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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC5A2 Gene

protein-coding   GIFtS: 56
GCID: GC16P031494

solute carrier family 5 (sodium/glucose cotransporter),...


(Previous symbol: SGLT2)
 Explore 13 diseases affiliated with
SLC5A2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC5A2    

Aliases
for SLC5A2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 21 2     Na(+)/Glucose Cotransporter 22 3
SGLT21 2 3 5     Sodium/Glucose Cotransporter 22
Low Affinity Sodium-Glucose Cotransporter2 3     Solute Carrier Family 5 (Sodium/Glucose Transporter), Member 22
Solute Carrier Family 5 Member 22 3     

External Ids:    HGNC: 110371   Entrez Gene: 65242   Ensembl: ENSG000001406757   OMIM: 1823815   UniProtKB: P316393   

Export aliases for SLC5A2 gene to outside databases

Previous GC identifers: GC16P030575 GC16P031991 GC16P031491 GC16P031530 GC16P031403 GC16P029054


Summaries
for SLC5A2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC5A2:
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport
proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in
this gene are associated with renal glucosuria. (provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: SC5A2_HUMAN, P31639
Function: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1
Function: Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high
capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules

Gene Wiki entry for SLC5A2


Genomic Views
for SLC5A2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC5A2 gene promoter:
         COUP-TF1   Sp1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC5A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC5A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC5A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

SLC5A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC5A2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031494:  view genomic region     (about GC identifiers)

Start:
 31,494,323 bp from pter      End:
 31,502,181 bp from pter
Size:
 7,859 bases      Orientation:
 plus strand

Proteins
for SLC5A2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SC5A2_HUMAN, P31639 (See protein sequence)
Recommended Name: Sodium/glucose cotransporter 2  
Size: 672 amino acids; 72897 Da
Subcellular location: Membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for SLC5A2: NX_P31639

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P31639

    • SLC5A2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003032.1  
    ENSEMBL proteins: 
     ENSP00000455143   ENSP00000410601   ENSP00000327943  
    Reactome Protein details: P31639
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC5A2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0031526brush border membrane ----


    SLC5A2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC5A2

    Protein Domains /
    Families
    for SLC5A2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC5A2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR019900 Na/solute_symporter_subgr
     IPR018212 Na/solute_symporter_CS
     IPR001734 Na/solute_symporter

    Graphical View of Domain Structure for InterPro Entry P31639

    ProtoNet protein and cluster: P31639

    1 Blocks protein family: IPB001734 Na+/solute symporter

    UniProtKB/Swiss-Prot: SC5A2_HUMAN, P31639
    Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family


    Function
    for SLC5A2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SC5A2_HUMAN, P31639
    Function: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1
    Function: Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high
    capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules

         Genatlas biochemistry entry for SLC5A2:
    solute carrier family 5 (sodium/glucose cotransporter),member 2

    miRNA
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    hsa-miR-296-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SLC5A2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005362low-affinity glucose:sodium symporter activity TAS8244402
    GO:0005412glucose:sodium symporter activity ----
    GO:0005515protein binding ----


    SLC5A2 for ontologies           About GeneDecksing


    Animal Models:
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Slc5a2):
     behavior/neurological  homeostasis/metabolism  no phenotypic analysis  renal/urinary system 

    SLC5A2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC5A2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    2Na+-dependent glucose transporters
    		Na+-dependent glucose transporters1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SLC5A2
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Na+-dependent glucose transporters



    SLC5A2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC5A2

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS8244402
    GO:0006810transport TAS8244402
    GO:0015758glucose transport ----
    GO:0055085transmembrane transport TAS--


    SLC5A2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC5A2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC5A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC5A2

    1 HMDB Compound for SLC5A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--
    6 Novoseek chemical compound relationships for SLC5A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phlorizin 87.1 8 8357822 (2), 18063724 (1), 12716745 (1), 11688937 (1) (see all 5)
    glucose 67.1 99 15610225 (3), 19965550 (3), 19357717 (3), 17050778 (3) (see all 44)
    methyl alpha-d-glucopyranoside 62.8 8 8282810 (2), 18322949 (1)
    galactose 36.1 1 8282810 (1)
    sodium 28.4 3 14614622 (1), 10626651 (1), 16518345 (1)
    arginine 0 2 15610225 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC5A2 / SC5A2 

    Transcripts
    for SLC5A2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC5A2 gene: 
    NM_003041.3  

    Unigene Cluster for SLC5A2:

    Solute carrier family 5 (sodium/glucose cotransporter), member 2
    Hs.709195  [show with all ESTs]
    Unigene Representative Sequence: AK054830
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000569576 ENST00000419665 ENST00000330498(uc002ecf.4 uc010car.3)
    ENST00000562006 ENST00000565446 ENST00000568188 ENST00000568891 ENST00000567051
    ENST00000564197

    miRNA
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    hsa-miR-296-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SLC5A2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK054830.1 BC131542.1 M95549.1 

    9 DOTS entries:

    DT.95158103  DT.100686022  DT.95158101  DT.455822  DT.70101616  DT.120703945  DT.100645681  DT.100686036 
    DT.311093 

    24/49 AceView cDNA sequences (see all 49):

    BM069853 BX280245 AW612545 BF224456 BI763504 M95549 BI761897 AI380509 
    AI628969 AK054830 BF115079 NM_003041 AI651297 BF594800 AW194973 BX090234 
    BX367343 BQ940413 AI207344 BX444633 AI940516 AI222550 BX444285 BM069605 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:                    -                       -                       -                                         -                           
    SP2:        -           -                                                                                                                     
    SP3:                                            -                                                                                             
    SP4:                                                        -           -                                                                     
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for SLC5A2

    Expression
    for SLC5A2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC5A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGGCCTGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC5A2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyProximal TubuleProximal Tubule CellsKidney
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC5A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC5A2

    SOURCE GeneReport for Unigene cluster: Hs.709195
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    In Situ
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    Orthologs
    for SLC5A2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SLC5A2 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia SLC5A26
    		 --
    		 69(a)
    		 1 ↔ 1
    		 GL343516.1(34395-49472)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.43212 Transcribed sequence with moderate similarity to protein more 72.56(n)    BX713400.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii slc5a21 solute carrier family 5 (sodium/glucose cotransporter), more 63.82(n)
    69.77(a)    		   405862  NM_212926.1  NP_998091.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria yidK6
    putP6
    (see all 3)    		 proline:sodium symporter
    (see all 3)    		 24(a)
    17(a)
    (see all 3)    		 1 ↔ many
    possible ortholog
    (see all 3)    		 Chromosome(3856424-3858139)
    Chromosome(1078528-1080036)


    ENSEMBL Gene Tree for SLC5A2 (if available)
    TreeFam Gene Tree for SLC5A2 (if available) 

    Paralogs
    for SLC5A2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC5A2 gene
    SLC5A82  SLC5A12  SLC5A42  SLC5A52  SLC5A112  SLC5A92  SLC5A102  SLC5A32  
    SLC5A62  SLC5A122  SLC5A72  
    6 SIMAP similar genes for SLC5A2 using alignment to 4 protein entries:     SC5A2_HUMAN (see all proteins):
    SLC5A1    SLC5A9    SLC5A10    SLC5A4    SLC5A11    SLC5A3

    SLC5A2 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC5A2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/223 NCBI SNPs in SLC5A2 are shown (see all 223)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs617427391,2
    		C,F,pathogenic29062004(+) GGTCAA/GCCTCA 2 N S mis13Minor allele frequency- G:0.01NS NA EU 5409
    rs735383511,2
    		C,F,--29053217(+) GTGGCG/ATGCCC 1 -- us2k14Minor allele frequency- A:0.13WA EA 242
    rs788992021,2
    		F,--29053393(+) CATTTC/TTCTTC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs774996331,2
    		F,--29054499(+) AGACCA/GGCCTT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs773717041,2
    		--29054548(+) GGAGCG/AGGAAT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs740155441,2
    		C,--29054953(+) CATTCC/TTCCCT 1 -- int12Minor allele frequency- T:0.11WA 120
    rs286871241,2
    		C,F,--29055138(+) GATGGA/GACTAG 1 -- int11Minor allele frequency- G:0.16WA 118
    rs795340831,2
    		C,--29055240(+) AAACCG/ATATCT 1 -- int12Minor allele frequency- A:0.12WA 120
    rs99270391,2
    		C,--29055882(+) ggttgC/Tagtga 1 -- int10--------
    rs765773281,2
    		C,--29056257(+) TGGTGC/TGGTGG 2 R W mis11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for SLC5A2 (31494323 - 31502181 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC5A2: --
    Human Gene Mutation Database (HGMD): SLC5A2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC5A2
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    Disorders / Diseases
    for SLC5A2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC5A2 for disorders           About GeneDecksing

    OMIM gene information: 182381   
    OMIM disorders: 233100  
    UniProtKB/Swiss-Prot: SC5A2_HUMAN, P31639
  • Defects in SLC5A2 are the cause of renal glucosuria (GLYS1) [MIM:233100]. GLYS1 is an autosomal recessive
    • disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a
    normal glucose tolerance test

    13 diseases for SLC5A2:    About MalaCards
    renal glucosuria    type 2 diabetes mellitus    renal glycosuria    aminoaciduria
    insulin resistance    short bowel syndrome    cysticercosis    diabetes mellitus
    hyperglycemia    prostate cancer    cerebritis    prostatitis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SLC5A2:
    Renal glycosuria

    6 Novoseek disease relationships for SLC5A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal tubular disorder 77.7 1 18622023 (1)
    aminoaciduria 65.4 3 15610225 (2)
    hyperglycemia 60.8 15 19232040 (3), 20425568 (1), 19357717 (1), 19125776 (1) (see all 5)
    malabsorption 46.8 1 19965550 (1)
    niddm 35.7 4 19892839 (2), 18996802 (1), 19129749 (1), 19243283 (1)
    insulin resistance 0 1 19232040 (1)

    Genatlas disease: SLC5A2
    glycosuria,renal

    Human Genome Epidemiology (HuGE) Navigator: SLC5A2 (1 document)

    Export disorders for SLC5A2 gene to outside databases

    Publications
    for SLC5A2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC5A2 gene, integrated from 9 sources (see all 75):
    (articles sorted by number of sources associating them with SLC5A2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria. (PubMed id 14614622)1, 2, 9 Calado J.... Rueff J. (2004)
    2. Localization of the Na+/glucose cotransporter gene SGLT2 to human chromosome 16 close to the centromere. (PubMed id 8244402)1, 3, 9 Wells R.G....Hediger M.A. (1993)
    3. Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter. (PubMed id 1415574)1, 2, 9 Wells R.G.... Hediger M.A. (1992)
    4. A novel missense mutation in SLC5A2 encoding SGLT2 underlies autosomal-recessive renal glucosuria and aminoaciduria. (PubMed id 15610225)1, 9 Magen D....Skorecki K. (2005)
    5. Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2). (PubMed id 12436245)1, 9 van den Heuvel L.P....Monnens L. (2002)
    6. Molecular analysis of the SGLT2 gene in patients with renal glucosuria. (PubMed id 14569097)1, 9 Santer R....Klaerke D. (2003)
    7. Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. (PubMed id 18622023)1, 9 Calado J....Santer R. (2008)
    8. Thioglycosides as inhibitors of hSGLT1 and hSGLT2: potential therapeutic agents for the control of hyperglycemia in diabetes. (PubMed id 17505558)1, 9 Castaneda F....Kinne R.K. (2007)
    9. Regulation of the human Na+-dependent glucose cotransp orter hSGLT2. (PubMed id 22673616)1 Ghezzi C. and Wright E.M. (2012)
    10. Efficacy and safety of SGLT2 inhibitors in the treatme nt of type 2 diabetes mellitus. (PubMed id 22528597)1 Abdul-Ghani M.A....DeFronzo R.A. (2012)

    External Searches for SLC5A2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC5A2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6524 HGNC: 11037 AceView: SLC5A2 Ensembl:ENSG00000140675 euGenes: HUgn6524
    ECgene: SLC5A2 H-InvDB: SLC5A2

    Other Databases showing SLC5A2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC5A2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC5A2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC5A2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SLC5A2

    Intellectual Property
    for SLC5A2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC5A2 gene:
    Search GeneIP for patents involving SLC5A2

    GeneCards and IP:
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