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Aliases for SLC6A16 Gene

Aliases for SLC6A16 Gene

  • Solute Carrier Family 6 Member 16 2 3 4 5
  • Solute Carrier Family 6 (Neurotransmitter Transporter), Member 16 2 3
  • Solute Carrier Family 6, Member 16 2 3
  • NTT5 3 4
  • NTT5 Protein 2
  • NT5 3

External Ids for SLC6A16 Gene

Previous GeneCards Identifiers for SLC6A16 Gene

  • GC00U990833
  • GC19M054484
  • GC19M049792
  • GC19M046169

Summaries for SLC6A16 Gene

Entrez Gene Summary for SLC6A16 Gene

  • SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC6A16 Gene

SLC6A16 (Solute Carrier Family 6 Member 16) is a Protein Coding gene. GO annotations related to this gene include neurotransmitter:sodium symporter activity and neurotransmitter transporter activity. An important paralog of this gene is SLC6A18.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A16 Gene

Genomics for SLC6A16 Gene

Regulatory Elements for SLC6A16 Gene

Enhancers for SLC6A16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC6A16 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC6A16 Gene

49,289,632 bp from pter
49,331,701 bp from pter
42,070 bases
Minus strand

Genomic View for SLC6A16 Gene

Genes around SLC6A16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC6A16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC6A16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A16 Gene

Proteins for SLC6A16 Gene

  • Protein details for SLC6A16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
    Protein Accession:
    Secondary Accessions:
    • Q8IYV4
    • Q9Y5I9

    Protein attributes for SLC6A16 Gene

    736 amino acids
    Molecular mass:
    82200 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC6A16 Gene


neXtProt entry for SLC6A16 Gene

Proteomics data for SLC6A16 Gene at MOPED

Post-translational modifications for SLC6A16 Gene

  • Glycosylation at Asn 229
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC6A16 Gene

No data available for DME Specific Peptides for SLC6A16 Gene

Domains & Families for SLC6A16 Gene

Gene Families for SLC6A16 Gene


Protein Domains for SLC6A16 Gene


Suggested Antigen Peptide Sequences for SLC6A16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A16 subfamily.
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A16 subfamily.
genes like me logo Genes that share domains with SLC6A16: view

Function for SLC6A16 Gene

Gene Ontology (GO) - Molecular Function for SLC6A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005326 neurotransmitter transporter activity NAS 11112352
GO:0015171 amino acid transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC6A16: view
genes like me logo Genes that share phenotypes with SLC6A16: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC6A16

CRISPR Products

miRNA for SLC6A16 Gene

miRTarBase miRNAs that target SLC6A16

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC6A16 Gene

Localization for SLC6A16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A16 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC6A16 Gene COMPARTMENTS Subcellular localization image for SLC6A16 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC6A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 11112352
genes like me logo Genes that share ontologies with SLC6A16: view

Pathways & Interactions for SLC6A16 Gene

SuperPathways for SLC6A16 Gene

No Data Available

Interacting Proteins for SLC6A16 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000338627 for SLC6A16 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SLC6A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC6A16: view

No data available for Pathways by source and SIGNOR curated interactions for SLC6A16 Gene

Drugs & Compounds for SLC6A16 Gene

(1) Additional Compounds for SLC6A16 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC6A16: view

Transcripts for SLC6A16 Gene

Unigene Clusters for SLC6A16 Gene

Solute carrier family 6, member 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A16 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - -
SP2: - -
SP4: - -

Relevant External Links for SLC6A16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC6A16 Gene

mRNA expression in normal human tissues for SLC6A16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC6A16 Gene

This gene is overexpressed in Testis (x16.1).

Protein differential expression in normal tissues from HIPED for SLC6A16 Gene

This gene is overexpressed in Testis (39.0) and Spleen (30.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC6A16 Gene

SOURCE GeneReport for Unigene cluster for SLC6A16 Gene Hs.130949

mRNA Expression by UniProt/SwissProt for SLC6A16 Gene

Tissue specificity: Highly expressed in peripheral tissues, particularly in testis, pancreas, and prostate.
genes like me logo Genes that share expression patterns with SLC6A16: view

Protein tissue co-expression partners for SLC6A16 Gene

- Elite partner

Primer Products

Orthologs for SLC6A16 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC6A16 35
  • 75.08 (n)
  • 58.77 (a)
SLC6A16 36
  • 58 (a)
(Canis familiaris)
Mammalia SLC6A16 35
  • 77.28 (n)
  • 63.84 (a)
SLC6A16 36
  • 63 (a)
(Mus musculus)
Mammalia Slc6a16 35
  • 67.09 (n)
  • 50.42 (a)
Slc6a16 16
Slc6a16 36
  • 47 (a)
(Pan troglodytes)
Mammalia SLC6A16 35
  • 99.23 (n)
  • 98.64 (a)
SLC6A16 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc6a16 35
  • 67 (n)
  • 48.94 (a)
(Monodelphis domestica)
Mammalia SLC6A16 36
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
-- 36
  • 36 (a)
(Anolis carolinensis)
Reptilia SLC6A16 36
  • 36 (a)
(Danio rerio)
Actinopterygii SLC6A16 (1 of 2) 36
  • 33 (a)
SLC6A16 (2 of 2) 36
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10804 36
  • 25 (a)
CG43066 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
CSA.3644 36
  • 33 (a)
Species with no ortholog for SLC6A16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC6A16 Gene

Gene Tree for SLC6A16 (if available)
Gene Tree for SLC6A16 (if available)

Paralogs for SLC6A16 Gene

Paralogs for SLC6A16 Gene

genes like me logo Genes that share paralogs with SLC6A16: view

Variants for SLC6A16 Gene

Sequence variations from dbSNP and Humsavar for SLC6A16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs35860981 - 49,311,024(+) GTTTT(G/T)CTGGA reference, missense, utr-variant-5-prime
VAR_064753 -
rs7256363 -- 49,324,547(+) CAACT(C/T)CTAGG intron-variant
rs8099837 -- 49,325,517(+) TCTAG(C/G/T)CTTCA intron-variant, upstream-variant-2KB
rs12981865 -- 49,332,623(+) gtatc(C/T)tgaga upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC6A16 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv52n68 CNV Loss 17160897
esv2658176 CNV Deletion 23128226
nsv912261 CNV Loss 21882294

Variation tolerance for SLC6A16 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC6A16 Gene

Disorders for SLC6A16 Gene

Relevant External Links for SLC6A16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC6A16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC6A16 Gene

Publications for SLC6A16 Gene

  1. Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na(+)/Cl(-)-dependent neurotransmitter transporter gene family. (PMID: 11112352) Farmer M.K. … Pangalos M.N. (Genomics 2000) 2 3 4 67
  2. Neurotransmitter transporters in the central nervous system. (PMID: 10471414) Masson J. … El Mestikawy S. (Pharmacol. Rev. 1999) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3

Products for SLC6A16 Gene

Sources for SLC6A16 Gene