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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC5A3 Gene

protein-coding   GIFtS: 54
GCID: GC21P035459

solute carrier family 5 (sodium/myo-inositol cotransporter),...

(Previous names: solute carrier family 5 (inositol transporter), member...)
 Explore 4 diseases affiliated with
SLC5A3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC5A3    

Aliases
for SLC5A3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
Aliases
Solute Carrier Family 5 (Sodium/Myo-Inositol Cotransporter), Member 31 2     Human Solute Carrier Family 5, Member 3, Sodium,Myo-Inositol Cotransporter11
SMIT11 2 3     SMIT22
SMIT1 2     BCW2 Protein2
Solute Carrier Family 5 (Inositol Transporter), Member 31 2     Human Solute Carrier Family 5, Member 3, Sodium/Myo-Inositol Cotransporter2
Sodium/Myo-Inositol Transporter 12 3     Sodium/Myo-Inositol Cotransporter2
Solute Carrier Family 5 Member 32 3     Sodium/Myo-Inositol Cotransporter 12
Na(+)/Myo-Inositol Cotransporter2 3     Solute Carrier Family 5 (Inositol Transporters), Member 32

External Ids:    HGNC: 110381   Entrez Gene: 65262   Ensembl: ENSG000001987437   OMIM: 6004445   UniProtKB: P537943   

Export aliases for SLC5A3 gene to outside databases

Previous GC identifers: GC21P032044 GC21P034387 GC21P034389 GC21P035447 GC21P035449 GC21P020945 GC21P035451 GC21P035453 GC21P035455 GC21P035457


Summaries
for SLC5A3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SC5A3_HUMAN, P53794
Function: Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in
impairment of cellular function

Gene Wiki entry for SLC5A3


Genomic Views
for SLC5A3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC5A3 gene promoter:
         ISGF-3   GCNF   FOXO3   LCR-F1   FOXO3b   GATA-1   PPAR-gamma1   FOXO3a   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

   Search SABiosciences Chromatin IP Primers for SLC5A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC5A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.12   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.11
Nature(405: 311-319) cytogenetic band:   21q22.12
SLC5A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC5A3 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P035459:   GeneLoc Nature:405,311-319
Start:
 35,445,870 bp from pter       21,022,392 bp from centromere
End:
 35,478,561 bp from pter 21,053,127 bp from centromere
Size:
 32,692 bases 30,736 bases
Orientation:
 plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: AF027153
genomic clones: R338L7 CTD2344F14


Proteins
for SLC5A3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SC5A3_HUMAN, P53794 (See protein sequence)
Recommended Name: Sodium/myo-inositol cotransporter  
Size: 718 amino acids; 79694 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O43489

Explore the universe of human proteins at neXtProt for SLC5A3: NX_P53794

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P53794

    • SLC5A3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008864.3  
    ENSEMBL proteins: 
     ENSP00000370543  
    Reactome Protein details: P53794
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: SLC5A3
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    Novus Biologicals SLC5A3 Proteins
    Novus Biologicals SLC5A3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC5A3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS1372904
    GO:0016021integral to membrane TAS7789985


    SLC5A3 for ontologies           About GeneDecksing



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    Assay Products for SLC5A3: 
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    Uscn ELISAs and CLIAs for SLC5A3

    Protein Domains /
    Families
    for SLC5A3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC5A3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR019900 Na/solute_symporter_subgr
     IPR018212 Na/solute_symporter_CS
     IPR001734 Na/solute_symporter

    Graphical View of Domain Structure for InterPro Entry P53794

    ProtoNet protein and cluster: P53794

    1 Blocks protein family: IPB001734 Na+/solute symporter

    UniProtKB/Swiss-Prot: SC5A3_HUMAN, P53794
    Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family


    Function
    for SLC5A3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SC5A3_HUMAN, P53794
    Function: Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in
    impairment of cellular function

         Genatlas biochemistry entry for SLC5A3:
    solute carrier family 5 (inositol transport),member 3,expressed predominantly in brain,kidney,placenta,involved in
    cellular osmoregulation

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC5A3
    8/161 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC5A3 (see all 161):
    hsa-miR-579 hsa-miR-106a hsa-miR-128 hsa-miR-342-3p hsa-miR-519a hsa-miR-200b hsa-miR-374b* hsa-miR-34c-5p
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    Inhib. RNA
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    OriGene shRNA RFP: SLC5A3
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC5A3 

    Cell Line
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    Search LifeMap BioReagents cell lines for SLC5A3

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005367myo-inositol:sodium symporter activity TAS1372904


    SLC5A3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for SLC5A3: Slc5a3tm1Skc Slc5a3tm1Gtb
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Slc5a3):
     growth/size  homeostasis/metabolism  mortality/aging  nervous system  respiratory system 

    SLC5A3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC5A3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    2Inositol transporters
    		Inositol transporters1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SLC5A3
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Inositol transporters



    SLC5A3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC5A3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for SLC5A3 (P537943 ENSP000003705434) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    CLN3Q132863I2D: score=1 
    IQCB1ENSP000003115054STRING: ENSP00000311505
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006020inositol metabolic process IEA--
    GO:0006810transport TAS1372904
    GO:0007422peripheral nervous system development IEA--
    GO:0015798myo-inositol transport ----
    GO:0043576regulation of respiratory gaseous exchange IEA--


    SLC5A3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC5A3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC5A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC5A3

    1 HMDB Compound for SLC5A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--
    10/15 Novoseek chemical compound relationships for SLC5A3 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 87.5 55 19032932 (3), 10773690 (3), 9820807 (3), 10996657 (3) (see all 26)
    betaine 68.5 6 9633613 (3), 10051678 (2), 18557924 (1)
    inositol monophosphate 62.3 1 16531065 (1)
    aldose 55.6 3 10051678 (2), 10201006 (1)
    carbamazepine 54.6 1 16420717 (1)
    valproate 53.4 3 16420717 (3)
    lithium 50.3 3 16420717 (3)
    sodium 44.8 9 19032932 (2), 10051678 (2), 12140271 (1), 10759869 (1) (see all 6)
    cycloheximide 34.8 4 9820807 (1), 10794675 (1), 8928755 (1)
    mannitol 34.7 3 10051678 (1), 10201006 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC5A3 / SC5A3 

    Transcripts
    for SLC5A3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC5A3 gene: 
    NM_006933.4  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000381151(uc002yto.3)

    miRNA
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    8/161 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC5A3 (see all 161):
    hsa-miR-579 hsa-miR-106a hsa-miR-128 hsa-miR-342-3p hsa-miR-519a hsa-miR-200b hsa-miR-374b* hsa-miR-34c-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC5A3 (see all 7)
    OriGene shRNA RFP: SLC5A3
    OriGene siRNA: SLC5A3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC5A3
    Clone
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    Primer
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    24/460 AceView cDNA sequences (see all 460):

    AI419482 CA390529 BX280448 CD675371 AI129261 BM562952 AA468597 AW237470 
    BQ232870 CF128900 AA449772 AI140453 BE708320 AX750579 BQ673266 F09353 
    BQ003126 BU156601 BF726865 AA449060 CB270163 AI371048 BQ069591 AI332649 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:                        
    SP3:                        


    ECgene alternative splicing isoforms for SLC5A3

    Expression
    for SLC5A3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC5A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC5A3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    BrainChoroid PlexusBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)

    See SLC5A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC5A3
        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC5A3: 
              Stress & Toxicity PathwayFinder in human mouse rat
              Osmotic Stress in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A3

    Orthologs
    for SLC5A3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SLC5A3 gene from 3/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC5A31 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 less 79.1(n)
    87.24(a)    		   770758  XM_001234083.2  XP_001234084.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5683381 sodium/myo-inositol cotransporter-like 65.81(n)
    68.58(a)    		   568338  XM_691663.2  XP_696755.2 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria yidK6
    putP6
    (see all 3)    		 proline:sodium symporter
    (see all 3)    		 23(a)
    16(a)
    (see all 3)    		 1 ↔ many
    possible ortholog
    (see all 3)    		 Chromosome(3856424-3858139) b3679
    Chromosome(1078528-1080036)


    ENSEMBL Gene Tree for SLC5A3 (if available)
    TreeFam Gene Tree for SLC5A3 (if available) 

    Paralogs
    for SLC5A3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC5A3 gene
    SLC5A82  SLC5A12  SLC5A42  SLC5A52  SLC5A112  SLC5A92  SLC5A102  SLC5A22  
    SLC5A62  SLC5A122  SLC5A72  
    6 SIMAP similar genes for SLC5A3 using alignment to 1 protein entry:     SC5A3_HUMAN:
    SLC5A10    SLC5A2    SLC5A4    SLC5A1    SLC5A11    SLC5A9

    SLC5A3 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC5A3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/760 NCBI SNPs in SLC5A3 are shown (see all 760)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1465601071,2
    		--35443910(+) AAAATG/TTTAAA 2 -- us2k10--------
    rs1412901981,2
    		--35444031(+) ACTCTA/CATCTT 2 -- us2k10--------
    rs1927069061,2
    		--35444087(+) TCTTCA/CTCTGT 2 -- us2k10--------
    rs1851074091,2
    		--35444123(+) GGGTAA/GAGGGG 2 -- us2k10--------
    rs1900425141,2
    		--35444139(+) AAAAGC/TACTTT 2 -- us2k10--------
    rs1450699721,2
    		--35444151(+) TTTCTA/GTTACT 2 -- us2k10--------
    rs1482394621,2
    		--35444156(+) ATTACC/TGTATG 2 -- us2k10--------
    rs1168431381,2
    		F,--35444237(+) CCTCTG/CTTTAA 2 -- us2k11Minor allele frequency- C:0.04EA 120
    rs1454536211,2
    		C,--35444250(+) AAATT-/ACTC  
                AGTGA     		2 -- us2k10--------
    rs1822657601,2
    		--35444281(+) TAAGAA/GAGACT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC5A3 (35445870 - 35478561 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SLC5A3
         1 CNV: 73629

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    Disorders / Diseases
    for SLC5A3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC5A3 for disorders           About GeneDecksing

    OMIM gene information: 600444    OMIM disorders: --

    4 diseases for SLC5A3:    About MalaCards
    brain injury    down syndrome    myocardial infarction    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SLC5A3:
    Down syndrome

    1 Novoseek disease relationship for SLC5A3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 33.3 2 9441750 (1), 7789985 (1)

    Human Genome Epidemiology (HuGE) Navigator: SLC5A3 (4 documents)

    Export disorders for SLC5A3 gene to outside databases

    Publications
    for SLC5A3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC5A3 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with SLC5A3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21. (PubMed id 7789985)1, 2, 3, 9 Berry G.T....Spinner N.B. (1995)
    2. The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter. (PubMed id 9441750)1, 2, 9 Mallee J.J.... Berry G.T. (1997)
    3. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    4. The 21q22.1 STS marker, VN02 (EST00541 cDNA), is part of the 3' sequence of the human Na+/myo-inositol cotransporter (SLC5A3) gene. (PubMed id 8646889)1, 9 Berry G.T....Antonarakis S.E. (1996)
    5. Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. (PubMed id 19032932)1, 9 Lin X....Ostlund R.E. (2009)
    6. Human Na(+)-myo-inositol cotransporter gene: alternate splicing generates diverse transcripts. (PubMed id 9612208)1, 9 Porcellati F....Killen P.D. (1998)
    7. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Additive effect of multiple genetic variants on the r isk of coronary artery disease. (PubMed id 20738937)1 LluA-s-Ganella C....Elosua R. (2010)

    External Searches for SLC5A3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC5A3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6526 HGNC: 11038 AceView: SLC5A3 Ensembl:ENSG00000198743 euGenes: HUgn6526
    ECgene: SLC5A3 H-InvDB: SLC5A3

    Other Databases showing SLC5A3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC5A3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC5A3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC5A3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC5A3 gene:
    Search GeneIP for patents involving SLC5A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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