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SLC5A8 Gene

protein-coding   GIFtS: 52
GCID: GC12M101549

Solute Carrier Family 5 (Sodium/Monocarboxylate Cotransporter),...

(Previous names: solute carrier family 5 (iodide transporter), member 8)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 5 (Sodium/Monocarboxylate Cotransporter), Member
81 2
     Electrogenic Sodium Monocarboxylate Cotransporter2 3
AIT2 3 5     Sodium Iodide-Related Cotransporter2 3
SMCT2 3 5     Solute Carrier Family 5 Member 82 3
Solute Carrier Family 5 (Iodide Transporter), Member 81 2     SMCT12 3
Apical Iodide Transporter2 3     Sodium-Coupled Monocarboxylate Transporter 12

External Ids:    HGNC: 191191   Entrez Gene: 1607282   Ensembl: ENSG000002568707   OMIM: 6080445   UniProtKB: Q8N6953   

Export aliases for SLC5A8 gene to outside databases

Previous GC identifers: GC12M101483 GC12M100052 GC12M100051 GC12M098610


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC5A8 Gene:
SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 (PubMed 12107270)) and
monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 (PubMed
15322102)). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in
reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 (PubMed
16873376)).(supplied by OMIM, Dec 2008)

GeneCards Summary for SLC5A8 Gene:
SLC5A8 (solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8) is a protein-coding gene. GO annotations related to this gene include symporter activity. An important paralog of this gene is ENSG00000272962.

UniProtKB/Swiss-Prot: SC5A8_HUMAN, Q8N695
Function: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter,
including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate,
acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and
5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a
Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide.
Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be
responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor
suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a
critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical
Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons

Gene Wiki entry for SLC5A8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC5A8 gene promoter:
         E2F-4   E2F-3a   E2F-5   AML1a   Brachyury   E2F-2   CREB   FAC1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC5A8 promoter sequence
   Search Chromatin IP Primers for SLC5A8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC5A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.1   Ensembl cytogenetic band:  12q23.2   HGNC cytogenetic band: 12q23.1

SLC5A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC5A8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M101549:  view genomic region     (about GC identifiers)

Start:
101,549,271 bp from pter      End:
101,604,185 bp from pter
Size:
54,915 bases      Orientation:
minus strand

1 alternative location:
Chr12+,NW_003315942 48,058-102,080     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SC5A8_HUMAN, Q8N695 (See protein sequence)
Recommended Name: Sodium-coupled monocarboxylate transporter 1  
Size: 610 amino acids; 66578 Da
Miscellaneous: Increase of iodide influx inhibited by addition of perchlorate (NaClO(4)), a competitive inhibitor
of iodide uptake catalyzed by sodium iodide symporter (NIS). Cotransport of monocarboxylates and nicotinate
strongly inhibited by probenecid, nonsteroid anti-inflammatory drugs (ibuprofen, fenoprofen, ketprofen, naproxen)
in a Na(+)-dependent manner or by prolonged exposure to external concentrations of monocarboxylates
Secondary accessions: Q2TB99 Q7Z2H9

Explore the universe of human proteins at neXtProt for SLC5A8: NX_Q8N695

Explore proteomics data for SLC5A8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn485
  • Modification sites at PhosphoSitePlus

  • See SLC5A8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_666018.3  
    ENSEMBL proteins: 
     ENSP00000445340  
    Reactome Protein details: Q8N695

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SMCT1
    Sodium iodide symporter, sodium-dependent multivitamin transporter and sodium-coupled monocarboxylate transporters

    2 InterPro protein domains:
     IPR019900 Na/solute_symporter_subgr
     IPR001734 Na/solute_symporter

    Graphical View of Domain Structure for InterPro Entry Q8N695

    ProtoNet protein and cluster: Q8N695

    1 Blocks protein domain: IPB001734 Na+/solute symporter

    UniProtKB/Swiss-Prot: SC5A8_HUMAN, Q8N695
    Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family


    Find genes that share domains with SLC5A8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC5A8_HUMAN, Q8N695
    Function: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter,
    including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate,
    acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and
    5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a
    Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide.
    Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be
    responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor
    suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a
    critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical
    Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons
    Biophysicochemical properties: Kinetic parameters: KM=1442 uM for beta-D-hydroxybutyate; KM=2327 uM for
    beta-L-hydroxybutyate; KM=1088 uM for D-lactate; KM=184 uM for L-lactate; KM=387 uM for pyruvate; KM=213 uM for
    acetoacetate; KM=209 uM for alpha-ketoisocaproate;
    Induction: Down-regulated in some primary cancers; due to aberrant methylation in primary colon cancers,
    astrocytomas and oligodendrogliomas as well as in cancers of the colon, prostate and gastric regions, and glial
    cell lines. Expression reactivated on treatment with a demethylating drug, 5-azacytidine

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0015293symporter activity IEA--
         
    Find genes that share ontologies with SLC5A8           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc5a8):
     digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism  no phenotypic analysis  renal/urinary system 
     tumorigenesis 

    Find genes that share phenotypes with SLC5A8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc5a8tm1.1Boet for SLC5A8

       genOway: Develop your customized and physiologically relevant rodent model for SLC5A8

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SC5A8_HUMAN, Q8N695: Apical cell membrane; Multi-pass membrane protein. Note=Expressed at the apical membrane of
    normal tall thyrocytes and of colonic epithelial cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0016324apical plasma membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with SLC5A8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC5A8 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Organic anion transporters0.00


    Find genes that share SuperPaths with SLC5A8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC5A8
        Organic anion transporters


        Pathway & Disease-focused RT2 Profiler PCR Array including SLC5A8: 
              Prostate Cancer in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC5A8

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006811ion transport TAS--
    GO:0006814sodium ion transport IEA--
    GO:0006915apoptotic process IEA--
    GO:0055085transmembrane transport TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for SLC5A8 (SC5A8)

    2 HMDB Compounds for SLC5A8    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    SodiumSodium (see all 2)7440-23-5--

    3 IUPHAR Ligands for SLC5A8 (SMCT1)    About this table
    LigandTypeActionAffinityPubmed IDs
    ibuprofen
    InhibitorInhibition4.2--
    fenoprofen
    InhibitorInhibition4.2--
    ketoprofen
    InhibitorInhibition4.2--

    8 Novoseek inferred chemical compound relationships for SLC5A8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iodide 82.9 20 15001644 (2), 18037591 (1), 19951699 (1), 19196800 (1) (see all 9)
    butyrate 65.1 2 14966140 (1), 15322102 (1)
    propionate 64.2 2 14966140 (1), 15322102 (1)
    sodium 55.8 4 15361710 (1), 16076943 (1), 17488796 (1)
    iodine 50.5 1 16648292 (1)
    pyruvate 48.7 10 17178845 (6), 14966140 (1), 15322102 (1)
    lactate 46.1 11 15322102 (6), 17178845 (3), 14966140 (1), 16805814 (1)
    glucose 11.1 2 14966140 (1), 17488796 (1)



    Find genes that share compounds with SLC5A8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC5A8 gene: 
    NM_145913.3  

    Unigene Cluster for SLC5A8:

    Solute carrier family 5 (iodide transporter), member 8
    Hs.444536  [show with all ESTs]
    Unigene Representative Sequence: AF536216
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000536262(uc001thz.4)
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    Additional mRNA sequence: 

    AF536216.1 AK075263.1 AK313788.1 AY081220.1 BC110492.2 

    1 DOTS entry:

    DT.75101382 

    22 AceView cDNA sequences:

    AI241058 AI222544 AW166360 AW614230 CK429529 BE048873 AI261687 AI206025 
    AI733709 AI793005 AW025046 AF536216 BG570430 BG402434 CB987734 AI793183 
    AK075263 NM_145913 AI433656 AY081220 AI792431 BQ018911 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC5A8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC5A8 Expression
    About this image


    SLC5A8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Hindgut
     
     Kidney (Urinary System)
    SLC5A8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC5A8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444536

    UniProtKB/Swiss-Prot: SC5A8_HUMAN, Q8N695
    Tissue specificity: Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid
    lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon
    aberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and
    breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast
    tumors

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC5A8: 
              Prostate Cancer in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC5A8 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc5a81 , 5 solute carrier family 5 (iodide transporter), member more1, 5 86.5(n)1
    86.56(a)1
      10 (44.34 cM)5
    2162251  NM_145423.21  NP_663398.21 
     888859925 
    chicken
    (Gallus gallus)
    Aves SLC5A81 solute carrier family 5 (iodide transporter), member more 74.47(n)
    76.74(a)
      417932  XM_416173.4  XP_416173.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC5A86
    solute carrier family 5 (sodium/monocarboxylate co...
    72(a)
    1 ↔ 1
    5(28318783-28340168)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.63922 Xenopus laevis sodium solute transporter Vito-b (Vito) more 74.65(n)    AY260729.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc5a8l1 solute carrier family 5 (iodide transporter), member more 61.44(n)
    58.85(a)
      556156  NM_001034969.1  NP_001030141.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG326691 CG32669 49.34(n)
    43.67(a)
      326229  NM_167256.2  NP_727460.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK822.56
    F52H2.46
    Protein F52H2.4 (F52H2.4) mRNA, complete cds
    29(a)
    29(a)
    many ↔ many
    many ↔ many
    IV(11937403-11940655) WBGene00014092
    X(2543345-2548028) WBGene00018716


    ENSEMBL Gene Tree for SLC5A8 (if available)
    TreeFam Gene Tree for SLC5A8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC5A8 gene
    ENSG000002729622  SLC5A12  SLC5A42  SLC5A52  SLC5A112  SLC5A92  SLC5A102  SLC5A32  
    SLC5A22  SLC5A62  SLC5A122  
    4 SIMAP similar genes for SLC5A8 using alignment to 1 protein entry:     SC5A8_HUMAN:
    SLC5A12    SLC5A5    SLC5A6    DKFZp434F152

    Find genes that share paralogs with SLC5A8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC5A8 (see all 1235)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1129398761,2
    C,F--101549515(+) TCAAGC/TGATCT 1 -- ds50013Minor allele frequency- T:0.02NA EA 242
    rs781084181,2
    --101549590(+) TTTTTA/TAAATT 1 -- ds50011Minor allele frequency- T:0.00CSA 1
    rs1165611171,2
    C,F--101549655(+) AACACG/ATATCA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1512228841,2
    --101549676(+) ATAAAA/GTTATT 1 -- ds50010--------
    rs1919916831,2
    --101549717(+) TATTTC/GTCTTA 1 -- ds50010--------
    rs1469160931,2
    C--101549730(+) TTTCT-/AAAAAA 1 -- ds50010--------
    rs733891981,2
    C,F--101549754(+) AAAGAA/GCTTTT 1 -- ds50012Minor allele frequency- G:0.07WA 120
    rs26251521,2
    C,F,A,H--101549838(+) GAACAT/CAGCAA 1 -- ds500120Minor allele frequency- C:0.19NS EA NA WA CSA 2236
    rs1403599051,2
    --101549921(+) CAGACA/GTTTTA 1 -- ds50010--------
    rs1503600001,2
    --101549976(+) AAATAC/TACCGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC5A8 (101549271 - 101604185 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC5A8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv857CNV Insertion18451855
    nsv899471CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SLC5A8
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC5A8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608044    OMIM disorders: --


    Find genes that share disorders with SLC5A8           About GenesLikeMe

    3 Novoseek inferred disease relationships for SLC5A8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 27.7 21 18037591 (7), 17178845 (6), 14966140 (2), 15361710 (1) (see all 6)
    colon cancer 22.8 2 14966140 (2)
    colorectal cancer 13.5 1 15361710 (1)

    Genetic Association Database (GAD): SLC5A8
    Human Genome Epidemiology (HuGE) Navigator: SLC5A8 (3 documents)

    Export disorders for SLC5A8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC5A8 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with SLC5A8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. (PubMed id 12829793)1, 2, 3 Li H.... Markowitz S.D. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes. (PubMed id 12107270)1, 2, 3 Rodriguez A.-M.... Pourcher T. (J. Clin. Endocrinol. Metab. 2002)
    3. Candidate tumor suppressor gene SLC5A8 is frequently down-regulated by promoter hypermethylation in prostate tumor. (PubMed id 18037591)1, 2, 9 Park J.Y....Pow-Sang J. (Cancer Detect. Prev. 2007)
    4. Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters. (PubMed id 15001644)1, 2, 9 Lacroix L.... Bidart J.-M. (J. Clin. Endocrinol. Metab. 2004)
    5. Functional identification of SLC5A8, a tumor suppressor down- regulated in colon cancer, as a Na(+)-coupled transporter for short- chain fatty acids. (PubMed id 14966140)1, 2, 9 Miyauchi S.... Ganapathy V. (J. Biol. Chem. 2004)
    6. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    7. Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract. (PubMed id 17245649)1, 2 Gopal E....Ganapathy V. (Pharm. Res. 2007)
    8. Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8. (PubMed id 15867356)1, 2 Hong C.... Costello J.F. (Cancer Res. 2005)
    9. SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases. (PubMed id 17178845)2, 9 Thangaraju M.... Ganapathy V. (Cancer Res. 2006)
    10. Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate. (PubMed id 15322102)1, 9 Gopal E....Ganapathy V. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 160728 HGNC: 19119 AceView: SLC5A8 Ensembl:ENSG00000256870 euGenes: HUgn160728
    ECgene: SLC5A8 H-InvDB: SLC5A8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC5A8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC5A8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC5A8 gene:
    Search GeneIP for patents involving SLC5A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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