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SLC5A3 Gene

protein-coding   GIFtS: 58
GCID: GC21P035461

Solute Carrier Family 5 (Sodium/Myo-Inositol Cotransporter),...

(Previous names: solute carrier family 5 (inositol transporter), member 3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Solute Carrier Family 5 (Sodium/Myo-Inositol Cotransporter), Member
31 2
     SMIT2
Solute Carrier Family 5 (Inositol Transporter), Member 31 2     SMIT22
Sodium/Myo-Inositol Transporter 12 3     BCW2 Protein2
Solute Carrier Family 5 Member 32 3     Human Solute Carrier Family 5, Member 3, Sodium/Myo-Inositol Cotransporter2
SMIT12 3     Sodium/Myo-Inositol Cotransporter2
Na(+)/Myo-Inositol Cotransporter2 3     Sodium/Myo-Inositol Cotransporter 12
Human Solute Carrier Family 5, Member 3, Sodium,Myo-Inositol Cotransporter11     Solute Carrier Family 5 (Inositol Transporters), Member 32

External Ids:    HGNC: 110381   Entrez Gene: 65262   Ensembl: ENSG000001987437   OMIM: 6004445   UniProtKB: P537943   

Export aliases for SLC5A3 gene to outside databases

Previous GC identifers: GC21P032044 GC21P034387 GC21P034389 GC21P035447 GC21P035449 GC21P020945 GC21P035451 GC21P035453 GC21P035455 GC21P035457 GC21P035459


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC5A3 Gene:
SLC5A3 (solute carrier family 5 (sodium/myo-inositol cotransporter), member 3) is a protein-coding gene. Diseases associated with SLC5A3 include labyrinthitis, and down syndrome. GO annotations related to this gene include myo-inositol:sodium symporter activity. An important paralog of this gene is ENSG00000272962.

UniProtKB/Swiss-Prot: SC5A3_HUMAN, P53794
Function: Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in
impairment of cellular function

Gene Wiki entry for SLC5A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SLC5A3 gene promoter:
         ISGF-3   GCNF   FOXO3   LCR-F1   FOXO3b   GATA-1   PPAR-gamma1   FOXO3a   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

   Search Chromatin IP Primers for SLC5A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC5A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.12   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.11
Nature(405: 311-319) cytogenetic band:   21q22.12
SLC5A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC5A3 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P035461:   GeneLoc Nature:405,311-319
Start:
35,445,870 bp from pter       21,022,392 bp from centromere
End:
35,478,561 bp from pter 21,053,127 bp from centromere
Size:
32,692 bases 30,736 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: AF027153
genomic clones: R338L7 CTD2344F14


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SC5A3_HUMAN, P53794 (See protein sequence)
Recommended Name: Sodium/myo-inositol cotransporter  
Size: 718 amino acids; 79694 Da
Secondary accessions: O43489

Explore the universe of human proteins at neXtProt for SLC5A3: NX_P53794

Explore proteomics data for SLC5A3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys290, Lys596
  • Glycosylation2 at Asn232
  • Modification sites at PhosphoSitePlus

  • See SLC5A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008864.3  
    ENSEMBL proteins: 
     ENSP00000370543  
    Reactome Protein details: P53794

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SMIT
    Sodium myo-inositol cotransporter transporters

    3 InterPro protein domains:
     IPR019900 Na/solute_symporter_subgr
     IPR018212 Na/solute_symporter_CS
     IPR001734 Na/solute_symporter

    Graphical View of Domain Structure for InterPro Entry P53794

    ProtoNet protein and cluster: P53794

    1 Blocks protein domain: IPB001734 Na+/solute symporter

    UniProtKB/Swiss-Prot: SC5A3_HUMAN, P53794
    Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family


    SLC5A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC5A3_HUMAN, P53794
    Function: Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in
    impairment of cellular function

         Genatlas biochemistry entry for SLC5A3:
    solute carrier family 5 (inositol transport),member 3,expressed predominantly in brain,kidney,placenta,involved in
    cellular osmoregulation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005367myo-inositol:sodium symporter activity TAS1372904
         
    SLC5A3 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc5a3):
     growth/size/body  homeostasis/metabolism  mortality/aging  nervous system  respiratory system 

    SLC5A3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SLC5A3: Slc5a3tm1Skc Slc5a3tm1Gtb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC5A3
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    miRNA
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    miRTarBase miRNAs that target SLC5A3:
    hsa-mir-183-5p (MIRT047069), hsa-mir-130b-3p (MIRT020185), hsa-mir-335-5p (MIRT018102), hsa-mir-21-5p (MIRT030910), hsa-mir-128-3p (MIRT022015), hsa-mir-26b-5p (MIRT029655), hsa-mir-93-5p (MIRT028159), hsa-mir-877-3p (MIRT037180)

    Block miRNA regulation of human, mouse, rat SLC5A3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC5A3 (see all 161):
    hsa-miR-579 hsa-miR-106a hsa-miR-128 hsa-miR-342-3p hsa-miR-519a hsa-miR-200b hsa-miR-374b* hsa-miR-34c-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SC5A3_HUMAN, P53794: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1372904
    GO:0016020membrane ----
    GO:0016021integral component of membrane TAS7789985

    SLC5A3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC5A3 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Inositol transporters0.00
    Transmembrane transport of small molecules0.47
    Na+-dependent glucose transporters0.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    2Regulation of Glucokinase by Glucokinase Regulatory Protein
    Hexose transport0.87
    3MPS VI - Maroteaux-Lamy syndrome
    Metabolism of carbohydrates0.45
    4Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for SLC5A3
        Hexose transport
    Inositol transporters
    Na+-dependent glucose transporters



    SLC5A3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC5A3: 
              Stress & Toxicity PathwayFinder in human mouse rat
              Osmotic Stress in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC5A3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for SLC5A3 (P537943 ENSP000003705434) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    CLN3Q132863I2D: score=1 
    IQCB1ENSP000003115054STRING: ENSP00000311505
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006020inositol metabolic process ----
    GO:0006810transport TAS1372904
    GO:0007422peripheral nervous system development ----
    GO:0015798myo-inositol transport TAS1372904
    GO:0043576regulation of respiratory gaseous exchange ----

    SLC5A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC5A3 (SC5A3)

    1 HMDB Compound for SLC5A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    1 IUPHAR Ligand for SLC5A3 (SMIT)    About this table
    LigandTypeActionAffinityPubmed IDs
    phlorizin
    InhibitorInhibition--

    Selected Novoseek inferred chemical compound relationships for SLC5A3 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 87.5 55 19032932 (3), 10773690 (3), 9820807 (3), 10996657 (3) (see all 26)
    betaine 68.5 6 9633613 (3), 10051678 (2), 18557924 (1)
    inositol monophosphate 62.3 1 16531065 (1)
    aldose 55.6 3 10051678 (2), 10201006 (1)
    carbamazepine 54.6 1 16420717 (1)
    valproate 53.4 3 16420717 (3)
    lithium 50.3 3 16420717 (3)
    sodium 44.8 9 19032932 (2), 10051678 (2), 12140271 (1), 10759869 (1) (see all 6)
    cycloheximide 34.8 4 9820807 (1), 10794675 (1), 8928755 (1)
    mannitol 34.7 3 10051678 (1), 10201006 (1)



    SLC5A3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC5A3 gene: 
    NM_006933.5  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000381151(uc002yto.3)
    miRNA
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    hsa-miR-579 hsa-miR-106a hsa-miR-128 hsa-miR-342-3p hsa-miR-519a hsa-miR-200b hsa-miR-374b* hsa-miR-34c-5p
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    Selected AceView cDNA sequences (see all 460):

    BE708320 AI431331 BI493912 BE384048 BQ947008 AA449060 BX280448 N91757 
    AW104950 CR597333 BG684737 AA029258 AW241378 AI372882 AI280479 BM477310 
    BM830659 F09353 AI423415 AI422744 CA313245 AA490044 C00620 AI332649 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:                        
    SP3:                        


    ECgene alternative splicing isoforms for SLC5A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC5A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC5A3 Expression
    About this image


    SLC5A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Eye (Sensory Organs)
             Retina
     
     Thyroid (Endocrine System)
    SLC5A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC5A3 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC5A3: 
              Stress & Toxicity PathwayFinder in human mouse rat
              Osmotic Stress in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC5A3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc5a31 , 5 solute carrier family 5 (inositol transporters), member 3 less1, 5 90.71(n)1
    93.59(a)1
      16 (53.44 cM)5
    538811  NM_017391.31  NP_059087.21 
     920583225 
    chicken
    (Gallus gallus)
    Aves SLC5A31 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 less 79.15(n)
    87.24(a)
      770758  XM_004934532.1  XP_004934589.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5683381 sodium/myo-inositol cotransporter-like 65.85(n)
    68.58(a)
      568338  XM_005167791.1  XP_005167848.1 


    ENSEMBL Gene Tree for SLC5A3 (if available)
    TreeFam Gene Tree for SLC5A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC5A3 gene
    ENSG000002729622  SLC5A82  SLC5A12  SLC5A42  SLC5A52  SLC5A112  SLC5A92  SLC5A102  
    SLC5A22  SLC5A62  SLC5A122  
    6 SIMAP similar genes for SLC5A3 using alignment to 1 protein entry:     SC5A3_HUMAN:
    SLC5A10    SLC5A2    SLC5A4    SLC5A1    SLC5A11    SLC5A9

    SLC5A3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for SLC5A3    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs48176171,2,4
    ----see VAR_0618762 mis40--------
    rs81298911,2,4
    ----see VAR_0618752 mis40--------

    HapMap Linkage Disequilibrium report for SLC5A3 (35445870 - 35478561 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLC5A3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv28721CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC5A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC5A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600444    OMIM disorders: --

    10 diseases for SLC5A3:    
    About MalaCards
    labyrinthitis    down syndrome    brain injury    coronary artery disease
    endotheliitis    coronary heart disease    choroiditis    myocardial infarction
    retinitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SLC5A3:
    Down syndrome

    SLC5A3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SLC5A3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 33.3 2 9441750 (1), 7789985 (1)

    Genetic Association Database (GAD): SLC5A3
    Human Genome Epidemiology (HuGE) Navigator: SLC5A3 (4 documents)

    Export disorders for SLC5A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC5A3 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with SLC5A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21. (PubMed id 7789985)1, 2, 3, 9 Berry G.T....Spinner N.B. (Genomics 1995)
    2. The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter. (PubMed id 9441750)1, 2, 9 Mallee J.J.... Berry G.T. (Genomics 1997)
    3. Additive effect of multiple genetic variants on the risk of coronary artery disease. (PubMed id 20738937)1, 4 LluA-s-Ganella C....Elosua R. (Rev Esp Cardiol 2010)
    4. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. (PubMed id 20971364)1, 4 Ripatti S....Kathiresan S. (Lancet 2010)
    5. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. (PubMed id 19198609)1, 4  ....Altshuler D. (Nat. Genet. 2009)
    6. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    7. The 21q22.1 STS marker, VN02 (EST00541 cDNA), is part of the 3' sequence of the human Na+/myo-inositol cotransporter (SLC5A3) gene. (PubMed id 8646889)1, 9 Berry G.T....Antonarakis S.E. (Cytogenet. Cell Genet. 1996)
    8. Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. (PubMed id 19032932)1, 9 Lin X....Ostlund R.E. (Arch. Biochem. Biophys. 2009)
    9. Human Na(+)-myo-inositol cotransporter gene: alternate splicing generates diverse transcripts. (PubMed id 9612208)1, 9 Porcellati F....Killen P.D. (Am. J. Physiol. 1998)
    10. Down-regulation of the myoinositol transporter SMIT by JAK2. (PubMed id 23207989)1 Hosseinzadeh Z....Lang F. (Cell. Physiol. Biochem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6526 HGNC: 11038 AceView: SLC5A3 Ensembl:ENSG00000198743 euGenes: HUgn6526
    ECgene: SLC5A3 H-InvDB: SLC5A3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC5A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC5A3 gene:
    Search GeneIP for patents involving SLC5A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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