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Aliases for SLC6A16 Gene

Aliases for SLC6A16 Gene

  • Solute Carrier Family 6 Member 16 2 3 4 5
  • Solute Carrier Family 6 (Neurotransmitter Transporter), Member 16 2 3
  • NTT5 3 4
  • Orphan Sodium- And Chloride-Dependent Neurotransmitter Transporter NTT5 3
  • Solute Carrier Family 6, Member 16 2
  • NTT5 Protein 2
  • CTC-301O7.4 3
  • NT5 3

External Ids for SLC6A16 Gene

Previous GeneCards Identifiers for SLC6A16 Gene

  • GC00U990833
  • GC19M054484
  • GC19M049792
  • GC19M046169

Summaries for SLC6A16 Gene

Entrez Gene Summary for SLC6A16 Gene

  • SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC6A16 Gene

SLC6A16 (Solute Carrier Family 6 Member 16) is a Protein Coding gene. Diseases associated with SLC6A16 include Retinitis Pigmentosa 11. Among its related pathways are NRF2 pathway. GO annotations related to this gene include neurotransmitter:sodium symporter activity and neurotransmitter transporter activity. An important paralog of this gene is SLC6A17.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A16 Gene

Genomics for SLC6A16 Gene

Regulatory Elements for SLC6A16 Gene

Enhancers for SLC6A16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G049207 1.6 FANTOM5 Ensembl ENCODE 11.2 +123.4 123370 1.4 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 ZNF121 FOS SP5 PPP1R15A CD37 SNRNP70 PPFIA3 C19orf73 LIN7B NTF4 CGB7 SLC6A16 KCNA7
GH19G049145 1.5 Ensembl ENCODE dbSUPER 10.5 +185.3 185320 1.6 ATF1 ARNT ARID4B SIN3A ZNF121 GLIS2 ZNF143 SP3 REST ZNF592 PPFIA3 PRR12 C19orf73 LIN7B KCNA7 SNRNP70 NTF4 CGB7 CD37 SLC6A16
GH19G049210 1.2 Ensembl ENCODE 11.2 +120.8 120839 1.7 HDGF PKNOX1 ATF1 THRB RAD21 EGR1 RCOR1 CREM SMARCA5 SP3 SNRNP70 PPFIA3 C19orf73 LIN7B NTF4 CGB7 SLC6A16 CD37 KCNA7 CCDC155
GH19G049457 1.2 Ensembl ENCODE dbSUPER 10.1 -126.7 -126665 1.6 HDGF HCFC1 L3MBTL2 BHLHE40 NR2F1 DPF2 ZBTB40 ZNF592 GABPA POLR2A RPL13A SNORD32A SNORD33 SNORD34 SNORD35A SLC6A16 CD37 FLT3LG PIH1D1 ENSG00000269469
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC6A16 on UCSC Golden Path with GeneCards custom track

Promoters for SLC6A16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110876 803 201 CBX3 PKNOX1 KLF1 TAF1 TEAD4 SIN3A MAX YY1 ETS1 ELK1
ENSR00000288871 1203 201 CTCF SCRT1 PKNOX1 KLF1 ZNF687 POLR2A KLF9

Genomic Location for SLC6A16 Gene

49,289,632 bp from pter
49,331,701 bp from pter
42,070 bases
Minus strand

Genomic View for SLC6A16 Gene

Genes around SLC6A16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC6A16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC6A16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A16 Gene

Proteins for SLC6A16 Gene

  • Protein details for SLC6A16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
    Protein Accession:
    Secondary Accessions:
    • Q8IYV4
    • Q9Y5I9

    Protein attributes for SLC6A16 Gene

    736 amino acids
    Molecular mass:
    82200 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC6A16 Gene


neXtProt entry for SLC6A16 Gene

Post-translational modifications for SLC6A16 Gene

  • Glycosylation at isoforms=2229
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC6A16 Gene

Domains & Families for SLC6A16 Gene

Gene Families for SLC6A16 Gene


Protein Domains for SLC6A16 Gene


Suggested Antigen Peptide Sequences for SLC6A16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A16 subfamily.
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A16 subfamily.
genes like me logo Genes that share domains with SLC6A16: view

Function for SLC6A16 Gene

Gene Ontology (GO) - Molecular Function for SLC6A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005326 neurotransmitter transporter activity NAS 11112352
GO:0005328 neurotransmitter:sodium symporter activity IEA --
GO:0015171 amino acid transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC6A16: view
genes like me logo Genes that share phenotypes with SLC6A16: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC6A16

CRISPR Products

miRNA for SLC6A16 Gene

miRTarBase miRNAs that target SLC6A16

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC6A16 Gene

Localization for SLC6A16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A16 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC6A16 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC6A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 11112352
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC6A16: view

Pathways & Interactions for SLC6A16 Gene

SuperPathways for SLC6A16 Gene

SuperPathway Contained pathways
1 NRF2 pathway
genes like me logo Genes that share pathways with SLC6A16: view

Pathways by source for SLC6A16 Gene

1 BioSystems pathway for SLC6A16 Gene

Gene Ontology (GO) - Biological Process for SLC6A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IEA --
GO:0006810 transport IEA --
GO:0006836 neurotransmitter transport NAS,IEA 11112352
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC6A16: view

No data available for SIGNOR curated interactions for SLC6A16 Gene

Drugs & Compounds for SLC6A16 Gene

(1) Additional Compounds for SLC6A16 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC6A16: view

Transcripts for SLC6A16 Gene

Unigene Clusters for SLC6A16 Gene

Solute carrier family 6, member 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A16 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - -
SP2: - -
SP4: - -

Relevant External Links for SLC6A16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC6A16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC6A16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC6A16 Gene

This gene is overexpressed in Testis (x16.1).

Protein differential expression in normal tissues from HIPED for SLC6A16 Gene

This gene is overexpressed in Testis (39.0) and Spleen (30.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC6A16 Gene

Protein tissue co-expression partners for SLC6A16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC6A16 Gene:


SOURCE GeneReport for Unigene cluster for SLC6A16 Gene:


mRNA Expression by UniProt/SwissProt for SLC6A16 Gene:

Tissue specificity: Highly expressed in peripheral tissues, particularly in testis, pancreas, and prostate.
genes like me logo Genes that share expression patterns with SLC6A16: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC6A16 Gene

Orthologs for SLC6A16 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC6A16 34 35
  • 99.23 (n)
(Canis familiaris)
Mammalia SLC6A16 34 35
  • 77.28 (n)
(Bos Taurus)
Mammalia SLC6A16 34 35
  • 75.08 (n)
(Mus musculus)
Mammalia Slc6a16 34 16 35
  • 67.09 (n)
(Rattus norvegicus)
Mammalia Slc6a16 34
  • 67 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 49 (a)
-- 35
  • 36 (a)
(Monodelphis domestica)
Mammalia SLC6A16 35
  • 34 (a)
(Anolis carolinensis)
Reptilia SLC6A16 35
  • 36 (a)
(Danio rerio)
Actinopterygii SLC6A16 (2 of 2) 35
  • 34 (a)
SLC6A16 (1 of 2) 35
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43066 35
  • 27 (a)
CG10804 35
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3644 35
  • 33 (a)
-- 35
  • 30 (a)
Species where no ortholog for SLC6A16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC6A16 Gene

Gene Tree for SLC6A16 (if available)
Gene Tree for SLC6A16 (if available)

Paralogs for SLC6A16 Gene

Paralogs for SLC6A16 Gene

genes like me logo Genes that share paralogs with SLC6A16: view

Variants for SLC6A16 Gene

Sequence variations from dbSNP and Humsavar for SLC6A16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000045942 -- 49,331,368(+) TTGTA(G/T)ACAGG intron-variant, upstream-variant-2KB
rs1000065054 -- 49,324,608(+) TCACA(C/T)TACCT intron-variant
rs1000285092 -- 49,289,551(+) CTGCC(A/G)TCATG downstream-variant-500B
rs1000305843 -- 49,296,350(+) TTTGG(A/G)AAAAA intron-variant
rs1000362798 -- 49,304,699(+) TGTTC(A/G)ATGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC6A16 Gene

Variant ID Type Subtype PubMed ID
dgv52n68 CNV loss 17160897
esv2658176 CNV deletion 23128226
esv3348764 CNV insertion 20981092
esv3644620 CNV loss 21293372
esv3644621 CNV loss 21293372
nsv474708 CNV novel sequence insertion 20440878
nsv9739 CNV gain+loss 18304495

Variation tolerance for SLC6A16 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC6A16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC6A16 Gene

Disorders for SLC6A16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC6A16 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 11
  • rp11
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC6A16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC6A16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC6A16 Gene

Publications for SLC6A16 Gene

  1. Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na(+)/Cl(-)-dependent neurotransmitter transporter gene family. (PMID: 11112352) Farmer M.K. … Pangalos M.N. (Genomics 2000) 2 3 4 64
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  3. Neurotransmitter transporters in the central nervous system. (PMID: 10471414) Masson J. … El Mestikawy S. (Pharmacol. Rev. 1999) 2 3 64
  4. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I. … Futreal P.A. (Nature 2011) 4 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for SLC6A16 Gene

Sources for SLC6A16 Gene

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