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Aliases for SLC5A11 Gene

Aliases for SLC5A11 Gene

  • Solute Carrier Family 5 (Sodium/Inositol Cotransporter), Member 11 2 3
  • SMIT2 3 4 6
  • KST1 3 4 6
  • Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 11 2 3
  • Sodium-Dependent Glucose Cotransporter 3 4
  • Na(+)/Myo-Inositol Cotransporter 2 3 4
  • Sodium/Glucose Cotransporter KST1 3 4
  • Sodium/Myo-Inositol Transporter 2 3 4
  • SGLT6 3 6
  • Putative Sodium-Coupled Cotransporter RKST1 3
  • Sodium/Myo-Inositol Cotransporter 2 3
  • Solute Carrier Family 5 Member 11 4
  • Homolog Of Rabbit KST1 3
  • RKST1 3
  • SLGTX 4

External Ids for SLC5A11 Gene

Previous GeneCards Identifiers for SLC5A11 Gene

  • GC16P024825
  • GC16P024765
  • GC16P022948

Summaries for SLC5A11 Gene

Entrez Gene Summary for SLC5A11 Gene

  • Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive active transport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002) [PubMed 12039040].[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC5A11 Gene

SLC5A11 (Solute Carrier Family 5 (Sodium/Inositol Cotransporter), Member 11) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include symporter activity. An important paralog of this gene is SLC5A10.

UniProtKB/Swiss-Prot for SLC5A11 Gene

  • Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC5A11 Gene

Genomics for SLC5A11 Gene

Regulatory Elements for SLC5A11 Gene

Genomic Location for SLC5A11 Gene

Start:
24,845,841 bp from pter
End:
24,911,628 bp from pter
Size:
65,788 bases
Orientation:
Plus strand

Genomic View for SLC5A11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC5A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC5A11 Gene

Proteins for SLC5A11 Gene

  • Protein details for SLC5A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWX8-SC5AB_HUMAN
    Recommended name:
    Sodium/myo-inositol cotransporter 2
    Protein Accession:
    Q8WWX8
    Secondary Accessions:
    • B7Z329
    • Q05BF1
    • Q6PF02
    • Q6ZUW3
    • Q86Y55
    • Q96PP5

    Protein attributes for SLC5A11 Gene

    Size:
    675 amino acids
    Molecular mass:
    74036 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Acts as an autoimmune modifier in systemic lupus erythematosus (SLE) as it is significantly associated with low complement component 4 (C4), anti-Smith antibody, serositis, and alopecia

    Alternative splice isoforms for SLC5A11 Gene

neXtProt entry for SLC5A11 Gene

Proteomics data for SLC5A11 Gene at MOPED

Post-translational modifications for SLC5A11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SLC5A11 Gene

Domains for SLC5A11 Gene

Gene Families for SLC5A11 Gene

Protein Domains for SLC5A11 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WWX8

UniProtKB/Swiss-Prot:

SC5AB_HUMAN :
  • Q8WWX8
Family:
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
genes like me logo Genes that share domains with SLC5A11: view

Function for SLC5A11 Gene

Molecular function for SLC5A11 Gene

UniProtKB/Swiss-Prot Function:
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.

Gene Ontology (GO) - Molecular Function for SLC5A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005515 protein binding IPI 25416956
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC5A11: view

Phenotypes for SLC5A11 Gene

GenomeRNAi human phenotypes for SLC5A11:
genes like me logo Genes that share phenotypes with SLC5A11: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC5A11 Gene

Localization for SLC5A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC5A11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC5A11 Gene COMPARTMENTS Subcellular localization image for SLC5A11 gene
Compartment Confidence
plasma membrane 4
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC5A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC5A11: view

Pathways for SLC5A11 Gene

genes like me logo Genes that share pathways with SLC5A11: view

Interacting Proteins for SLC5A11 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000289932%0d%0a9606.ENSP00000261667%0d%0a
Selected Interacting proteins: ENSP00000289932 Q8WWX8-SC5AB_HUMAN for SLC5A11 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SLC5A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006814 sodium ion transport IEA --
GO:0006915 apoptotic process IEA --
GO:0008643 carbohydrate transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC5A11: view

Compounds for SLC5A11 Gene

(1) ApexBio Compounds for SLC5A11 Gene

Compound Action Cas Number
Empagliflozin (BI 10773) SGLT-2 inhibitor for oral treatment of type 2 diabetes [864070-44-0]

(2) HMDB Compounds for SLC5A11 Gene

Compound Synonyms Cas Number PubMed IDs
D-Xylose
  • d-Xylose
58-86-6
Sodium
  • Sodium
7440-23-5

(1) IUPHAR Ligand for SLC5A11 Gene

Ligand Type Action Affinity Pubmed IDs
phlorizin Inhibitor Inhibition
genes like me logo Genes that share compounds with SLC5A11: view

Transcripts for SLC5A11 Gene

Unigene Clusters for SLC5A11 Gene

Solute carrier family 5 (sodium/glucose cotransporter), member 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC5A11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A11 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
SP1:
SP2: - -
SP3: - - -
SP4: -

Relevant External Links for SLC5A11 Gene

GeneLoc Exon Structure for
SLC5A11
ECgene alternative splicing isoforms for
SLC5A11

Expression for SLC5A11 Gene

mRNA expression in normal human tissues for SLC5A11 Gene

mRNA differential expression in normal tissues according to GTEx for SLC5A11 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (15.5), Brain - Substantia nigra (12.1), and Brain - Hippocampus (4.7).

Protein differential expression in normal tissues for SLC5A11 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC5A11 Gene

SOURCE GeneReport for Unigene cluster for SLC5A11 Gene Hs.164118

mRNA Expression by UniProt/SwissProt for SLC5A11 Gene

Q8WWX8-SC5AB_HUMAN
Tissue specificity: Highest expression in heart, skeletal muscle, kidney, liver and placenta. Weaker expression in brain, colon, spleen, lung and peripheral blood leukocytes.
genes like me logo Genes that share expressions with SLC5A11: view

Expression partners for SLC5A11 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC5A11 Gene

Orthologs for SLC5A11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC5A11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC5A11 35
  • 87.83 (n)
  • 88.28 (a)
SLC5A11 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC5A11 35
  • 87.73 (n)
  • 89.09 (a)
SLC5A11 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc5a11 35
  • 85.64 (n)
  • 86.63 (a)
Slc5a11 16
Slc5a11 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC5A11 35
  • 97.86 (n)
  • 97.19 (a)
SLC5A11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc5a11 35
  • 85.09 (n)
  • 86.78 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC5A11 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC5A11 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC5A11 35
  • 71.91 (n)
  • 72.16 (a)
SLC5A11 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC5A11 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc5a11 35
  • 66.87 (n)
  • 70.85 (a)
African clawed frog
(Xenopus laevis)
Amphibia sglt-1-like-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii slc5a11 35
  • 64.15 (n)
  • 63.84 (a)
slc5a11 36
  • 63 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
Species with no ortholog for SLC5A11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC5A11 Gene

ENSEMBL:
Gene Tree for SLC5A11 (if available)
TreeFam:
Gene Tree for SLC5A11 (if available)

Paralogs for SLC5A11 Gene

Selected SIMAP similar genes for SLC5A11 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC5A11: view

Variants for SLC5A11 Gene

Sequence variations from dbSNP and Humsavar for SLC5A11 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs166666 -- 24,899,565(+) TGCCC(A/G)GCTAA intron-variant
rs172076 -- 24,854,432(+) AAAGT(A/T)TTTTT intron-variant
rs192441 -- 24,868,372(+) gatca(C/T)gaggt intron-variant
rs274067 -- 24,887,002(+) TGTAG(C/T)GAGCT intron-variant
rs274068 -- 24,887,651(+) AAGTA(A/C)ATGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC5A11 Gene

Variant ID Type Subtype PubMed ID
nsv833175 CNV Loss 17160897
esv2714116 CNV Deletion 23290073
esv2415734 CNV Deletion 18987734
esv2714117 CNV Deletion 23290073
esv2714119 CNV Deletion 23290073
nsv509607 CNV Insertion 20534489
esv2670890 CNV Deletion 23128226

Relevant External Links for SLC5A11 Gene

HapMap Linkage Disequilibrium report
SLC5A11
Human Gene Mutation Database (HGMD)
SLC5A11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC5A11 Gene

Disorders for SLC5A11 Gene

Relevant External Links for SLC5A11

Genetic Association Database (GAD)
SLC5A11
Human Genome Epidemiology (HuGE) Navigator
SLC5A11

No disorders were found for SLC5A11 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SLC5A11 Gene

Publications for SLC5A11 Gene

  1. The sodium-dependent glucose cotransporter SLC5A11 as an autoimmune modifier gene in SLE. (PMID: 18069935) Tsai L.-J. … Lan J.-L. (Tissue Antigens 2008) 3 4 48
  2. New human sodium/glucose cotransporter gene (KST1): identification, characterization, and mutation analysis in ICCA (infantile convulsions and choreoathetosis) and BFIC (benign familial infantile convulsions) families. (PMID: 12039040) Roll P. … Szepetowski P. (Gene 2002) 2 3 4
  3. Identification of a novel Na+/myo-inositol cotransporter. (PMID: 12133831) Coady M.J. … Lapointe J.Y. (J. Biol. Chem. 2002) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48

Products for SLC5A11 Gene

Sources for SLC5A11 Gene

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