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Aliases for SLC6A16 Gene

Aliases for SLC6A16 Gene

  • Solute Carrier Family 6, Member 16 2 3
  • Solute Carrier Family 6 (Neurotransmitter Transporter), Member 16 2 3
  • NTT5 3 4
  • NT5 3 6
  • Orphan Sodium- And Chloride-Dependent Neurotransmitter Transporter NTT5 3
  • Solute Carrier Family 6 Member 16 4
  • NTT5 Protein 2

External Ids for SLC6A16 Gene

Summaries for SLC6A16 Gene

Entrez Gene Summary for SLC6A16 Gene

  • SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC6A16 Gene

SLC6A16 (Solute Carrier Family 6, Member 16) is a Protein Coding gene. GO annotations related to this gene include neurotransmitter:sodium symporter activity and neurotransmitter transporter activity. An important paralog of this gene is SLC6A18.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A16 Gene

Genomics for SLC6A16 Gene

Genomic Location for SLC6A16 Gene

Start:
49,289,632 bp from pter
End:
49,331,093 bp from pter
Size:
41,462 bases
Orientation:
Minus strand

Genomic View for SLC6A16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC6A16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A16 Gene

Regulatory Elements for SLC6A16 Gene

Proteins for SLC6A16 Gene

  • Protein details for SLC6A16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZN6-S6A16_HUMAN
    Recommended name:
    Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
    Protein Accession:
    Q9GZN6
    Secondary Accessions:
    • Q8IYV4
    • Q9Y5I9

    Protein attributes for SLC6A16 Gene

    Size:
    736 amino acids
    Molecular mass:
    82200 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC6A16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC6A16 Gene

Proteomics data for SLC6A16 Gene at MOPED

Post-translational modifications for SLC6A16 Gene

Other Protein References for SLC6A16 Gene

No data available for DME Specific Peptides for SLC6A16 Gene

Domains for SLC6A16 Gene

Gene Families for SLC6A16 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC6A16 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

S6A16_HUMAN
Family:
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A16 subfamily.:
    • Q9GZN6
genes like me logo Genes that share domains with SLC6A16: view

Function for SLC6A16 Gene

Gene Ontology (GO) - Molecular Function for SLC6A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005326 neurotransmitter transporter activity NAS 11112352
GO:0005328 neurotransmitter:sodium symporter activity IEA --
genes like me logo Genes that share ontologies with SLC6A16: view

Phenotypes for SLC6A16 Gene

GenomeRNAi human phenotypes for SLC6A16:
genes like me logo Genes that share phenotypes with SLC6A16: view

miRNA for SLC6A16 Gene

miRTarBase miRNAs that target SLC6A16

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC6A16 Gene

Localization for SLC6A16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A16 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC6A16 Gene COMPARTMENTS Subcellular localization image for SLC6A16 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC6A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 11112352
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC6A16: view

Pathways for SLC6A16 Gene

SuperPathways for SLC6A16 Gene

No Data Available

Interacting Proteins for SLC6A16 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000338627%0d%0a9606.ENSP00000369699%0d%0a
Selected Interacting proteins: ENSP00000338627 for SLC6A16 Gene via STRING

Symbol External ID(s) Details
TMEM27

Gene Ontology (GO) - Biological Process for SLC6A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006836 neurotransmitter transport NAS 11112352
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC6A16: view

No data available for Pathways by source for SLC6A16 Gene

Compounds for SLC6A16 Gene

(1) HMDB Compounds for SLC6A16 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
genes like me logo Genes that share compounds with SLC6A16: view

Transcripts for SLC6A16 Gene

Unigene Clusters for SLC6A16 Gene

Solute carrier family 6, member 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A16 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - -
SP2: - -
SP3:
SP4: - -

Relevant External Links for SLC6A16 Gene

GeneLoc Exon Structure for
SLC6A16
ECgene alternative splicing isoforms for
SLC6A16

Expression for SLC6A16 Gene

mRNA expression in normal human tissues for SLC6A16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC6A16 Gene

This gene is overexpressed in Testis (16.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC6A16 Gene

SOURCE GeneReport for Unigene cluster for SLC6A16 Gene Hs.130949

mRNA Expression by UniProt/SwissProt for SLC6A16 Gene

Q9GZN6-S6A16_HUMAN
Tissue specificity: Highly expressed in peripheral tissues, particularly in testis, pancreas, and prostate
genes like me logo Genes that share expressions with SLC6A16: view

Orthologs for SLC6A16 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC6A16 36
  • 99.23 (n)
  • 98.64 (a)
SLC6A16 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC6A16 36
  • 75.08 (n)
  • 58.77 (a)
SLC6A16 37
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC6A16 36
  • 77.28 (n)
  • 63.84 (a)
SLC6A16 37
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc6a16 36
  • 67.09 (n)
  • 50.42 (a)
Slc6a16 16
Slc6a16 37
  • 47 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC6A16 37
  • 34 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 49 (a)
OneToMany
-- 37
  • 36 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc6a16 36
  • 67 (n)
  • 48.94 (a)
lizard
(Anolis carolinensis)
Reptilia SLC6A16 37
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SLC6A16 (1 of 2) 37
  • 33 (a)
OneToMany
SLC6A16 (2 of 2) 37
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10804 37
  • 25 (a)
ManyToMany
CG43066 37
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
ManyToMany
CSA.3644 37
  • 33 (a)
ManyToMany
Species with no ortholog for SLC6A16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC6A16 Gene

ENSEMBL:
Gene Tree for SLC6A16 (if available)
TreeFam:
Gene Tree for SLC6A16 (if available)

Paralogs for SLC6A16 Gene

Paralogs for SLC6A16 Gene

genes like me logo Genes that share paralogs with SLC6A16: view

Variants for SLC6A16 Gene

Sequence variations from dbSNP and Humsavar for SLC6A16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs168498 -- 49,321,197(-) accat(C/T)cttgc intron-variant
rs171342 -- 49,298,249(-) tgtca(A/G)ttttt intron-variant
rs181344 -- 49,327,989(+) catgg(C/T)cggaa intron-variant
rs183049 -- 49,312,596(-) TTGCC(C/T)TTTCT intron-variant, utr-variant-5-prime
rs184790 -- 49,313,262(-) tcctt(C/T)gaacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC6A16 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv52n68 CNV Loss 17160897
esv2658176 CNV Deletion 23128226
nsv912261 CNV Loss 21882294

Relevant External Links for SLC6A16 Gene

HapMap Linkage Disequilibrium report
SLC6A16

Disorders for SLC6A16 Gene

No disorders were found for SLC6A16 Gene.

No data available for UniProtKB/Swiss-Prot for SLC6A16 Gene

Publications for SLC6A16 Gene

  1. Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na(+)/Cl(-)-dependent neurotransmitter transporter gene family. (PMID: 11112352) Farmer M.K. … Pangalos M.N. (Genomics 2000) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Neurotransmitter transporters in the central nervous system. (PMID: 10471414) Masson J. … El Mestikawy S. (Pharmacol. Rev. 1999) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4

Products for SLC6A16 Gene

Sources for SLC6A16 Gene

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