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Aliases for SLC5A10 Gene

Aliases for SLC5A10 Gene

  • Solute Carrier Family 5 Member 10 2 3 4 5
  • Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 10 2 3
  • Solute Carrier Family 5 (Sodium/Sugar Cotransporter), Member 10 2 3
  • Na(+)/Glucose Cotransporter 5 3 4
  • SGLT5 3 4
  • Sodium/Glucose Cotransporter 5 3
  • SGLT-5 3

External Ids for SLC5A10 Gene

Previous GeneCards Identifiers for SLC5A10 Gene

  • GC17P019062
  • GC17P019054
  • GC17P018794
  • GC17P018796
  • GC17P018853
  • GC17P018422

Summaries for SLC5A10 Gene

Entrez Gene Summary for SLC5A10 Gene

  • This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for SLC5A10 Gene

SLC5A10 (Solute Carrier Family 5 Member 10) is a Protein Coding gene. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLC5A9.

UniProtKB/Swiss-Prot for SLC5A10 Gene

  • High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC5A10 Gene

Genomics for SLC5A10 Gene

Regulatory Elements for SLC5A10 Gene

Enhancers for SLC5A10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F018992 1.2 Ensembl ENCODE 13 +43.5 43508 2.9 ZNF280D ZMYM3 ZIC2 ZNF121 ZFHX2 HDAC2 IKZF1 SETDB1 EGR2 SPI1 ENSG00000196893 SLC5A10 ENSG00000212618 ENSG00000262319 ENSG00000230197 FAM83G GC17P019000 ENSG00000263045
GH17F018919 1.1 FANTOM5 Ensembl ENCODE 12.4 -29.0 -29002 3.4 PKNOX1 ARID4B SIN3A CBX5 ZNF207 JUNB TBX21 MIER3 PBX2 NBN ENSG00000212618 SLC5A10 ENSG00000196893 PRPSAP2 TVP23B FAM83G TRIM16L LOC100419620 GC17P018945
GH17F019239 0.5 ENCODE 5.3 +288.8 288790 0.3 KDM1A EGR2 ENSG00000262319 MIR1180 SLC5A10 LOC388436 EPN2-IT1
GH17F018949 0.6 ENCODE 0.8 +0.2 153 2.2 CEBPA CEBPG MIXL1 PRPSAP2 LOC100419436 ENSG00000196893 SLC5A10
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC5A10 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC5A10 Gene

Chromosome:
17
Start:
18,950,345 bp from pter
End:
19,022,595 bp from pter
Size:
72,251 bases
Orientation:
Plus strand

Genomic View for SLC5A10 Gene

Genes around SLC5A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC5A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC5A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC5A10 Gene

Proteins for SLC5A10 Gene

  • Protein details for SLC5A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PJK1-SC5AA_HUMAN
    Recommended name:
    Sodium/glucose cotransporter 5
    Protein Accession:
    A0PJK1
    Secondary Accessions:
    • A8MUC9
    • B4DPI0
    • B7WPR4
    • Q6P5X0
    • Q8IXM4
    • Q96LQ1

    Protein attributes for SLC5A10 Gene

    Size:
    596 amino acids
    Molecular mass:
    64342 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71619.1; Type=Frameshift; Positions=156; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC5A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC5A10 Gene

Post-translational modifications for SLC5A10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC5A10 Gene

Domains & Families for SLC5A10 Gene

Gene Families for SLC5A10 Gene

Protein Domains for SLC5A10 Gene

Graphical View of Domain Structure for InterPro Entry

A0PJK1

UniProtKB/Swiss-Prot:

SC5AA_HUMAN :
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Family:
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
genes like me logo Genes that share domains with SLC5A10: view

Function for SLC5A10 Gene

Molecular function for SLC5A10 Gene

UniProtKB/Swiss-Prot Function:
High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.

Gene Ontology (GO) - Molecular Function for SLC5A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015293 symporter activity IBA --
genes like me logo Genes that share ontologies with SLC5A10: view
genes like me logo Genes that share phenotypes with SLC5A10: view

Animal Models for SLC5A10 Gene

MGI Knock Outs for SLC5A10:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC5A10

miRNA for SLC5A10 Gene

miRTarBase miRNAs that target SLC5A10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC5A10 Gene

Localization for SLC5A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC5A10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC5A10 Gene COMPARTMENTS Subcellular localization image for SLC5A10 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC5A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC5A10: view

Pathways & Interactions for SLC5A10 Gene

genes like me logo Genes that share pathways with SLC5A10: view

Interacting Proteins for SLC5A10 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000379008%0d%0a9606.ENSP00000361021%0d%0a
Selected Interacting proteins: A0PJK1-SC5AA_HUMAN ENSP00000379008 for SLC5A10 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SLC5A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC5A10: view

No data available for SIGNOR curated interactions for SLC5A10 Gene

Drugs & Compounds for SLC5A10 Gene

(1) Drugs for SLC5A10 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Empagliflozin (BI 10773) Pharma SGLT-2 inhibitor for oral treatment of type 2 diabetes 0

(1) Additional Compounds for SLC5A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5

(1) ApexBio Compounds for SLC5A10 Gene

Compound Action Cas Number
Empagliflozin (BI 10773) SGLT-2 inhibitor for oral treatment of type 2 diabetes 864070-44-0
genes like me logo Genes that share compounds with SLC5A10: view

Transcripts for SLC5A10 Gene

Unigene Clusters for SLC5A10 Gene

Solute carrier family 5 (sodium/glucose cotransporter), member 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A10 Gene

No ASD Table

Relevant External Links for SLC5A10 Gene

GeneLoc Exon Structure for
SLC5A10
ECgene alternative splicing isoforms for
SLC5A10

Expression for SLC5A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC5A10 Gene

mRNA differential expression in normal tissues according to GTEx for SLC5A10 Gene

This gene is overexpressed in Kidney - Cortex (x46.2).

Protein differential expression in normal tissues from HIPED for SLC5A10 Gene

This gene is overexpressed in Urine (61.7) and Kidney (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC5A10 Gene



Protein tissue co-expression partners for SLC5A10 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC5A10 Gene:

SLC5A10

SOURCE GeneReport for Unigene cluster for SLC5A10 Gene:

Hs.462418

mRNA Expression by UniProt/SwissProt for SLC5A10 Gene:

A0PJK1-SC5AA_HUMAN
Tissue specificity: Seems to be exclusively expressed in kidney.
genes like me logo Genes that share expression patterns with SLC5A10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC5A10 Gene

Orthologs for SLC5A10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC5A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC5A10 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC5A10 34 35
  • 87.52 (n)
dog
(Canis familiaris)
Mammalia SLC5A10 34 35
  • 87.45 (n)
mouse
(Mus musculus)
Mammalia Slc5a10 34 16 35
  • 84.06 (n)
rat
(Rattus norvegicus)
Mammalia Slc5a10 34
  • 83.45 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC5A10 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 76 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC5A10 34 35
  • 74.16 (n)
lizard
(Anolis carolinensis)
Reptilia SLC5A10 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc5a10 34
  • 70.13 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-9d4.5 34
  • 68.62 (n)
SLC5A10 35
  • 65 (a)
OneToOne
Species where no ortholog for SLC5A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC5A10 Gene

ENSEMBL:
Gene Tree for SLC5A10 (if available)
TreeFam:
Gene Tree for SLC5A10 (if available)

Paralogs for SLC5A10 Gene

(6) SIMAP similar genes for SLC5A10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC5A10: view

Variants for SLC5A10 Gene

Sequence variations from dbSNP and Humsavar for SLC5A10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10451246 -- 18,975,855(+) gtgaa(C/T)tatat intron-variant
rs10533006 -- 18,953,636(+) TAGCA(-/GTG)GTGGT intron-variant
rs1076203 -- 19,018,226(-) CCTGG(C/T)TGTGG intron-variant
rs11078427 -- 19,008,816(+) TTAtt(A/T)ttttt intron-variant
rs111274831 -- 18,970,952(+) GGGGA(C/G)CCCAG intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC5A10 Gene

Variant ID Type Subtype PubMed ID
dgv3116n100 CNV gain 25217958
dgv5491n54 CNV gain 21841781
dgv565e214 CNV gain 21293372
dgv895e212 CNV loss 25503493
esv1783904 CNV insertion 17803354
esv2758678 CNV gain+loss 17122850
esv3310541 CNV novel sequence insertion 20981092
esv33572 CNV gain 17666407
esv3424584 CNV duplication 20981092
esv3572465 CNV gain 25503493
esv3892975 CNV loss 25118596
nsv1055999 CNV gain 25217958
nsv1057803 CNV loss 25217958
nsv428336 CNV gain+loss 18775914
nsv457699 CNV gain 19166990
nsv470581 CNV gain 18288195
nsv474110 CNV novel sequence insertion 20440878
nsv479430 CNV novel sequence insertion 20440878
nsv523721 CNV gain 19592680
nsv574552 CNV gain 21841781
nsv7291 OTHER inversion 18451855
nsv833390 CNV loss 17160897
nsv833391 CNV loss 17160897
nsv9504 CNV gain+loss 18304495
nsv953842 CNV deletion 24416366

Variation tolerance for SLC5A10 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC5A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC5A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC5A10 Gene

Disorders for SLC5A10 Gene

Relevant External Links for SLC5A10

Genetic Association Database (GAD)
SLC5A10
Human Genome Epidemiology (HuGE) Navigator
SLC5A10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC5A10

No disorders were found for SLC5A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC5A10 Gene

Publications for SLC5A10 Gene

  1. Functional characterisation of human SGLT-5 as a novel kidney- specific sodium-dependent sugar transporter. (PMID: 22212718) Grempler R. … Eickelmann P. (FEBS Lett. 2012) 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Fingerprints of hSGLT5 sugar and cation selectivity. (PMID: 24573086) Ghezzi C. … Wright E.M. (Am. J. Physiol., Cell Physiol. 2014) 3 64
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64

Products for SLC5A10 Gene

Sources for SLC5A10 Gene

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