Aliases for SLC6A1 Gene
External Ids for SLC6A1 Gene
Previous GeneCards Identifiers for SLC6A1 Gene
The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009]
GeneCards Summary for SLC6A1 Gene
SLC6A1 (Solute Carrier Family 6 Member 1) is a Protein Coding gene. Diseases associated with SLC6A1 include Myoclonic-Atonic Epilepsy and Myoclonic-Astastic Epilepsy. Among its related pathways are Circadian entrainment and Neurotransmitter Release Cycle. GO annotations related to this gene include neurotransmitter:sodium symporter activity and gamma-aminobutyric acid:sodium symporter activity. An important paralog of this gene is SLC6A13.
UniProtKB/Swiss-Prot for SLC6A1 Gene
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
GABA transporters are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) that mediate the rapid removal of GABA and maintain low extracellular levels. Four 12-TM domain transporters have been identified and localized to neurons and glia.