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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC5A5 Gene

protein-coding   GIFtS: 64
GCID: GC19P017982

Solute Carrier Family 5 (Sodium/Iodide Cotransporter), Member...

(Previous names: solute carrier family 5 (sodium iodide symporter), member...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 5 (Sodium/Iodide Cotransporter), Member 51 2     TDH12 5
NIS2 3 5     Sodium/Iodide Cotransporter2
Solute Carrier Family 5 (Sodium Iodide Symporter), Member 51 2     Sodium-Iodide Symporter3
Na(+)/I(-) Cotransporter2 3     Solute Carrier Family 5 Member 53
Na(+)/I(-) Symporter2 3     

External Ids:    HGNC: 110401   Entrez Gene: 65282   Ensembl: ENSG000001056417   OMIM: 6018435   UniProtKB: Q929113   

Export aliases for SLC5A5 gene to outside databases

Previous GC identifers: GC19P018476 GC19P018374 GC19P017827 GC19P017843 GC19P017548


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC5A5 Gene:
This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the
uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid
is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in
this gene are associated with thyroid dyshormonogenesis 1.(provided by RefSeq, Sep 2009)

GeneCards Summary for SLC5A5 Gene: 
SLC5A5 (solute carrier family 5 (sodium/iodide cotransporter), member 5) is a protein-coding gene. Diseases associated with SLC5A5 include neonatal hypothyroidism, and thyroid hormonogenesis defect i, and among its related super-pathways are Amino acid transport across the plasma membrane and Transmembrane transport of small molecules. GO annotations related to this gene include iodide transmembrane transporter activity and sodium:iodide symporter activity. An important paralog of this gene is SLC5A8.

UniProtKB/Swiss-Prot: SC5A5_HUMAN, Q92911
Function: Mediates iodide uptake in the thyroid gland

Gene Wiki entry for SLC5A5 (Sodium-iodide symporter) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC5A5 gene promoter:
         STAT5B   AP-1   NRSF form 1   MyoD   c-Jun   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC5A5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC5A5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC5A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

SLC5A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC5A5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017982:  view genomic region     (about GC identifiers)

Start:
17,982,782 bp from pter      End:
18,005,983 bp from pter
Size:
23,202 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SC5A5_HUMAN, Q92911 (See protein sequence)
Recommended Name: Sodium/iodide cotransporter  
Size: 643 amino acids; 68666 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O43702 Q2M335 Q9NYB6

Explore the universe of human proteins at neXtProt for SLC5A5: NX_Q92911

Explore proteomics data for SLC5A5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92911

  • SLC5A5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC5A5 Protein Expression
    REFSEQ proteins: NP_000444.1  
    ENSEMBL proteins: 
     ENSP00000222248  
    Reactome Protein details: Q92911
    Human Recombinant Protein Products for SLC5A5: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15961562
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SLC5A5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: NIS 
    Sodium iodide symporter, sodium-dependent multivitamin transporter and sodium-coupled monocarboxylate transporters

    3 InterPro protein domains:
     IPR019900 Na/solute_symporter_subgr
     IPR018212 Na/solute_symporter_CS
     IPR001734 Na/solute_symporter

    Graphical View of Domain Structure for InterPro Entry Q92911

    ProtoNet protein and cluster: Q92911

    1 Blocks protein domain: IPB001734 Na+/solute symporter

    UniProtKB/Swiss-Prot: SC5A5_HUMAN, Q92911
    Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family


    SLC5A5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC5A5_HUMAN, Q92911
    Function: Mediates iodide uptake in the thyroid gland

         Genatlas biochemistry entry for SLC5A5:
    solute carrier family 5 member 5,sodium iodide symporter,expressed in thyroid,breast,colon and ovary,involved in
    thyroid hormone synthesis and metabolism pathway

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0008507sodium:iodide symporter activity IEA--
    GO:0015111iodide transmembrane transporter activity IMP12021185
    GO:0015293symporter activity ----
         
    SLC5A5 for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC5A5 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC5A5 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Amino acid and oligopeptide SLC transporters
    Amino acid and oligopeptide SLC transporters0.63
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    2SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    3Regulation of thyroid hormone activity
    Thyroxine biosynthesis0.50
    Amine-derived hormones0.43
    4Metabolism
    Metabolism0.40
    5Insulin secretion
    Thyroid hormone synthesis0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SLC5A5
        Sodium channels and transporters- inward current


    5/9        Reactome Pathways for SLC5A5 (see all 9)
        Thyroxine biosynthesis
    Amine-derived hormones
    Metabolism
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules


    1         Kegg Pathway  (Kegg details for SLC5A5):
        Thyroid hormone synthesis


    SLC5A5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC5A5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for SLC5A5 (Q929113 ENSP000002222484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2IPQ96RT13I2D: score=1 
    --ENSP000002992334STRING: ENSP00000299233
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006590thyroid hormone generation TAS--
    GO:0006810transport TAS8806637
    GO:0006811ion transport TAS--
    GO:0015705iodide transport IMP12021185
    GO:0034641cellular nitrogen compound metabolic process TAS--

    SLC5A5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC5A5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC5A5 (SC5A5)

    1 HMDB Compound for SLC5A5    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    9 Novoseek inferred chemical compound relationships for SLC5A5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sodium iodide 95 13 18205108 (3), 10895037 (1), 16500013 (1), 19098211 (1) (see all 7)
    iodide 91.4 50 18708479 (5), 12028133 (3), 10487695 (3), 15850642 (3) (see all 23)
    perchlorate 69.2 3 15850642 (1), 16500013 (1), 14633711 (1)
    iodine 60.8 2 18205108 (1), 14757968 (1)
    sodium 58.1 9 12028133 (1), 20123735 (1), 11061512 (1), 10487695 (1) (see all 9)
    125i 56.1 2 15347726 (2)
    luteolin 51.5 1 15080787 (1)
    kaempferol 48.7 1 15080787 (1)
    oligonucleotide 2.02 1 9589686 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC5A5 / SC5A5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC5A5 gene: 
    NM_000453.2  

    Unigene Cluster for SLC5A5:

    Solute carrier family 5 (sodium iodide symporter), member 5
    Hs.584804  [show with all ESTs]
    Unigene Representative Sequence: NM_000453
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222248(uc002nhr.4) ENST00000597109
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AF260700.1 BC105047.1 BC105049.1 BX648217.1 D87920.1 U66088.1 

    2 DOTS entries:

    DT.106024  DT.101975701 

    6 AceView cDNA sequences:

    U66088 NM_000453 AF260700 BX648217 D87920 BX509090 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15
    SP1:                                                                                                      
    SP2:                                                                                                      


    ECgene alternative splicing isoforms for SLC5A5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC5A5 expression in normal human tissues (normalized intensities)      SLC5A5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTACTGA
    SLC5A5 Expression
    About this image


    SLC5A5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Choroid Plexus Cells Choroid Plexus
             hippocampus   
     
     Choroid Plexus (Nervous System)
             Mature Choroid Plexus Cells Choroid Plexus

    See SLC5A5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC5A5

    SOURCE GeneReport for Unigene cluster: Hs.584804

    UniProtKB/Swiss-Prot: SC5A5_HUMAN, Q92911
    Tissue specificity: Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and
    ovary. Expression is reduced in tumors

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC5A5 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc5a51 , 5 solute carrier family 5 (sodium iodide symporter), more1, 5 80.69(n)1
    84.62(a)1
      8 (34.36 cM)5
    1144791  NM_053248.21  NP_444478.21 
     708828895 
    chicken
    (Gallus gallus)
    Aves SLC5A51 solute carrier family 5 (sodium iodide symporter), more 73.95(n)
    76.08(a)
      431544  XM_429095.3  XP_429095.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.194892 Transcribed sequence with moderate similarity to protein more 75.09(n)    AL881480.2 
    zebrafish
    (Danio rerio)
    Actinopterygii slc5a51 solute carrier family 5 (sodium iodide symporter), more 62.72(n)
    64.17(a)
      561445  NM_001089391.1  NP_001082860.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG104443 sodium dependent multivitamin
    transporter
    38(a)
    (best of 12)
      56F14   --
    worm
    (Caenorhabditis elegans)
    Secernentea ZK822.53 sodium/proline symporter like 31(a)
    (best of 2)
      IV(11937591-11940680)   --


    ENSEMBL Gene Tree for SLC5A5 (if available)
    TreeFam Gene Tree for SLC5A5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC5A5 gene
    SLC5A82  SLC5A12  SLC5A42  SLC5A112  SLC5A92  SLC5A102  SLC5A32  SLC5A22  
    SLC5A62  SLC5A122  
    3 SIMAP similar genes for SLC5A5 using alignment to 1 protein entry:     SC5A5_HUMAN:
    SLC5A8    SLC5A12    SLC5A6

    SLC5A5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/718 SNPs in SLC5A5 are shown (see all 718)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0102674
    Thyroid dyshormonogenesis 1 (TDH1)4--see VAR_0102672 G R mis40--------
    VAR_0102664
    Thyroid dyshormonogenesis 1 (TDH1)4--see VAR_0102662 T P mis40--------
    VAR_0102634
    Thyroid dyshormonogenesis 1 (TDH1)4--see VAR_0102632 G R mis40--------
    VAR_0102694
    Thyroid dyshormonogenesis 1 (TDH1)4--see VAR_0102692 G E mis40--------
    VAR_0102654
    Thyroid dyshormonogenesis 1 (TDH1)4--see VAR_0102652 Q E mis40--------
    rs1219091801,2
    Cpathogenic117924404(+) TCTACA/GGATCG 2 R G mis10--------
    rs1219091771,2
    Cpathogenic117930641(+) TATTAC/G/TGGTGC 2 Y * stg11NA 4552
    VAR_0102704
    ----see VAR_0102702 S Q mis40--------
    VAR_0102684
    ----see VAR_0102682 T Q mis40--------
    VAR_0102644
    ----see VAR_0102642 A P mis40--------

    HapMap Linkage Disequilibrium report for SLC5A5 (17982782 - 18005983 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLC5A5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672635CNV Deletion23128226
    dgv3766n71CNV Loss21882294
    nsv911219CNV Loss21882294
    nsv911214CNV Loss21882294
    nsv911209CNV Loss21882294
    nsv833772CNV Gain+Loss17160897


    Human Gene Mutation Database (HGMD): SLC5A5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC5A5
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC5A5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601843   
    OMIM disorders: 274400  
    UniProtKB/Swiss-Prot: SC5A5_HUMAN, Q92911
  • Thyroid dyshormonogenesis 1 (TDH1) [MIM:274400]: A disorder characterized by the inability of the thyroid
    to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland,
    leading to congenital hypothyroidism. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 20/31 diseases for SLC5A5 (see all 31):    About MalaCards
    neonatal hypothyroidism    thyroid hormonogenesis defect i    thyroid dyshormonogenesis 1    rapsn-related congenital myasthenic syndrome
    follicular thyroid carcinoma    congenital hypothyroidism    hypothyroidism    goiter
    thyroid cancer    thyroid adenoma    papillary thyroid carcinoma    thyroiditis
    barrett's esophagus    papillary carcinoma    measles    autoimmune thyroiditis
    graves' disease    choriocarcinoma    influenza    pneumonia

    3 diseases from the University of Copenhagen DISEASES database for SLC5A5:
    Thyroid cancer     Hypothyroidism     Pneumonia

    SLC5A5 for disorders           About GeneDecksing

    10/11 Novoseek inferred disease relationships for SLC5A5 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congenital hypothyroidism 74.1 4 10895037 (1), 10487695 (1), 19916865 (1), 20153805 (1)
    thyroid cancer 67.2 5 11061512 (3), 14757968 (1), 18202121 (1)
    thyroid carcinoma 55 4 11454507 (2), 11061512 (1)
    goiter 53.6 1 20153805 (1)
    autoimmune thyroid disease 42.9 1 14550956 (1)
    thyroid diseases 40.5 6 16121204 (1), 18205108 (1), 11716040 (1)
    hypothyroidism 38.6 14 16418213 (2), 20153805 (1)
    thyroid papillary carcinoma 37.3 1 17639055 (1)
    tumors 19.4 14 14633711 (2), 18058866 (2), 18676766 (1), 17931047 (1) (see all 8)
    cancer 6.48 2 18205108 (1), 17854396 (1)

    Genatlas disease: SLC5A5
    congenital hypothyroidism with goiter,low thyroidal and salivary gland radioiodide uptake

    Human Genome Epidemiology (HuGE) Navigator: SLC5A5 (1 document)

    Export disorders for SLC5A5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC5A5 gene, integrated from 9 sources (see all 145):
    (articles sorted by number of sources associating them with SLC5A5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel mutation in the sodium/iodide symporter gene in the largest family with iodide transport defect. (PubMed id 10487695)1, 2, 9 Kosugi S.... Dean H.J. (1999)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Congenital hypothyroidism due to mutations in the sodium/iodide symporter: identification of a nonsense mutation producing a downstream cryptic 3' splice site. (PubMed id 9486973)1, 2 Pohlenz J....Refetoff S. (1998)
    5. Novel, missense and loss-of-function mutations in the sodium/iodide symporter gene causing iodide transport defect in three Japanese patients. (PubMed id 9745458)1, 2 Kosugi S.... Jhiang S.M. (1998)
    6. Increased expression of the Na+/I- symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissue. (PubMed id 9329364)1, 2 Saito T....Onaya T. (1997)
    7. Expression, exon-intron organization, and chromosome mapping of the human sodium iodide symporter. (PubMed id 9231811)1, 3 Smanik P.A....Jhiang S.M. (1997)
    8. Congenital hypothyroidism caused by a mutation in the Na(+)/I(-) symporter. (PubMed id 9171822)1, 2 Fujiwara H....Amino N. (1997)
    9. Cloning of the human sodium iodide symporter. (PubMed id 8806637)1, 2 Smanik P.A....Jhiang S.M. (1996)
    10. Genetics and phenomics of hypothyroidism and goiter d ue to NIS mutations. (PubMed id 20153805)1, 9 Spitzweg C. and Morris J.C. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6528 HGNC: 11040 AceView: SLC5A5 Ensembl:ENSG00000105641 euGenes: HUgn6528
    ECgene: SLC5A5 Kegg: 6528 H-InvDB: SLC5A5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC5A5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC5A5 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SLC5A5

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC5A5 gene:
    Search GeneIP for patents involving SLC5A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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