)TAGGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLC6A17 Gene

Variant ID Type Subtype PubMed ID
nsv2354 CNV Insertion 18451855
nsv2365 CNV Loss 18451855

Relevant External Links for SLC6A17 Gene

HapMap Linkage Disequilibrium report
SLC6A17
Human Gene Mutation Database (HGMD)
SLC6A17

Disorders for SLC6A17 Gene

Relevant External Links for SLC6A17

Genetic Association Database (GAD)
SLC6A17
Human Genome Epidemiology (HuGE) Navigator
SLC6A17
genes like me logo Genes that share disorders with SLC6A17: view

No data available for UniProtKB/Swiss-Prot for SLC6A17 Gene

Publications for SLC6A17 Gene

  1. Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport. (PMID: 19147495) Zaia K.A. … Reimer R.J. (J. Biol. Chem. 2009) 3 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The repertoire of solute carriers of family 6: identification of new human and rodent genes. (PMID: 16125675) Hoglund P.J. … Fredriksson R. (Biochem. Biophys. Res. Commun. 2005) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for SLC6A17 Gene

Sources for SLC6A17 Gene

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