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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC6A11 Gene

protein-coding   GIFtS: 56
GCID: GC03P010857

solute carrier family 6 (neurotransmitter transporter, GABA),...
 Explore 12 diseases affiliated with
SLC6A11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC6A11    

Aliases
for SLC6A11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 111 2     GAT42 5
GAT31 2 3 5     Sodium- And Chloride-Dependent GABA Transporter 32
Solute Carrier Family 6 Member 112 3     GABT33
GAT-32 3     

External Ids:    HGNC: 110441   Entrez Gene: 65382   Ensembl: ENSG000001321647   OMIM: 6079525   UniProtKB: P480663   

Export aliases for SLC6A11 gene to outside databases

Previous GC identifers: GC03P010787 GC03P010832 GC03P010792


Summaries
for SLC6A11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC6A11:
Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABAergic neurotransmission is terminated by the
uptake of GABA into the presynaptic terminal and the surrounding astroglial cells by sodium-dependent transporters,
such as SLC6A11 (Borden et al., 1994 (PubMed 7874447)).(supplied by OMIM, Nov 2010)

UniProtKB/Swiss-Prot: S6A11_HUMAN, P48066
Function: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals

summary for SLC6A11:
GABA transporters are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) that
mediate the rapid removal of GABA and maintain low extracellular levels. Four 12-TM domain transporters
(GAT-1, GAT-2, GAT-3 and BGT-1) have been identified and localized to neurons and glia. While GAT-1, GAT-2,
GAT-3 and BGT-1 bind GABA with varying affinities, they share structural motifs including 12-TM domains,
extracellular glycosylation sites and intracellular consensus sites for phosphorylation. A vesicular
transporter (VGAT) has also been identified. This member of the SCL32 family is both structurally and
functionally distinct, containing 10-TM domains and being found in GABAergic and glycinergic neurons. Some
anticonvulsants have been reported to act upon the GABA transporters. There is evidence to suggest that GABA
transporters are linked to epilepsy, affective disorders and schizophrenia.




Genomic Views
for SLC6A11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC6A11 gene promoter:
         Lmo2   Pax-2a   C/EBPalpha   HNF-4alpha1   Meis-1b   PPAR-gamma1   Meis-1a   PPAR-gamma2   Meis-1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC6A11 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC6A11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC6A11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.3

SLC6A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC6A11 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P010857:  view genomic region     (about GC identifiers)

Start:
 10,857,885 bp from pter      End:
 10,982,419 bp from pter
Size:
 124,535 bases      Orientation:
 plus strand

Proteins
for SLC6A11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S6A11_HUMAN, P48066 (See protein sequence)
Recommended Name: Sodium- and chloride-dependent GABA transporter 3  
Size: 632 amino acids; 70606 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B2R6U6

Explore the universe of human proteins at neXtProt for SLC6A11: NX_P48066

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P48066

    • SLC6A11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055044.1  
    ENSEMBL proteins: 
     ENSP00000254488   ENSP00000404120  
    Reactome Protein details: P48066
    Human Recombinant Protein Products: 
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    Novus Biologicals SLC6A11 Proteins
    Novus Biologicals SLC6A11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC6A11

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0016021integral to membrane TAS1400419


    SLC6A11 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC6A11

    Protein Domains /
    Families
    for SLC6A11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC6A11 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000175 Na/ntran_symport
     IPR002982 Na/ntran_symport_GABA_GAT3

    Graphical View of Domain Structure for InterPro Entry P48066

    ProtoNet protein and cluster: P48066

    1 Blocks protein family: IPB002982 GAT-3 GABA neurotransmitter transporter signature

    UniProtKB/Swiss-Prot: S6A11_HUMAN, P48066
    Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily


    Function
    for SLC6A11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S6A11_HUMAN, P48066
    Function: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals

    miRNA
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    hsa-miR-579
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for SLC6A11

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC6A11

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005328neurotransmitter:sodium symporter activity IEA--
    GO:0005332gamma-aminobutyric acid:sodium symporter activity IEA--
    GO:0042165neurotransmitter binding IEA--


    SLC6A11 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLC6A11:
     Increased gamma-H2AX phosphory 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc6a11):
     behavior/neurological  mortality/aging  nervous system 

    SLC6A11 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC6A11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    2GABA synthesis, release, reuptake and degradation
    		GABA synthesis, release, reuptake and degradation1.00
    		Neurotransmitter Release Cycle0.53
    3Transmission across Chemical Synapses
    		Transmission across Chemical Synapses1.00
    		Neuronal System0.67
    4Amine compound SLC transporters
    		Amine compound SLC transporters1.00
    		Na+/Cl- dependent neurotransmitter transporters0.63
    5Reuptake of GABA
    		Reuptake of GABA1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SLC6A11
        GABA signaling in brain


    5/10        Reactome Pathways for SLC6A11 (see all 10)
        Transmission across Chemical Synapses
    GABA synthesis, release, reuptake and degradation
    Na+/Cl- dependent neurotransmitter transporters
    Amine compound SLC transporters
    Neurotransmitter Release Cycle

    1 PharmGKB Pathway for SLC6A11
        Benzodiazepine Pathway, Pharmacodynamics


    SLC6A11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC6A11

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006836neurotransmitter transport ----
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0007420brain development IEA--
    GO:0042493response to drug IEA--


    SLC6A11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC6A11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC6A11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SLC6A11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Riluzole hydrochlorideGlutamate release inhibitor/GABA uptake inhibitor[1744-22-5]
    (±)-Nipecotic acidGABA uptake inhibitor[60252-41-7]
    beta-Alanine Endogenous glycine agonist, more selective than taurine (Cat. No. 0209) [107-95-9]
    SKF 89976A hydrochloridePotent GABA uptake inhibitor. Penetrates blood brain barrier[85375-15-1]
    (S)-SNAP 5114GABA uptake inhibitor[157604-55-2]

    1 HMDB Compound for SLC6A11    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--
    4 Novoseek chemical compound relationships for SLC6A11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tiagabine 79.6 1 7935337 (1)
    gaba 77 27 7935337 (4), 7854065 (2), 11824941 (1), 12196583 (1) (see all 16)
    beta-alanine 71.5 3 7499392 (2), 19703969 (1)
    glutamate 27.7 4 10025773 (1), 15269970 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC6A11 / S6A11 

    Transcripts
    for SLC6A11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC6A11 gene: 
    NM_014229.1  

    Unigene Cluster for SLC6A11:

    Solute carrier family 6 (neurotransmitter transporter, GABA), member 11
    Hs.657405  [show with all ESTs]
    Unigene Representative Sequence: BC036083
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254488(uc003bvz.3) ENST00000454147(uc003bvy.1) ENST00000464828


    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate SLC6A11:
    hsa-miR-579
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC6A11 (see all 7)
    OriGene shRNA RFP: SLC6A11
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK312719.1 BC036083.1 S75989.1 

    2 DOTS entries:

    DT.102827257  DT.99943028 

    24/30 AceView cDNA sequences (see all 30):

    CD625390 NM_014229 CD625388 CD625392 S75989 AW162113 CD625378 BC036083 
    CD625396 F05686 BX490582 AW160496 CD625386 CD625394 CD625381 BE720229 
    CD625379 CD625384 BM930014 CD625374 H10775 CD625376 Z38635 AU098988 

    GeneLoc Exon Structure


    Expression
    for SLC6A11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC6A11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC6A11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC6A11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC6A11

    SOURCE GeneReport for Unigene cluster: Hs.657405

    UniProtKB/Swiss-Prot: S6A11_HUMAN, P48066
    Tissue specificity: Widespread distribution in the brain

        SABiosciences Expression via Pathway-Focused PCR Array including SLC6A11: 
              GABA & Glutamate in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC6A11

    Orthologs
    for SLC6A11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLC6A11 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC6A111 solute carrier family 6 (neurotransmitter transporter, more 76.56(n)
    89.84(a)    		   415959  XM_414302.3  XP_414302.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC6A116
    		 --
    		 91(a)
    		 1 ↔ 1
    		 2(157203820-157344310)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01071681.16
    		 --
    		 82(a)
    		 1 ↔ 1
    		 11(1090557-1119600)
    worm
    (Caenorhabditis elegans)    		 Secernentea snf-113 Na(+)/Cl(-)-dependent GABA transporter 48(a)
    (best of 7)    		   V(11307950-11311658)   --


    ENSEMBL Gene Tree for SLC6A11 (if available)
    TreeFam Gene Tree for SLC6A11 (if available) 

    Paralogs
    for SLC6A11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC6A11 gene
    SLC6A62  SLC6A122  SLC6A142  SLC6A52  SLC6A82  SLC6A12  SLC6A32  SLC6A132  
    SLC6A42  SLC6A22  SLC6A72  SLC6A92  
    18/19 SIMAP similar genes for SLC6A11 using alignment to 2 protein entries:     S6A11_HUMAN (see all proteins) (see all similar genes):
    SLC6A12    SLC6A13    SLC6A6    SLC6A1    SLC6A8    SLC6A3
    SLC6A5    SLC6A7    SLC6A9    SLC6A15    SLC6A2    SLC6A4
    SLC6A14    DKFZp761I0921    SLC6A17    SLC6A19    SLC6A16    SLC6A18

    SLC6A11 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC6A11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2218 NCBI SNPs in SLC6A11 are shown (see all 2218)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1452333171,2
    		--10855967(+) CCTACC/TGAGGC 1 -- us2k10--------
    rs1883599091,2
    		--10856000(+) GTGAGA/GTCAGA 1 -- us2k10--------
    rs1899851121,2
    		--10856110(+) TTCAGC/TATAGT 1 -- us2k10--------
    rs1424349531,2
    		--10856162(+) CTAGGC/TAGCAC 1 -- us2k10--------
    rs1829236021,2
    		--10856259(+) AACCAC/GAGAAG 1 -- us2k10--------
    rs1872204971,2
    		--10856388(+) GGATGG/TAAAAG 1 -- us2k10--------
    rs1920742621,2
    		--10856577(+) GAAGAC/TGGTGG 1 -- us2k10--------
    rs1459121631,2
    		--10856683(+) TCAAAA/GCAAGG 1 -- us2k10--------
    rs25812191,2
    		C,F,A,H,--10856773(-) CTGGAG/AAAGTC 1 -- us2k125Minor allele frequency- A:0.18NS EA NA WA CSA 2236
    rs1842025561,2
    		--10857015(+) GAAGAC/TGGACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC6A11 (10857885 - 10982419 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SLC6A11
         1 Indel: 91185
    Human Gene Mutation Database (HGMD): SLC6A11

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    Disorders / Diseases
    for SLC6A11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC6A11 for disorders           About GeneDecksing

    OMIM gene information: 607952    OMIM disorders: --

    12 diseases for SLC6A11:    About MalaCards
    meconium aspiration syndrome    temporal lobe epilepsy    pulmonary valve insufficiency    tardive dyskinesia
    secondary hyperparathyroidism    neuronitis    schizophrenia    hyperparathyroidism
    seizures    hypertension    cerebritis    alcoholism

    1 disease from the University of Copenhagen DISEASES database for SLC6A11:
    Pulmonary valve insufficiency
    Human Genome Epidemiology (HuGE) Navigator: SLC6A11 (9 documents)

    Export disorders for SLC6A11 gene to outside databases

    Publications
    for SLC6A11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC6A11 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with SLC6A11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. (PubMed id 7874447)1, 2, 3 Borden L.A.... Weinshank R.L. (1994)
    2. Genome-wide association analysis implicates the involv ement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PubMed id 22491018)1 Wang J....Platt A. (2012)
    3. Association of a synonymous GAT3 polymorphism with ant iepileptic drug pharmacoresistance. (PubMed id 21776001)1 Kim D.U....Lee M.C. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1 Yokoyama K....Hosoya T. (2010)
    6. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1 Tabakoff B....Hoffman P.L. (2009)
    7. Substrate-Na+ complex formation: coupling mechanism f or gamma-aminobutyrate symporters. (PubMed id 19450549)1 PallA^ A....Kardos J. (2009)
    8. Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia. (PubMed id 18334916)1 Inada T....Arinami T. (2008)
    9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1 GratacA^s M....Carracedo A. (2008)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    External Searches for SLC6A11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing SLC6A11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6538 HGNC: 11044 AceView: SLC6A11 Ensembl:ENSG00000132164 euGenes: HUgn6538
    ECgene: SLC6A11 H-InvDB: SLC6A11

    Other Databases showing SLC6A11 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC6A11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC6A11 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC6A11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC6A11 gene:
    Search GeneIP for patents involving SLC6A11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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