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Aliases for SLC5A4 Gene

Aliases for SLC5A4 Gene

  • Solute Carrier Family 5 Member 4 2 3 4 5
  • Solute Carrier Family 5 (Low Affinity Glucose Cotransporter), Member 4 2 3
  • Solute Carrier Family 5 (Glucose Activated Ion Channel), Member 4 2 3
  • Sodium/Glucose Cotransporter 3 3 4
  • Na(+)/Glucose Cotransporter 3 3 4
  • SAAT1 3 4
  • Solute Carrier Family 5 (Neutral Amino Acid Transporters, System A), Member 4 3
  • Low Affinity Sodium-Glucose Cotransporter 3
  • Sodium Transporter 3
  • DJ90G24.4 3
  • SGLT2 4
  • SGLT3 3

External Ids for SLC5A4 Gene

Previous GeneCards Identifiers for SLC5A4 Gene

  • GC22M029310
  • GC22M030939
  • GC22M032614
  • GC22M015572

Summaries for SLC5A4 Gene

GeneCards Summary for SLC5A4 Gene

SLC5A4 (Solute Carrier Family 5 Member 4) is a Protein Coding gene. Diseases associated with SLC5A4 include Glucose Metabolism Disease and Endocrine Pancreas Disease. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and symporter activity. An important paralog of this gene is SLC5A1.

UniProtKB/Swiss-Prot for SLC5A4 Gene

  • Sodium-dependent glucose transporter.

Gene Wiki entry for SLC5A4 Gene

Additional gene information for SLC5A4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC5A4 Gene

Genomics for SLC5A4 Gene

Regulatory Elements for SLC5A4 Gene

Enhancers for SLC5A4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H031623 2.1 VISTA Ensembl ENCODE dbSUPER 21.7 +725.3 725325 8.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 SP3 MXD4 TUG1 PRR14L DEPDC5 SLC5A4 LOC100422292 MORC2 SFI1 DUSP18 RTCB PIK3IP1-AS1
GH22H032050 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +301.5 301533 2.8 PKNOX1 ZNF766 GLIS2 ATF7 FOS RUNX3 JUNB ZNF518A NFIL3 SMARCA4 SLC5A4 BPIFC ENSG00000241954 RFPL3S LOC100422292 IGLVIVOR22-2 LOC339666 SLC5A1 PIR57309
GH22H032406 0.9 Ensembl ENCODE 18.6 -54.6 -54582 1.7 HDGF BMI1 ELF1 DPF2 ZNF217 IKZF1 NBN HNF4A ZNF24 ETV6 SLC5A4 LOC100422292 ENSG00000241954 RFPL3S LOC339666 IGLVIVOR22-2 FBXO7 RTCB GC22P032387
GH22H032137 1.1 Ensembl ENCODE 10.4 +215.0 214986 2 HDAC1 HDGF PKNOX1 IRF2 SAP130 ARID4B SIN3A MAX ZBTB40 ZNF644 SLC5A4 BPIFC SLC5A1 PIR36978 ENSG00000239674
GH22H032078 1.1 Ensembl ENCODE dbSUPER 10.3 +273.8 273779 2.2 FOXA2 PRDM6 JUND ATF3 HNF4A FOXA1 YY1 SLC5A1 SLC5A4 BPIFC PIR57309
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC5A4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC5A4 Gene

Genomic Locations for SLC5A4 Gene
134,588 bases
Minus strand

Genomic View for SLC5A4 Gene

Genes around SLC5A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC5A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC5A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC5A4 Gene

Proteins for SLC5A4 Gene

  • Protein details for SLC5A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Low affinity sodium-glucose cotransporter
    Protein Accession:
    Secondary Accessions:
    • O15279

    Protein attributes for SLC5A4 Gene

    659 amino acids
    Molecular mass:
    72456 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC5A4 Gene

Post-translational modifications for SLC5A4 Gene

  • Glycosylation at isoforms=248
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC5A4 Gene

No data available for DME Specific Peptides for SLC5A4 Gene

Domains & Families for SLC5A4 Gene

Gene Families for SLC5A4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC5A4 Gene

Suggested Antigen Peptide Sequences for SLC5A4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
genes like me logo Genes that share domains with SLC5A4: view

Function for SLC5A4 Gene

Molecular function for SLC5A4 Gene

GENATLAS Biochemistry:
solute carrier family 5,neutral amino acid transporters,system A,member 4,expressed in kidney,small intestine,spleen,liver,muscle
UniProtKB/Swiss-Prot Function:
Sodium-dependent glucose transporter.

Phenotypes From GWAS Catalog for SLC5A4 Gene

Gene Ontology (GO) - Molecular Function for SLC5A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005412 glucose:sodium symporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC5A4: view

Phenotypes for SLC5A4 Gene

GenomeRNAi human phenotypes for SLC5A4:
genes like me logo Genes that share phenotypes with SLC5A4: view

Animal Model Products

CRISPR Products

miRNA for SLC5A4 Gene

miRTarBase miRNAs that target SLC5A4

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC5A4 Gene

Localization for SLC5A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC5A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC5A4 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC5A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC5A4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC5A4 Gene

Pathways & Interactions for SLC5A4 Gene

genes like me logo Genes that share pathways with SLC5A4: view

Pathways by source for SLC5A4 Gene

1 BioSystems pathway for SLC5A4 Gene

Interacting Proteins for SLC5A4 Gene

Gene Ontology (GO) - Biological Process for SLC5A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IBA --
GO:0008643 carbohydrate transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC5A4: view

No data available for SIGNOR curated interactions for SLC5A4 Gene

Drugs & Compounds for SLC5A4 Gene

(7) Drugs for SLC5A4 Gene - From: ClinicalTrials, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Canagliflozin Approved Pharma Inhibition, Inhibitor SGLT2 inhibitor,potent and selective 113
Hypoglycemic Agents Pharma 6047
Empagliflozin (BI 10773) Pharma SGLT-2 inhibitor for oral treatment of type 2 diabetes 0
PF-04971729 Pharma SGLT inhibitor 0
Glufosfamide Pharma inhibitor 0

(2) Additional Compounds for SLC5A4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion

(2) ApexBio Compounds for SLC5A4 Gene

Compound Action Cas Number
Empagliflozin (BI 10773) SGLT-2 inhibitor for oral treatment of type 2 diabetes 864070-44-0
PF-04971729 SGLT inhibitor 1210344-57-2
genes like me logo Genes that share compounds with SLC5A4: view

Drug Products

Transcripts for SLC5A4 Gene

mRNA/cDNA for SLC5A4 Gene

(6) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC5A4 Gene

Solute carrier family 5 (low affinity glucose cotransporter), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A4 Gene

No ASD Table

Relevant External Links for SLC5A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC5A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC5A4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC5A4 Gene:


SOURCE GeneReport for Unigene cluster for SLC5A4 Gene:


Evidence on tissue expression from TISSUES for SLC5A4 Gene

  • Intestine(4.4)
  • Nervous system(4.2)
  • Kidney(3.2)
  • Blood(2.4)
  • Urine(2.3)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with SLC5A4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC5A4 Gene

Orthologs for SLC5A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC5A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC5A4 33 34
  • 99.09 (n)
(Canis familiaris)
Mammalia LOC100685907 33
  • 85.03 (n)
SLC5A4 34
  • 84 (a)
(Bos Taurus)
Mammalia LOC527441 33
  • 84.72 (n)
SLC5A4 34
  • 81 (a)
(Rattus norvegicus)
Mammalia LOC102550704 33
  • 81.08 (n)
(Mus musculus)
Mammalia Slc5a4a 34
  • 79 (a)
Slc5a4b 34
  • 77 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 71 (a)
-- 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia SLC5A4 34
  • 65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.349 34
  • 53 (a)
-- 34
  • 52 (a)
-- 34
  • 50 (a)
Species where no ortholog for SLC5A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC5A4 Gene

Gene Tree for SLC5A4 (if available)
Gene Tree for SLC5A4 (if available)

Paralogs for SLC5A4 Gene

(6) SIMAP similar genes for SLC5A4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC5A4: view

Variants for SLC5A4 Gene

Sequence variations from dbSNP and Humsavar for SLC5A4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000001733 -- 32,304,417(+) GATTA(C/T)AGGCG intron-variant
rs1000076488 -- 32,352,011(+) TTTTG(A/T)CCCCT intron-variant
rs1000081190 -- 32,259,597(+) GGTTA(C/T)CTATT intron-variant
rs1000084762 -- 32,292,501(+) TGCTA(C/T)CTTAG intron-variant
rs1000098395 -- 32,300,262(+) GCTGC(C/T)GCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC5A4 Gene

Variant ID Type Subtype PubMed ID
nsv834178 CNV loss 17160897
nsv588895 CNV gain 21841781
nsv459874 CNV gain 19166990
nsv3597 CNV deletion 18451855
esv3893475 CNV gain 25118596
esv3893474 CNV gain 25118596
esv3647603 CNV loss 21293372
esv3575476 CNV gain 25503493
esv2672031 CNV deletion 23128226
esv2422247 CNV duplication 17116639

Variation tolerance for SLC5A4 Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC5A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC5A4 Gene

Disorders for SLC5A4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLC5A4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
glucose metabolism disease
  • disorder of glucose metabolism
endocrine pancreas disease
  • disorder of endocrine pancreas
pancreas disease
  • abnormality of the pancreas
acquired metabolic disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC5A4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC5A4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC5A4 Gene

Publications for SLC5A4 Gene

  1. A single amino acid change converts the sugar sensor SGLT3 into a sugar transporter. (PMID: 20421923) Bianchi L … Díez-Sampedro A (PloS one 2010) 3 22 60
  2. Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression. (PMID: 16319503) Munafò MR … Johnstone EC (Neuropsychobiology 2006) 3 45 60
  3. The sodium/substrate symporter family: structural and functional features. (PMID: 12354616) Jung H (FEBS letters 2002) 2 3 60
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 60
  5. Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1. (PMID: 9501190) Veyhl M … Koepsell H (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 60

Products for SLC5A4 Gene

Sources for SLC5A4 Gene

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