SLC5A4 Gene
protein-coding GIFtS: 51
GCID: GC22M032614
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solute carrier family 5 (low affinity glucose cotransporter),...
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Aliases
for SLC5A4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 5 (Low Affinity Glucose Cotransporter), Member 41 2 | | Na(+)/Glucose Cotransporter 32 3 | | SAAT11 2 3 | | Low Affinity Sodium Glucose Cotransporter2 | | DJ90G24.41 2 | | Low Affinity Sodium-Glucose Cotransporter2 | | SGLT31 2 | | Sodium Transporter2 | | Sodium/Glucose Cotransporter 32 3 | | Solute Carrier Family 5 (Neutral Amino Acid Transporters, System A), Member 42 | | Solute Carrier Family 5 Member 42 3 | | SGLT23 |
Export aliases for SLC5A4 gene to outside databasesPrevious GC identifers: GC22M029310 GC22M030939 GC22M015572 |
Summaries
for SLC5A4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SC5A4_HUMAN, Q9NY91Function: Sodium-dependent glucose transporter (By similarity)
Gene Wiki entry for SLC5A4
|
Genomic Views
for SLC5A4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC5A4 gene promoter:
AhR p53 Arnt AREB6 PPAR-gamma1 POU2F1 POU2F1a PPAR-gamma2 Pax-4a Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC5A4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC5A4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.3 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q12.3SLC5A4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M032614: view genomic region
(about GC identifiers)
Start:
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32,614,463 bp from pter |
End:
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32,651,328 bp from pter |
Size:
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36,866 bases |
Orientation:
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minus strand |
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Proteins
for SLC5A4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SC5A4_HUMAN, Q9NY91 (See
protein sequence)Recommended Name: Low affinity sodium-glucose cotransporter Size: 659 amino acids; 72456 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O15279Explore the universe of human proteins at neXtProt for SLC5A4: NX_Q9NY91
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NY91
SLC5A4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055042.1
ENSEMBL proteins: ENSP00000266086
Human Recombinant Protein Products for SLC5A4:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLC5A4 for ontologies About GeneDecksing
SLC5A4 Antibody Products:
Assay Products for SLC5A4: |
Protein
Domains /
Families
for SLC5A4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC5A4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NY91ProtoNet protein and cluster: Q9NY91 1 Blocks protein family: IPB001734 Na+/solute symporter
UniProtKB/Swiss-Prot: SC5A4_HUMAN, Q9NY91Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family |
Function
for SLC5A4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SC5A4_HUMAN, Q9NY91Function: Sodium-dependent glucose transporter (By similarity) Genatlas biochemistry entry for SLC5A4:solute carrier family 5,neutral amino acid transporters,system A,member 4,expressed in kidney,smallintestine,spleen,liver,muscle
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015293 | symporter activity |
IEA | -- |
SLC5A4 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC5A4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC5A4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC5A4 (NM_014227) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC5A4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC5A4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A4 |
|
Pathways & Interactions
for SLC5A4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sodium channels and transporters: inward current | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for SLC5A4
SLC5A4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC5A4
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006814 | sodium ion transport |
IEA | -- | | GO:0008643 | carbohydrate transport |
IEA | -- |
SLC5A4 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC5A4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SLC5A4 for compounds About GeneDecksing
 Browse Tocris compounds for SLC5A4
1 HMDB Compound for SLC5A4 About this table
3 Novoseek chemical compound relationships for SLC5A4 gene About this table
Search CenterWatch for drugs/clinical trials and news about SLC5A4 / SC5A4
|
Transcripts
for SLC5A4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC5A4 gene: NM_014227.2 Unigene Cluster for SLC5A4: Solute carrier family 5 (low affinity glucose cotransporter), member 4 Hs.130101 [show with all ESTs]Unigene Representative Sequence: AJ1331271 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000266086(uc003ami.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC5A4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC5A4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC5A4 (NM_014227) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC5A4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC5A4 |
Additional cDNA sequence: AJ133127.1 GQ292716.1 JQ340171.1 JQ519903.1 U41897.1 2 DOTS entries: DT.40271884 DT.421760 5 AceView cDNA sequences: H55471 AJ133127 NM_014227 BU157483 U41897
GeneLoc Exon Structure
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Expression
for SLC5A4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC5A4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTCCCTGA
About this image
See SLC5A4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC5A4
SOURCE GeneReport for Unigene cluster: Hs.130101
SABiosciences Expression via Pathway-Focused PCR Array including SLC5A4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC5A4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC5A4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC5A4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC5A4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A4 |
Orthologs
for SLC5A4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SLC5A4 gene from 4/18 species (see all 18) About this table
ENSEMBL Gene Tree for SLC5A4 (if available)
TreeFam Gene Tree for SLC5A4 (if available) |
Paralogs
for SLC5A4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC5A4 gene
- SLC5A82 SLC5A12 SLC5A52 SLC5A112 SLC5A92 SLC5A102 SLC5A32 SLC5A22
- SLC5A62 SLC5A122 SLC5A72
6 SIMAP similar genes for SLC5A4 using alignment to 2 protein entries: SC5A4_HUMAN (see all proteins):SLC5A1 SLC5A2 SLC5A10 SLC5A3 SLC5A9 SLC5A11
SLC5A4 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for SLC5A4
PGOHUM00000242921 PGOHUM00000234853 PGOHUM00000235001 PGOHUM00000244335 PGOHUM00000244336
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Genomic Variants
for SLC5A4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC5A4 (32614463 - 32651328 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC5A4
1 CNV: 5358 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC5A4 |
|
Disorders
/ Diseases
for SLC5A4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC5A4 for disorders About GeneDecksing
4  diseases for SLC5A4: About MalaCardsrenal glycosuria panic disorder lung cancer thyroiditis
1 disease from the University of Copenhagen DISEASES database for SLC5A4:Renal glycosuria Genetic Association Database (GAD): SLC5A4
Human Genome Epidemiology (HuGE) Navigator: SLC5A4 (2 documents)
Export disorders for SLC5A4 gene to outside databases
|
Publications
for SLC5A4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC5A4 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with SLC5A4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression. (PubMed id 16319503)1, 4 Munafo M.R....Johnstone E.C. (2006)
- The sodium/substrate symporter family: structural and functional features. (PubMed id 12354616)1, 3 Jung H. (2002)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1. (PubMed id 9501190)1, 3 Veyhl M....Koepsell H. (1998)
- A single amino acid change converts the sugar sensor SGLT3 into a sugar transporter. (PubMed id 20421923)1, 9 Bianchi L. and DA-ez-Sampedro A. (2010)
- A novel SGLT is expressed in the human kidney. (PubMed id 22766068)1 Kothinti R.K....Tabatabai N.M. (2012)
- Protection of muscle membrane excitability during cycling in humans: a role for SGLT3? (PubMed id 18198291)1 Fairchild T.J. (2008)
- Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis. (PubMed id 17705872)1 Blaya C....Manfro G.G. (2007)
- Imino sugars are potent agonists of the human glucose sensor SGLT3. (PubMed id 17110502)1 Voss A.A....Wright E.M. (2007)
- A glucose sensor hiding in a family of transporters. (PubMed id 13130073)1 Diez-Sampedro A....Koepsell H. (2003)
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External Searches for SLC5A4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC5A4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC5A4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC5A4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC5A4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC5A4 gene:
Search GeneIP for patents involving SLC5A4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC5A4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC5A4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC5A4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC5A4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC5A4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC5A4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC5A4 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A4 |
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