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SLC5A2 Gene

protein-coding   GIFtS: 56
GCID: GC16P031494

Solute Carrier Family 5 (Sodium/Glucose Cotransporter),...


(Previous symbol: SGLT2)
  See SLC5A2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 21 2     Na(+)/Glucose Cotransporter 22 3
SGLT21 2 3 5     Sodium/Glucose Cotransporter 22
Low Affinity Sodium-Glucose Cotransporter2 3     Solute Carrier Family 5 (Sodium/Glucose Transporter), Member 22
Solute Carrier Family 5 Member 22 3     

External Ids:    HGNC: 110371   Entrez Gene: 65242   Ensembl: ENSG000001406757   OMIM: 1823815   UniProtKB: P316393   

Export aliases for SLC5A2 gene to outside databases

Previous GC identifers: GC16P030575 GC16P031991 GC16P031491 GC16P031530 GC16P031403 GC16P029054


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC5A2 Gene:
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport
proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney.
Mutations in this gene are associated with renal glucosuria. (provided by RefSeq, Sep 2009)

GeneCards Summary for SLC5A2 Gene:
SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter), member 2) is a protein-coding gene. Diseases associated with SLC5A2 include aminoaciduria, and cysticercosis. GO annotations related to this gene include low-affinity glucose:sodium symporter activity. An important paralog of this gene is ENSG00000272962.

UniProtKB/Swiss-Prot: SC5A2_HUMAN, P31639
Function: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1
Function: Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity
high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney
proximal tubules

Gene Wiki entry for SLC5A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SLC5A2 gene promoter:
         COUP-TF1   Sp1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC5A2 promoter sequence
   Search Chromatin IP Primers for SLC5A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC5A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

SLC5A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC5A2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031494:  view genomic region     (about GC identifiers)

Start:
31,494,323 bp from pter      End:
31,502,181 bp from pter
Size:
7,859 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SC5A2_HUMAN, P31639 (See protein sequence)
Recommended Name: Sodium/glucose cotransporter 2  
Size: 672 amino acids; 72897 Da

Explore the universe of human proteins at neXtProt for SLC5A2: NX_P31639

Explore proteomics data for SLC5A2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn250, Asn399
  • Modification sites at PhosphoSitePlus

  • See SLC5A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003032.1  
    ENSEMBL proteins: 
     ENSP00000455143   ENSP00000410601   ENSP00000327943  
    Reactome Protein details: P31639

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    antibodies-online peptides for SLC5A2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SGLT2
    Hexose transporter family

    3 InterPro protein domains:
     IPR019900 Na/solute_symporter_subgr
     IPR018212 Na/solute_symporter_CS
     IPR001734 Na/solute_symporter

    Graphical View of Domain Structure for InterPro Entry P31639

    ProtoNet protein and cluster: P31639

    1 Blocks protein domain: IPB001734 Na+/solute symporter

    UniProtKB/Swiss-Prot: SC5A2_HUMAN, P31639
    Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family


    Find genes that share domains with SLC5A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC5A2_HUMAN, P31639
    Function: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1
    Function: Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity
    high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney
    proximal tubules

         Genatlas biochemistry entry for SLC5A2:
    solute carrier family 5 (sodium/glucose cotransporter),member 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005362low-affinity glucose:sodium symporter activity TAS8244402
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SLC5A2           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc5a2):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  immune system 
     no phenotypic analysis  renal/urinary system  skeleton 

    Find genes that share phenotypes with SLC5A2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC5A2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SC5A2_HUMAN, P31639: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with SLC5A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC5A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Inositol transporters0.00
    Transmembrane transport of small molecules0.47
    Na+-dependent glucose transporters0.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    2Regulation of Glucokinase by Glucokinase Regulatory Protein
    Hexose transport0.87
    3MPS VI - Maroteaux-Lamy syndrome
    Metabolism of carbohydrates0.45
    4Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with SLC5A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for SLC5A2
        Hexose transport
    Inositol transporters
    Na+-dependent glucose transporters


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC5A2
    Interactions:

        Search GeneGlobe Interaction Network for SLC5A2

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS8244402
    GO:0006810transport TAS8244402
    GO:0015758glucose transport TAS8244402
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with SLC5A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLC5A2 (SC5A2)

    1 HMDB Compound for SLC5A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    5 IUPHAR Ligands for SLC5A2 (SGLT2)    About this table
    LigandTypeActionAffinityPubmed IDs
    dapagliflozin
    InhibitorInhibition9--
    canagliflozin
    InhibitorInhibition8.7--
    empagliflozin
    InhibitorInhibition8.5--
    remogliflozin
    InhibitorInhibition7.9--
    sergliflozin
    InhibitorInhibition6.8--

    6 Novoseek inferred chemical compound relationships for SLC5A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phlorizin 87.1 8 8357822 (2), 18063724 (1), 12716745 (1), 11688937 (1) (see all 5)
    glucose 67.1 99 15610225 (3), 19965550 (3), 19357717 (3), 17050778 (3) (see all 44)
    methyl alpha-d-glucopyranoside 62.8 8 8282810 (2), 18322949 (1)
    galactose 36.1 1 8282810 (1)
    sodium 28.4 3 14614622 (1), 10626651 (1), 16518345 (1)
    arginine 0 2 15610225 (1)



    Find genes that share compounds with SLC5A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC5A2 gene: 
    NM_003041.3  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000569576 ENST00000419665 ENST00000330498(uc002ecf.4 uc010car.3)
    ENST00000562006 ENST00000565446 ENST00000568188 ENST00000568891 ENST00000567051
    ENST00000564197
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    Selected AceView cDNA sequences (see all 49):

    BI763504 M95549 NM_003041 AW612545 BX280245 AI651297 AI628969 AI380509 
    BM069853 BF224456 AK054830 BF115079 BI761897 BX367343 BX090234 AW194973 
    BQ940413 BF594800 BX444285 BX382472 AI207344 AI940516 BX444633 BM069605 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:                    -                       -                       -                                         -                           
    SP2:        -           -                                                                                                                     
    SP3:                                            -                                                                                             
    SP4:                                                        -           -                                                                     
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for SLC5A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC5A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGCCTGGC
    SLC5A2 Expression
    About this image


    SLC5A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Proximal Tubule Cells Proximal Tubule
             Metanephros
     
     Epithelial Cells
             Proximal Tubule Cells Proximal Tubule
     
     Testis (Reproductive System)
    SLC5A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC5A2 Protein Expression
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC5A2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc5a21 , 5 solute carrier family 5 (sodium/glucose cotransporter), more1, 5 84.75(n)1
    91.03(a)1
      7 (70.08 cM)5
    2467871  NM_133254.31  NP_573517.11 
     1282656575 
    lizard
    (Anolis carolinensis)
    Reptilia SLC5A26
    solute carrier family 5 (sodium/glucose cotranspor...
    71(a)
    1 ↔ 1
    GL343516.1(34320-51489)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.43212 Transcribed sequence with moderate similarity to protein more 72.56(n)    BX713400.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc5a21 solute carrier family 5 (sodium/glucose cotransporter), more 63.82(n)
    69.77(a)
      405862  NM_212926.1  NP_998091.1 


    ENSEMBL Gene Tree for SLC5A2 (if available)
    TreeFam Gene Tree for SLC5A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC5A2 gene
    ENSG000002729622  SLC5A82  SLC5A12  SLC5A42  SLC5A52  SLC5A112  SLC5A92  SLC5A102  
    SLC5A32  SLC5A62  SLC5A122  
    6 SIMAP similar genes for SLC5A2 using alignment to 4 protein entries:     SC5A2_HUMAN (see all proteins):
    SLC5A1    SLC5A9    SLC5A10    SLC5A4    SLC5A11    SLC5A3

    Find genes that share paralogs with SLC5A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC5A2 (see all 216)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs617427391,2,,4
    C,FRenal glucosuria (GLYS1)4 pathogenic132502793(+) GGTCAA/GCCTCA 2 N S mis13Minor allele frequency- G:0.01NS NA EU 5409
    rs58165301,2
    C--31498368(+) acaaaAACAAA/-
            
    caaaa
    1 -- cds11Minor allele frequency- -:0.00NA 2
    rs1827855581,2
    C--31498826(+) GGAGGA/GTCCCC 1 -- int10--------
    rs2004015371,2
    C--31498831(+) GTCCCC/TTGACG 1 -- int11Minor allele frequency- T:0.00EU 593
    rs11277231,2
    C--31498859(-) CACCTC/TGTGGA 2 K E mis12Minor allele frequency- T:0.00NA 4
    rs1387955311,2
    C,F--31498899(+) CCTGGG/AAGCAG 2 /E /G mis12Minor allele frequency- A:0.00NA EU 5865
    rs1881051011,2
    C--31498984(+) TCCTAC/TCACCT 2 Y syn10--------
    rs2019512581,2
    C--31499055(+) CGTCTC/TGGGCT 2 S L mis10--------
    rs2002281421,2
    C--31499085(+) GGTGCG/AGGTAT 1 -- int11Minor allele frequency- A:0.00EU 343
    rs3776761771,2
    C--31499107(+) TGCAGC/TAGGCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for SLC5A2 (31494323 - 31502181 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC5A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833194CNV Loss17160897
    dgv2673n71CNV Loss21882294
    nsv482193CNV Gain20164927
    nsv905747CNV Gain21882294

    Human Gene Mutation Database (HGMD): SLC5A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC5A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC5A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182381   
    OMIM disorders: 233100  
    UniProtKB/Swiss-Prot: SC5A2_HUMAN, P31639
  • Renal glucosuria (GLYS1) [MIM:233100]: Autosomal recessive disorder characterized by a normal fasting
    serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 5 diseases for SLC5A2:    
    About MalaCards
    aminoaciduria    cysticercosis    renal glycosuria    hyperglycemia
    type 2 diabetes mellitus

    1 disease from the University of Copenhagen DISEASES database for SLC5A2:
    Renal glycosuria

    Find genes that share disorders with SLC5A2           About GenesLikeMe

    6 Novoseek inferred disease relationships for SLC5A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal tubular disorder 77.7 1 18622023 (1)
    aminoaciduria 65.4 3 15610225 (2)
    hyperglycemia 60.8 15 19232040 (3), 20425568 (1), 19357717 (1), 19125776 (1) (see all 5)
    malabsorption 46.8 1 19965550 (1)
    niddm 35.7 4 19892839 (2), 18996802 (1), 19129749 (1), 19243283 (1)
    insulin resistance 0 1 19232040 (1)

    Genatlas disease: SLC5A2
    glycosuria,renal

    Human Genome Epidemiology (HuGE) Navigator: SLC5A2 (1 document)

    Export disorders for SLC5A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC5A2 gene, integrated from 10 sources (see all 79):
    (articles sorted by number of sources associating them with SLC5A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria. (PubMed id 14614622)1, 2, 9 Calado J.... Rueff J. (Hum. Genet. 2004)
    2. Localization of the Na+/glucose cotransporter gene SGLT2 to human chromosome 16 close to the centromere. (PubMed id 8244402)1, 3, 9 Wells R.G....Hediger M.A. (Genomics 1993)
    3. Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter. (PubMed id 1415574)1, 2, 9 Wells R.G.... Hediger M.A. (Am. J. Physiol. 1992)
    4. A novel missense mutation in SLC5A2 encoding SGLT2 underlies autosomal-recessive renal glucosuria and aminoaciduria. (PubMed id 15610225)1, 9 Magen D....Skorecki K. (Kidney Int. 2005)
    5. Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2). (PubMed id 12436245)1, 9 van den Heuvel L.P....Monnens L. (Hum. Genet. 2002)
    6. Molecular analysis of the SGLT2 gene in patients with renal glucosuria. (PubMed id 14569097)1, 9 Santer R....Klaerke D. (J. Am. Soc. Nephrol. 2003)
    7. Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. (PubMed id 18622023)1, 9 Calado J....Santer R. (Nephrol. Dial. Transplant. 2008)
    8. Thioglycosides as inhibitors of hSGLT1 and hSGLT2: potential therapeutic agents for the control of hyperglycemia in diabetes. (PubMed id 17505558)1, 9 Castaneda F....Kinne R.K. (Int J Med Sci 2007)
    9. Sodium glucose transporter 2 inhibition: a new approach to diabetes treatment. (PubMed id 23714218)1 Bloomgarden Z. (J Diabetes 2013)
    10. SGLT2: a potential target for the pharmacogenetics of Type 2 diabetes? (PubMed id 23651029)1 TAPnjes A. and Kovacs P. (Pharmacogenomics 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6524 HGNC: 11037 AceView: SLC5A2 Ensembl:ENSG00000140675 euGenes: HUgn6524
    ECgene: SLC5A2 H-InvDB: SLC5A2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC5A2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC5A2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=SLC5A2[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC5A2 gene:
    Search GeneIP for patents involving SLC5A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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