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GIFtS

SLC6A15 Gene

protein-coding   GIFtS: 54
GCID: GC12M085253

solute carrier family 6 (neutral amino acid transporter),...

(Previous names: solute carrier family 6 (neurotransmitter transporter),...)
 Explore 2 diseases affiliated with
SLC6A15 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC6A15    

Aliases
for SLC6A15 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 151 2     Transporter V7-32 3
NTT731 2 3     FLJ103161
SBAT11 2 3     Homolog Of Rat Orphan Transporter V7-32
V7-31 2     Orphan Sodium- And Chloride-Dependent Neurotransmitter Transporter NTT732
Hv7-31     Orphan Transporter V7-32
Solute Carrier Family 6 (Neurotransmitter Transporter), Member 151 2     Sodium-Dependent Neutral Amino Acid Transporter B(0)AT22
Sodium- And Chloride-Dependent Neurotransmitter Transporter NTT732 3     Sodium/Chloride Dependent Neurotransmitter Transporter Homo Sapiens Orphan
Neurotransmitter Transporter NTT72
Sodium-Coupled Branched-Chain Amino-Acid Transporter 12 3     Solute Carrier Family 6, Member 152
Solute Carrier Family 6 Member 152 3     B0AT23

External Ids:    HGNC: 136211   Entrez Gene: 551172   Ensembl: ENSG000000720417   OMIM: 6079715   UniProtKB: Q9H2J73   

Export aliases for SLC6A15 gene to outside databases

Previous GC identifers: GC00U990834 GC12M083757 GC12M083756 GC12M082310


Summaries
for SLC6A15 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC6A15:
This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The
encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with
major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: S6A15_HUMAN, Q9H2J7
Function: Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain
amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and
electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for
neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family,
does not appear to be chloride-dependent

Gene Wiki entry for SLC6A15


Genomic Views
for SLC6A15 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC6A15 gene promoter:
         HFH-3   USF1   USF2   USF-1:USF-2   CREB   FOXI1   POU2F1   deltaCREB   POU2F1a   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC6A15 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC6A15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC6A15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.3   Ensembl cytogenetic band:  12q21.31   HGNC cytogenetic band: 12q21.3

SLC6A15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC6A15 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M085253:  view genomic region     (about GC identifiers)

Start:
 85,253,267 bp from pter      End:
 85,307,394 bp from pter
Size:
 54,128 bases      Orientation:
 minus strand

Proteins
for SLC6A15 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S6A15_HUMAN, Q9H2J7 (See protein sequence)
Recommended Name: Sodium-dependent neutral amino acid transporter B(0)AT2  
Size: 730 amino acids; 81836 Da
Subcellular location: Membrane; Multi-pass membrane protein (Probable)
Secondary accessions: A8K592 B7Z2P7 E7ESJ5 Q9H9F5
Alternative splicing: 3 isoforms:  Q9H2J7-1   Q9H2J7-2   Q9H2J7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC6A15: NX_Q9H2J7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H2J7

    • SLC6A15 Protein expression data from MOPED and PaxDb:    About this image 
    SLC6A15 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001139807.1  NP_060527.2  NP_877499.1  

    ENSEMBL proteins: 
     ENSP00000311645   ENSP00000266682   ENSP00000450145   ENSP00000447728   ENSP00000448410  
     ENSP00000449619   ENSP00000449263   ENSP00000390706   ENSP00000448308  
    Reactome Protein details: Q9H2J7
    Human Recombinant Protein Products for SLC6A15: 
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    Novus Biologicals SLC6A15 Protein
    Novus Biologicals SLC6A15 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC6A15

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0016021integral to membrane NAS11112352

    SLC6A15 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC6A15

    Protein Domains /
    Families
    for SLC6A15 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC6A15 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000175 Na/ntran_symport
     IPR002438 Na/ntran_symport_orphan

    Graphical View of Domain Structure for InterPro Entry Q9H2J7

    ProtoNet protein and cluster: Q9H2J7

    1 Blocks protein family: IPB002438 Orphan neurotransmitter transporter signature

    UniProtKB/Swiss-Prot: S6A15_HUMAN, Q9H2J7
    Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily


    Function
    for SLC6A15 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S6A15_HUMAN, Q9H2J7
    Function: Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain
    amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and
    electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for
    neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family,
    does not appear to be chloride-dependent
    Biophysicochemical properties: Kinetic parameters: KM=0.16 mM for L-leucine (at pH 7.5, 100 mM NaCL, -70 mV); KM=0.16
    mM for L-valine (at pH 7.5, 100 mM NaCL, -70 mV)); KM=0.08 mM for L-isoleucine (at pH 7.5, 100 mM NaCL, -70 mV);
    KM=0.11 mM for L-methionine (at pH 7.5, 100 mM NaCL, -70 mV); KM=0.38 mM for L-proline (at pH 7.5, 100 mM NaCL, -70
    mV); pH dependence: Optimum pH is 7.5-8.5. Strongly inhibited at acidic PH;

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005298proline:sodium symporter activity IEA--
    GO:0005326neurotransmitter transporter activity NAS11112352
    GO:0005328neurotransmitter:sodium symporter activity IEA--
         
    SLC6A15 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Slc6a15):
     behavior/neurological  nervous system  reproductive system 

    SLC6A15 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for SLC6A15: Slc6a15tm1Uhl Slc6a15tm1Lex
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC6A15 

    miRNA
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    hsa-miR-520e hsa-miR-607 hsa-miR-1258 hsa-miR-3653 hsa-miR-30d hsa-miR-3161 hsa-miR-30a hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmid: SLC6A15 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for SLC6A15 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amino acid and oligopeptide SLC transporters
    		Amino acid and oligopeptide SLC transporters1.00
    		Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    		Amino acid transport across the plasma membrane0.63
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    3Amine compound SLC transporters
    		Amine compound SLC transporters1.00
    		Na+/Cl- dependent neurotransmitter transporters0.63

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for SLC6A15 (see all 8)
        Na+/Cl- dependent neurotransmitter transporters
    Amino acid transport across the plasma membrane
    Amine compound SLC transporters
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules



    SLC6A15 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC6A15

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC6A15 (ENSP000002666824) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006836neurotransmitter transport NAS11112352
    GO:0006865amino acid transport TAS--
    GO:0015804neutral amino acid transport IDA16226721
    GO:0015820leucine transport ISS--

    SLC6A15 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC6A15 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC6A15

    1 HMDB Compound for SLC6A15    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--
    Search CenterWatch for drugs/clinical trials and news about SLC6A15 / S6A15 

    Transcripts
    for SLC6A15 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC6A15 gene (3 alternative transcripts): 
    NM_001146335.2  NM_018057.6  NM_182767.5  

    Unigene Cluster for SLC6A15:

    Solute carrier family 6 (neutral amino acid transporter), member 15
    Hs.44424  [show with all ESTs]
    Unigene Representative Sequence: NM_182767
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309283 ENST00000266682(uc001szv.3 uc010sul.2) ENST00000552192
    ENST00000548267 ENST00000551818 ENST00000551388 ENST00000551612 ENST00000450363(uc001szy.3)
    ENST00000547240 ENST00000549540 ENST00000551010

    miRNA
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    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC6A15 (see all 74):
    hsa-miR-520e hsa-miR-607 hsa-miR-1258 hsa-miR-3653 hsa-miR-30d hsa-miR-3161 hsa-miR-30a hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmid: SLC6A15 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF265577.1 AF351619.1 AK001178.1 AK022853.1 AK291207.1 AK294945.1 AL050066.1 BC022253.1 
    BC070040.1 CR749673.1 

    5 DOTS entries:

    DT.307408  DT.97839618  DT.408582  DT.121215547  DT.121215584 

    24/74 AceView cDNA sequences (see all 74):

    CF529695 BM701139 BX109857 CR749673 N40589 AI275144 BM696062 BQ023730 
    CA391176 BC070040 CR613550 CF529868 AF265577 AL050066 AL583592 AI803656 
    AI368909 AI086395 NM_182767 NM_018057 CA398071 BQ011656 BX474329 AK001178 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A15 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
    SP1:                                                                          -                                                         
    SP2:                    -     -     -     -                                                                                             
    SP3:                                                                                                                                    
    SP4:        -           -     -                                                                                                         
    SP5:                    -     -     -     -     -     -     -     -           -                                                         


    ECgene alternative splicing isoforms for SLC6A15

    Expression
    for SLC6A15 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC6A15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGTTTTGAT
    SLC6A15 Expression
    About this image

    SLC6A15 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    BrainChoroid PlexusBrain
    BrainMedulla OblongataBrain
    Gut TubeMidgutGut Tube
    Neural TubeDiencephalic Roof PlateNeural Tube
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)

    See SLC6A15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC6A15

    SOURCE GeneReport for Unigene cluster: Hs.44424

    UniProtKB/Swiss-Prot: S6A15_HUMAN, Q9H2J7
    Tissue specificity: Almost exclusively expressed in the brain

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    Orthologs
    for SLC6A15 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLC6A15 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC6A151 solute carrier family 6 (neutral amino acid transporter), more 82.49(n)
    89.16(a)    		   417881  XM_416124.3  XP_416124.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC6A156
    		 --
    		 88(a)
    		 1 ↔ 1
    		 5(35069779-35095606)
    zebrafish
    (Danio rerio)    		 Actinopterygii slc6a151 solute carrier family 6 (neutral amino acid transporter), more 69.1(n)
    76.89(a)    		   565315  XM_688593.2  XP_693685.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea snf-66
    snf-126
    		 Sodium-dependent acetylcholine transporter
    Sodium:Neurotransmitter symporter Family family me...
    		 22(a)
    15(a)
    		 possible ortholog
    possible ortholog
    		 III(1520216-1532760)
    X(9029423-9033904)


    ENSEMBL Gene Tree for SLC6A15 (if available)
    TreeFam Gene Tree for SLC6A15 (if available) 

    Paralogs
    for SLC6A15 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC6A15 gene
    SLC6A202  SLC6A172  SLC6A182  SLC6A192  SLC6A162  
    18/20 SIMAP similar genes for SLC6A15 using alignment to 8 protein entries:     S6A15_HUMAN (see all proteins) (see all similar genes):
    DKFZp761I0921    SLC6A17    DAT1    SLC6A18    SLC6A20    SLC6A19
    SLC6A3    SLC6A11    SLC6A2    SLC6A4    SLC6A12    SLC6A9
    SLC6A1    SLC6A16    SLC6A8    SLC6A13    SLC6A5    SLC6A7

    SLC6A15 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC6A15
    PGOHUM00000234370


    Genomic Variants
    for SLC6A15 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1120 NCBI SNPs in SLC6A15 are shown (see all 1120)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1490850621,2
    		--85252779(+) ATAGCC/TAAGAT 2 -- int10--------
    rs1851840251,2
    		--85252807(+) GTCAAG/TCAATG 2 -- int10--------
    rs1448868421,2
    		--85252892(+) TGGAGG/TACATT 2 -- int10--------
    rs1387359141,2
    		--85253035(+) CGGGAA/GGAAGG 2 -- int10--------
    rs1419787201,2
    		--85253121(+) TGAAAA/GTAATA 2 -- int10--------
    rs1149332151,2
    		C,F--85253131(+) AGTTAA/GTAATA 2 -- int11Minor allele frequency- G:0.02WA 118
    rs1882624911,2
    		--85253204(+) ATGTAA/GCTATG 2 -- int10--------
    rs1927904901,2
    		--85253207(+) TAACTA/GTGGGA 2 -- int10--------
    rs1844176421,2
    		--85253222(+) ATGGAC/GAAGTT 2 -- int10--------
    rs1456527681,2
    		--85253251(+) TATGTA/CTATCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for SLC6A15 (85253267 - 85307394 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SLC6A15
         3 CNVs: 29925 29924 53198

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    Disorders / Diseases
    for SLC6A15 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC6A15 for disorders           About GeneDecksing

    OMIM gene information: 607971    OMIM disorders: --

    2 diseases for SLC6A15:    About MalaCards
    neuronitis    pneumonia

    Human Genome Epidemiology (HuGE) Navigator: SLC6A15 (1 document)

    Export disorders for SLC6A15 gene to outside databases

    Publications
    for SLC6A15 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC6A15 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with SLC6A15)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na(+)/Cl(-)-dependent neurotransmitter transporter gene family. (PubMed id 11112352)1, 2, 3 Farmer M.K.... Pangalos M.N. (2000)
    2. Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain. (PubMed id 16226721)1, 2, 9 Takanaga H....Hediger M.A. (2005)
    3. The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2). (PubMed id 16185194)1, 3 Broer A....Broer S. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Neurotransmitter transporters in the central nervous system. (PubMed id 10471414)1, 3 Masson J....El Mestikawy S. (1999)
    7. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    8. Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for SLC6A15 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing SLC6A15 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55117 HGNC: 13621 AceView: SLC6A15 Ensembl:ENSG00000072041 euGenes: HUgn55117
    ECgene: SLC6A15 H-InvDB: SLC6A15

    Other Databases showing SLC6A15 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC6A15 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC6A15 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC6A15 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC6A15 gene:
    Search GeneIP for patents involving SLC6A15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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