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Aliases for SLC5A9 Gene

Aliases for SLC5A9 Gene

  • Solute Carrier Family 5 (Sodium/Sugar Cotransporter), Member 9 2 3
  • Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 9 2 3
  • Solute Carrier Family 5 Member 9 3 4
  • Na(+)/Glucose Cotransporter 4 3 4
  • HSGLT4 3 4
  • SGLT4 3 4
  • Sodium/Glucose Cotransporter 4 3

External Ids for SLC5A9 Gene

Previous GeneCards Identifiers for SLC5A9 Gene

  • GC01P048059
  • GC01P048400
  • GC01P048688
  • GC01P046806

Summaries for SLC5A9 Gene

GeneCards Summary for SLC5A9 Gene

SLC5A9 (Solute Carrier Family 5 (Sodium/Sugar Cotransporter), Member 9) is a Protein Coding gene. Among its related pathways are Metabolism and MPS VI - Maroteaux-Lamy syndrome. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLC5A10.

UniProtKB/Swiss-Prot for SLC5A9 Gene

  • Involved in sodium-dependent transport of D-mannose, D-glucose and D-fructose.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC5A9 Gene

Genomics for SLC5A9 Gene

Regulatory Elements for SLC5A9 Gene

Genomic Location for SLC5A9 Gene

48,222,685 bp from pter
48,248,644 bp from pter
25,960 bases
Plus strand

Genomic View for SLC5A9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC5A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC5A9 Gene

Proteins for SLC5A9 Gene

  • Protein details for SLC5A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/glucose cotransporter 4
    Protein Accession:
    Secondary Accessions:
    • B3KY87
    • B7ZL45
    • B7ZL47
    • E9PAK4
    • E9PJ08
    • Q5TET3

    Protein attributes for SLC5A9 Gene

    681 amino acids
    Molecular mass:
    74073 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI18915.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC5A9 Gene


neXtProt entry for SLC5A9 Gene

Proteomics data for SLC5A9 Gene at MOPED

Post-translational modifications for SLC5A9 Gene

  • Glycosylation at Asn251
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC5A9 Gene

No data available for DME Specific Peptides for SLC5A9 Gene

Domains for SLC5A9 Gene

Gene Families for SLC5A9 Gene

  • SLC :Solute carriers

Protein Domains for SLC5A9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q2M3M2
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
genes like me logo Genes that share domains with SLC5A9: view

Function for SLC5A9 Gene

Molecular function for SLC5A9 Gene

UniProtKB/Swiss-Prot Function: Involved in sodium-dependent transport of D-mannose, D-glucose and D-fructose.

Gene Ontology (GO) - Molecular Function for SLC5A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
genes like me logo Genes that share ontologies with SLC5A9: view

Phenotypes for SLC5A9 Gene

GenomeRNAi human phenotypes for SLC5A9:
genes like me logo Genes that share phenotypes with SLC5A9: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC5A9 Gene

Localization for SLC5A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC5A9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC5A9 Gene COMPARTMENTS Subcellular localization image for SLC5A9 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC5A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC5A9: view

Compounds for SLC5A9 Gene

(1) HMDB Compounds for SLC5A9 Gene

Compound Synonyms Cas Number PubMed IDs
  • Sodium
genes like me logo Genes that share compounds with SLC5A9: view

Transcripts for SLC5A9 Gene

mRNA/cDNA for SLC5A9 Gene

Unigene Clusters for SLC5A9 Gene

Solute carrier family 5 (sodium/glucose cotransporter), member 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC5A9

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC5A9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18
SP1: - - - -
SP2: - - - - -
SP4: - -

Relevant External Links for SLC5A9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC5A9 Gene

mRNA expression in normal human tissues for SLC5A9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC5A9 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (18.0), Kidney - Cortex (7.8), and Liver (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC5A9 Gene

SOURCE GeneReport for Unigene cluster for SLC5A9 Gene Hs.37890

mRNA Expression by UniProt/SwissProt for SLC5A9 Gene

Tissue specificity: Expressed in the small intestine, kidney and liver.
genes like me logo Genes that share expressions with SLC5A9: view

In Situ Assay Products

Orthologs for SLC5A9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC5A9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC5A9 35
  • 99.24 (n)
  • 99.58 (a)
SLC5A9 36
  • 97 (a)
(Bos Taurus)
Mammalia SLC5A9 35
  • 86.62 (n)
  • 86.1 (a)
SLC5A9 36
  • 88 (a)
(Canis familiaris)
Mammalia SLC5A9 35
  • 85.15 (n)
  • 85.69 (a)
SLC5A9 36
  • 85 (a)
(Mus musculus)
Mammalia Slc5a9 35
  • 84.64 (n)
  • 86.12 (a)
Slc5a9 16
Slc5a9 36
  • 85 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
-- 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia SLC5A9 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Slc5a9 35
  • 86.67 (n)
  • 89.47 (a)
(Gallus gallus)
Aves SLC5A9 35
  • 72.09 (n)
  • 75.84 (a)
SLC5A9 36
  • 72 (a)
(Anolis carolinensis)
Reptilia SLC5A9 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc5a9 35
  • 66.93 (n)
  • 74.29 (a)
Str.1258 35
(Danio rerio)
Actinopterygii slc5a9 35
  • 68.7 (n)
  • 73.24 (a)
slc5a9 36
  • 71 (a)
Species with no ortholog for SLC5A9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC5A9 Gene

Gene Tree for SLC5A9 (if available)
Gene Tree for SLC5A9 (if available)

Paralogs for SLC5A9 Gene

Selected SIMAP similar genes for SLC5A9 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SLC5A9: view

Variants for SLC5A9 Gene

Sequence variations from dbSNP and Humsavar for SLC5A9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs172480 -- 48,247,120(+) CAGAA(C/T)GTAGT intron-variant
rs177111 -- 48,244,154(+) CTGGA(C/T)GGAGT intron-variant
rs212972 -- 48,236,261(-) TGGAT(C/T)AAATT intron-variant
rs212984 -- 48,220,833(+) tctta(C/G)tactg upstream-variant-2KB
rs212985 -- 48,221,194(+) CTGCC(C/T)CTCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC5A9 Gene

Variant ID Type Subtype PubMed ID
nsv871053 CNV Gain 21882294
esv4009 CNV Deletion 18987735
esv2748030 CNV Deletion 23290073

Relevant External Links for SLC5A9 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC5A9 Gene

Disorders for SLC5A9 Gene

Relevant External Links for SLC5A9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC5A9: view

No data available for UniProtKB/Swiss-Prot for SLC5A9 Gene

Publications for SLC5A9 Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48
  2. SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. (PMID: 15607332) Tazawa S. … Isaji M. (Life Sci. 2005) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4

Products for SLC5A9 Gene

  • antibodies-online peptides for SLC5A9
  • antibodies-online antibodies for SLC5A9
  • antibodies-online kits for SLC5A9

Sources for SLC5A9 Gene

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