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SLC6A14 Gene

protein-coding   GIFtS: 59
GCID: GC0XP115481

Solute Carrier Family 6 (Amino Acid Transporter), Member...

(Previous names: solute carrier family 6 (neurotransmitter transporter),...)
  See SLC6A14-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 6 (Amino Acid Transporter), Member 141 2     Amino Acid Transporter B0+2
Solute Carrier Family 6 (Neurotransmitter Transporter), Member 141 2     Sodium- And Chloride-Dependent Neutral And Basic Amino Acid Transporter
B(0+)2
Amino Acid Transporter ATB0+2 3     Solute Carrier Family 6 Member 143
BMIQ112 5     OBX5

External Ids:    HGNC: 110471   Entrez Gene: 112542   Ensembl: ENSG000000879167   OMIM: 3004445   UniProtKB: Q9UN763   

Export aliases for SLC6A14 gene to outside databases

Previous GC identifers: GC0XP110424 GC0XP112654 GC0XP113582 GC0XP114351 GC0XP115379 GC0XP105105


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC6A14 Gene:
This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride
dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids.
This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked
obesity. A pseudogene of this gene is found on chromosome X.(provided by RefSeq, May 2010)

GeneCards Summary for SLC6A14 Gene:
SLC6A14 (solute carrier family 6 (amino acid transporter), member 14) is a protein-coding gene. Diseases associated with SLC6A14 include obesity bmiq11, and meconium ileus. GO annotations related to this gene include neurotransmitter:sodium symporter activity and amino acid transmembrane transporter activity. An important paralog of this gene is SLC6A6.

UniProtKB/Swiss-Prot: S6A14_HUMAN, Q9UN76
Function: Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline)
in a Na(+)/Cl(-)-dependent manner

Gene Wiki entry for SLC6A14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_028405.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC6A14 gene promoter:
         STAT1   STAT4   STAT1beta   NF-kappaB   STAT1alpha   POU2F1   POU2F1a   STAT2   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC6A14 promoter sequence
   Search Chromatin IP Primers for SLC6A14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC6A14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq23   Ensembl cytogenetic band:  Xq23   HGNC cytogenetic band: Xq23

SLC6A14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC6A14 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP115481:  view genomic region     (about GC identifiers)

Start:
115,567,747 bp from pter      End:
115,592,625 bp from pter
Size:
24,879 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S6A14_HUMAN, Q9UN76 (See protein sequence)
Recommended Name: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)  
Size: 642 amino acids; 72153 Da
Miscellaneous: Transport inhibited by BCH (2-aminobicyclo-[2.2.1]-heptane-2-carboxylic acid)
Secondary accessions: Q5H942

Explore the universe of human proteins at neXtProt for SLC6A14: NX_Q9UN76

Explore proteomics data for SLC6A14 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn155, Asn163, Asn174, Asn189, Asn197, Asn202, Asn230, Asn302
  • Modification sites at PhosphoSitePlus

  • See SLC6A14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009162.1  
    ENSEMBL proteins: 
     ENSP00000360967  
    Reactome Protein details: Q9UN76

    SLC6A14 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: ATB0,+
    Glycine transporter subfamily

    1 InterPro protein domain:
     IPR000175 Na/ntran_symport

    Graphical View of Domain Structure for InterPro Entry Q9UN76

    ProtoNet protein and cluster: Q9UN76

    UniProtKB/Swiss-Prot: S6A14_HUMAN, Q9UN76
    Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A14 subfamily


    Find genes that share domains with SLC6A14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S6A14_HUMAN, Q9UN76
    Function: Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline)
    in a Na(+)/Cl(-)-dependent manner

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005328neurotransmitter:sodium symporter activity IEA--
    GO:0015171amino acid transmembrane transporter activity TAS10446133
         
    Find genes that share ontologies with SLC6A14           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC6A14:
     Decreased Salmonella enterica   Lamellipodia cells 

         1 MGI phenotypic allele for Slc6a14 (no phenotypes)

    Find genes that share phenotypes with SLC6A14           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC6A14
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    miRNA
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    miRTarBase miRNAs that target SLC6A14:
    hsa-mir-26b-5p (MIRT030183)

    Block miRNA regulation of human, mouse, rat SLC6A14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC6A14 (see all 37):
    hsa-miR-548j hsa-miR-29a hsa-miR-374a hsa-miR-548l hsa-miR-186 hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidSLC6A14 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S6A14_HUMAN, Q9UN76: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0031526brush border membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with SLC6A14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC6A14 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Amino acid transport across the plasma membrane0.32
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Na+/Cl- dependent neurotransmitter transporters0.00


    Find genes that share SuperPaths with SLC6A14           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for SLC6A14
        Na+/Cl- dependent neurotransmitter transporters
    Amino acid transport across the plasma membrane


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC6A14
    Interactions:

        Search GeneGlobe Interaction Network for SLC6A14

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003333amino acid transmembrane transport TAS10446133
    GO:0006520cellular amino acid metabolic process TAS10446133
    GO:0006810transport TAS10446133
    GO:0006811ion transport TAS--
    GO:0006836neurotransmitter transport ----

    Find genes that share ontologies with SLC6A14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC6A14 (S6A14)

    1 HMDB Compound for SLC6A14    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    4 DrugBank Compounds for SLC6A14    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3target--17139284 17016423
    D-Serine-- 312-84-5transporter--11846403
    ValaciclovirValaciclovir Hcl (see all 6)124832-27-5transporter--15290873
    ValganciclovirCymeval (see all 2)175865-60-8transporter--15290873

    1 IUPHAR Ligand for SLC6A14 (ATB0,+)    About this table
    LigandTypeActionAffinityPubmed IDs
    alpha-methyl-D,L-tryptophan
    InhibitorInhibition3.618522536



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC6A14 gene: 
    NM_007231.4  

    Unigene Cluster for SLC6A14:

    Solute carrier family 6 (amino acid transporter), member 14
    Hs.522109  [show with all ESTs]
    Unigene Representative Sequence: NM_007231
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371900(uc011mtm.2 uc004eqi.3) ENST00000463626
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC6A14 (see all 37):
    hsa-miR-548j hsa-miR-29a hsa-miR-374a hsa-miR-548l hsa-miR-186 hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-23a
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC6A14
      QuantiFast Probe-based Assays in human, mouse, rat SLC6A14

    Additional mRNA sequence: 

    AF151978.1 AK304243.1 AK313390.1 BC093710.1 BC093712.1 

    1 DOTS entry:

    DT.40235975 

    Selected AceView cDNA sequences (see all 35):

    AA552658 BQ082831 BM856524 BX951397 BX642162 AF151978 BX951304 BQ311065 
    BU687102 BQ016954 BV184027 NM_007231 BU686768 AW192480 CA312866 CB122805 
    AW190954 BQ378136 AI669617 BE003214 BM826722 AA541466 AW812970 BQ311137 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A14    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                                                                          
    SP2:                                                                          -               


    ECgene alternative splicing isoforms for SLC6A14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC6A14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTCTACCA
    SLC6A14 Expression
    About this image


    SLC6A14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Lung (Respiratory System)
             Alveolar type II cells
    SLC6A14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC6A14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522109

    UniProtKB/Swiss-Prot: S6A14_HUMAN, Q9UN76
    Tissue specificity: Levels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels
    detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC6A14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC6A14 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc6a141 , 5 solute carrier family 6 (neurotransmitter transporter), more1, 5 87.98(n)1
    89.5(a)1
      X (16.78 cM)5
    567741  NM_020049.41  NP_064433.31 
     217148965 
    chicken
    (Gallus gallus)
    Aves SLC6A141 solute carrier family 6 (amino acid transporter), member more 71.14(n)
    74.09(a)
      100857521  XM_003641135.2  XP_003641183.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC6A146
    solute carrier family 6 (amino acid transporter), ...
    70(a)
    1 ↔ 1
    GL343403.1(425345-458478)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.234712 Xenopus laevis transcribed sequence with weak similarity more 74.15(n)    BU900196.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc6a141 solute carrier family 6 (amino acid transporter), member more 63.66(n)
    65.65(a)
      100150665  XM_001923561.3  XP_001923596.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55493 glycine:sodium symporter 43(a)
    (best of 4)
        --


    ENSEMBL Gene Tree for SLC6A14 (if available)
    TreeFam Gene Tree for SLC6A14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC6A14 gene
    SLC6A62  SLC6A112  SLC6A122  SLC6A82  SLC6A52  SLC6A32  SLC6A12  SLC6A42  
    SLC6A132  SLC6A22  SLC6A72  SLC6A92  
    18 SIMAP similar genes for SLC6A14 using alignment to 1 protein entry:     S6A14_HUMAN:
    SLC6A5    SLC6A7    SLC6A4    SLC6A2    SLC6A1    SLC6A12
    SLC6A3    SLC6A9    SLC6A11    SLC6A13    SLC6A8    SLC6A6
    SLC6A18    DKFZp761I0921    SLC6A15    SLC6A17    SLC6A19    SLC6A20

    Find genes that share paralogs with SLC6A14           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for SLC6A14
    PGOHUM00000240281 PGOHUM00000241508 PGOHUM00000241964


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC6A14 (see all 439)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828332281,2
    --105115062(-) TTTCAC/TAGGGT 1 -- int10--------
    rs39655551,2
    C,A--105115172(-) ACCAAC/AAATTA 1 -- int12Minor allele frequency- A:0.00NA CSA 3
    rs23350181,2
    C,F,A,H--105115199(-) TAAAAC/TATAAC 2 Y C mis111Minor allele frequency- N:0.00NS EA NA CSA 638
    rs1897661621,2
    --105115381(-) GGCATC/TTGCTT 1 -- int10--------
    rs1854563361,2
    --105115429(-) TGTTGC/TGAGCT 1 -- int10--------
    rs285819571,2
    C--105115471(-) ATATCG/CTAGTG 1 -- int13Minor allele frequency- C:0.00NA 5
    rs1809374041,2
    --105115650(-) TCAACA/TTGCAG 1 -- int10--------
    rs1458401051,2
    C--105115679(-) TTATCC/TAATAA 1 -- int10--------
    rs1918790601,2
    --105115995(-) TGTAGC/TACACT 1 -- int10--------
    rs1439085171,2
    --105116004(-) CATACC/TATCTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for SLC6A14 (115567747 - 115592625 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC6A14:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv438153CNV Loss16468122
    nsv526428CNV Gain19592680
    dgv526n21CNV Gain19592680
    nsv523582CNV Gain19592680
    nsv527804CNV Gain19592680

    Human Gene Mutation Database (HGMD): SLC6A14
    Locus Specific Mutation Databases (LSDB): SLC6A14

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC6A14
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC6A14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300444   
    OMIM disorders: 300306  
    UniProtKB/Swiss-Prot: S6A14_HUMAN, Q9UN76
  • Note=Genetic variations in SLC6A14 may be associated with obesity in some populations, as shown by
    significant differences in allele frequencies between obese and non-obese individuals

  • 5 diseases for SLC6A14:    
    About MalaCards
    obesity bmiq11    meconium ileus    ileus    autism spectrum disorder
    obesity


    Find genes that share disorders with SLC6A14           About GenesLikeMe

    Genetic Association Database (GAD): SLC6A14
    Human Genome Epidemiology (HuGE) Navigator: SLC6A14 (8 documents)

    Export disorders for SLC6A14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SLC6A14 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with SLC6A14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The SLC6A14 gene shows evidence of association with obesity. (PubMed id 14660752)1, 2, 4, 9 Suviolahti E.... Pajukanta P. (J. Clin. Invest. 2003)
    2. Cloning and functional expression of a human Na(+) and Cl(-)- dependent neutral and cationic amino acid transporter B(0+). (PubMed id 10446133)1, 2, 3 Sloan J.L. and Mager S. (J. Biol. Chem. 1999)
    3. Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study. (PubMed id 19876004)1, 4 Corpeleijn E....Blaak E.E. (Obesity (Silver Spring) 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    6. Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians. (PubMed id 15331564)1, 4 Durand E....Froguel P. (Diabetes 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Human solute carrier SLC6A14 is the beta-alanine carrier. (PubMed id 18599538)1, 9 Anderson C.M....Thwaites D.T. (J. Physiol. (Lond.) 2008)
    9. Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis. (PubMed id 22466613)1 Sun L....Strug L.J. (Nat. Genet. 2012)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 11254 HGNC: 11047 AceView: SLC6A14 Ensembl:ENSG00000087916 euGenes: HUgn11254
    ECgene: SLC6A14 H-InvDB: SLC6A14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC6A14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC6A14 gene:
    Search GeneIP for patents involving SLC6A14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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