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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC5A7 Gene

protein-coding GIFtS: 59
GCID: GC02P108602

solute carrier family 5 (choline transporter), member 7

Explore 13 diseases affiliated with
SLC5A7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 5 (Choline Transporter), Member 7¹ ²		CHT² ³
CHT1¹ ² ³		HMN7A²
HCHT¹		High Affinity Choline Transporter 1²
Hemicholinium-3-Sensitive Choline Transporter² ³		High Affinity Choline Transporter; Hemicholinium-3-Sensitive Choline Transporter²
Solute Carrier Family 5 Member 7² ³

External Ids:	HGNC: 14025¹	Entrez Gene: 60482²	Ensembl: ENSG00000115665⁷	OMIM: 608761⁵	UniProtKB: Q9GZV3³

Export aliases for SLC5A7 gene to outside databases

Previous GC identifers: GC02P106508 GC02P107083 GC02P108207 GC02P108224 GC02P108061 GC02P107969 GC02P102202

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC5A7:

Choline is a direct precursor of acetylcholine (ACh), a neurotransmitter of the central and peripheral nervous system

that regulates a variety of autonomic, cognitive, and motor functions. SLC5A7 is a Na(+)- and Cl(-)- dependent

high-affinity transporter that mediates the uptake of choline for acetylcholine synthesis in cholinergic neurons

(Apparsundaram et al., 2000 (PubMed 11027560)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SC5A7_HUMAN, Q9GZV3

Function: Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the

rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022171.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC5A7 gene promoter:
p53 Egr-1 ATF-2 NRSF form 1 NRSF form 2 Roaz Egr-4 CREB deltaCREB Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC5A7 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC5A7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC5A7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12 Ensembl cytogenetic band: 2q12.3 HGNC cytogenetic band: 2q12

SLC5A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC5A7 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P108602: view genomic region (about GC identifiers)

Start:	108,602,979 bp from pter	End:	108,630,450 bp from pter
Size:	27,472 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SC5A7_HUMAN, Q9GZV3 (See protein sequence)

Recommended Name: High affinity choline transporter 1

Size: 580 amino acids; 63204 Da

Subunit: Homo-oligomerizes at cell surface

Subcellular location: Membrane; Multi-pass membrane protein

Miscellaneous: Specifically inhibited by nanomolar concentrations of hemicholinium 3

Secondary accessions: Q53TF2

Explore the universe of human proteins at neXtProt for SLC5A7: NX_Q9GZV3

Post-translational modifications:

Phosphorylated (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9GZV3

SLC5A7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_068587.1

ENSEMBL proteins:

ENSP00000387346 ENSP00000264047 ENSP00000445351

Reactome Protein details: Q9GZV3
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IDA	11027560
GO:0043025	neuronal cell body	IEA	--

SLC5A7 for ontologies About GeneDecksing

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	ThermoFisher Antibodies for SLC5A7

Assay Products for SLC5A7:

	Browse Kits and Assays available from EMD Millipore
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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC5A7 for domains About GeneDecksing

1 InterPro domain/family:

IPR001734 Na/solute_symporter

Graphical View of Domain Structure for InterPro Entry Q9GZV3

ProtoNet protein and cluster: Q9GZV3

1 Blocks protein family: IPB001734 Na+/solute symporter

UniProtKB/Swiss-Prot: SC5A7_HUMAN, Q9GZV3

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SC5A7_HUMAN, Q9GZV3

Function: Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the

rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent

miRNA Products:		OriGene 3'-UTR Clone: SLC5A7 Browse MicroRNA Expression Plasmids
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		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC5A7 (see all 19):
		hsa-miR-137 hsa-miR-767-5p hsa-miR-16-1* hsa-miR-548l hsa-miR-376a* hsa-miR-103a-2* hsa-miR-3163 hsa-miR-548p

		SwitchGear 3'UTR luciferase reporter plasmid: SLC5A7 3' UTR sequence

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Gene Editing
Products:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A7

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005307	choline:sodium symporter activity	IMP	12237312
GO:0005515	protein binding	--	--
GO:0015220	choline transmembrane transporter activity	IMP	11068039
GO:0033265	choline binding	IEA	--

SLC5A7 for ontologies About GeneDecksing

Animal Models:
6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc5a7):

behavior/neurological	homeostasis/metabolism	integument	mortality/aging	nervous system
respiratory system

SLC5A7 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SLC-mediated transmembrane transport

	SLC-mediated transmembrane transport	1.00			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.38
	Transmembrane transport of small molecules	0.50

Transmission across Chemical Synapses

Transmission across Chemical Synapses

1.00

Neuronal System

0.67

Sympathetic Nerve Pathway (Neuroeffector Junction)

Sympathetic Nerve Pathway (Neuroeffector Junction)

1.00

Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

1.00

Synaptic transmission: ion currents

Synaptic transmission: ion currents

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SLC5A7

Synaptic transmission- ion currents

1 BioSystems Pathway for SLC5A7

Monoamine Transport

5/8 Reactome Pathways for SLC5A7 (see all 8)

	Acetylcholine Neurotransmitter Release Cycle
	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transmission across Chemical Synapses
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

2 PharmGKB Pathways for SLC5A7

	Sympathetic Nerve Pathway (Neuroeffector Junction)
	Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

1 Kegg Pathway (Kegg details for SLC5A7):

Cholinergic synapse

SLC5A7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SLC5A7

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for SLC5A7 (Q9GZV3³ ENSP00000264047⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PAWR	Q96IZ0³, ENSP00000328088⁴	I2D: score=2 STRING: ENSP00000328088
CHAT	ENSP00000337103⁴	STRING: ENSP00000337103
NEDD4	ENSP00000345530⁴	STRING: ENSP00000345530
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007268	synaptic transmission	TAS	--
GO:0007269	neurotransmitter secretion	TAS	--
GO:0007271	synaptic transmission, cholinergic	IEA	--
GO:0007274	neuromuscular synaptic transmission	IEA	--
GO:0008292	acetylcholine biosynthetic process	IMP	11068039

SLC5A7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC5A7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC5A7

3 HMDB Compounds for SLC5A7 About this table

Compound	Synonyms	CAS #	PubMed Ids
Chlorine	Cl2 (see all 13)	16887-00-6	--
Choline	(2-Hydroxyethyl)trimethyl ammonium (see all 19)	62-49-7	--
Sodium	Sodium (see all 2)	7440-23-5	--

1 DrugBank Compound for SLC5A7 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Choline	Bilineurine (see all 7)	62-49-7	transporter	substrate	15953352 16675138 16051538 16539662 16278103

3 Novoseek chemical compound relationships for SLC5A7 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
choline	87.9	181	15090548 (7), 11483303 (7), 17005849 (5), 15953352 (4) (see all 51)
acetylcholine	73.7	37	15953352 (2), 14594623 (2), 12406342 (1), 16862394 (1) (see all 20)
glucose	0	3	17005849 (1), 11027560 (1)

Search CenterWatch for drugs/clinical trials and news about SLC5A7 / SC5A7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC5A7 gene:

NM_021815.2

Unigene Cluster for SLC5A7:

Solute carrier family 5 (choline transporter), member 7

Hs.287758 [show with all ESTs]

Unigene Representative Sequence: AB043997

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409059 ENST00000264047(uc002tdv.3 uc010ywm.2 uc010fjj.3 uc010ywn.2)

ENST00000540517

miRNA Products:		OriGene 3'-UTR Clone: SLC5A7 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC5A7
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC5A7 (see all 19):
		hsa-miR-137 hsa-miR-767-5p hsa-miR-16-1* hsa-miR-548l hsa-miR-376a* hsa-miR-103a-2* hsa-miR-3163 hsa-miR-548p

		SwitchGear 3'UTR luciferase reporter plasmid: SLC5A7 3' UTR sequence

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC5A7

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		GenScript: all cDNA clones in your preferred vector: SLC5A7 (NM_021815)
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Additional cDNA sequence:

AB043997.1 AB084377.1 AF276871.1 AJ401466.1 AK300801.1 AK315280.1 BC111524.1 BC111525.1

1 DOTS entry:

DT.40263675

11 AceView cDNA sequences:

BU150451 AB043997 AJ401466 AF276871 NM_021815 BU149113 AB084377 AV709773

AA363955 AA364959 AA364965

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A7 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9
SP1:
SP2:

ECgene alternative splicing isoforms for SLC5A7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC5A7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

SLC5A7 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC5A7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC5A7

SOURCE GeneReport for Unigene cluster: Hs.287758

UniProtKB/Swiss-Prot: SC5A7_HUMAN, Q9GZV3

Tissue specificity: Expressed in putamen, spinal cord and medulla. Specific for cholinergic neurons

SABiosciences Custom PCR Arrays for SLC5A7

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC5A7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SLC5A7 gene from 6/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC5A7¹	solute carrier family 5 (choline transporter), member more	78.26(n) 85.47(a)		414870 NM_001001763.1 NP_001001763.1
lizard (Anolis carolinensis)	Reptilia	SLC5A7⁶	--	83(a)	1 ↔ 1	3(107711970-107735882)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-24h22.4¹	si:dkey-24h22.4	69.47(n) 76.32(a)		100005589 XM_001344561.1 XP_001344597.1
fruit fly (Drosophila melanogaster)	Insecta	CG7708^{1 , 3}	proline:sodium symporter³ CG7708¹	58(a)³ 58.28(n)¹ 60.48(a)¹		91C1³ 42245¹ NM_142486.2¹ NP_650743.1¹
worm (Caenorhabditis elegans)	Secernentea	cho-1^{1 , 3}	choline transporter³ Protein CHO-1¹	53(a)³ 57.58(n)¹ 56.91(a)¹		IV(13210128-13214728)³ 178274¹ NM_070138.6¹ NP_502539.1¹
E. coli (Escherichia coli)	Gamma proteobacteria	putP⁶ panF⁶	pantothenate:sodium symporter	18(a) 14(a)	possible ortholog possible ortholog	Chromosome(1078528-1080036) Chromosome(3405629-3407080)

ENSEMBL Gene Tree for SLC5A7 (if available)
TreeFam Gene Tree for SLC5A7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC5A7 gene

SLC5A8² SLC5A1² SLC5A4² SLC5A5² SLC5A11² SLC5A9² SLC5A3² SLC5A10²

SLC5A2² SLC5A6² SLC5A12²

SLC5A7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116847713^1,2	F,	--	108617347(+)	`TGCTCG/AGCACC`	1	--	int¹		1		EA	120
rs115740036^1,2	F,	--	108617348(+)	`GCTCGG/ACACCA`	1	--	int¹		1		NA	120
rs111624921^1,2	C,	--	108617433(+)	`AGGTTG/AGTATG`	1	--	int¹		2		WA	120
rs116668917^1,2		--	108617447(+)	`TGTCCA/GGTCTC`	1	--	int¹		1		WA	118
rs140839667^1,2		--	108617474(+)	`TGCCTC/GCAAGG`	1	--	int¹		0	--	--	--	--
rs76605307^1,2	C,	--	108617614(+)	`CCCCCC/TACCCA`	1	--	int¹		3		WA NA	240
rs180844471^1,2		--	108617636(+)	`ATATAC/TATCTC`	1	--	int¹		0	--	--	--	--
rs13387198^1,2	H	--	108617750(+)	`ttgacA/GgataT`	1	--	int¹		4		NS EA	386
rs150104135^1,2		--	108617794(+)	`TGTTGC/GTGCTG`	1	--	int¹		0	--	--	--	--
rs35097745^1,2	C,	--	108622813(+)	`CGTAT-/TATATAG`	1	--	int¹		1		NA	2

HapMap Linkage Disequilibrium report for SLC5A7 (108602979 - 108630450 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SLC5A7
5 CNVs: 1594 3382 8382 2403 2059
Human Gene Mutation Database (HGMD): SLC5A7

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC5A7 for disorders           About GeneDecksing

OMIM gene information: 608761    OMIM disorders: --

13 diseases for SLC5A7:    About MalaCards

anus adenocarcinoma brain edema tracheal cancer congenital hypothyroidism

cellulitis neuronitis hypothyroidism parkinson's disease

alzheimer's disease dementia prostate cancer glioblastoma

prostatitis

2 diseases from the University of Copenhagen DISEASES database for SLC5A7:

Congenital hypothyroidism Lung cancer

3 Novoseek disease relationships for SLC5A7 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	41.5	4	8624084 (1), 16524384 (1), 16722248 (1), 8040324 (1)
dementia	16.3	1	14993474 (1)
parkinson disease	0	1	16722248 (1)

Genetic Association Database (GAD): SLC5A7
Human Genome Epidemiology (HuGE) Navigator: SLC5A7 (6 documents)

Export disorders for SLC5A7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC5A7 gene, integrated from 9 sources (see all 72):
(articles sorted by number of sources associating them with SLC5A7)

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Molecular cloning of a human, hemicholinium-3-sensitive choline transporter. (PubMed id 11027560)^{1, 2, 3, 9} Apparsundaram S.... Blakely R.D. (2000)
Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate. (PubMed id 12237312)^{1, 2, 9} Okuda T.... Gurwitz D. (2002)
Heart rate variability is associated with polymorphic variation in the choline transporter gene. (PubMed id 15784779)^{1, 4, 9} Neumann S.A....Manuck S.B. (2005)
Functional characterization of the human high-affinity choline transporter. (PubMed id 11068039)^{1, 2, 9} Okuda T. and Haga T. (2000)
Transmembrane topology and oligomeric structure of the high-affinity choline transporter. (PubMed id 23132865)^{1, 2} Okuda T.... Haga T. (2012)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Na+, Cl-, and pH dependence of the human choline transporter (hCHT) in Xenopus oocytes: the proton inactivation hypothesis of hCHT in synaptic vesicles. (PubMed id 17005849)^{1, 9} Iwamoto H....De Felice L.J. (2006)
Constitutive high-affinity choline transporter endocytosis is determined by a carboxyl-terminal tail dileucine motif. (PubMed id 15953352)^{7, 9} Ribeiro F.M....Ferguson S.S. (2005)
Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane. (PubMed id 15090548)^{1, 9} Xie J. and Guo Q. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 60482	HGNC: 14025	AceView: SLC5A7	Ensembl:ENSG00000115665	euGenes: HUgn60482
ECgene: SLC5A7	Kegg: 60482	H-InvDB: SLC5A7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC5A7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC5A7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC5A7 gene:
Search GeneIP for patents involving SLC5A7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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SLC5A7 Gene

solute carrier family 5 (choline transporter), member 7

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SLC5A7 Gene

solute carrier family 5 (choline transporter), member 7

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