Aliases for SLC6A13 Gene
- Solute Carrier Family 6 (Neurotransmitter Transporter), Member 13 2 3
- GAT2 3 4 6
- Solute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 13 2 3
- GABA Transporter 2 2 3
- GAT-2 3 4
- GAT3 3 6
- Sodium- And Chloride-Dependent GABA Transporter 2 3
- Solute Carrier Family 6 Member 13 4
- GABA Transport Protein 3
External Ids for SLC6A13 Gene
GeneCards Summary for SLC6A13 Gene
SLC6A13 (Solute Carrier Family 6 (Neurotransmitter Transporter), Member 13) is a Protein Coding gene. Diseases associated with SLC6A13 include schizophrenia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transmission across Chemical Synapses. GO annotations related to this gene include neurotransmitter:sodium symporter activity and gamma-aminobutyric acid:sodium symporter activity. An important paralog of this gene is SLC6A4.
UniProtKB/Swiss-Prot for SLC6A13 Gene
Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport.
GABA transporters are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) that mediate the rapid removal of GABA and maintain low extracellular levels. Four 12-TM domain transporters (GAT-1, GAT-2, GAT-3 and BGT-1) have been identified and localized to neurons and glia. While GAT-1, GAT-2, GAT-3 and BGT-1 bind GABA with varying affinities, they share structural motifs including 12-TM domains, extracellular glycosylation sites and intracellular consensus sites for phosphorylation. A vesicular transporter (VGAT) has also been identified. This member of the SCL32 family is both structurally and functionally distinct, containing 10-TM domains and being found in GABAergic and glycinergic neurons. Some anticonvulsants have been reported to act upon the GABA transporters. There is evidence to suggest that GABA transporters are linked to epilepsy, affective disorders and schizophrenia.