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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC5A3 Gene

protein-coding   GIFtS: 57
GCID: GC21P035461

Solute Carrier Family 5 (Sodium/Myo-Inositol Cotransporter),...

(Previous names: solute carrier family 5 (inositol transporter), member 3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Solute Carrier Family 5 (Sodium/Myo-Inositol Cotransporter), Member
31 2
     SMIT2
Solute Carrier Family 5 (Inositol Transporter), Member 31 2     SMIT22
Sodium/Myo-Inositol Transporter 12 3     BCW2 Protein2
Solute Carrier Family 5 Member 32 3     Human Solute Carrier Family 5, Member 3, Sodium/Myo-Inositol Cotransporter2
SMIT12 3     Sodium/Myo-Inositol Cotransporter2
Na(+)/Myo-Inositol Cotransporter2 3     Sodium/Myo-Inositol Cotransporter 12
Human Solute Carrier Family 5, Member 3, Sodium,Myo-Inositol Cotransporter11     Solute Carrier Family 5 (Inositol Transporters), Member 32

External Ids:    HGNC: 110381   Entrez Gene: 65262   Ensembl: ENSG000001987437   OMIM: 6004445   UniProtKB: P537943   

Export aliases for SLC5A3 gene to outside databases

Previous GC identifers: GC21P032044 GC21P034387 GC21P034389 GC21P035447 GC21P035449 GC21P020945 GC21P035451 GC21P035453 GC21P035455 GC21P035457 GC21P035459


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC5A3 Gene: 
SLC5A3 (solute carrier family 5 (sodium/myo-inositol cotransporter), member 3) is a protein-coding gene. Diseases associated with SLC5A3 include down syndrome, and brain injury, and among its related super-pathways are Transmembrane transport of small molecules and Glucose transport. GO annotations related to this gene include myo-inositol:sodium symporter activity. An important paralog of this gene is SLC5A8.

UniProtKB/Swiss-Prot: SC5A3_HUMAN, P53794
Function: Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in
impairment of cellular function

Gene Wiki entry for SLC5A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC5A3 gene promoter:
         ISGF-3   GCNF   FOXO3   LCR-F1   FOXO3b   GATA-1   PPAR-gamma1   FOXO3a   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

   Search SABiosciences Chromatin IP Primers for SLC5A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC5A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.12   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.11
Nature(405: 311-319) cytogenetic band:   21q22.12
SLC5A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC5A3 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P035461:   GeneLoc Nature:405,311-319
Start:
35,445,870 bp from pter       21,022,392 bp from centromere
End:
35,478,561 bp from pter 21,053,127 bp from centromere
Size:
32,692 bases 30,736 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: AF027153
genomic clones: R338L7 CTD2344F14


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SC5A3_HUMAN, P53794 (See protein sequence)
Recommended Name: Sodium/myo-inositol cotransporter  
Size: 718 amino acids; 79694 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O43489

Explore the universe of human proteins at neXtProt for SLC5A3: NX_P53794

Explore proteomics data for SLC5A3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P53794

  • SLC5A3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC5A3 Protein Expression
    REFSEQ proteins: NP_008864.3  
    ENSEMBL proteins: 
     ENSP00000370543  
    Reactome Protein details: P53794
    Human Recombinant Protein Products for SLC5A3: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS1372904
    GO:0016020membrane ----
    GO:0016021integral to membrane TAS7789985

    SLC5A3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SMIT 
    Sodium myo-inositol cotransporter transporters

    3 InterPro protein domains:
     IPR019900 Na/solute_symporter_subgr
     IPR018212 Na/solute_symporter_CS
     IPR001734 Na/solute_symporter

    Graphical View of Domain Structure for InterPro Entry P53794

    ProtoNet protein and cluster: P53794

    1 Blocks protein domain: IPB001734 Na+/solute symporter

    UniProtKB/Swiss-Prot: SC5A3_HUMAN, P53794
    Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family


    SLC5A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC5A3_HUMAN, P53794
    Function: Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in
    impairment of cellular function

         Genatlas biochemistry entry for SLC5A3:
    solute carrier family 5 (inositol transport),member 3,expressed predominantly in brain,kidney,placenta,involved in
    cellular osmoregulation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005367myo-inositol:sodium symporter activity TAS1372904
         
    SLC5A3 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc5a3):
     growth/size  homeostasis/metabolism  mortality/aging  nervous system  respiratory system 

    SLC5A3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SLC5A3: Slc5a3tm1Skc Slc5a3tm1Gtb

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC5A3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC5A3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    2Regulation of Glucokinase by Glucokinase Regulatory Protein
    Hexose transport0.87
    3MPS IIIC - Sanfilippo syndrome C
    Metabolism of carbohydrates0.48
    4Metabolism
    Metabolism0.40
    5Na+-dependent glucose transporters
    Na+-dependent glucose transporters

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for SLC5A3 (see all 8)
        Metabolism of carbohydrates
    Hexose transport
    Metabolism
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules



    SLC5A3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC5A3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for SLC5A3 (P537943 ENSP000003705434) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    CLN3Q132863I2D: score=1 
    IQCB1ENSP000003115054STRING: ENSP00000311505
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006020inositol metabolic process IEA--
    GO:0006810transport TAS1372904
    GO:0007422peripheral nervous system development IEA--
    GO:0015798myo-inositol transport ----
    GO:0043576regulation of respiratory gaseous exchange IEA--

    SLC5A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC5A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC5A3 (SC5A3)

    1 HMDB Compound for SLC5A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    1 IUPHAR Ligand for SLC5A3 (SMIT)    About this table 
    LigandTypeActionAffinityPubmed IDs
    phlorizin
    InhibitorInhibition--

    10/15 Novoseek inferred chemical compound relationships for SLC5A3 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 87.5 55 19032932 (3), 10773690 (3), 9820807 (3), 10996657 (3) (see all 26)
    betaine 68.5 6 9633613 (3), 10051678 (2), 18557924 (1)
    inositol monophosphate 62.3 1 16531065 (1)
    aldose 55.6 3 10051678 (2), 10201006 (1)
    carbamazepine 54.6 1 16420717 (1)
    valproate 53.4 3 16420717 (3)
    lithium 50.3 3 16420717 (3)
    sodium 44.8 9 19032932 (2), 10051678 (2), 12140271 (1), 10759869 (1) (see all 6)
    cycloheximide 34.8 4 9820807 (1), 10794675 (1), 8928755 (1)
    mannitol 34.7 3 10051678 (1), 10201006 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC5A3 / SC5A3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC5A3 gene: 
    NM_006933.4  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000381151(uc002yto.3)
    miRNA
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    24/460 AceView cDNA sequences (see all 460):

    AI375330 AI991426 BU622555 AI332649 CB128613 N91757 BU156601 BE384048 
    AA029258 AI422744 AA621183 AI935495 BQ071658 CB270163 BI493912 AI129261 
    AI280479 AI867198 AA468597 AI140453 AA678475 BC000547 AI371048 BM563952 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:                        
    SP3:                        


    ECgene alternative splicing isoforms for SLC5A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC5A3 expression in normal human tissues (normalized intensities)      SLC5A3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC5A3 Expression
    About this image


    SLC5A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/eye/cornea   
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             cd31+ cells   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See SLC5A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC5A3
        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC5A3: 
              Stress & Toxicity PathwayFinder in human mouse rat
              Osmotic Stress in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC5A3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc5a31 , 5 solute carrier family 5 (inositol transporters), member more1, 5 90.71(n)1
    93.59(a)1
      16 (53.44 cM)5
    538811  NM_017391.31  NP_059087.21 
     920583225 
    chicken
    (Gallus gallus)
    Aves SLC5A31 solute carrier family 5 (sodium/myo-inositol cotransporter), more 79.1(n)
    87.24(a)
      770758  XM_001234083.2  XP_001234084.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC5A36
    solute carrier family 5 (sodium/myo-inositol cotra...
    18(a)
    1 ↔ 1
    3(196035212-196048042)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5683381 sodium/myo-inositol cotransporter-like 65.81(n)
    68.58(a)
      568338  XM_691663.2  XP_696755.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG77086
    --
    17(a)
    1 → many
    3R(14506328-14511029)
    worm
    (Caenorhabditis elegans)
    Secernentea cho-16
    High-affinity choline transporter 1
    18(a)
    1 → many
    IV(13209729-13214566)


    ENSEMBL Gene Tree for SLC5A3 (if available)
    TreeFam Gene Tree for SLC5A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC5A3 gene
    SLC5A82  SLC5A12  SLC5A42  SLC5A52  SLC5A112  SLC5A92  SLC5A102  SLC5A22  
    SLC5A62  SLC5A122  
    6 SIMAP similar genes for SLC5A3 using alignment to 1 protein entry:     SC5A3_HUMAN:
    SLC5A10    SLC5A2    SLC5A4    SLC5A1    SLC5A11    SLC5A9

    SLC5A3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in SLC5A3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0618764
    ----see VAR_0618762 Q K mis40--------
    VAR_0618754
    ----see VAR_0618752 T A mis40--------

    HapMap Linkage Disequilibrium report for SLC5A3 (35445870 - 35478561 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLC5A3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv28721CNV Loss19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600444    OMIM disorders: --

    5 diseases for SLC5A3:    About MalaCards
    down syndrome    brain injury    myocardial infarction    endotheliitis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SLC5A3:
    Down syndrome

    SLC5A3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SLC5A3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 33.3 2 9441750 (1), 7789985 (1)

    Genetic Association Database (GAD): SLC5A3
    Human Genome Epidemiology (HuGE) Navigator: SLC5A3 (4 documents)

    Export disorders for SLC5A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC5A3 gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with SLC5A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21. (PubMed id 7789985)1, 2, 3, 9 Berry G.T....Spinner N.B. (1995)
    2. The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter. (PubMed id 9441750)1, 2, 9 Mallee J.J.... Berry G.T. (1997)
    3. Additive effect of multiple genetic variants on the r isk of coronary artery disease. (PubMed id 20738937)1, 4 LluA-s-Ganella C....Elosua R. (2010)
    4. A multilocus genetic risk score for coronary heart di sease: case-control and prospective cohort analyses. (PubMed id 20971364)1, 4 Ripatti S....Kathiresan S. (2010)
    5. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. (PubMed id 19198609)1, 4  ....Altshuler D. (2009)
    6. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    7. The 21q22.1 STS marker, VN02 (EST00541 cDNA), is part of the 3' sequence of the human Na+/myo-inositol cotransporter (SLC5A3) gene. (PubMed id 8646889)1, 9 Berry G.T....Antonarakis S.E. (1996)
    8. Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. (PubMed id 19032932)1, 9 Lin X....Ostlund R.E. (2009)
    9. Human Na(+)-myo-inositol cotransporter gene: alternate splicing generates diverse transcripts. (PubMed id 9612208)1, 9 Porcellati F....Killen P.D. (1998)
    10. Down-regulation of the myoinositol transporter SMIT by JAK2. (PubMed id 23207989)1 Hosseinzadeh Z....Lang F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6526 HGNC: 11038 AceView: SLC5A3 Ensembl:ENSG00000198743 euGenes: HUgn6526
    ECgene: SLC5A3 H-InvDB: SLC5A3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC5A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC5A3 gene:
    Search GeneIP for patents involving SLC5A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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