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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC5A9 Gene

protein-coding GIFtS: 49
GCID: GC01P048688

solute carrier family 5 (sodium/glucose cotransporter),...

Search for SLC5A9
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 9¹ ²
SGLT4¹ ² ³
Solute Carrier Family 5 Member 9² ³
HSGLT4¹
Na(+)/Glucose Cotransporter 4² ³
Sodium/Glucose Cotransporter 4²

External Ids:	HGNC: 22146¹	Entrez Gene: 200010²	Ensembl: ENSG00000117834⁷	UniProtKB: Q2M3M2³

Export aliases for SLC5A9 gene to outside databases

Previous GC identifers: GC01P048059 GC01P048400 GC01P046806

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SC5A9_HUMAN, Q2M3M2

Function: Involved in sodium-dependent transport of D-mannose, D-glucose and D-fructose

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC5A9 gene promoter:
AML1a MyoD NF-E2 p45 C/EBPalpha CHOP-10 HEN1 PPAR-gamma1 PPAR-gamma2 TGIF NF-E2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC5A9 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC5A9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC5A9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33 Ensembl cytogenetic band: 1p33 HGNC cytogenetic band: 1p33

SLC5A9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC5A9 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P048688: view genomic region (about GC identifiers)

Start:	48,688,357 bp from pter	End:	48,714,316 bp from pter
Size:	25,960 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SC5A9_HUMAN, Q2M3M2 (See protein sequence)

Recommended Name: Sodium/glucose cotransporter 4

Size: 681 amino acids; 74073 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Sequence caution: Sequence=CAI18915.1; Type=Erroneous gene model prediction;

Secondary accessions: B3KY87 B7ZL47 E9PAK4 Q5TET3

Alternative splicing: 2 isoforms: Q2M3M2-1 Q2M3M2-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC5A9: NX_Q2M3M2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q2M3M2

SLC5A9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001011547.2 NP_001128653.1

ENSEMBL proteins:

ENSP00000404982 ENSP00000431900 ENSP00000401730 ENSP00000236495 ENSP00000399991

ENSP00000431196 ENSP00000408881

Reactome Protein details: Q2M3M2
Human Recombinant Protein Products for SLC5A9:

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	Uscn Proteins for SLC5A9

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

SLC5A9 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC5A9 for domains About GeneDecksing

3 InterPro domains/families:

IPR019900 Na/solute_symporter_subgr

IPR018212 Na/solute_symporter_CS

IPR001734 Na/solute_symporter

Graphical View of Domain Structure for InterPro Entry Q2M3M2

ProtoNet protein and cluster: Q2M3M2

1 Blocks protein family: IPB001734 Na+/solute symporter

UniProtKB/Swiss-Prot: SC5A9_HUMAN, Q2M3M2

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SC5A9_HUMAN, Q2M3M2

Function: Involved in sodium-dependent transport of D-mannose, D-glucose and D-fructose

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	IEA	--

SLC5A9 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SLC5A9:

Increased cell number in G1, a

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC5A9

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A9

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SLC-mediated transmembrane transport

	SLC-mediated transmembrane transport	1.00			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.38
	Transmembrane transport of small molecules	0.50

Na+-dependent glucose transporters

Na+-dependent glucose transporters

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for SLC5A9

	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Na+-dependent glucose transporters

SLC5A9 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC5A9

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006814	sodium ion transport	IEA	--
GO:0055085	transmembrane transport	TAS	--

SLC5A9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC5A9

1 HMDB Compound for SLC5A9 About this table

Compound	Synonyms	CAS #	PubMed Ids
Sodium	Sodium (see all 2)	7440-23-5	--

Search CenterWatch for drugs/clinical trials and news about SLC5A9 / SC5A9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC5A9 gene (2 alternative transcripts):

NM_001011547.2 NM_001135181.1

Unigene Cluster for SLC5A9:

Solute carrier family 5 (sodium/glucose cotransporter), member 9

Hs.37890 [show with all ESTs]

Unigene Representative Sequence: NM_001135181

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000425816(uc010oms.1) ENST00000533824 ENST00000438567 ENST00000236495(uc001crn.2 uc001cro.2 uc010omt.1 uc010omu.1)

ENST00000493837(uc001crp.2) ENST00000441260 ENST00000527929 ENST00000525901

ENST00000532322 ENST00000471020(uc009vyt.1) ENST00000420136

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		hsa-miR-520d-5p hsa-let-7d hsa-miR-330-5p hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-326

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Additional cDNA sequence:

AK131200.1 AK311580.1 BC025411.1 BC104857.1 BC104863.1 BC143570.1 BC143572.1 BC143587.1

BX648549.1

5 DOTS entries:

DT.40260905 DT.97792523 DT.95298738 DT.40111855 DT.75111840

6 AceView cDNA sequences:

CA425537 BC032417 BU742383 BM718726 BI838281 AI917836

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A9 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17a	·	17b	^	18
SP1:									-																												-		-		-
SP2:									-		-																										-		-		-
SP3:
SP4:																																					-		-
SP5:

ECgene alternative splicing isoforms for SLC5A9

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC5A9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGACAGATG

About this image

SLC5A9 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Late limb mesenchymal cells (LLM cells) (Primary Cell)

Bone, Cartilage, Limb

Definitive endoderm-like cells (Generation and expan...)

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC5A9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC5A9

SOURCE GeneReport for Unigene cluster: Hs.37890

UniProtKB/Swiss-Prot: SC5A9_HUMAN, Q2M3M2

Tissue specificity: Expressed in the small intestine, kidney and liver

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SLC5A9 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC5A9¹	solute carrier family 5 (sodium/glucose cotransporter), more	73.12(n) 77.66(a)		424625 XM_422460.3 XP_422460.3
lizard (Anolis carolinensis)	Reptilia	SLC5A9⁶	--	79(a)	1 ↔ 1	GL343249.1(397126-415779)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.1258²	Transcribed sequence with weak similarity to protein more	72.31(n)		BQ389844.1
zebrafish (Danio rerio)	Actinopterygii	slc5a9¹	solute carrier family 5 (sodium/glucose cotransporter), more	67.95(n) 72.27(a)		564815 NM_001113605.1 NP_001107077.1
E. coli (Escherichia coli)	Gamma proteobacteria	yidK⁶ putP⁶ (see all 3)	proline:sodium symporter (see all 3)	22(a) 16(a) (see all 3)	1 ↔ many possible ortholog (see all 3)	Chromosome(3856424-3858139) Chromosome(1078528-1080036)

ENSEMBL Gene Tree for SLC5A9 (if available)
TreeFam Gene Tree for SLC5A9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC5A9 gene

SLC5A8² SLC5A1² SLC5A4² SLC5A5² SLC5A11² SLC5A10² SLC5A3² SLC5A2²

SLC5A6² SLC5A12² SLC5A7²

6 SIMAP similar genes for SLC5A9 using alignment to 7 protein entries: SC5A9_HUMAN (see all proteins):

SLC5A2 SLC5A1 SLC5A10 SLC5A11 SLC5A4 SLC5A3

SLC5A9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6679095^1,2	C,A	--	48686360(+)	`GACGGC/TACCTT`	2	--	us2k¹		4		NA WA EA	360
rs142069523^1,2		--	48686464(+)	`GGAGAA/GGCCCT`	2	--	us2k¹		0	--	--	--	--
rs151152414^1,2		--	48686465(+)	`GAGAAG/TCCCTC`	2	--	us2k¹		0	--	--	--	--
rs139013773^1,2		--	48686472(+)	`CCTCAC/TGGGCT`	2	--	us2k¹		0	--	--	--	--
rs189170794^1,2		--	48686549(+)	`GGAAGA/CAACAC`	2	--	us2k¹		0	--	--	--	--
rs75911342^1,2	F	--	48686574(+)	`TAGCAA/GACCCC`	2	--	us2k¹		1		WA	118
rs117825556^1,2	C,F	--	48686666(+)	`TTCCCA/GTCTCT`	2	--	us2k¹		1		EA	120
rs181519521^1,2		--	48686715(+)	`GCTCAG/TAGGCC`	2	--	us2k¹		0	--	--	--	--
rs149917460^1,2		--	48686716(+)	`CTCAGA/GGGCCT`	2	--	us2k¹		0	--	--	--	--
rs117157188^1,2	C,F	--	48686782(+)	`TCATTC/TCCCAC`	2	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for SLC5A9 (48688357 - 48714316 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC5A9
1 Indel: 41845

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC5A9 for disorders About MalaCards

SLC5A9 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: SLC5A9 (1 document)

Export disorders for SLC5A9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC5A9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC5A9)

Utopia: connect your pdf to the dynamic
world of online information

SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. (PubMed id 15607332)^{1, 2} Tazawa S....Isaji M. (2005)
Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)¹ Flachsbart F....Nebel A. (2010)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 200010	HGNC: 22146	AceView: SLC5A9.1	Ensembl:ENSG00000117834	euGenes: HUgn200010
ECgene: SLC5A9	H-InvDB: SLC5A9

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC5A9	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC5A9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC5A9 gene:
Search GeneIP for patents involving SLC5A9

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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