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Aliases for SLC6A16 Gene

Aliases for SLC6A16 Gene

  • Solute Carrier Family 6 Member 16 2 3 4 5
  • Solute Carrier Family 6 (Neurotransmitter Transporter), Member 16 2 3
  • NTT5 3 4
  • Orphan Sodium- And Chloride-Dependent Neurotransmitter Transporter NTT5 3
  • Solute Carrier Family 6, Member 16 2
  • NTT5 Protein 2
  • CTC-301O7.4 3
  • NT5 3

External Ids for SLC6A16 Gene

Previous GeneCards Identifiers for SLC6A16 Gene

  • GC00U990833
  • GC19M054484
  • GC19M049792
  • GC19M046169

Summaries for SLC6A16 Gene

Entrez Gene Summary for SLC6A16 Gene

  • SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC6A16 Gene

SLC6A16 (Solute Carrier Family 6 Member 16) is a Protein Coding gene. Diseases associated with SLC6A16 include Retinitis Pigmentosa 11. Among its related pathways are NRF2 pathway. GO annotations related to this gene include neurotransmitter:sodium symporter activity and neurotransmitter transporter activity. An important paralog of this gene is SLC6A17.

Additional gene information for SLC6A16 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A16 Gene

Genomics for SLC6A16 Gene

Regulatory Elements for SLC6A16 Gene

Enhancers for SLC6A16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H048958 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +367.7 367672 10 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC MEF2D NUP62 PRR12 ENSG00000269321 RUVBL2 PPP1R15A TSKS ENSG00000268047 IRF3 PIH1D1 CPT1C
GH19H049486 1.7 Ensembl ENCODE dbSUPER 10.2 -158.5 -158539 7 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 NUP62 RPS11 POLD1 PRR12 ENSG00000268047 ALDH16A1 ENSG00000268093 SNORD35A IRF3 FLT3LG
GH19H048632 1.7 Ensembl ENCODE dbSUPER 10.1 +695.2 695225 7 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 GLIS1 NBN PRR12 SNRNP70 GRWD1 PIH1D1 SNORD35A RPS11 NOP53-AS1 NOP53 RPL18 ALDH16A1
GH19H049589 1.7 FANTOM5 ENCODE dbSUPER 10.1 -260.3 -260342 5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 NUP62 PRR12 POLD1 ENSG00000268047 IRF3 ZNF473 PNKP ALDH16A1 SNORD35A SNORD35B
GH19H049207 1.5 FANTOM5 Ensembl ENCODE 11.2 +123.4 123370 1 HDAC1 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 RAD21 RFX5 ZNF366 SNRNP70 PPP1R15A PRR12 CD37 PPFIA3 C19orf73 LIN7B CGB7 NTF4 SLC6A16
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC6A16 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC6A16 Gene

Chromosome:
19
Start:
49,289,632 bp from pter
End:
49,331,701 bp from pter
Size:
42,070 bases
Orientation:
Minus strand

Genomic View for SLC6A16 Gene

Genes around SLC6A16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC6A16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC6A16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A16 Gene

Proteins for SLC6A16 Gene

  • Protein details for SLC6A16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZN6-S6A16_HUMAN
    Recommended name:
    Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
    Protein Accession:
    Q9GZN6
    Secondary Accessions:
    • Q8IYV4
    • Q9Y5I9

    Protein attributes for SLC6A16 Gene

    Size:
    736 amino acids
    Molecular mass:
    82200 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC6A16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC6A16 Gene

Post-translational modifications for SLC6A16 Gene

  • Glycosylation at Asn229
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC6A16 Gene

Domains & Families for SLC6A16 Gene

Gene Families for SLC6A16 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC6A16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC6A16 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZN6

UniProtKB/Swiss-Prot:

S6A16_HUMAN :
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A16 subfamily.
Family:
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A16 subfamily.
genes like me logo Genes that share domains with SLC6A16: view

Function for SLC6A16 Gene

Phenotypes From GWAS Catalog for SLC6A16 Gene

Gene Ontology (GO) - Molecular Function for SLC6A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005326 neurotransmitter transporter activity NAS 11112352
GO:0005328 neurotransmitter:sodium symporter activity IEA --
GO:0015171 amino acid transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC6A16: view
genes like me logo Genes that share phenotypes with SLC6A16: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC6A16

CRISPR Products

miRNA for SLC6A16 Gene

miRTarBase miRNAs that target SLC6A16

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC6A16
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC6A16 Gene

Localization for SLC6A16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A16 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC6A16 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC6A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 11112352
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC6A16: view

Pathways & Interactions for SLC6A16 Gene

SuperPathways for SLC6A16 Gene

SuperPathway Contained pathways
1 NRF2 pathway
genes like me logo Genes that share pathways with SLC6A16: view

Pathways by source for SLC6A16 Gene

1 BioSystems pathway for SLC6A16 Gene

Gene Ontology (GO) - Biological Process for SLC6A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IEA --
GO:0006810 transport IEA --
GO:0006836 neurotransmitter transport IEA,NAS 11112352
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC6A16: view

No data available for SIGNOR curated interactions for SLC6A16 Gene

Drugs & Compounds for SLC6A16 Gene

(1) Additional Compounds for SLC6A16 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC6A16: view

Transcripts for SLC6A16 Gene

Unigene Clusters for SLC6A16 Gene

Solute carrier family 6, member 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC6A16
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A16 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - -
SP2: - -
SP3:
SP4: - -

Relevant External Links for SLC6A16 Gene

GeneLoc Exon Structure for
SLC6A16
ECgene alternative splicing isoforms for
SLC6A16

Expression for SLC6A16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC6A16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC6A16 Gene

This gene is overexpressed in Testis (x16.1).

Protein differential expression in normal tissues from HIPED for SLC6A16 Gene

This gene is overexpressed in Testis (39.0) and Spleen (30.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC6A16 Gene



Protein tissue co-expression partners for SLC6A16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC6A16 Gene:

SLC6A16

SOURCE GeneReport for Unigene cluster for SLC6A16 Gene:

Hs.130949

mRNA Expression by UniProt/SwissProt for SLC6A16 Gene:

Q9GZN6-S6A16_HUMAN
Tissue specificity: Highly expressed in peripheral tissues, particularly in testis, pancreas, and prostate.
genes like me logo Genes that share expression patterns with SLC6A16: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC6A16 Gene

Orthologs for SLC6A16 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC6A16 33 34
  • 99.23 (n)
dog
(Canis familiaris)
Mammalia SLC6A16 33 34
  • 77.28 (n)
cow
(Bos Taurus)
Mammalia SLC6A16 33 34
  • 75.08 (n)
mouse
(Mus musculus)
Mammalia Slc6a16 33 16 34
  • 67.09 (n)
rat
(Rattus norvegicus)
Mammalia Slc6a16 33
  • 67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 49 (a)
OneToMany
-- 34
  • 36 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SLC6A16 34
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC6A16 34
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SLC6A16 (2 of 2) 34
  • 34 (a)
OneToMany
SLC6A16 (1 of 2) 34
  • 33 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43066 34
  • 27 (a)
ManyToMany
CG10804 34
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3644 34
  • 33 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
Species where no ortholog for SLC6A16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC6A16 Gene

ENSEMBL:
Gene Tree for SLC6A16 (if available)
TreeFam:
Gene Tree for SLC6A16 (if available)

Paralogs for SLC6A16 Gene

Paralogs for SLC6A16 Gene

genes like me logo Genes that share paralogs with SLC6A16: view

Variants for SLC6A16 Gene

Sequence variations from dbSNP and Humsavar for SLC6A16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000045942 -- 49,331,368(+) TTGTA(G/T)ACAGG intron-variant, upstream-variant-2KB
rs1000065054 -- 49,324,608(+) TCACA(C/T)TACCT intron-variant
rs1000285092 -- 49,289,551(+) CTGCC(A/G)TCATG downstream-variant-500B
rs1000305843 -- 49,296,350(+) TTTGG(A/G)AAAAA intron-variant
rs1000362798 -- 49,304,699(+) TGTTC(A/G)ATGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC6A16 Gene

Variant ID Type Subtype PubMed ID
dgv52n68 CNV loss 17160897
esv2658176 CNV deletion 23128226
esv3348764 CNV insertion 20981092
esv3644620 CNV loss 21293372
esv3644621 CNV loss 21293372
nsv474708 CNV novel sequence insertion 20440878
nsv9739 CNV gain+loss 18304495

Variation tolerance for SLC6A16 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC6A16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC6A16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC6A16 Gene

Disorders for SLC6A16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC6A16 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 11
  • rp11
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC6A16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC6A16
genes like me logo Genes that share disorders with SLC6A16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC6A16 Gene

Publications for SLC6A16 Gene

  1. Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family. (PMID: 11112352) Farmer MK … Pangalos MN (Genomics 2000) 2 3 4 60
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 60
  3. Neurotransmitter transporters in the central nervous system. (PMID: 10471414) Masson J … El Mestikawy S (Pharmacological reviews 1999) 2 3 60
  4. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I … Futreal PA (Nature 2011) 4 60
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60

Products for SLC6A16 Gene

Sources for SLC6A16 Gene

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