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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC6A16 Gene

protein-coding GIFtS: 46
GCID: GC19M049792

solute carrier family 6, member 16

(Previous names: solute carrier family 6 (neurotransmitter transporter),...)

Explore 2 diseases affiliated with
SLC6A16 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 6, Member 16¹ ²
NTT5¹ ² ³
Solute Carrier Family 6 (Neurotransmitter Transporter), Member 16¹ ²
Orphan Sodium- And Chloride-Dependent Neurotransmitter Transporter NTT5²
Solute Carrier Family 6 Member 16³

External Ids:	HGNC: 13622¹	Entrez Gene: 28968²	Ensembl: ENSG00000063127⁷	OMIM: 607972⁵	UniProtKB: Q9GZN6³

Export aliases for SLC6A16 gene to outside databases

Previous GC identifers: GC00U990833 GC19M054484 GC19M046169

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC6A16:

SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12

transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple

N-glycosylation sites.(supplied by OMIM, Mar 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC6A16 gene promoter:
RP58 USF1 GCNF Lmo2 USF2 USF-1:USF-2 HEN1 USF-1 HFH-1 Zic3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC6A16 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC6A16

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC6A16

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.33

SLC6A16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC6A16 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M049792: view genomic region (about GC identifiers)

Start:	49,792,889 bp from pter	End:	49,828,474 bp from pter
Size:	35,586 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S6A16_HUMAN, Q9GZN6 (See protein sequence)

Recommended Name: Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

Size: 736 amino acids; 82200 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q9Y5I9

Explore the universe of human proteins at neXtProt for SLC6A16: NX_Q9GZN6

SLC6A16 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_054756.2

ENSEMBL proteins:

ENSP00000338627 ENSP00000404022

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	Uscn Proteins for SLC6A16

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	NAS	11112352
GO:0016021	integral to membrane	IEA	--

SLC6A16 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC6A16 for domains About GeneDecksing

1 InterPro domain/family:

IPR000175 Na/ntran_symport

Graphical View of Domain Structure for InterPro Entry Q9GZN6

ProtoNet protein and cluster: Q9GZN6

UniProtKB/Swiss-Prot: S6A16_HUMAN, Q9GZN6

Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A16 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005326	neurotransmitter transporter activity	NAS	11112352
GO:0005328	neurotransmitter:sodium symporter activity	IEA	--

SLC6A16 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SLC6A16:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC6A16

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SLC6A16 (ENSP00000338627⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STX1A	ENSP00000222812⁴	STRING: ENSP00000222812
TBL3	ENSP00000331815⁴	STRING: ENSP00000331815

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006836	neurotransmitter transport	NAS	11112352

SLC6A16 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC6A16

1 HMDB Compound for SLC6A16 About this table

Compound	Synonyms	CAS #	PubMed Ids
Sodium	Sodium (see all 2)	7440-23-5	--

Search CenterWatch for drugs/clinical trials and news about SLC6A16 / S6A16

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for SLC6A16 gene:

NM_014037.2

Unigene Cluster for SLC6A16:

Solute carrier family 6, member 16

Hs.130949 [show with all ESTs]

Unigene Representative Sequence: BC034948

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000335875(uc002pmz.3) ENST00000454748(uc002pna.3)

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Additional cDNA sequence:

AF151977.1 AF265578.1 AL136856.1 BC034948.1 BC039336.1

7 DOTS entries:

DT.211403 DT.211404 DT.100748604 DT.95178079 DT.91746353 DT.91819915 DT.99989723

24/60 AceView cDNA sequences (see all 60):

AF265578 BI828550 AL136856 AA868681 CD300308 BI826017 BX114792 CD359331

AA609875 AI208927 BI825960 BI460126 AA403002 BX112834 BC034948 AW664090

AA412031 BC039336 AI025570 BI463932 BI828810 BE672405 AF151977 BI462222

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A16 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b
SP1:															-								-
SP2:															-								-
SP3:
SP4:											-		-

ECgene alternative splicing isoforms for SLC6A16

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC6A16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCTGAGCA

About this image

SLC6A16 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC6A16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC6A16

SOURCE GeneReport for Unigene cluster: Hs.130949

UniProtKB/Swiss-Prot: S6A16_HUMAN, Q9GZN6

Tissue specificity: Highly expressed in peripheral tissues, particularly in testis, pancreas, and prostate

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SLC6A16 gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	SLC6A16⁶	--	34(a)	1 ↔ 1	GL343355.1(26562-33868)
zebrafish (Danio rerio)	Actinopterygii	zgc:162925⁶ si:dkey-29b22.6⁶	si:dkey-29b22.6	33(a) 31(a)	1 ↔ many 1 ↔ many	24(40126163-40158383) 3(16186342-16215766)
worm (Caenorhabditis elegans)	Secernentea	snf-6⁶ snf-12⁶	Sodium-dependent acetylcholine transporter Sodium:Neurotransmitter symporter Family family me...	19(a) 12(a)	possible ortholog possible ortholog	III(1520216-1532760) X(9029423-9033904)

ENSEMBL Gene Tree for SLC6A16 (if available)
TreeFam Gene Tree for SLC6A16 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC6A16 gene

SLC6A15² SLC6A20² SLC6A17² SLC6A18² SLC6A19²

7 SIMAP similar genes for SLC6A16 using alignment to 6 protein entries: S6A16_HUMAN (see all proteins):

DKFZp761I0921 SLC6A17 SLC6A15 SLC6A20 SLC6A18 SLC6A11

SLC6A19

SLC6A16 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145029602^1,2		--	49792722(+)	`ATCTCA/GTGATA`	1	--	ds500¹		0	--	--	--	--
rs139432952^1,2	C,	--	49792790(+)	`CCTCA-/TTTTTT`	1	--	ds500¹		0	--	--	--	--
rs58292184^1,2		--	49792820(+)	`AAGAAA/GTGCCT`	1	--	ds500¹		2		CSA WA	120
rs191051191^1,2		--	49792830(+)	`TTTCAC/TCTCCC`	1	--	ds500¹		0	--	--	--	--
rs147630258^1,2		--	49793021(+)	`CAGTCC/TTTGGA`	1	--	ut3¹		0	--	--	--	--
rs182764325^1,2		--	49793034(+)	`TCCAGC/TAGACT`	1	--	ut3¹		0	--	--	--	--
rs185820245^1,2		--	49793487(+)	`TAGGGA/TTGTGG`	2	T S	mis¹		0	--	--	--	--
rs142309154^1,2	C,	--	49793508(+)	`AGGCCC/TGTCTC`	2	R G	mis¹		0	--	--	--	--
rs34486225^1,2	C,F,H,	--	49793509(+)	`GGCCCG/ATCTCC`	2	/D	syn¹		9		NS NA WA EU	2241
rs34817563^1,2	C,F,	--	49793620(+)	`GCCCAC/TGGTGG`	2	P	syn¹		5		NA WA EU	1519

HapMap Linkage Disequilibrium report for SLC6A16 (49792889 - 49828474 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC6A16
1 CNV: 32261

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC6A16 for disorders           About GeneDecksing

OMIM gene information: 607972    OMIM disorders: --

2 diseases for SLC6A16:    About MalaCards

pneumonia prostatitis

Export disorders for SLC6A16 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC6A16 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC6A16)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na(+)/Cl(-)-dependent neurotransmitter transporter gene family. (PubMed id 11112352)^{1, 2, 3} Farmer M.K.... Pangalos M.N. (2000)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Neurotransmitter transporters in the central nervous system. (PubMed id 10471414)^{1, 3} Masson J....El Mestikawy S. (1999)
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)² Varela I....Futreal P.A. (2011)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 28968	HGNC: 13622	AceView: SLC6A16	Ensembl:ENSG00000063127	euGenes: HUgn28968
ECgene: SLC6A16	H-InvDB: SLC6A16

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC6A16	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC6A16 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SLC6A16 gene:
Search GeneIP for patents involving SLC6A16

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for SLC6A16
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC6A16
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	GenScript Custom Purified and Recombinant Proteins Services for SLC6A16		GenScript cDNA clones with any tag delivered in your preferred vector for SLC6A16
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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SLC6A16 Gene

solute carrier family 6, member 16

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SLC6A16 Gene

solute carrier family 6, member 16

Aliasesfor SLC6A16 gene

Summariesfor SLC6A16 gene

Genomic Viewsfor SLC6A16 gene

Proteinsfor SLC6A16 gene

Protein Domains /Familiesfor SLC6A16 gene

Functionfor SLC6A16 gene

Pathways & Interactionsfor SLC6A16 gene

Drugs & Compoundsfor SLC6A16 gene

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Expression for SLC6A16 gene

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Paralogsfor SLC6A16 gene

Genomic Variantsfor SLC6A16 gene

Disorders / Diseasesfor SLC6A16 gene

Publicationsfor SLC6A16 gene

External Searches for SLC6A16 gene

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for SLC6A16 gene

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for SLC6A16 gene

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for SLC6A16 gene

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for SLC6A16 gene

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for SLC6A16 gene

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Expression
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Orthologs
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