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Aliases for SLC6A11 Gene

Aliases for SLC6A11 Gene

  • Solute Carrier Family 6 (Neurotransmitter Transporter), Member 11 2 3
  • GAT3 3 4 6
  • Solute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 11 2 3
  • Solute Carrier Family 6 Member 11 3 4
  • GABA Transporter 3 2 3
  • GAT-3 3 4
  • GAT4 3 6
  • Sodium- And Chloride-Dependent GABA Transporter 3 3
  • GABT3 4

External Ids for SLC6A11 Gene

Previous GeneCards Identifiers for SLC6A11 Gene

  • GC03P010787
  • GC03P010832
  • GC03P010792

Summaries for SLC6A11 Gene

Entrez Gene Summary for SLC6A11 Gene

  • Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABAergic neurotransmission is terminated by the uptake of GABA into the presynaptic terminal and the surrounding astroglial cells by sodium-dependent transporters, such as SLC6A11 (Borden et al., 1994 [PubMed 7874447]).[supplied by OMIM, Nov 2010]

GeneCards Summary for SLC6A11 Gene

SLC6A11 (Solute Carrier Family 6 (Neurotransmitter Transporter), Member 11) is a Protein Coding gene. Diseases associated with SLC6A11 include pulmonary valve insufficiency and meconium aspiration syndrome. Among its related pathways are Metabolism and Metabolism of amino acids and derivatives. GO annotations related to this gene include neurotransmitter:sodium symporter activity and gamma-aminobutyric acid:sodium symporter activity. An important paralog of this gene is SLC6A4.

UniProtKB/Swiss-Prot for SLC6A11 Gene

  • Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals

Tocris Summary for SLC6A11 Gene

  • GABA transporters are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) that mediate the rapid removal of GABA and maintain low extracellular levels. Four 12-TM domain transporters (GAT-1, GAT-2, GAT-3 and BGT-1) have been identified and localized to neurons and glia. While GAT-1, GAT-2, GAT-3 and BGT-1 bind GABA with varying affinities, they share structural motifs including 12-TM domains, extracellular glycosylation sites and intracellular consensus sites for phosphorylation. A vesicular transporter (VGAT) has also been identified. This member of the SCL32 family is both structurally and functionally distinct, containing 10-TM domains and being found in GABAergic and glycinergic neurons. Some anticonvulsants have been reported to act upon the GABA transporters. There is evidence to suggest that GABA transporters are linked to epilepsy, affective disorders and schizophrenia.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A11 Gene

Genomics for SLC6A11 Gene

Regulatory Elements for SLC6A11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC6A11 Gene

10,816,200 bp from pter
10,940,733 bp from pter
124,534 bases
Plus strand

Genomic View for SLC6A11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC6A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A11 Gene

Proteins for SLC6A11 Gene

  • Protein details for SLC6A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium- and chloride-dependent GABA transporter 3
    Protein Accession:
    Secondary Accessions:
    • B2R6U6
    • Q8IYC9

    Protein attributes for SLC6A11 Gene

    632 amino acids
    Molecular mass:
    70606 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC6A11 Gene


neXtProt entry for SLC6A11 Gene

Proteomics data for SLC6A11 Gene at MOPED

Post-translational modifications for SLC6A11 Gene

  • Glycosylation at Asn187, Asn190, and Asn198
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC6A11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC6A11 Gene

Domains for SLC6A11 Gene

Gene Families for SLC6A11 Gene


Protein Domains for SLC6A11 Gene

Suggested Antigen Peptide Sequences for SLC6A11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily.
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily.
genes like me logo Genes that share domains with SLC6A11: view

Function for SLC6A11 Gene

Molecular function for SLC6A11 Gene

UniProtKB/Swiss-Prot Function:
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals

Gene Ontology (GO) - Molecular Function for SLC6A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004014 adenosylmethionine decarboxylase activity --
GO:0005328 neurotransmitter:sodium symporter activity IEA --
GO:0005332 gamma-aminobutyric acid:sodium symporter activity IEA --
GO:0042165 neurotransmitter binding IEA --
genes like me logo Genes that share ontologies with SLC6A11: view

Phenotypes for SLC6A11 Gene

genes like me logo Genes that share phenotypes with SLC6A11: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC6A11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC6A11 Gene

Localization for SLC6A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC6A11 Gene COMPARTMENTS Subcellular localization image for SLC6A11 gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC6A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane TAS 1400419
genes like me logo Genes that share ontologies with SLC6A11: view

Pathways for SLC6A11 Gene

genes like me logo Genes that share pathways with SLC6A11: view

Pathways by source for SLC6A11 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC6A11 Gene

Gene Ontology (GO) - Biological Process for SLC6A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006836 neurotransmitter transport --
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0007420 brain development IEA --
GO:0008295 spermidine biosynthetic process --
genes like me logo Genes that share ontologies with SLC6A11: view

Drugs for SLC6A11 Gene

(2) Drugbank Compounds for SLC6A11 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • 1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine
22316-47-8 2789 Transporter Other approved, illicit
498-96-4 Target inhibitor experimental

(5) Tocris Compounds for SLC6A11 Gene

Compound Action Cas Number
(S)-SNAP 5114 GABA uptake inhibitor [157604-55-2]
NNC 05-2090 hydrochloride GABA uptake inhibitor; moderately BGT-1 selective [184845-18-9]
NNC 711 Selective inhibitor of GAT-1 [145645-62-1]
SKF 89976A hydrochloride Potent GABA uptake inhibitor. Penetrates blood brain barrier [85375-15-1]
Tiagabine hydrochloride GABA uptake inhibitor; anticonvulsant [145821-59-6]

(1) HMDB Compounds for SLC6A11 Gene

Compound Synonyms Cas Number PubMed IDs
  • Sodium

(4) Novoseek inferred chemical compound relationships for SLC6A11 Gene

Compound -log(P) Hits PubMed IDs
tiagabine 79.6 1
gaba 77 20
beta-alanine 71.5 3
glutamate 27.7 2
genes like me logo Genes that share compounds with SLC6A11: view

Transcripts for SLC6A11 Gene

mRNA/cDNA for SLC6A11 Gene

Unigene Clusters for SLC6A11 Gene

Solute carrier family 6 (neurotransmitter transporter, GABA), member 11:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC6A11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A11 Gene

No ASD Table

Relevant External Links for SLC6A11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC6A11 Gene

mRNA expression in normal human tissues for SLC6A11 Gene

mRNA differential expression in normal tissues according to GTEx for SLC6A11 Gene

This gene is overexpressed in Brain - Substantia nigra (8.3), Brain - Hypothalamus (7.4), and Brain - Nucleus accumbens (basal ganglia) (5.7).

Protein differential expression in normal tissues for SLC6A11 Gene

This gene is overexpressed in Fetal Brain (32.1), Frontal cortex (11.2), and Retina (10.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC6A11 Gene

SOURCE GeneReport for Unigene cluster for SLC6A11 Gene Hs.657405

mRNA Expression by UniProt/SwissProt for SLC6A11 Gene

Tissue specificity: Widespread distribution in the brain
genes like me logo Genes that share expressions with SLC6A11: view

Expression partners for SLC6A11 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC6A11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC6A11 35
  • 90.21 (n)
  • 93.33 (a)
SLC6A11 36
  • 93 (a)
(Canis familiaris)
Mammalia SLC6A11 35
  • 91.27 (n)
  • 94.92 (a)
SLC6A11 36
  • 95 (a)
(Mus musculus)
Mammalia Slc6a11 35
  • 86.76 (n)
  • 94.26 (a)
Slc6a11 16
Slc6a11 36
  • 95 (a)
(Pan troglodytes)
Mammalia SLC6A11 35
  • 99.31 (n)
  • 99.52 (a)
SLC6A11 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Slc6a11 35
  • 87.29 (n)
  • 94.42 (a)
(Monodelphis domestica)
Mammalia SLC6A11 36
  • 91 (a)
(Gallus gallus)
Aves SLC6A11 35
  • 76.02 (n)
  • 89.35 (a)
SLC6A11 36
  • 90 (a)
(Anolis carolinensis)
Reptilia SLC6A11 36
  • 89 (a)
(Danio rerio)
Actinopterygii SLC6A11 36
  • 82 (a)
fruit fly
(Drosophila melanogaster)
Insecta BG:DS03431.1 37
  • 36 (a)
CG10804 37
  • 38 (a)
CG1698 37
  • 36 (a)
CG1732 37
  • 52 (a)
CG4476 37
  • 35 (a)
CG5549 37
  • 40 (a)
CG7075 37
  • 35 (a)
CG8850 37
  • 37 (a)
ine 37
  • 41 (a)
(Caenorhabditis elegans)
Secernentea snf-11 37
  • 48 (a)
snf-2 37
  • 32 (a)
snf-3 37
  • 39 (a)
snf-5 37
  • 28 (a)
snf-6 37
  • 30 (a)
snf-8 37
  • 23 (a)
snf-9 37
  • 31 (a)
Species with no ortholog for SLC6A11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC6A11 Gene

Gene Tree for SLC6A11 (if available)
Gene Tree for SLC6A11 (if available)

Paralogs for SLC6A11 Gene

Paralogs for SLC6A11 Gene

genes like me logo Genes that share paralogs with SLC6A11: view

Variants for SLC6A11 Gene

Sequence variations from dbSNP and Humsavar for SLC6A11 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs9859040 -- 10,817,254(+) GGGTC(C/T)GAGAG intron-variant
rs9855154 -- 10,908,227(+) ATGAA(A/C)AGTAT intron-variant
rs9855033 -- 10,840,689(+) GGTGA(C/T)GTTAG intron-variant
rs9851830 -- 10,864,934(+) CTGCT(C/G)CCCCC intron-variant
rs9851587 -- 10,864,935(+) TGCTG(A/C)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC6A11 Gene

Variant ID Type Subtype PubMed ID
dgv809e201 CNV Deletion 23290073
nsv436362 CNV Deletion 17901297
nsv436869 CNV Insertion 17901297
esv4117 CNV Complex 18987735
nsv876533 CNV Loss 21882294
nsv3696 CNV Insertion 18451855
esv2657761 CNV Deletion 23128226
nsv522643 CNV Loss 19592680

Relevant External Links for SLC6A11 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC6A11 Gene

Disorders for SLC6A11 Gene

(2) University of Copenhagen DISEASES for SLC6A11 Gene

Relevant External Links for SLC6A11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC6A11: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SLC6A11 Gene

Publications for SLC6A11 Gene

  1. Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. (PMID: 7874447) Borden L.A. … Weinshank R.L. (Recept. Channels 1994) 2 3 4
  2. Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia. (PMID: 18334916) Inada T. … Arinami T. (Pharmacogenet. Genomics 2008) 3 48
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48
  4. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PMID: 22491018) Wang J. … Platt A. (Pharmacogenomics J. 2013) 3 48
  5. Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B. … Hoffman P.L. (BMC Biol. 2009) 3 48

Products for SLC6A11 Gene

Sources for SLC6A11 Gene

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