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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC5A6 Gene

protein-coding   GIFtS: 60
GCID: GC02M027422

solute carrier family 5 (sodium-dependent vitamin transporter),...
 Explore 23 diseases affiliated with
SLC5A6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC5A6    

Aliases
for SLC5A6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Solute Carrier Family 5 (Sodium-Dependent Vitamin Transporter), Member 61 2
SMVT1 2 3
Solute Carrier Family 5 Member 62 3
Na(+)-Dependent Multivitamin Transporter2 3
Na+-Dependent Multivitamin Transporter2
Sodium-Dependent Multivitamin Transporter2

External Ids:    HGNC: 110411   Entrez Gene: 88842   Ensembl: ENSG000001380747   OMIM: 6040245   UniProtKB: Q9Y2893   
ORGUL members:    fRNAdb10:FR330827      
H-InvDB:HIT000079729    
NCBI:AF442150    
NONCODE:n333195 n408180    
RNAdb:HIV2388    

Export aliases for SLC5A6 gene to outside databases

Previous GC identifers: GC02M027343 GC02M027515 GC02M027396 GC02M027335 GC02M027276 GC02M027164


Summaries
for SLC5A6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SC5A6_HUMAN, Q9Y289
Function: Transports pantothenate, biotin and lipoate in the presence of sodium

Gene Wiki entry for SLC5A6

fRNAdb sequence ontology for SLC5A6:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for SLC5A6

Genomic Views
for SLC5A6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC5A6 gene promoter:
         c-Fos   AP-1   TFIID   MyoD   c-Jun   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC5A6 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC5A6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC5A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23

SLC5A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC5A6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M027422:  view genomic region     (about GC identifiers)

Start:
 27,422,455 bp from pter      End:
 27,435,826 bp from pter
Size:
 13,372 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

  • n408180
  • FR0330827
  • n333195
27422454 27428815 27435175 chr2

Proteins
for SLC5A6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SC5A6_HUMAN, Q9Y289 (See protein sequence)
Recommended Name: Sodium-dependent multivitamin transporter  
Size: 635 amino acids; 68642 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B2RB85 D6W549 Q969Y5

Explore the universe of human proteins at neXtProt for SLC5A6: NX_Q9Y289

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y289

    • SLC5A6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066918.2  
    ENSEMBL proteins: 
     ENSP00000310208   ENSP00000384853   ENSP00000411361   ENSP00000403851   ENSP00000384265  
     ENSP00000411536   ENSP00000401347   ENSP00000404032   ENSP00000402903   ENSP00000399299  
     ENSP00000412115  
    Reactome Protein details: Q9Y289
    Human Recombinant Protein Products: 
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    Novus Biologicals SLC5A6 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC5A6

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9516450
    GO:0012506vesicle membrane IEA--
    GO:0016020membrane TAS9516450


    SLC5A6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC5A6

    Protein Domains /
    Families
    for SLC5A6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC5A6 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR019900 Na/solute_symporter_subgr
     IPR018212 Na/solute_symporter_CS
     IPR001734 Na/solute_symporter

    Graphical View of Domain Structure for InterPro Entry Q9Y289

    ProtoNet protein and cluster: Q9Y289

    1 Blocks protein family: IPB001734 Na+/solute symporter

    UniProtKB/Swiss-Prot: SC5A6_HUMAN, Q9Y289
    Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family


    Function
    for SLC5A6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SC5A6_HUMAN, Q9Y289
    Function: Transports pantothenate, biotin and lipoate in the presence of sodium

         Genatlas biochemistry entry for SLC5A6:
    solute carrier family 5,member A6,sodium dependent multivitamin transporter mediating the upstake of
    pentothenate,biotin,lipoate,expressed in placenta,small intestine,kidney

    miRNA
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    hsa-miR-98 hsa-miR-3938 hsa-miR-642a hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-29b-1* hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmid: SLC5A6 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008523sodium-dependent multivitamin transmembrane transporter activity IEA--


    SLC5A6 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Slc5a6):
     mortality/aging 

    SLC5A6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC5A6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Vitamin B5 (pantothenate) metabolism
    		Vitamin B5 (pantothenate) metabolism1.00
    		Metabolism of water-soluble vitamins and cofactors0.21
    		Metabolism of vitamins and cofactors0.21
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    3Metabolism
    		Metabolism1.00
    4Vitamin digestion and absorption
    		Vitamin digestion and absorption1.00
    5Biotin transport and metabolism
    		Biotin transport and metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for SLC5A6 (see all 8)
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Metabolism
    Transport of vitamins, nucleosides, and related molecules
    Biotin transport and metabolism


    1         Kegg Pathway  (Kegg details for SLC5A6):
        Vitamin digestion and absorption


    SLC5A6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC5A6

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for SLC5A6 (Q9Y2893 ENSP000003102084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLN3Q132863I2D: score=1 
    ERBB2IPQ96RT13I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    GALNT6ENSP000003486684STRING: ENSP00000348668
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006768biotin metabolic process TAS--
    GO:0006810transport TAS9516450
    GO:0015878biotin transport IEA--


    SLC5A6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC5A6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC5A6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC5A6

    2 HMDB Compounds for SLC5A6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Biotin(+)-Biotin (see all 42)58-85-5--
    SodiumSodium (see all 2)7440-23-5--

    2 DrugBank Compounds for SLC5A6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Biotin(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid (see all 7)58-85-5target--17135299 17038304 16749865 17374649
    Lipoic Acid1,2-Dithiolane-3R-pentanoic acid (see all 4)62-46-4target--10334869 11955628 12214555

    10/28 Novoseek chemical compound relationships for SLC5A6 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    multivitamin 87 46 16749865 (3), 19211916 (2), 11955628 (2), 12214555 (2) (see all 23)
    dethiobiotin 83 2 11496954 (2)
    pantothenate 82.3 7 10329687 (2), 11955628 (1), 12214555 (1), 17024033 (1)
    d-biotin 81.2 4 16749865 (2), 15146028 (1)
    biotin 79.1 72 17904341 (6), 15905112 (6), 19056636 (5), 11496954 (2) (see all 19)
    sodium 73.5 85 17571744 (3), 19654544 (3), 15021199 (3), 9848104 (2) (see all 55)
    alpha lipoic acid 73.2 5 10329687 (2), 11955628 (1), 12214555 (1)
    zotepine 64 2 9776389 (1), 10685875 (1)
    desipramine 50.8 2 14756813 (1), 14515337 (1)
    phlorizin 45.7 2 10356291 (1), 15218699 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC5A6 / SC5A6 

    Transcripts
    for SLC5A6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    		 1 fRNAdb Secondary structure:


    REFSEQ mRNAs for SLC5A6 gene: 
    NM_021095.2  

    Unigene Cluster for SLC5A6:

    Solute carrier family 5 (sodium-dependent vitamin transporter), member 6
    Hs.435735  [show with all ESTs]
    Unigene Representative Sequence: NR_028323
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461757 ENST00000310574(uc002rjd.3) ENST00000488743(uc010eyv.1)
    ENST00000408041 ENST00000461319 ENST00000481751 ENST00000492069 ENST00000476319
    ENST00000464538 ENST00000445802 ENST00000412471(uc002rje.1) ENST00000401463
    ENST00000432106 ENST00000426119 ENST00000414408 ENST00000428518 ENST00000430186
    ENST00000442731

    miRNA
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    hsa-miR-98 hsa-miR-3938 hsa-miR-642a hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-29b-1* hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmid: SLC5A6 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF069307.1 AF081571.1 AF288781.1 AF442149.1 AF442150.1 AK075078.1 AK293162.1 AK314545.1 
    AL096737.1 BC012806.2 BC015631.2 NR_028323.1 

    22 DOTS entries:

    DT.91919621  DT.218168  DT.95222292  DT.100890844  DT.102835036  DT.100890831  DT.100665354  DT.75109830 
    DT.95348238  DT.120996052  DT.97862633  DT.100890823  DT.92033290  DT.92436746  DT.100703506  DT.100770201 
    DT.100890857  DT.100890859  DT.100890872  DT.95222294  DT.97857151  DT.92445187 

    24/276 AceView cDNA sequences (see all 276):

    BM741838 AI200128 BM840109 AA512981 BG289749 AF069307 AF442150 CD358843 
    BQ421644 NM_021095 R75947 AA703070 BQ669714 BQ651664 BM480275 BM719520 
    BM784183 BX282514 BM695353 BC012806 BQ441155 AL042563 BQ643487 AI206256 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A6 (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^
    SP1:                                -     -     -     -           -     -                                               -                       -     -         
    SP2:                                -     -     -     -           -     -                                               -                       -     -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25
    SP1:  -                             -                                                               
    SP2:  -                                                                                             
    SP3:  -                             -                                                               
    SP4:                                -                                                               
    SP5:                                -                                                               


    ECgene alternative splicing isoforms for SLC5A6

    Expression
    for SLC5A6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC5A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCAGGTCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SLC5A6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC5A6

    SOURCE GeneReport for Unigene cluster: Hs.435735
        SABiosciences Custom PCR Arrays for SLC5A6
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    Orthologs
    for SLC5A6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLC5A6 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia SLC5A66
    		 --
    		 63(a)
    		 1 ↔ 1
    		 GL344234.1(2023-37109)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkey-5g7.31 si:dkey-5g7.3 64.7(n)
    66.34(a)    		   563356  NM_001025529.1  NP_001020700.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG104441 , 3 sodium dependent multivitamin transporter3
    CG104441    		 40(a)
    (best of 11)3
    52.19(n)1
    41.31(a)1    		   56F143
    372941  NM_137621.21  NP_611465.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea ZK822.53 sodium/proline symporter like 31(a)
    (best of 2)    		   IV(11937591-11940680)   --


    ENSEMBL Gene Tree for SLC5A6 (if available)
    TreeFam Gene Tree for SLC5A6 (if available) 

    Paralogs
    for SLC5A6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC5A6 gene
    SLC5A82  SLC5A12  SLC5A42  SLC5A52  SLC5A112  SLC5A92  SLC5A32  SLC5A102  
    SLC5A22  SLC5A122  SLC5A72  
    5 SIMAP similar genes for SLC5A6 using alignment to 10 protein entries:     SC5A6_HUMAN (see all proteins):
    SMVT    DKFZp434F152    SLC5A8    SLC5A12    SLC5A5

    SLC5A6 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC5A6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/270 NCBI SNPs in SLC5A6 are shown (see all 270)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs724933821,2
    		--27422145(+) GATGGA/GAACAT 2 -- int10--------
    rs1838723721,2
    		--27422270(+) AGGGTA/GTGCAT 2 -- int10--------
    rs1506273541,2
    		--27422300(+) AACACC/TGTCCC 2 -- int10--------
    rs1499668671,2
    		--27422367(+) AAGGTA/GACCTG 2 -- int10--------
    rs759775291,2
    		F,--27422387(+) TAGGAC/TTCCTT 2 -- int11Minor allele frequency- T:0.04WA 118
    rs1476360201,2
    		--27422510(+) GAAGAA/CACTCC 2 -- ut31 nc-transcript-variant0--------
    rs70811,2
    		C,F,O,A,H,--27422605(-) TGACCA/GGGTCC 2 -- nc-transcript-variantut31 ese343Minor allele frequency- G:0.23MN NA NS EA WA CSA 5241
    rs793738071,2
    		--27422654(+) TAAGTG/ATCCAT 2 -- nc-transcript-variantut311Minor allele frequency- A:0.01WA 118
    rs1891763361,2
    		--27423068(+) CCTACC/GAGCCT 2 -- ut31 nc-transcript-variant0--------
    rs1915101201,2
    		--27423113(+) AAAACA/G/TGTGCC 4 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for SLC5A6 (27422455 - 27435826 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC5A6: --

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    Disorders / Diseases
    for SLC5A6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC5A6 for disorders           About GeneDecksing

    OMIM gene information: 604024 600666 606415 607329 609402    
    20/23 diseases for SLC5A6 (see all 23):    About MalaCards
    biotin-responsive basal ganglia disease    basal ganglia disease    urinary tract obstruction    megaloblastic anemia
    insulin resistance    essential hypertension    hearing loss    pulmonary edema
    choriocarcinoma    hypercalcemia    hypertension    diarrhea
    migraine    aldosteronism    ovarian carcinoma    choroiditis
    retinoblastoma    anemia    pneumonia    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for SLC5A6:
    biotin-responsive basal ganglia disease

    5 Novoseek disease relationships for SLC5A6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    essential hypertension 32.1 2 2065466 (1), 17885550 (1)
    choriocarcinoma 25.9 2 10329687 (1), 14991266 (1)
    tumors 2.41 1 12829793 (1)
    insulin resistance 0 1 1789946 (1)
    cancer 0 4 11355005 (1), 12829793 (1), 8564963 (1)

    Human Genome Epidemiology (HuGE) Navigator: SLC5A6 (2 documents)

    Export disorders for SLC5A6 gene to outside databases

    Publications
    for SLC5A6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC5A6 gene, integrated from 9 sources (see all 133):
    (articles sorted by number of sources associating them with SLC5A6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. (PubMed id 10329687)1, 2, 3, 9 Wang H....Prasad P.D. (1999)
    2. Molecular and functional characterization of the intestinal Na+- dependent multivitamin transporter. (PubMed id 10334869)1, 2, 7 Prasad P.D....Ganapathy V. (1999)
    3. Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. (PubMed id 16749865)1, 7, 9 Luo S....Mitra A.K. (2006)
    4. Characterization of the 5' regulatory region of the human sodium- dependent multivitamin transporter, hSMVT. (PubMed id 11955628)1, 7, 9 Dey S.... Said H.M. (2002)
    5. Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo. (PubMed id 17135299)1, 7, 9 Reidling J.C. and Said H.M. (2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate. (PubMed id 9516450)1, 3 Prasad P.D....Ganapathy V. (1998)
    8. Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus. (PubMed id 17904341)1, 9 Gralla M....Zempleni J. (2008)
    9. Synthesis of a rabbit polyclonal antibody to the human sodium-dependent multivitamin transporter. (PubMed id 12214555)7, 9 Griffin J.B....Zempleni J. (2002)
    10. Membrane targeting and intracellular trafficking of the human sodium-dependent multivitamin transporter in polarized epithelial cells. (PubMed id 19211916)1, 9 Subramanian V.S....Said H.M. (2009)

    External Searches for SLC5A6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing SLC5A6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8884 HGNC: 11041 AceView: SLC5A6 Ensembl:ENSG00000138074 euGenes: HUgn8884
    ECgene: SLC5A6 Kegg: 8884 H-InvDB: SLC5A6

    Other Databases showing SLC5A6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC5A6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC5A6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC5A6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC5A6 gene:
    Search GeneIP for patents involving SLC5A6

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