Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC5A6 Gene

protein-coding   GIFtS: 65
GCID: GC02M027422

Solute Carrier Family 5 (Sodium/Multivitamin And Iodide...

(Previous names: solute carrier family 5 (sodium-dependent vitamin transporter),...)
  See SLC5A6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 5 (Sodium/Multivitamin And Iodide Cotransporter),
Member 61 2
     Na(+)-Dependent Multivitamin Transporter2 3
Solute Carrier Family 5 (Sodium-Dependent Vitamin Transporter), Member 61 2     Na+-Dependent Multivitamin Transporter2
Solute Carrier Family 5 Member 62 3     Sodium-Dependent Multivitamin Transporter2
SMVT2 3     

External Ids:    HGNC: 110411   Entrez Gene: 88842   Ensembl: ENSG000001380747   OMIM: 6040245   UniProtKB: Q9Y2893   

Export aliases for SLC5A6 gene to outside databases

Previous GC identifers: GC02M027343 GC02M027515 GC02M027396 GC02M027335 GC02M027276 GC02M027164


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SLC5A6 Gene:
SLC5A6 (solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6) is a protein-coding gene. Diseases associated with SLC5A6 include biotin-responsive basal ganglia disease, and basal ganglia disease. GO annotations related to this gene include sodium-dependent multivitamin transmembrane transporter activity. An important paralog of this gene is ENSG00000272962.

UniProtKB/Swiss-Prot: SC5A6_HUMAN, Q9Y289
Function: Transports pantothenate, biotin and lipoate in the presence of sodium

Gene Wiki entry for SLC5A6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC5A6 gene promoter:
         c-Fos   AP-1   TFIID   MyoD   c-Jun   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC5A6 promoter sequence
   Search Chromatin IP Primers for SLC5A6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC5A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23

SLC5A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC5A6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M027422:  view genomic region     (about GC identifiers)

Start:
27,422,455 bp from pter      End:
27,435,826 bp from pter
Size:
13,372 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for SLC5A6

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SC5A6_HUMAN, Q9Y289 (See protein sequence)
Recommended Name: Sodium-dependent multivitamin transporter  
Size: 635 amino acids; 68642 Da
Secondary accessions: B2RB85 D6W549 Q969Y5

Explore the universe of human proteins at neXtProt for SLC5A6: NX_Q9Y289

Explore proteomics data for SLC5A6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys579, Lys599
  • Glycosylation2 at Asn138, Asn489, Asn498
  • Modification sites at PhosphoSitePlus

  • See SLC5A6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066918.2  
    ENSEMBL proteins: 
     ENSP00000310208   ENSP00000384853   ENSP00000411361   ENSP00000403851   ENSP00000384265  
     ENSP00000411536   ENSP00000401347   ENSP00000404032   ENSP00000402903   ENSP00000399299  
     ENSP00000412115  
    Reactome Protein details: Q9Y289

    SLC5A6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC5A6
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC5A6
    GenScript Custom Purified and Recombinant Proteins Services for SLC5A6
    Novus Biologicals SLC5A6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC5A6 

     
    Search antibodies-online for proteins for SLC5A6 

     
    Search antibodies-online for peptides for SLC5A6

    SLC5A6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SLC5A6
    OriGene Custom Antibody Services for SLC5A6
    Novus Biologicals SLC5A6 Antibodies
    Abcam antibodies for SLC5A6
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for SLC5A6
    antibodies-online antibodies for SLC5A6 (23 products) 

    SLC5A6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC5A6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC5A6
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SLC5A6 
    antibodies-online kits for SLC5A6 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SMVT
    Sodium iodide symporter, sodium-dependent multivitamin transporter and sodium-coupled monocarboxylate transporters

    3 InterPro protein domains:
     IPR019900 Na/solute_symporter_subgr
     IPR018212 Na/solute_symporter_CS
     IPR001734 Na/solute_symporter

    Graphical View of Domain Structure for InterPro Entry Q9Y289

    ProtoNet protein and cluster: Q9Y289

    1 Blocks protein domain: IPB001734 Na+/solute symporter

    UniProtKB/Swiss-Prot: SC5A6_HUMAN, Q9Y289
    Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family


    Find genes that share domains with SLC5A6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC5A6_HUMAN, Q9Y289
    Function: Transports pantothenate, biotin and lipoate in the presence of sodium

         Genatlas biochemistry entry for SLC5A6:
    solute carrier family 5,member A6,sodium dependent multivitamin transporter mediating the upstake of
    pentothenate,biotin,lipoate,expressed in placenta,small intestine,kidney

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0008523sodium-dependent multivitamin transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC5A6           About GenesLikeMe


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc5a6):
     behavior/neurological  cardiovascular system  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     homeostasis/metabolism  immune system  limbs/digits/tail  liver/biliary system  mortality/aging 
     nervous system  renal/urinary system  respiratory system  skeleton 

    Find genes that share phenotypes with SLC5A6           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC5A6

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC5A6:
    hsa-mir-98-5p (MIRT027678), hsa-mir-27b-3p (MIRT046193), hsa-mir-24-3p (MIRT030522)

    Block miRNA regulation of human, mouse, rat SLC5A6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC5A6 (see all 14):
    hsa-miR-98 hsa-miR-3938 hsa-miR-642a hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-29b-1* hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidSLC5A6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC5A6
    Predesigned siRNA for gene silencing in human, mouse, rat SLC5A6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC5A6

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC5A6 (see all 6)
    OriGene ORF clones in mouse, rat for SLC5A6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC5A6 (NM_021095)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC5A6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC5A6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC5A6
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC5A6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SC5A6_HUMAN, Q9Y289: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9516450
    GO:0012506vesicle membrane IEA--
    GO:0016020membrane TAS9516450
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SLC5A6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC5A6 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Defective BTD causes biotidinase deficiency
    Defective BTD causes biotidinase deficiency1.00
    Metabolism of vitamins and cofactors1.00
    Defective AMN causes hereditary megaloblastic anemia 11.00
    Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC1.00
    Defective MMAA causes methylmalonic aciduria type cblA1.00
    Defective MUT causes methylmalonic aciduria mut type1.00
    Defective CD320 causes methylmalonic aciduria1.00
    Defects in cobalamin (B12) metabolism1.00
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    3Metabolism
    Metabolism0.38
    4Vitamin digestion and absorption
    Vitamin digestion and absorption
    5Transport of vitamins, nucleosides, and related molecules
    Transport of vitamins, nucleosides, and related molecules


    Find genes that share SuperPaths with SLC5A6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for SLC5A6
        Transport of vitamins, nucleosides, and related molecules
    Biotin transport and metabolism
    Vitamin B5 (pantothenate) metabolism


    1 Kegg Pathway  (Kegg details for SLC5A6):
        Vitamin digestion and absorption

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC5A6
    Interactions:

        Search GeneGlobe Interaction Network for SLC5A6

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for SLC5A6 (Q9Y2893 ENSP000003102084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLN3Q132863I2D: score=1 
    ERBB2IPQ96RT13I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    GALNT6ENSP000003486684STRING: ENSP00000348668
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006768biotin metabolic process TAS--
    GO:0006810transport TAS9516450
    GO:0015878biotin transport IEA--

    Find genes that share ontologies with SLC5A6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC5A6 (SC5A6)

    2 HMDB Compounds for SLC5A6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Biotin(+)-Biotin (see all 42)58-85-5--
    SodiumSodium (see all 2)7440-23-5--

    3 DrugBank Compounds for SLC5A6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Biotin(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid (see all 7)58-85-5target--17135299 17038304 16749865 17374649
    Lipoic Acid1,2-Dithiolane-3R-pentanoic acid (see all 4)62-46-4target--10334869 11955628 12214555
    gabapentin enacarbil-- 478296-72-9transportersubstrate15146028

    Selected Novoseek inferred chemical compound relationships for SLC5A6 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    multivitamin 87 46 16749865 (3), 19211916 (2), 11955628 (2), 12214555 (2) (see all 23)
    dethiobiotin 83 2 11496954 (2)
    pantothenate 82.3 7 10329687 (2), 11955628 (1), 12214555 (1), 17024033 (1)
    d-biotin 81.2 4 16749865 (2), 15146028 (1)
    biotin 79.1 72 17904341 (6), 15905112 (6), 19056636 (5), 11496954 (2) (see all 19)
    sodium 73.5 85 17571744 (3), 19654544 (3), 15021199 (3), 9848104 (2) (see all 55)
    alpha lipoic acid 73.2 5 10329687 (2), 11955628 (1), 12214555 (1)
    zotepine 64 2 9776389 (1), 10685875 (1)
    desipramine 50.8 2 14756813 (1), 14515337 (1)
    phlorizin 45.7 2 10356291 (1), 15218699 (1)



    Find genes that share compounds with SLC5A6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC5A6 gene: 
    NM_021095.2  

    Unigene Cluster for SLC5A6:

    Solute carrier family 5 (sodium-dependent vitamin transporter), member 6
    Hs.435735  [show with all ESTs]
    Unigene Representative Sequence: NR_028323
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461757 ENST00000310574(uc002rjd.3) ENST00000488743(uc010eyv.1)
    ENST00000408041 ENST00000461319 ENST00000481751 ENST00000492069 ENST00000476319
    ENST00000464538 ENST00000445802 ENST00000412471(uc002rje.1) ENST00000401463
    ENST00000432106 ENST00000426119 ENST00000414408 ENST00000428518 ENST00000430186
    ENST00000442731
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC5A6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC5A6 (see all 14):
    hsa-miR-98 hsa-miR-3938 hsa-miR-642a hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-29b-1* hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidSLC5A6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC5A6
    Predesigned siRNA for gene silencing in human, mouse, rat SLC5A6
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC5A6 (see all 6)
    OriGene ORF clones in mouse, rat for SLC5A6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC5A6 (NM_021095)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC5A6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC5A6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC5A6
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC5A6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC5A6
      QuantiTect SYBR Green Assays in human, mouse, rat SLC5A6
      QuantiFast Probe-based Assays in human, mouse, rat SLC5A6

    Additional mRNA sequence: 

    AF069307.1 AF081571.1 AF288781.1 AF442149.1 AF442150.1 AK075078.1 AK293162.1 AK314545.1 
    AL096737.1 BC012806.2 BC015631.2 NR_028323.1 

    22 DOTS entries:

    DT.91919621  DT.218168  DT.95222292  DT.100890844  DT.102835036  DT.100890831  DT.100665354  DT.75109830 
    DT.95348238  DT.120996052  DT.97862633  DT.100890823  DT.92033290  DT.92436746  DT.100703506  DT.100770201 
    DT.100890857  DT.100890859  DT.100890872  DT.95222294  DT.97857151  DT.92445187 

    Selected AceView cDNA sequences (see all 276):

    BM719520 AI148979 BC012806 AA512981 BU147208 AI200128 BQ643487 BX282514 
    BQ651664 AF069307 BG289749 AI206256 BM480275 R75947 AA703070 AA318121 
    BQ421644 NM_021095 AL042563 BQ669714 BM784183 CD358843 BQ441155 BM695353 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A6 (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^
    SP1:                                -     -     -     -           -     -                                               -                       -     -         
    SP2:                                -     -     -     -           -     -                                               -                       -     -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25
    SP1:  -                             -                                                               
    SP2:  -                                                                                             
    SP3:  -                             -                                                               
    SP4:                                -                                                               
    SP5:                                -                                                               


    ECgene alternative splicing isoforms for SLC5A6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC5A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCAGGTCCA
    SLC5A6 Expression
    About this image


    SLC5A6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Placenta (Extraembryonic Tissues)
     
     Stomach (Gastrointestinal Tract)
    SLC5A6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC5A6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435735
        Custom PCR Arrays for SLC5A6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC5A6
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC5A6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC5A6
    QuantiTect SYBR Green Assays in human, mouse, rat SLC5A6
    QuantiFast Probe-based Assays in human, mouse, rat SLC5A6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SLC5A6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc5a61 , 5 solute carrier family 5 (sodium-dependent vitamin transporter), more1, 5 83.15(n)1
    82.78(a)1
      5 (16.93 cM)5
    3300641  NM_001177621.11  NP_001171092.11 
     310360365 
    chicken
    (Gallus gallus)
    Aves SLC5A66
    solute carrier family 5 (sodium/multivitamin and i...
    77(a)
    1 ↔ 1
    AADN03013461.1(21-1247)
    lizard
    (Anolis carolinensis)
    Reptilia SLC5A66
    solute carrier family 5 (sodium/multivitamin and i...
    64(a)
    1 ↔ 1
    GL344234.1(2023-37109)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc5a61 solute carrier family 5 (sodium/multivitamin and iodide more 71.55(n)
    73.31(a)
      448188  NM_001005686.1  NP_001005686.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-5g7.31 si:dkey-5g7.3 64.45(n)
    66.07(a)
      563356  NM_001025529.2  NP_001020700.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG104443 sodium dependent multivitamin
    transporter
    40(a)
    (best of 11)
      56F14   --


    ENSEMBL Gene Tree for SLC5A6 (if available)
    TreeFam Gene Tree for SLC5A6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC5A6 gene
    ENSG000002729622  SLC5A82  SLC5A12  SLC5A42  SLC5A52  SLC5A112  SLC5A92  SLC5A102  
    SLC5A32  SLC5A22  SLC5A122  
    5 SIMAP similar genes for SLC5A6 using alignment to 10 protein entries:     SC5A6_HUMAN (see all proteins):
    SMVT    DKFZp434F152    SLC5A8    SLC5A12    SLC5A5

    Find genes that share paralogs with SLC5A6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC5A6 (see all 315)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs724933821,2
    F--27422145(+) GATGGA/GAACAT 2 -- int10--------
    rs1838723721,2
    --27422270(+) AGGGTA/GTGCAT 2 -- int10--------
    rs1506273541,2
    --27422300(+) AACACC/TGTCCC 2 -- int10--------
    rs1499668671,2
    --27422367(+) AAGGTA/GACCTG 2 -- int10--------
    rs759775291,2
    F--27422387(+) TAGGAC/TTCCTT 2 -- int11Minor allele frequency- T:0.04WA 118
    rs1476360201,2
    C--27422510(+) GAAGAA/CACTCC 2 -- ut31 nc-transcript-variant0--------
    rs70811,2
    C,F,O,A,H--27422605(-) TGACCA/GGGTCC 2 -- ut31 nc-transcript-variantese343Minor allele frequency- G:0.23MN NA NS EA WA CSA 5241
    rs793738071,2
    C,F--27422654(+) TAAGTG/ATCCAT 2 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.01WA 118
    rs1891763361,2
    --27423068(+) CCTACC/GAGCCT 2 -- ut31 nc-transcript-variant0--------
    rs1915101201,2
    C--27423113(+) AAAACA/G/TGTGCC 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for SLC5A6 (27422455 - 27435826 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC5A6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873754CNV Loss21882294
    nsv833603CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC5A6
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC5A6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604024    OMIM disorders: --

    4 diseases for SLC5A6:    
    About MalaCards
    biotin-responsive basal ganglia disease    basal ganglia disease    urinary tract obstruction    biotin deficiency

    1 disease from the University of Copenhagen DISEASES database for SLC5A6:
    biotin-responsive basal ganglia disease

    Find genes that share disorders with SLC5A6           About GenesLikeMe

    5 Novoseek inferred disease relationships for SLC5A6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    essential hypertension 32.1 2 2065466 (1), 17885550 (1)
    choriocarcinoma 25.9 2 10329687 (1), 14991266 (1)
    tumors 2.41 1 12829793 (1)
    insulin resistance 0 1 1789946 (1)
    cancer 0 4 11355005 (1), 12829793 (1), 8564963 (1)

    Genetic Association Database (GAD): SLC5A6
    Human Genome Epidemiology (HuGE) Navigator: SLC5A6 (2 documents)

    Export disorders for SLC5A6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC5A6 gene, integrated from 10 sources (see all 137):
    (articles sorted by number of sources associating them with SLC5A6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. (PubMed id 10329687)1, 2, 3, 9 Wang H.... Prasad P.D. (J. Biol. Chem. 1999)
    2. Molecular and functional characterization of the intestinal Na+- dependent multivitamin transporter. (PubMed id 10334869)1, 2, 7 Prasad P.D....Ganapathy V. (Arch. Biochem. Biophys. 1999)
    3. Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. (PubMed id 16749865)1, 7, 9 Luo S....Mitra A.K. (Mol. Pharm. 2006)
    4. Characterization of the 5' regulatory region of the human sodium- dependent multivitamin transporter, hSMVT. (PubMed id 11955628)1, 7, 9 Dey S.... Said H.M. (Biochim. Biophys. Acta 2002)
    5. Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo. (PubMed id 17135299)1, 7, 9 Reidling J.C. and Said H.M. (Am. J. Physiol., Cell Physiol. 2007)
    6. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (Nat. Genet. 2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate. (PubMed id 9516450)1, 3 Prasad P.D....Ganapathy V. (J. Biol. Chem. 1998)
    9. Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus. (PubMed id 17904341)1, 9 Gralla M....Zempleni J. (J. Nutr. Biochem. 2008)
    10. Synthesis of a rabbit polyclonal antibody to the human sodium-dependent multivitamin transporter. (PubMed id 12214555)7, 9 Griffin J.B....Zempleni J. (Int J Vitam Nutr Res 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8884 HGNC: 11041 AceView: SLC5A6 Ensembl:ENSG00000138074 euGenes: HUgn8884
    ECgene: SLC5A6 Kegg: 8884 H-InvDB: SLC5A6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC5A6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC5A6 gene:
    Search GeneIP for patents involving SLC5A6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SLC5A6   OriGene RNAi products in human, mouse, rat for SLC5A6  
     OriGene qPCR primer pairs and template standards for SLC5A6   OriGene Protein Over-expression Lysate for SLC5A6  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC5A6  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC5A6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC5A6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC5A6   OriGene Custom Protein Services for SLC5A6  

     
     
     Block miRNA regulation of human, mouse, rat SLC5A6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC5A6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC5A6 Predesigned siRNA for gene silencing in human, mouse, rat SLC5A6
     QuantiFast Probe-based Assays in human, mouse, rat SLC5A6 QuantiTect SYBR Green Assays in human, mouse, rat SLC5A6
     Custom PCR Arrays for SLC5A6 Search Chromatin IP Primers for SLC5A6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC5A6  Search GeneGlobe Interaction Network for SLC5A6
     Regulatory tfbs in SLC5A6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC5A6 GenScript cDNA clones with any tag delivered in your preferred vector for SLC5A6
     GenScript Custom Assay Services for SLC5A6 GenScript Custom overexpressing Cell Line Services for SLC5A6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC5A6 (SC5A6)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC5A6 antibodies
     SLC5A6 lysates
     Antibodies for SLC5A6
     See all of Abcam's Antibodies, Kits and Proteins for SLC5A6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC5A6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A6
     SwitchGear 3'UTR luciferase reporter plasmids for SLC5A6
     SwitchGear Promoter luciferase reporter plasmids for SLC5A6
     ThermoFisher Antibodies for SLC5A6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC5A6
     Browse compounds at ApexBio
     Search Addgene for plasmids for SLC5A6
      Search eBioscience for proteins for SLC5A6
      Search eBioscience for elisas for SLC5A6
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SLC5A6
     antibodies-online antibodies for SLC5A6 (23 products)
     antibodies-online kits for SLC5A6 (8 products)
      Search antibodies-online for peptides for SLC5A6
      Search antibodies-online for proteins for SLC5A6
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC5A6 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4