SLC5A8 Gene
protein-coding GIFtS: 48
GCID: GC12M101549
|
|
solute carrier family 5 (iodide transporter), member 8
| |
Aliases
for SLC5A8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 5 (Iodide Transporter), Member 81 2 | | Sodium Iodide-Related Cotransporter2 3 | | AIT1 2 3 5 | | Solute Carrier Family 5 Member 82 3 | | SMCT2 3 5 | | SMCT12 3 | | Apical Iodide Transporter2 3 | | Sodium-Coupled Monocarboxylate Transporter 12 | | Electrogenic Sodium Monocarboxylate Cotransporter2 3 | | |
Export aliases for SLC5A8 gene to outside databasesPrevious GC identifers: GC12M101483 GC12M100052 GC12M100051 GC12M098610 |
Summaries
for SLC5A8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC5A8:
SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 (PubMed 12107270)) andmonocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 (PubMed 15322102)). Inkidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate andmaintenance of blood lactate levels (Thangaraju et al., 2006 (PubMed 16873376)).(supplied by OMIM, Dec 2008)
UniProtKB/Swiss-Prot: SC5A8_HUMAN, Q8N695Function: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter,including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate,propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with aNa(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediatesiodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for theabsorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressingcolony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry ofL-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contributeto the maintenance of the energy status and function of neurons
Gene Wiki entry for SLC5A8
|
Genomic Views
for SLC5A8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC5A8 gene promoter:
E2F-4 E2F-3a E2F-5 AML1a Brachyury E2F-2 CREB FAC1 E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC5A8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC5A8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q23.1 Ensembl cytogenetic band: 12q23.2 HGNC cytogenetic band: 12q23.1SLC5A8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M101549: view genomic region
(about GC identifiers)
Start:
|
101,549,271 bp from pter |
End:
|
101,604,185 bp from pter |
Size:
|
54,915 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr12+,PATCHES 101,548,339-101,602,361 |
|
Proteins
for SLC5A8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SC5A8_HUMAN, Q8N695 (See
protein sequence)Recommended Name: Sodium-coupled monocarboxylate transporter 1 Size: 610 amino acids; 66578 Da
Subcellular location: Apical cell membrane; Multi-pass membrane protein. Note=Expressed at the apical membrane ofnormal tall thyrocytes and of colonic epithelial cells
Miscellaneous: Increase of iodide influx inhibited by addition of perchlorate (NaClO(4)), a competitive inhibitor ofiodide uptake catalyzed by sodium iodide symporter (NIS). Cotransport of monocarboxylates and nicotinate stronglyinhibited by probenecid, nonsteroid anti-inflammatory drugs (ibuprofen, fenoprofen, ketprofen, naproxen) in aNa(+)-dependent manner or by prolonged exposure to external concentrations of monocarboxylates
Secondary accessions: Q2TB99 Q7Z2H9Explore the universe of human proteins at neXtProt for SLC5A8: NX_Q8N695
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N695
SLC5A8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_666018.3
ENSEMBL proteins: ENSP00000445340 Reactome Protein details: Q8N695
Human Recombinant Protein Products for SLC5A8:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SLC5A8 for ontologies About GeneDecksing
SLC5A8 Antibody Products:
Assay Products for SLC5A8: |
Protein
Domains /
Families
for SLC5A8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC5A8 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N695ProtoNet protein and cluster: Q8N695 1 Blocks protein family: IPB001734 Na+/solute symporter
UniProtKB/Swiss-Prot: SC5A8_HUMAN, Q8N695Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family |
Function
for SLC5A8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SC5A8_HUMAN, Q8N695Function: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter,including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate,propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with aNa(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediatesiodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for theabsorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressingcolony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry ofL-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contributeto the maintenance of the energy status and function of neuronsBiophysicochemical properties: Kinetic parameters: KM=1442 uM for beta-D-hydroxybutyate; KM=2327 uM forbeta-L-hydroxybutyate; KM=1088 uM for D-lactate; KM=184 uM for L-lactate; KM=387 uM for pyruvate; KM=213 uM foracetoacetate; KM=209 uM for alpha-ketoisocaproate;Induction: Down-regulated in some primary cancers; due to aberrant methylation in primary colon cancers, astrocytomasand oligodendrogliomas as well as in cancers of the colon, prostate and gastric regions, and glial cell lines.Expression reactivated on treatment with a demethylating drug, 5-azacytidine Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015293 | symporter activity |
IEA | -- |
SLC5A8 for ontologies About GeneDecksing
Phenotypes:
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Slc5a8):
SLC5A8 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Slc5a8tm1.1Boet for SLC5A8
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC5A8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC5A8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC5A8 (NM_145913) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC5A8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC5A8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A8 |
|
Pathways & Interactions
for SLC5A8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Amino acid and oligopeptide SLC transporters | | | 2 | SLC-mediated transmembrane transport | | | 3 | Organic anion transporters | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for SLC5A8
SLC5A8 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC5A8
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SLC5A8 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC5A8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SLC5A8 for compounds About GeneDecksing
 Browse Tocris compounds for SLC5A8
2 HMDB Compounds for SLC5A8 About this table
8 Novoseek chemical compound relationships for SLC5A8 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| iodide |
82.9 |
20 |
15001644 (2), 18037591 (1), 19951699 (1), 19196800 (1) (see all 9) |
| butyrate |
65.1 |
2 |
14966140 (1), 15322102 (1) |
| propionate |
64.2 |
2 |
14966140 (1), 15322102 (1) |
| sodium |
55.8 |
4 |
15361710 (1), 16076943 (1), 17488796 (1) |
| iodine |
50.5 |
1 |
16648292 (1) |
| pyruvate |
48.7 |
10 |
17178845 (6), 14966140 (1), 15322102 (1) |
| lactate |
46.1 |
11 |
15322102 (6), 17178845 (3), 14966140 (1), 16805814 (1) |
| glucose |
11.1 |
2 |
14966140 (1), 17488796 (1) |
Search CenterWatch for drugs/clinical trials and news about SLC5A8 / SC5A8
|
Transcripts
for SLC5A8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC5A8 gene: NM_145913.3 Unigene Cluster for SLC5A8: Solute carrier family 5 (iodide transporter), member 8 Hs.444536 [show with all ESTs]Unigene Representative Sequence: AF5362161 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000536262(uc001thz.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC5A8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC5A8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC5A8 (NM_145913) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC5A8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC5A8 |
Additional cDNA sequence: AF536216.1 AK075263.1 AK313788.1 AY081220.1 BC110492.2 1 DOTS entry: DT.75101382 22 AceView cDNA sequences: AI206025 CK429529 AI222544 BE048873 AW614230 AI733709 AI241058 AW166360 AI261687 AI433656 AI793005 AF536216 AW025046 AK075263 AY081220 BG570430 NM_145913 AI793183 CB987734 BG402434 AI792431 BQ018911
GeneLoc Exon Structure
|
Expression
for SLC5A8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC5A8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SLC5A8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC5A8
SOURCE GeneReport for Unigene cluster: Hs.444536
UniProtKB/Swiss-Prot: SC5A8_HUMAN, Q8N695Tissue specificity: Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloidlumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colonaberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and breasttissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast tumors
SABiosciences Expression via Pathway-Focused PCR Array including SLC5A8:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC5A8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC5A8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC5A8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC5A8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A8 |
Orthologs
for SLC5A8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SLC5A8 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for SLC5A8 (if available)
TreeFam Gene Tree for SLC5A8 (if available) |
Paralogs
for SLC5A8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC5A8 gene
- SLC5A12 SLC5A42 SLC5A52 SLC5A112 SLC5A92 SLC5A32 SLC5A102 SLC5A22
- SLC5A62 SLC5A122 SLC5A72
4 SIMAP similar genes for SLC5A8 using alignment to 1 protein entry: SC5A8_HUMAN:SLC5A12 SLC5A5 SLC5A6 DKFZp434F152
SLC5A8 for paralogs About GeneDecksing
|
Genomic Variants
for SLC5A8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC5A8 (101549271 - 101604185 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC5A8: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SLC5A8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC5A8 for disorders About GeneDecksing
OMIM gene information: 608044
OMIM disorders: --
20/23  diseases for SLC5A8 (see all 23): About MalaCardspapillary thyroid carcinoma acute myeloid leukemia myeloid leukemia squamous cell carcinoma
thyroid carcinoma goiter colon cancer oligodendroglioma
colorectal cancer thyroiditis thyroid cancer gastric cancer
pancreatic cancer leukemia astrocytoma carcinoma
prostate cancer pancreatitis adenoma pneumonia
3 diseases from the University of Copenhagen DISEASES database for SLC5A8:Autoimmune thyroiditis Hypothyroidism Goiter 3 Novoseek disease relationships for SLC5A8 gene About this table
Human Genome Epidemiology (HuGE) Navigator: SLC5A8 (3 documents)
Export disorders for SLC5A8 gene to outside databases
|
Publications
for SLC5A8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC5A8 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with SLC5A8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. (PubMed id 12829793)1, 2, 3 Li H....Markowitz S.D. (2003)
- Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes. (PubMed id 12107270)1, 2, 3 Rodriguez A.M.... Pourcher T. (2002)
- Candidate tumor suppressor gene SLC5A8 is frequently down-regulated by promoter hypermethylation in prostate tumor. (PubMed id 18037591)1, 2, 9 Park J.Y....Pow-Sang J. (2007)
- Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters. (PubMed id 15001644)1, 2, 9 Lacroix L.... Bidart J.-M. (2004)
- Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids. (PubMed id 14966140)1, 2, 9 Miyauchi S....Ganapathy V. (2004)
- Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract. (PubMed id 17245649)1, 2 Gopal E....Ganapathy V. (2007)
- Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8. (PubMed id 15867356)1, 2 Hong C.... Costello J.F. (2005)
- SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases. (PubMed id 17178845)2, 9 Thangaraju M.... Ganapathy V. (2006)
- Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate. (PubMed id 15322102)1, 9 Gopal E....Ganapathy V. (2004)
- Silencing of the candidate tumor suppressor gene solute carrier family 5 member 8 (SLC5A8) in human pancreatic cancer. (PubMed id 18437076)1, 9 Park J.Y....Malafa M.P. (2008)
|
External Searches for SLC5A8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC5A8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC5A8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC5A8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC5A8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC5A8 gene:
Search GeneIP for patents involving SLC5A8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC5A8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC5A8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC5A8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC5A8 | | | OriGene Protein Over-expression Lysate for SLC5A8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC5A8 | | OriGene 3'-UTR Clone for SLC5A8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC5A8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC5A8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLC5A8 | | OriGene Custom Protein Services for SLC5A8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC5A8 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC5A8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC5A8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC5A8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC5A8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC5A8 |
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| | | | Search Tocris compounds for SLC5A8 |
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 | | | SLC5A8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A8 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SLC5A8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC5A8 |
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