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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC5A4 Gene

protein-coding   GIFtS: 54
GCID: GC22M032614

Solute Carrier Family 5 (Glucose Activated Ion Channel),...

(Previous names: solute carrier family 5 (low affinity glucose cotransporter),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 5 (Glucose Activated Ion Channel), Member 41 2     SGLT32
Solute Carrier Family 5 (Low Affinity Glucose Cotransporter), Member 41 2     Low Affinity Sodium Glucose Cotransporter2
Sodium/Glucose Cotransporter 32 3     Low Affinity Sodium-Glucose Cotransporter2
Solute Carrier Family 5 Member 42 3     Sodium Transporter2
SAAT12 3     Solute Carrier Family 5 (Neutral Amino Acid Transporters, System A),
Member 42
Na(+)/Glucose Cotransporter 32 3     SGLT23
DJ90G24.42     

External Ids:    HGNC: 110391   Entrez Gene: 65272   Ensembl: ENSG000001001917   UniProtKB: Q9NY913   

Export aliases for SLC5A4 gene to outside databases

Previous GC identifers: GC22M029310 GC22M030939 GC22M015572


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC5A4 Gene: 
SLC5A4 (solute carrier family 5 (glucose activated ion channel), member 4) is a protein-coding gene. Diseases associated with SLC5A4 include renal glycosuria, and panic disorder, and among its related super-pathways are Transmembrane transport of small molecules and Glucose transport. GO annotations related to this gene include symporter activity. An important paralog of this gene is SLC5A8.

UniProtKB/Swiss-Prot: SC5A4_HUMAN, Q9NY91
Function: Sodium-dependent glucose transporter (By similarity)

Gene Wiki entry for SLC5A4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC5A4 gene promoter:
         AhR   p53   Arnt   AREB6   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   Pax-4a   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC5A4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC5A4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC5A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q12.3

SLC5A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC5A4 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M032614:  view genomic region     (about GC identifiers)

Start:
32,614,463 bp from pter      End:
32,651,328 bp from pter
Size:
36,866 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SC5A4_HUMAN, Q9NY91 (See protein sequence)
Recommended Name: Low affinity sodium-glucose cotransporter  
Size: 659 amino acids; 72456 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O15279

Explore the universe of human proteins at neXtProt for SLC5A4: NX_Q9NY91

Explore proteomics data for SLC5A4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NY91

  • SLC5A4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC5A4 Protein Expression
    REFSEQ proteins: NP_055042.1  
    ENSEMBL proteins: 
     ENSP00000266086  
    Reactome Protein details: Q9NY91
    Human Recombinant Protein Products for SLC5A4: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SLC5A4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SGLT3 
    Hexose transporter family

    3 InterPro protein domains:
     IPR019900 Na/solute_symporter_subgr
     IPR018212 Na/solute_symporter_CS
     IPR001734 Na/solute_symporter

    Graphical View of Domain Structure for InterPro Entry Q9NY91

    ProtoNet protein and cluster: Q9NY91

    1 Blocks protein domain: IPB001734 Na+/solute symporter

    UniProtKB/Swiss-Prot: SC5A4_HUMAN, Q9NY91
    Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family


    SLC5A4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC5A4_HUMAN, Q9NY91
    Function: Sodium-dependent glucose transporter (By similarity)

         Genatlas biochemistry entry for SLC5A4:
    solute carrier family 5,neutral amino acid transporters,system A,member 4,expressed in kidney,small
    intestine,spleen,liver,muscle

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0015293symporter activity IEA--
         
    SLC5A4 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC5A4 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    2Regulation of Glucokinase by Glucokinase Regulatory Protein
    Hexose transport0.87
    3MPS IIIC - Sanfilippo syndrome C
    Metabolism of carbohydrates0.48
    4Metabolism
    Metabolism0.40
    5Na+-dependent glucose transporters
    Na+-dependent glucose transporters

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SLC5A4
        Sodium channels and transporters- inward current


    5/7        Reactome Pathways for SLC5A4 (see all 7)
        Metabolism of carbohydrates
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Hexose transport
    Metabolism



    SLC5A4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC5A4

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006814sodium ion transport IEA--
    GO:0008643carbohydrate transport IEA--
    GO:0055085transmembrane transport ----

    SLC5A4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC5A4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC5A4 (SC5A4)

    1 HMDB Compound for SLC5A4    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    3 Novoseek inferred chemical compound relationships for SLC5A4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methyl alpha-d-glucopyranoside 68.8 1 7493971 (1)
    glucose 52.1 38 7493971 (3), 7730974 (2), 11509120 (2), 11025446 (2) (see all 12)
    galactose 36 4 11602601 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC5A4 / SC5A4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC5A4 gene: 
    NM_014227.2  

    Unigene Cluster for SLC5A4:

    Solute carrier family 5 (low affinity glucose cotransporter), member 4
    Hs.130101  [show with all ESTs]
    Unigene Representative Sequence: AJ133127
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000266086(uc003ami.3)
    miRNA
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    Additional mRNA sequence: 

    AJ133127.1 GQ292716.1 JQ340171.1 JQ519903.1 U41897.1 

    2 DOTS entries:

    DT.40271884  DT.421760 

    5 AceView cDNA sequences:

    H55471 AJ133127 NM_014227 BU157483 U41897 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC5A4 expression in normal human tissues (normalized intensities)      SLC5A4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTCCCTGA
    SLC5A4 Expression
    About this image


    SLC5A4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 4 entries
             small intestine ; glandular cells   
             ileum   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See SLC5A4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC5A4

    SOURCE GeneReport for Unigene cluster: Hs.130101
        SABiosciences Expression via Pathway-Focused PCR Array including SLC5A4: 
              Drug Transporters in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SLC5A4 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc5a4a1 , 5 solute carrier family 5, member 4a1, 5 80.92(n)1
    79.24(a)1
      10 (38.71 cM)5
    644521  NM_133184.21  NP_573447.21 
     761474515 
    chicken
    (Gallus gallus)
    Aves SLC5A16
    Uncharacterized protein
    70(a)
    1 → many
    15(8768960-8794948)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    69(a)
    66(a)
    many ↔ many
    many ↔ many
    GL344191.1(87618-96791)
    AAWZ02037698(8856-14937)
    zebrafish
    (Danio rerio)
    Actinopterygii slc5a16
    solute carrier family 5 (sodium/glucose cotranspor...
    64(a)
    1 → many
    10(16991289-17015419)


    ENSEMBL Gene Tree for SLC5A4 (if available)
    TreeFam Gene Tree for SLC5A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC5A4 gene
    SLC5A82  SLC5A12  SLC5A52  SLC5A112  SLC5A92  SLC5A102  SLC5A32  SLC5A22  
    SLC5A62  SLC5A122  
    6 SIMAP similar genes for SLC5A4 using alignment to 2 protein entries:     SC5A4_HUMAN (see all proteins):
    SLC5A1    SLC5A2    SLC5A10    SLC5A3    SLC5A9    SLC5A11

    SLC5A4 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for SLC5A4
    PGOHUM00000242921 PGOHUM00000234853 PGOHUM00000235001 PGOHUM00000244335 PGOHUM00000244336


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/900 SNPs in SLC5A4 are shown (see all 900)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59983141,2
    C,F,A,H--32614104(+) TATAAC/AATGAA 1 -- int117Minor allele frequency- A:0.24NS EA NA WA CSA 1201
    rs1813580161,2
    C--32614464(+) ATTATG/TAAGAA 1 -- ut310--------
    rs774172821,2
    C--32614524(+) AATAAA/GGACCA 2 L F mis10--------
    rs1482815241,2
    C,F--32614536(+) CACAGC/TCAGGA 2 T A mis11Minor allele frequency- T:0.00NA 4552
    rs2018368351,2
    --32614694(+) ATCCAC/TGTGAT 2 H R mis10--------
    rs1139976311,2
    C,F--32614712(+) GATAAT/CCTGGA 2 /D /G mis11Minor allele frequency- C:0.00NA 4550
    rs781445891,2
    C--32614713(+) ATAATC/TTGGAA 1 -- spa10--------
    rs1908285861,2
    --32614895(+) GGCACA/GAAGTT 1 -- int10--------
    rs1468678831,2
    --32614962(+) ACAAAC/GGGTTT 1 -- int10--------
    rs1826305321,2
    --32614986(+) TATAAC/TGGGTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SLC5A4 (32614463 - 32651328 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC5A4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672031CNV Deletion23128226
    esv2422247CNV Duplication17116639
    nsv3597CNV Loss18451855
    nsv834178CNV Loss17160897
    nsv459874CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for SLC5A4:    About MalaCards
    renal glycosuria    panic disorder    lung cancer    thyroiditis


    SLC5A4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC5A4
    Human Genome Epidemiology (HuGE) Navigator: SLC5A4 (2 documents)

    Export disorders for SLC5A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC5A4 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with SLC5A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression. (PubMed id 16319503)1, 4 Munafo M.R....Johnstone E.C. (2006)
    2. The sodium/substrate symporter family: structural and functional features. (PubMed id 12354616)1, 3 Jung H. (2002)
    3. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    4. Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1. (PubMed id 9501190)1, 3 Veyhl M....Koepsell H. (1998)
    5. A single amino acid change converts the sugar sensor SGLT3 into a sugar transporter. (PubMed id 20421923)1, 9 Bianchi L. and DA-ez-Sampedro A. (2010)
    6. A novel SGLT is expressed in the human kidney. (PubMed id 22766068)1 Kothinti R.K....Tabatabai N.M. (2012)
    7. Protection of muscle membrane excitability during cycling in humans: a role for SGLT3? (PubMed id 18198291)1 Fairchild T.J. (2008)
    8. Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis. (PubMed id 17705872)1 Blaya C....Manfro G.G. (2007)
    9. Imino sugars are potent agonists of the human glucose sensor SGLT3. (PubMed id 17110502)1 Voss A.A....Wright E.M. (2007)
    10. A glucose sensor hiding in a family of transporters. (PubMed id 13130073)1 Diez-Sampedro A....Koepsell H. (2003)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6527 HGNC: 11039 AceView: SLC5A4 Ensembl:ENSG00000100191 euGenes: HUgn6527
    ECgene: SLC5A4 H-InvDB: SLC5A4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC5A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC5A4 gene:
    Search GeneIP for patents involving SLC5A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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