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Aliases for SLC5A4 Gene

Aliases for SLC5A4 Gene

  • Solute Carrier Family 5 (Glucose Activated Ion Channel), Member 4 2 3
  • Solute Carrier Family 5 (Low Affinity Glucose Cotransporter), Member 4 2 3
  • Solute Carrier Family 5 Member 4 3 4
  • Sodium/Glucose Cotransporter 3 3 4
  • Na(+)/Glucose Cotransporter 3 3 4
  • SAAT1 3 4
  • Solute Carrier Family 5 (Neutral Amino Acid Transporters, System A), Member 4 3
  • Low Affinity Sodium-Glucose Cotransporter 3
  • Low Affinity Sodium Glucose Cotransporter 3
  • Sodium Transporter 3
  • DJ90G24.4 3
  • SGLT2 4
  • SGLT3 3

External Ids for SLC5A4 Gene

Summaries for SLC5A4 Gene

GeneCards Summary for SLC5A4 Gene

SLC5A4 (Solute Carrier Family 5 (Glucose Activated Ion Channel), Member 4) is a Protein Coding gene. Among its related pathways are Metabolism and MPS VI - Maroteaux-Lamy syndrome. GO annotations related to this gene include symporter activity. An important paralog of this gene is SLC5A10.

UniProtKB/Swiss-Prot for SLC5A4 Gene

  • Sodium-dependent glucose transporter.

Gene Wiki entry for SLC5A4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC5A4 Gene

Genomics for SLC5A4 Gene

Genomic Location for SLC5A4 Gene

Start:
32,218,476 bp from pter
End:
32,352,898 bp from pter
Size:
134,423 bases
Orientation:
Minus strand

Genomic View for SLC5A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC5A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC5A4 Gene

Regulatory Elements for SLC5A4 Gene

Proteins for SLC5A4 Gene

  • Protein details for SLC5A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY91-SC5A4_HUMAN
    Recommended name:
    Low affinity sodium-glucose cotransporter
    Protein Accession:
    Q9NY91
    Secondary Accessions:
    • O15279

    Protein attributes for SLC5A4 Gene

    Size:
    659 amino acids
    Molecular mass:
    72456 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC5A4 Gene

Proteomics data for SLC5A4 Gene at MOPED

Post-translational modifications for SLC5A4 Gene

Other Protein References for SLC5A4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC5A4 Gene

Domains for SLC5A4 Gene

Gene Families for SLC5A4 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC5A4 Gene

Suggested Antigen Peptide Sequences for SLC5A4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NY91

UniProtKB/Swiss-Prot:

SC5A4_HUMAN
Family:
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.:
    • Q9NY91
genes like me logo Genes that share domains with SLC5A4: view

Function for SLC5A4 Gene

Molecular function for SLC5A4 Gene

GENATLAS Biochemistry: solute carrier family 5,neutral amino acid transporters,system A,member 4,expressed in kidney,small intestine,spleen,liver,muscle
UniProtKB/Swiss-Prot Function: Sodium-dependent glucose transporter.

Gene Ontology (GO) - Molecular Function for SLC5A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC5A4: view

miRNA for SLC5A4 Gene

miRTarBase miRNAs that target SLC5A4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC5A4 Gene

Localization for SLC5A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC5A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC5A4 Gene COMPARTMENTS Subcellular localization image for SLC5A4 gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC5A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC5A4: view

Pathways for SLC5A4 Gene

genes like me logo Genes that share pathways with SLC5A4: view

Interacting Proteins for SLC5A4 Gene

Gene Ontology (GO) - Biological Process for SLC5A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006814 sodium ion transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC5A4: view

Compounds for SLC5A4 Gene

(1) HMDB Compounds for SLC5A4 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(3) Novoseek inferred chemical compound relationships for SLC5A4 Gene

Compound -log(P) Hits PubMed IDs
methyl alpha-d-glucopyranoside 68.8 1
glucose 52.1 17
galactose 36 1
genes like me logo Genes that share compounds with SLC5A4: view

Transcripts for SLC5A4 Gene

mRNA/cDNA for SLC5A4 Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC5A4 Gene

Solute carrier family 5 (low affinity glucose cotransporter), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A4 Gene

No ASD Table

Relevant External Links for SLC5A4 Gene

GeneLoc Exon Structure for
SLC5A4
ECgene alternative splicing isoforms for
SLC5A4

Expression for SLC5A4 Gene

mRNA expression in normal human tissues for SLC5A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for SLC5A4 Gene Hs.130101

genes like me logo Genes that share expressions with SLC5A4: view

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for SLC5A4 Gene

Orthologs for SLC5A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC5A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC5A4 35
  • 99.09 (n)
  • 98.94 (a)
SLC5A4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC527441 35
  • 84.72 (n)
  • 81.03 (a)
SLC5A4 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100685907 35
  • 85.03 (n)
  • 83.76 (a)
SLC5A4 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc5a4a 16
Slc5a4a 36
  • 79 (a)
OneToMany
Slc5a4b 36
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC5A4 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102550704 35
  • 81.08 (n)
  • 80.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
CSA.349 36
  • 53 (a)
ManyToMany
Species with no ortholog for SLC5A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC5A4 Gene

ENSEMBL:
Gene Tree for SLC5A4 (if available)
TreeFam:
Gene Tree for SLC5A4 (if available)

Paralogs for SLC5A4 Gene

Selected SIMAP similar genes for SLC5A4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC5A4: view

Variants for SLC5A4 Gene

Sequence variations from dbSNP and Humsavar for SLC5A4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs135414 -- 32,335,853(-) TCCAG(A/C/T)TCGGA intron-variant
rs136710 -- 32,315,883(+) GATGG(-/G)CAGgg intron-variant
rs713764 -- 32,287,391(+) GGGTA(G/T)GAGCT intron-variant
rs732884 -- 32,335,859(+) CTGGA(C/G)GGTGC intron-variant
rs732885 -- 32,335,882(+) GGGAG(C/T)GAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC5A4 Gene

Variant ID Type Subtype PubMed ID
esv2422247 CNV Duplication 17116639
nsv834178 CNV Loss 17160897
nsv459874 CNV Gain 19166990
nsv3597 CNV Loss 18451855
esv2672031 CNV Deletion 23128226

Relevant External Links for SLC5A4 Gene

HapMap Linkage Disequilibrium report
SLC5A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC5A4 Gene

Disorders for SLC5A4 Gene

Relevant External Links for SLC5A4

Genetic Association Database (GAD)
SLC5A4
Human Genome Epidemiology (HuGE) Navigator
SLC5A4
genes like me logo Genes that share disorders with SLC5A4: view

No data available for UniProtKB/Swiss-Prot for SLC5A4 Gene

Publications for SLC5A4 Gene

  1. A single amino acid change converts the sugar sensor SGLT3 into a sugar transporter. (PMID: 20421923) Bianchi L. … DA-ez-Sampedro A. (PLoS ONE 2010) 3 23
  2. Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1. (PMID: 9501190) Veyhl M. … Koepsell H. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  4. The sodium/substrate symporter family: structural and functional features. (PMID: 12354616) Jung H. (FEBS Lett. 2002) 2 3
  5. Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression. (PMID: 16319503) MunafA^ M.R. … Johnstone E.C. (Neuropsychobiology 2006) 3 48

Products for SLC5A4 Gene

  • antibodies-online peptides for SLC5A4
  • antibodies-online antibodies for SLC5A4
  • antibodies-online kits for SLC5A4

Sources for SLC5A4 Gene

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