Aliases for SLC6A1 Gene
External Ids for SLC6A1 Gene
Previous GeneCards Identifiers for SLC6A1 Gene
The protein encoded by this gene is a gamma-aminobutyric acid (GABA) transporter that localizes to the plasma membrane. The encoded protein removes GABA from the synaptic cleft, restoring it to presynaptic terminals. [provided by RefSeq, Jan 2017]
GeneCards Summary for SLC6A1 Gene
SLC6A1 (Solute Carrier Family 6 Member 1) is a Protein Coding gene. Diseases associated with SLC6A1 include Myoclonic-Atonic Epilepsy and Myoclonic-Astastic Epilepsy. Among its related pathways are GABAergic synapse and Neurotransmitter Release Cycle. GO annotations related to this gene include neurotransmitter:sodium symporter activity and gamma-aminobutyric acid:sodium symporter activity. An important paralog of this gene is SLC6A11.
UniProtKB/Swiss-Prot for SLC6A1 Gene
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
GABA transporters are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) that mediate the rapid removal of GABA and maintain low extracellular levels. Four 12-TM domain transporters have been identified and localized to neurons and glia.