SLC5A10 Gene
protein-coding GIFtS: 44
GCID: GC17P018853
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solute carrier family 5 (sodium/glucose cotransporter),...
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Aliases
for SLC5A10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 101 2 | | SGLT51 2 3 | | Na(+)/Glucose Cotransporter 52 3 | | SGLT-52 | | Sodium/Glucose Cotransporter 52 | | Solute Carrier Family 5 Member 103 |
Export aliases for SLC5A10 gene to outside databasesPrevious GC identifers: GC17P019062 GC17P019054 GC17P018794 GC17P018796 GC17P018422 |
Summaries
for SLC5A10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC5A10:
This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependenttransporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and thesecond that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. Theprotein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed inthe kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter.Alternative splicing results in multiple transcript variants that encode different protein isoforms. (provided byRefSeq, Jul 2012)
UniProtKB/Swiss-Prot: SC5AA_HUMAN, A0PJK1Function: High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose
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Genomic Views
for SLC5A10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC5A10 gene promoter:
HNF-1A HEN1 AREB6 POU2F1 COMP1 POU2F1a HNF-1 LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC5A10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC5A10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2SLC5A10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P018853: view genomic region
(about GC identifiers)
Start:
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18,853,658 bp from pter |
End:
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18,925,908 bp from pter |
Size:
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72,251 bases |
Orientation:
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plus strand |
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Proteins
for SLC5A10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SC5AA_HUMAN, A0PJK1 (See
protein sequence)Recommended Name: Sodium/glucose cotransporter 5 Size: 596 amino acids; 64342 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAB71619.1; Type=Frameshift; Positions=156;
Secondary accessions: A8MUC9 B4DPI0 B7WPR4 Q6P5X0 Q8IXM4 Q96LQ1Alternative splicing: 5 isoforms: A0PJK1-1 A0PJK1-2 A0PJK1-3 A0PJK1-4 A0PJK1-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLC5A10: NX_A0PJK1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A0PJK1
SLC5A10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001035915.1 NP_001257577.1 NP_001257578.1 NP_689564.3
ENSEMBL proteins: ENSP00000324346 ENSP00000379008 ENSP00000379005 ENSP00000379007 ENSP00000401875 ENSP00000379004
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SLC5A10 for ontologies About GeneDecksing
SLC5A10 Antibody Products:
Assay Products for SLC5A10: |
Protein
Domains /
Families
for SLC5A10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC5A10 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A0PJK1ProtoNet protein and cluster: A0PJK1 UniProtKB/Swiss-Prot: SC5AA_HUMAN, A0PJK1Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family |
Function
for SLC5A10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SC5AA_HUMAN, A0PJK1Function: High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC5A10 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A10 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005215 | transporter activity |
IEA | -- |
SLC5A10 for ontologies About GeneDecksing
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Pathways & Interactions
for SLC5A10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC5A10
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SLC5A10 (ENSP000003790084) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006814 | sodium ion transport |
IEA | -- | | GO:0055085 | transmembrane transport |
IEA | -- |
SLC5A10 for ontologies About GeneDecksing
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Drugs & Compounds
for SLC5A10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC5A10
1 HMDB Compound for SLC5A10 About this table
Search CenterWatch for drugs/clinical trials and news about SLC5A10 / SC5AA
|
Transcripts
for SLC5A10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC5A10 gene (4 alternative transcripts): NM_001042450.2 NM_001270648.1 NM_001270649.1 NM_152351.4 Unigene Cluster for SLC5A10: Solute carrier family 5 (sodium/glucose cotransporter), member 10 Hs.462418 [show with all ESTs]Unigene Representative Sequence: BC0398687 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000317977(uc002gur.1) ENST00000395647(uc002guu.1 uc002gut.1 uc002guv.1 uc010vyl.1)
ENST00000395643 ENST00000395645 ENST00000584658 ENST00000417251 ENST00000395642
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC5A10 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC5A10 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SLC5A10 (NM_152351) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC5A10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC5A10 |
Additional cDNA sequence: AK057946.1 AK298345.1 BC034380.1 BC039868.1 BC062617.1 NR_073067.1 5 DOTS entries: DT.100734993 DT.421598 DT.40127220 DT.75143620 DT.95262511 24/39 AceView cDNA sequences (see all 39): AJ230824 BX119120 AA970307 AI733311 AI347280 BC034380 BC062617 AJ230787 BX402941 AW577412 BI765329 BX377205 AA983237 AJ230788 BX401443 BI762467 BC039868 AJ230822 AI793336 NM_152351 AK057946 BX106391 AI936410 BX448481
GeneLoc Exon Structure
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Expression
for SLC5A10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC5A10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SLC5A10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC5A10
SOURCE GeneReport for Unigene cluster: Hs.462418
UniProtKB/Swiss-Prot: SC5AA_HUMAN, A0PJK1Tissue specificity: Seems to be exclusively expressed in kidney
SABiosciences Custom PCR Arrays for SLC5A10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC5A10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC5A10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC5A10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC5A10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A10 |
Orthologs
for SLC5A10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SLC5A10 gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for SLC5A10 (if available)
TreeFam Gene Tree for SLC5A10 (if available) |
Paralogs
for SLC5A10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC5A10 gene
- SLC5A82 SLC5A12 SLC5A42 SLC5A52 SLC5A112 SLC5A92 SLC5A32 SLC5A22
- SLC5A62 SLC5A122 SLC5A72
6 SIMAP similar genes for SLC5A10 using alignment to 1 protein entry: SC5AA_HUMAN:SLC5A1 SLC5A2 SLC5A11 SLC5A3 SLC5A9 SLC5A4
SLC5A10 for paralogs About GeneDecksing
|
Genomic Variants
for SLC5A10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for SLC5A10 (18853658 - 18925908 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for SLC5A10
6 CNVs: 88374 7145 30808 23520 4025 77543 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC5A10 |
|
Disorders
/ Diseases
for SLC5A10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SLC5A10 for disorders About MalaCards
SLC5A10 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SLC5A10 (3 documents)
Export disorders for SLC5A10 gene to outside databases
|
Publications
for SLC5A10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC5A10 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SLC5A10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter. (PubMed id 22212718)1, 2 Grempler R....Eickelmann P. (2012)
- Quantitative PCR tissue expression profiling of the hu man SGLT2 gene and related family members. (PubMed id 22127746)1 Chen J....Feder J.N. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- A neural network model for constructing endophenotypes of common complex diseases: an application to male young-onset hypertension mic roarray data. (PubMed id 19237446)1 Lynn K.S....Pan W.H. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The sodium/glucose cotransport family SLC5. (PubMed id 12748858)1 Wright E.M. and Turk E. (2004)
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External Searches for SLC5A10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC5A10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC5A10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC5A10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC5A10 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLC5A10 gene:
Search GeneIP for patents involving SLC5A10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC5A10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC5A10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC5A10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC5A10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC5A10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC5A10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC5A10 |
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 | | | SLC5A10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A10 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLC5A10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC5A10 |
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