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Aliases for SLC5A9 Gene

Aliases for SLC5A9 Gene

  • Solute Carrier Family 5 Member 9 2 3 4 5
  • Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 9 2 3
  • Solute Carrier Family 5 (Sodium/Sugar Cotransporter), Member 9 2 3
  • Na(+)/Glucose Cotransporter 4 3 4
  • HSGLT4 3 4
  • SGLT4 3 4
  • Sodium/Glucose Cotransporter 4 3

External Ids for SLC5A9 Gene

Previous GeneCards Identifiers for SLC5A9 Gene

  • GC01P048059
  • GC01P048400
  • GC01P048688
  • GC01P046806

Summaries for SLC5A9 Gene

GeneCards Summary for SLC5A9 Gene

SLC5A9 (Solute Carrier Family 5 Member 9) is a Protein Coding gene. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLC5A10.

UniProtKB/Swiss-Prot for SLC5A9 Gene

  • Involved in sodium-dependent transport of D-mannose, D-glucose and D-fructose.

Additional gene information for SLC5A9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC5A9 Gene

Genomics for SLC5A9 Gene

Regulatory Elements for SLC5A9 Gene

Enhancers for SLC5A9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H048468 1 ENCODE 9.4 +248.7 248722 4 ATF1 YY1 GLIS2 ELK1 KLF7 SP3 TSHZ1 REST ZNF518A MBD2 ENSG00000272491 SLC5A9 SPATA6 GC01M048426
GH01H048493 1.1 Ensembl ENCODE 6.9 +272.1 272108 2.6 TBP TFAP4 FEZF1 ZIC2 ZNF644 TEAD3 ZSCAN5C FOS PRDM10 NR2F6 ENSG00000272491 SLC5A9 SKINT1L RPL21P25 SPATA6
GH01H048024 0.7 ENCODE 10.2 -196.2 -196196 2.7 JUN CEBPB CEBPG EP300 OSR2 FOSL1 JUND ZNF239 ZKSCAN8 FOS SLC5A9 ENSG00000226133 GC01M048001
GH01H048931 1.2 FANTOM5 Ensembl ENCODE 4.1 +709.6 709584 0.9 TBP ZNF362 ZBTB21 JUN CEBPB FEZF1 JUND POLR2A RCOR1 FOS SLC5A9 BEND5 GC01M048924 GC01P048862
GH01H048249 0.5 ENCODE 9.8 +28.8 28768 2.2 CTCF NFIA REST ENSG00000272491 SLC5A9 ENSG00000279214 GC01P048230
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC5A9 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC5A9 Gene

Genomic Locations for SLC5A9 Gene
26,375 bases
Plus strand

Genomic View for SLC5A9 Gene

Genes around SLC5A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC5A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC5A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC5A9 Gene

Proteins for SLC5A9 Gene

  • Protein details for SLC5A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/glucose cotransporter 4
    Protein Accession:
    Secondary Accessions:
    • B3KY87
    • B7ZL45
    • B7ZL47
    • E9PAK4
    • E9PJ08
    • Q5TET3

    Protein attributes for SLC5A9 Gene

    681 amino acids
    Molecular mass:
    74073 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI18915.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC5A9 Gene


neXtProt entry for SLC5A9 Gene

Post-translational modifications for SLC5A9 Gene

  • Glycosylation at Asn251
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC5A9 Gene

Domains & Families for SLC5A9 Gene

Gene Families for SLC5A9 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC5A9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
genes like me logo Genes that share domains with SLC5A9: view

Function for SLC5A9 Gene

Molecular function for SLC5A9 Gene

UniProtKB/Swiss-Prot Function:
Involved in sodium-dependent transport of D-mannose, D-glucose and D-fructose.

Gene Ontology (GO) - Molecular Function for SLC5A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005362 low-affinity glucose:sodium symporter activity TAS --
GO:0005412 glucose:sodium symporter activity IBA --
genes like me logo Genes that share ontologies with SLC5A9: view
genes like me logo Genes that share phenotypes with SLC5A9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC5A9 Gene

Localization for SLC5A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC5A9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC5A9 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC5A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC5A9: view

Pathways & Interactions for SLC5A9 Gene

genes like me logo Genes that share pathways with SLC5A9: view

Pathways by source for SLC5A9 Gene

1 BioSystems pathway for SLC5A9 Gene

Interacting Proteins for SLC5A9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000236495 for SLC5A9 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SLC5A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IBA --
GO:0008645 hexose transport TAS --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC5A9: view

No data available for SIGNOR curated interactions for SLC5A9 Gene

Drugs & Compounds for SLC5A9 Gene

(2) Drugs for SLC5A9 Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Canagliflozin Approved Pharma Inhibition, Inhibitor SGLT2 inhibitor,potent and selective 113
Hypoglycemic Agents Pharma 6047

(1) Additional Compounds for SLC5A9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC5A9: view

Transcripts for SLC5A9 Gene

Unigene Clusters for SLC5A9 Gene

Solute carrier family 5 (sodium/glucose cotransporter), member 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18
SP1: - - - -
SP2: - - - - -
SP4: - -

Relevant External Links for SLC5A9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC5A9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC5A9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC5A9 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x18.0), Kidney - Cortex (x7.8), and Liver (x4.4).

Protein differential expression in normal tissues from HIPED for SLC5A9 Gene

This gene is overexpressed in Bone marrow stromal cell (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC5A9 Gene

Protein tissue co-expression partners for SLC5A9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC5A9 Gene:


SOURCE GeneReport for Unigene cluster for SLC5A9 Gene:


mRNA Expression by UniProt/SwissProt for SLC5A9 Gene:

Tissue specificity: Expressed in the small intestine, kidney and liver.

Evidence on tissue expression from TISSUES for SLC5A9 Gene

  • Intestine(4.4)
  • Liver(4.1)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with SLC5A9: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC5A9 Gene

Orthologs for SLC5A9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC5A9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC5A9 33 34
  • 99.24 (n)
(Rattus norvegicus)
Mammalia Slc5a9 33
  • 86.67 (n)
(Bos Taurus)
Mammalia SLC5A9 33 34
  • 86.62 (n)
(Canis familiaris)
Mammalia SLC5A9 33 34
  • 85.15 (n)
(Mus musculus)
Mammalia Slc5a9 33 16 34
  • 84.64 (n)
(Ornithorhynchus anatinus)
Mammalia SLC5A9 34
  • 77 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 76 (a)
-- 34
  • 69 (a)
(Gallus gallus)
Aves SLC5A9 33 34
  • 72.09 (n)
(Anolis carolinensis)
Reptilia SLC5A9 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc5a9 33
  • 66.93 (n)
Str.1258 33
(Danio rerio)
Actinopterygii slc5a9 33 34
  • 68.7 (n)
Species where no ortholog for SLC5A9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC5A9 Gene

Gene Tree for SLC5A9 (if available)
Gene Tree for SLC5A9 (if available)

Paralogs for SLC5A9 Gene

(6) SIMAP similar genes for SLC5A9 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SLC5A9: view

Variants for SLC5A9 Gene

Sequence variations from dbSNP and Humsavar for SLC5A9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000013850 -- 48,240,702(+) TCCCC(A/C)GTTGA intron-variant
rs1000139813 -- 48,241,128(+) AGTGT(C/T)CCTTA intron-variant
rs1000223891 -- 48,225,553(+) ATCAG(C/T)CCCAG intron-variant
rs1000256565 -- 48,247,646(+) GATCA(C/G)AGAAG downstream-variant-500B, utr-variant-3-prime
rs1000339502 -- 48,228,657(+) TAGTT(C/T)CTTCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC5A9 Gene

Variant ID Type Subtype PubMed ID
nsv1011588 CNV gain 25217958
esv4009 CNV loss 18987735
esv3578249 CNV gain 25503493

Variation tolerance for SLC5A9 Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.77; 95.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC5A9 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC5A9 Gene

Disorders for SLC5A9 Gene

Relevant External Links for SLC5A9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC5A9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC5A9 Gene

Publications for SLC5A9 Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 45 60
  2. SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. (PMID: 15607332) Tazawa S … Isaji M (Life sciences 2005) 3 4 60
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales PA … Knepper MA (Journal of the American Society of Nephrology : JASN 2009) 3 60
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 60

Products for SLC5A9 Gene

Sources for SLC5A9 Gene

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