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Aliases for SLC5A5 Gene

Aliases for SLC5A5 Gene

  • Solute Carrier Family 5 (Sodium/Iodide Cotransporter), Member 5 2 3
  • Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5 2 3
  • Na(+)/I(-) Cotransporter 3 4
  • Na(+)/I(-) Symporter 3 4
  • NIS 3 4
  • Solute Carrier Family 5 Member 5 4
  • Sodium-Iodide Symporter 4
  • TDH1 3

External Ids for SLC5A5 Gene

Previous GeneCards Identifiers for SLC5A5 Gene

  • GC19P018476
  • GC19P018374
  • GC19P017827
  • GC19P017843
  • GC19P017982
  • GC19P017548
  • GC19P017976

Summaries for SLC5A5 Gene

Entrez Gene Summary for SLC5A5 Gene

  • This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009]

GeneCards Summary for SLC5A5 Gene

SLC5A5 (Solute Carrier Family 5 (Sodium/Iodide Cotransporter), Member 5) is a Protein Coding gene. Diseases associated with SLC5A5 include thyroid dyshormonogenesis 1 and thyroid hormonogenesis defect i. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and iodide transmembrane transporter activity. An important paralog of this gene is SLC5A10.

UniProtKB/Swiss-Prot for SLC5A5 Gene

  • Mediates iodide uptake in the thyroid gland

Gene Wiki entry for SLC5A5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC5A5 Gene

Genomics for SLC5A5 Gene

Regulatory Elements for SLC5A5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC5A5 Gene

17,871,411 bp from pter
17,895,174 bp from pter
23,764 bases
Plus strand

Genomic View for SLC5A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC5A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC5A5 Gene

Proteins for SLC5A5 Gene

  • Protein details for SLC5A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/iodide cotransporter
    Protein Accession:
    Secondary Accessions:
    • O43702
    • Q2M335
    • Q9NYB6

    Protein attributes for SLC5A5 Gene

    643 amino acids
    Molecular mass:
    68666 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC5A5 Gene

Proteomics data for SLC5A5 Gene at MOPED

Post-translational modifications for SLC5A5 Gene

  • Glycosylation at Asn 489 and Asn 502
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC5A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC5A5 Gene

Domains & Families for SLC5A5 Gene

Gene Families for SLC5A5 Gene


Protein Domains for SLC5A5 Gene

Suggested Antigen Peptide Sequences for SLC5A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
genes like me logo Genes that share domains with SLC5A5: view

Function for SLC5A5 Gene

Molecular function for SLC5A5 Gene

GENATLAS Biochemistry:
solute carrier family 5 member 5,sodium iodide symporter,expressed in thyroid,breast,colon and ovary,involved in thyroid hormone synthesis and metabolism pathway
UniProtKB/Swiss-Prot Function:
Mediates iodide uptake in the thyroid gland

Gene Ontology (GO) - Molecular Function for SLC5A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0008507 sodium:iodide symporter activity IEA --
GO:0015111 iodide transmembrane transporter activity IMP 12021185
GO:0015293 symporter activity --
genes like me logo Genes that share ontologies with SLC5A5: view

Phenotypes for SLC5A5 Gene

genes like me logo Genes that share phenotypes with SLC5A5: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC5A5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC5A5 Gene

Localization for SLC5A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC5A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC5A5 Gene COMPARTMENTS Subcellular localization image for SLC5A5 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC5A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15961562
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with SLC5A5: view

Pathways & Interactions for SLC5A5 Gene

genes like me logo Genes that share pathways with SLC5A5: view

Pathways by source for SLC5A5 Gene

Interacting Proteins for SLC5A5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q92911-SC5A5_HUMAN ENSP00000222248 for SLC5A5 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SLC5A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006590 thyroid hormone generation TAS --
GO:0006810 transport TAS 8806637
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport --
GO:0015705 iodide transport IMP 12021185
genes like me logo Genes that share ontologies with SLC5A5: view

No data available for SIGNOR curated interactions for SLC5A5 Gene

Drugs & Compounds for SLC5A5 Gene

(3) Drugs for SLC5A5 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Kaempferol Experimental Pharma Apoptosis inducer;antioxidant;flavonoid, Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter 0
Iodine Pharma 459
Luteolin Nutra Antioxidant and free radical scavenger 1

(6) Additional Compounds for SLC5A5 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
  • Iodide
  • Iodide anion
  • Iodide ion
  • Iodide Salt
  • Iodide(1-)
genes like me logo Genes that share compounds with SLC5A5: view

Transcripts for SLC5A5 Gene

mRNA/cDNA for SLC5A5 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC5A5 Gene

Solute carrier family 5 (sodium iodide symporter), member 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC5A5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15

Relevant External Links for SLC5A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC5A5 Gene

mRNA expression in normal human tissues for SLC5A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC5A5 Gene

This gene is overexpressed in Stomach (x22.6), Cervix - Endocervix (x8.5), Thyroid (x7.6), and Minor Salivary Gland (x5.1).

Protein differential expression in normal tissues from HIPED for SLC5A5 Gene

This gene is overexpressed in Stomach (49.2) and Salivary gland (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC5A5 Gene

SOURCE GeneReport for Unigene cluster for SLC5A5 Gene Hs.584804

mRNA Expression by UniProt/SwissProt for SLC5A5 Gene

Tissue specificity: Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.
genes like me logo Genes that share expression patterns with SLC5A5: view

Protein tissue co-expression partners for SLC5A5 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC5A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC5A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC5A5 35
  • 85.77 (n)
  • 88.61 (a)
SLC5A5 36
  • 85 (a)
(Canis familiaris)
Mammalia SLC5A5 35
  • 84.84 (n)
  • 85.2 (a)
SLC5A5 36
  • 85 (a)
(Mus musculus)
Mammalia Slc5a5 35
  • 80.59 (n)
  • 84.34 (a)
Slc5a5 16
Slc5a5 36
  • 85 (a)
(Pan troglodytes)
Mammalia SLC5A5 35
  • 99.48 (n)
  • 99.38 (a)
SLC5A5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc5a5 35
  • 80.15 (n)
  • 84.34 (a)
(Monodelphis domestica)
Mammalia SLC5A5 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia SLC5A5 36
  • 54 (a)
(Gallus gallus)
Aves SLC5A5 35
  • 71.66 (n)
  • 72.98 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc5a5 35
  • 64.54 (n)
  • 69.89 (a)
Str.19489 35
(Danio rerio)
Actinopterygii slc5a5 35
  • 62.08 (n)
  • 63.16 (a)
slc5a5 36
  • 60 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3359 35
fruit fly
(Drosophila melanogaster)
Insecta CG10444 37
  • 38 (a)
CG2187 37
  • 33 (a)
CG2191 37
  • 32 (a)
CG2196 37
  • 33 (a)
CG5687 37
  • 33 (a)
CG6723 37
  • 34 (a)
CG7720 37
  • 31 (a)
CG8451 37
  • 29 (a)
CG8934 37
  • 32 (a)
CG8957 37
  • 34 (a)
CG8966 37
  • 34 (a)
CG9657 37
  • 31 (a)
CG2187 36
  • 29 (a)
CG31262 36
  • 28 (a)
CG31668 36
  • 30 (a)
CG33124 36
  • 28 (a)
CG42235 36
  • 27 (a)
CG5687 36
  • 27 (a)
CG6723 36
  • 32 (a)
CG7720 36
  • 27 (a)
CG8451 36
  • 29 (a)
CG9657 36
  • 31 (a)
salt 36
  • 30 (a)
Smvt 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea F52H2.4 37
  • 29 (a)
ZK822.5 37
  • 31 (a)
F52H2.4 36
  • 28 (a)
ZK822.5 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for SLC5A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC5A5 Gene

Gene Tree for SLC5A5 (if available)
Gene Tree for SLC5A5 (if available)

Paralogs for SLC5A5 Gene

(3) SIMAP similar genes for SLC5A5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC5A5: view

Variants for SLC5A5 Gene

Sequence variations from dbSNP and Humsavar for SLC5A5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs740695 -- 17,872,752(-) CCAAA(A/G)CCCCA intron-variant, upstream-variant-2KB
rs755922 -- 17,872,330(+) GGCCG(A/T)GGAGA missense, reference, intron-variant, upstream-variant-2KB
rs2299454 -- 17,880,466(+) cacct(C/T)gacct intron-variant
rs4462721 -- 17,885,353(+) tttTG(G/T)TTTTT intron-variant
rs4808707 -- 17,886,722(+) tactc(A/G)ttatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC5A5 Gene

Variant ID Type Subtype PubMed ID
nsv911209 CNV Loss 21882294
nsv911214 CNV Loss 21882294
nsv911219 CNV Loss 21882294
dgv3766n71 CNV Loss 21882294
nsv833772 CNV Gain+Loss 17160897
esv2672635 CNV Deletion 23128226

Variation tolerance for SLC5A5 Gene

Residual Variation Intolerance Score: 10.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC5A5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC5A5 Gene

Disorders for SLC5A5 Gene

MalaCards: The human disease database

(12) MalaCards diseases for SLC5A5 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
thyroid dyshormonogenesis 1
  • chdh1
thyroid hormonogenesis defect i
  • iodide transport defect
neonatal hypothyroidism
  • congenital hypothyroidism
familial thyroid dyshormonogenesis
  • thyroid dyshormonogenesis
congenital hypothyroidism
  • cretinism
- elite association


  • Thyroid dyshormonogenesis 1 (TDH1) [MIM:274400]: A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. {ECO:0000269 PubMed:10487695, ECO:0000269 PubMed:9171822, ECO:0000269 PubMed:9486973, ECO:0000269 PubMed:9745458}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for SLC5A5 Gene

congenital hypothyroidism with goiter,low thyroidal and salivary gland radioiodide uptake

Relevant External Links for SLC5A5

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC5A5: view

Publications for SLC5A5 Gene

  1. Genetics and phenomics of hypothyroidism and goiter due to NIS mutations. (PMID: 20153805) Spitzweg C. … Morris J.C. (Mol. Cell. Endocrinol. 2010) 23 67
  2. Intronic elements in the Na+/I- symporter gene (NIS) interact with retinoic acid receptors and mediate initiation of transcription. (PMID: 20123735) Alotaibi H. … Tazebay U.H. (Nucleic Acids Res. 2010) 23 67
  3. Congenital hypothyroidism and late-onset goiter: identification and characterization of a novel mutation in the sodium/iodide symporter of the proband and family members. (PMID: 19916865) Montanelli L. … Tonacchera M. (Thyroid 2009) 23 67
  4. Quantitative molecular imaging of viral therapy for pancreatic cancer using an engineered measles virus expressing the sodium-iodide symporter reporter gene. (PMID: 19098211) Carlson S.K. … Russell S.J. (AJR Am J Roentgenol 2009) 23 67
  5. Alpha-fetoprotein promoter-targeted sodium iodide symporter gene therapy of hepatocellular carcinoma. (PMID: 17989705) Willhauck M.J. … Spitzweg C. (Gene Ther. 2008) 23 67

Products for SLC5A5 Gene

Sources for SLC5A5 Gene

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