Aliases for SLC5A2 Gene
External Ids for SLC5A2 Gene
Previous HGNC Symbols for SLC5A2 Gene
Previous GeneCards Identifiers for SLC5A2 Gene
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]
GeneCards Summary for SLC5A2 Gene
SLC5A2 (Solute Carrier Family 5 Member 2) is a Protein Coding gene. Diseases associated with SLC5A2 include Renal Glucosuria and Aminoaciduria. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Glycosaminoglycan metabolism. GO annotations related to this gene include transporter activity and low-affinity glucose:sodium symporter activity. An important paralog of this gene is SLC5A1.
UniProtKB/Swiss-Prot for SLC5A2 Gene
Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.
Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.