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Aliases for SLC5A8 Gene

Aliases for SLC5A8 Gene

  • Solute Carrier Family 5 (Sodium/Monocarboxylate Cotransporter), Member 8 2 3
  • Solute Carrier Family 5 (Iodide Transporter), Member 8 2 3
  • Electrogenic Sodium Monocarboxylate Cotransporter 3 4
  • Sodium Iodide-Related Cotransporter 3 4
  • Solute Carrier Family 5 Member 8 3 4
  • Apical Iodide Transporter 3 4
  • SMCT1 3 4
  • SMCT 3 4
  • AIT 3 4

External Ids for SLC5A8 Gene

Previous GeneCards Identifiers for SLC5A8 Gene

  • GC12M101483
  • GC12M100052
  • GC12M100051
  • GC12M098610
  • GC12M101549

Summaries for SLC5A8 Gene

Entrez Gene Summary for SLC5A8 Gene

  • SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008]

GeneCards Summary for SLC5A8 Gene

SLC5A8 (Solute Carrier Family 5 (Sodium/Monocarboxylate Cotransporter), Member 8) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and symporter activity. An important paralog of this gene is SLC5A10.

UniProtKB/Swiss-Prot for SLC5A8 Gene

  • Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

Gene Wiki entry for SLC5A8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC5A8 Gene

Genomics for SLC5A8 Gene

Regulatory Elements for SLC5A8 Gene

Genomic Location for SLC5A8 Gene

Chromosome:
12
Start:
101,155,493 bp from pter
End:
101,210,407 bp from pter
Size:
54,915 bases
Orientation:
Minus strand

Genomic View for SLC5A8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for SLC5A8 Gene

Proteins for SLC5A8 Gene

  • Protein details for SLC5A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N695-SC5A8_HUMAN
    Recommended name:
    Sodium-coupled monocarboxylate transporter 1
    Protein Accession:
    Q8N695
    Secondary Accessions:
    • Q2TB99
    • Q7Z2H9

    Protein attributes for SLC5A8 Gene

    Size:
    610 amino acids
    Molecular mass:
    66578 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Increase of iodide influx inhibited by addition of perchlorate (NaClO(4)), a competitive inhibitor of iodide uptake catalyzed by sodium iodide symporter (NIS). Cotransport of monocarboxylates and nicotinate strongly inhibited by probenecid, nonsteroid anti-inflammatory drugs (ibuprofen, fenoprofen, ketprofen, naproxen) in a Na(+)-dependent manner or by prolonged exposure to external concentrations of monocarboxylates

neXtProt entry for SLC5A8 Gene

Proteomics data for SLC5A8 Gene at MOPED

Post-translational modifications for SLC5A8 Gene

  • Glycosylation at Asn 485
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC5A8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SLC5A8 (SLC5A8/SMCT1)

No data available for DME Specific Peptides for SLC5A8 Gene

Domains & Families for SLC5A8 Gene

Gene Families for SLC5A8 Gene

Protein Domains for SLC5A8 Gene

Suggested Antigen Peptide Sequences for SLC5A8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N695

UniProtKB/Swiss-Prot:

SC5A8_HUMAN :
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Family:
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
genes like me logo Genes that share domains with SLC5A8: view

Function for SLC5A8 Gene

Molecular function for SLC5A8 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1442 uM for beta-D-hydroxybutyate {ECO:0000269 PubMed:16805814}; KM=2327 uM for beta-L-hydroxybutyate {ECO:0000269 PubMed:16805814}; KM=1088 uM for D-lactate {ECO:0000269 PubMed:16805814}; KM=184 uM for L-lactate {ECO:0000269 PubMed:16805814}; KM=387 uM for pyruvate {ECO:0000269 PubMed:16805814}; KM=213 uM for acetoacetate {ECO:0000269 PubMed:16805814}; KM=209 uM for alpha-ketoisocaproate {ECO:0000269 PubMed:16805814};
UniProtKB/Swiss-Prot Function:
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.
UniProtKB/Swiss-Prot Induction:
Down-regulated in some primary cancers; due to aberrant methylation in primary colon cancers, astrocytomas and oligodendrogliomas as well as in cancers of the colon, prostate and gastric regions, and glial cell lines. Expression reactivated on treatment with a demethylating drug, 5-azacytidine.

Gene Ontology (GO) - Molecular Function for SLC5A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC5A8: view
genes like me logo Genes that share phenotypes with SLC5A8: view

Animal Models for SLC5A8 Gene

MGI Knock Outs for SLC5A8:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC5A8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC5A8 Gene

Localization for SLC5A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC5A8 Gene

Apical cell membrane; Multi-pass membrane protein. Note=Expressed at the apical membrane of normal tall thyrocytes and of colonic epithelial cells. {ECO:0000269 PubMed:12107270, ECO:0000269 PubMed:15001644, ECO:0000269 PubMed:17245649}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC5A8 Gene COMPARTMENTS Subcellular localization image for SLC5A8 gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC5A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC5A8: view

Pathways & Interactions for SLC5A8 Gene

genes like me logo Genes that share pathways with SLC5A8: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC5A8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000445340%0d%0a9606.ENSP00000264380%0d%0a
Selected Interacting proteins: ENSP00000445340 for SLC5A8 Gene via STRING

Symbol External ID(s) Details
PIKFYVE

Gene Ontology (GO) - Biological Process for SLC5A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport IEA --
GO:0006915 apoptotic process IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC5A8: view

No data available for SIGNOR curated interactions for SLC5A8 Gene

Drugs & Compounds for SLC5A8 Gene

(8) Drugs for SLC5A8 Gene - From: DrugBank, IUPHAR, DGIdb, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fenoprofen Approved Pharma Inhibition, Inhibitor, inhibitor 0
Ibuprofen Approved Pharma Inhibition, Inhibitor, inhibitor 429
Ketoprofen Approved Pharma Inhibition, Inhibitor, inhibitor 74
gabapentin enacarbil Approved Pharma Transporter, substrate 0
Niacin Approved, Investigational Nutra Unknown, Agonist, Transporter 340,340

(7) Additional Compounds for SLC5A8 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
butyrate
glucose
iodide
  • Iodide
  • Iodide anion
  • Iodide ion
  • Iodide Salt
  • Iodide(1-)
20461-54-5
genes like me logo Genes that share compounds with SLC5A8: view

Transcripts for SLC5A8 Gene

mRNA/cDNA for SLC5A8 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC5A8 Gene

Solute carrier family 5 (iodide transporter), member 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC5A8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A8 Gene

No ASD Table

Relevant External Links for SLC5A8 Gene

GeneLoc Exon Structure for
SLC5A8
ECgene alternative splicing isoforms for
SLC5A8

Expression for SLC5A8 Gene

mRNA expression in normal human tissues for SLC5A8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC5A8 Gene

This gene is overexpressed in Thyroid (x20.4), Cervix - Endocervix (x13.5), and Kidney - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for SLC5A8 Gene

This gene is overexpressed in Urine (54.2) and Breast (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC5A8 Gene



SOURCE GeneReport for Unigene cluster for SLC5A8 Gene Hs.444536

mRNA Expression by UniProt/SwissProt for SLC5A8 Gene

Q8N695-SC5A8_HUMAN
Tissue specificity: Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon aberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast tumors.
genes like me logo Genes that share expression patterns with SLC5A8: view

Protein tissue co-expression partners for SLC5A8 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for SLC5A8 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC5A8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC5A8 35
  • 90.38 (n)
  • 89.34 (a)
SMCT1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC5A8 35
  • 91.79 (n)
  • 90.48 (a)
SLC5A8 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc5a8 35
  • 86.5 (n)
  • 86.56 (a)
Slc5a8 16
Slc5a8 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC5A8 35
  • 99.45 (n)
  • 99.67 (a)
SLC5A8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc5a8 35
  • 86.34 (n)
  • 86.89 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 23 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC5A8 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC5A8 35
  • 74.47 (n)
  • 76.74 (a)
SLC5A8 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC5A8 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc5a8 35
  • 70.97 (n)
  • 75.33 (a)
Str.16114 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6392 35
zebrafish
(Danio rerio)
Actinopterygii slc5a8l 35
  • 61.44 (n)
  • 58.85 (a)
SLC5A8 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32669 35
  • 49.34 (n)
  • 43.67 (a)
CG2187 36
  • 29 (a)
ManyToMany
CG31262 36
  • 30 (a)
ManyToMany
CG31668 36
  • 32 (a)
ManyToMany
CG33124 36
  • 31 (a)
ManyToMany
CG42235 36
  • 27 (a)
ManyToMany
CG5687 36
  • 30 (a)
ManyToMany
CG6723 36
  • 33 (a)
ManyToMany
CG7720 36
  • 27 (a)
ManyToMany
CG8451 36
  • 32 (a)
ManyToMany
CG9657 36
  • 32 (a)
ManyToMany
salt 36
  • 29 (a)
ManyToMany
Smvt 36
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F52H2.4 36
  • 29 (a)
ManyToMany
ZK822.5 36
  • 29 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1246 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
Species with no ortholog for SLC5A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC5A8 Gene

ENSEMBL:
Gene Tree for SLC5A8 (if available)
TreeFam:
Gene Tree for SLC5A8 (if available)

Paralogs for SLC5A8 Gene

(4) SIMAP similar genes for SLC5A8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC5A8: view

Variants for SLC5A8 Gene

Sequence variations from dbSNP and Humsavar for SLC5A8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs117211787 -- 101,190,041(+) CTGAA(A/T)ATGAA intron-variant
rs117158575 -- 101,158,218(+) AGTTT(C/T)CTAAC intron-variant, downstream-variant-500B
rs117109411 -- 101,211,991(+) CTGAT(A/G)TATGT upstream-variant-2KB
rs117086622 -- 101,186,289(+) AGGGT(A/G)TGTTT intron-variant
rs117066169 -- 101,171,567(+) ACAGA(C/G)AGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC5A8 Gene

Variant ID Type Subtype PubMed ID
nsv899471 CNV Loss 21882294
nsv857 CNV Insertion 18451855

Variation tolerance for SLC5A8 Gene

Residual Variation Intolerance Score: 79.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.21; 95.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC5A8 Gene

HapMap Linkage Disequilibrium report
SLC5A8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC5A8 Gene

Disorders for SLC5A8 Gene

Relevant External Links for SLC5A8

Genetic Association Database (GAD)
SLC5A8
Human Genome Epidemiology (HuGE) Navigator
SLC5A8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC5A8
genes like me logo Genes that share disorders with SLC5A8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC5A8 Gene

Publications for SLC5A8 Gene

  1. Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain. (PMID: 16805814) Martin P.M. … Ganapathy V. (J. Neurochem. 2006) 23 25 67
  2. Diclofenac-induced stimulation of SMCT1 (SLC5A8) in a heterologous expression system: a RPE specific phenomenon. (PMID: 20178774) Ananth S. … Martin P. (Biochem. Biophys. Res. Commun. 2010) 23 67
  3. Thyroglobulin (Tg) induces thyroid cell growth in a concentration-specific manner by a mechanism other than thyrotropin/cAMP stimulation. (PMID: 19951699) Noguchi Y. … Kohn L.D. (Biochem. Biophys. Res. Commun. 2010) 23 67
  4. Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. (PMID: 19196800) Bizhanova A. … Kopp P. (Endocrinology 2009) 23 67
  5. Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice. (PMID: 18562324) Frank H. … Boettger T. (J. Biol. Chem. 2008) 23 67

Products for SLC5A8 Gene

Sources for SLC5A8 Gene

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