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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC5A1 Gene

protein-coding GIFtS: 61
GCID: GC22P032439

solute carrier family 5 (sodium/glucose cotransporter),...

(Previous symbol: SGLT1)

Explore 19 diseases affiliated with
SLC5A1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 1¹ ²		Na+/Glucose Cotransporter 1²
SGLT1¹ ² ³ ⁵		Sodium/Glucose Cotransporter 1²
NAGT¹ ² ³		Na(+)/Glucose Cotransporter 1³
D22S675¹ ²		Solute Carrier Family 5 Member 1³
High Affinity Sodium-Glucose Cotransporter² ³

External Ids:	HGNC: 11036¹	Entrez Gene: 6523²	Ensembl: ENSG00000100170⁷	OMIM: 182380⁵	UniProtKB: P13866³

ORGUL members:
	NONCODE:n409244

Export aliases for SLC5A1 gene to outside databases

Previous GC identifers: GC22P029135 GC22P030763 GC22P030769 GC22P015394

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC5A1:

This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane

protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this

gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different

isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: SC5A1_HUMAN, P13866

Function: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1.

Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity

and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules

Gene Wiki entry for SLC5A1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC5A1 gene promoter:
c-Fos GR AP-1 AML1a p53 GR-beta Zic1 c-Myb c-Jun GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC5A1 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC5A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC5A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q12.3

SLC5A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC5A1 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P032439: view genomic region (about GC identifiers)

Start:	32,439,019 bp from pter	End:	32,509,016 bp from pter
Size:	69,998 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SC5A1_HUMAN, P13866 (See protein sequence)

Recommended Name: Sodium/glucose cotransporter 1

Size: 664 amino acids; 73498 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: B2R7E2 B7Z4Q9 B7ZA69

Alternative splicing: 2 isoforms: P13866-1 P13866-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC5A1: NX_P13866

Post-translational modifications:

N-glycosylation is not necessary for the cotransporter function¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P13866

SLC5A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000334.1 NP_001243243.1

ENSEMBL proteins:

ENSP00000266088 ENSP00000444898

Reactome Protein details: P13866
Human Recombinant Protein Products:

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	Uscn Proteins for SLC5A1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8563765
GO:0005903	brush border	--	--
GO:0005911	cell-cell junction	IEA	--
GO:0016021	integral to membrane	--	--

SLC5A1 for ontologies About GeneDecksing

SLC5A1 Antibody Products:

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Assay Products for SLC5A1:

	Browse Kits and Assays available from EMD Millipore
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	Uscn ELISAs and CLIAs for SLC5A1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC5A1 for domains About GeneDecksing

3 InterPro domains/families:

IPR019900 Na/solute_symporter_subgr

IPR018212 Na/solute_symporter_CS

IPR001734 Na/solute_symporter

Graphical View of Domain Structure for InterPro Entry P13866

ProtoNet protein and cluster: P13866

1 Blocks protein family: IPB001734 Na+/solute symporter

UniProtKB/Swiss-Prot: SC5A1_HUMAN, P13866

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SC5A1_HUMAN, P13866

Function: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1.

Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity

and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules

Genatlas biochemistry entry for SLC5A1:

solute carrier family 5 (sodium/glucose cotransporter),member 1

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		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC5A1 (see all 16):
		hsa-miR-485-5p hsa-miR-607 hsa-miR-892b hsa-miR-3653 hsa-miR-105 hsa-miR-1184 hsa-miR-641 hsa-miR-3658

		SwitchGear 3'UTR luciferase reporter plasmid: SLC5A1 3' UTR sequence

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Gene Editing
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DNA2.0 Custom Protein Engineering Service for SLC5A1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC5A1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005355	glucose transmembrane transporter activity	--	--
GO:0005412	glucose:sodium symporter activity	IDA	8563765
GO:0005515	protein binding	IPI	18455122

SLC5A1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Slc5a1^tm1.1Koep for SLC5A1
     4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc5a1):

digestive/alimentary

homeostasis/metabolism

mortality/aging

renal/urinary system

SLC5A1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SLC-mediated transmembrane transport

	SLC-mediated transmembrane transport	1.00			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.38
	Transmembrane transport of small molecules	0.50

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

Na+-dependent glucose transporters

Na+-dependent glucose transporters

1.00

Metabolism

Metabolism

1.00

Selected targets of HNF1

Selected targets of HNF1

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for SLC5A1

	Selected targets of HNF1
	Sodium channels and transporters- inward current

1 Cell Signaling Technology (CST) Pathway for SLC5A1

Glucose / Energy Metabolism

5/7 Reactome Pathways for SLC5A1 (see all 7)

	Metabolism of carbohydrates
	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Hexose transport
	Metabolism

3 Kegg Pathways (Kegg details for SLC5A1):

	Carbohydrate digestion and absorption
	Bile secretion
	Mineral absorption

SLC5A1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SLC5A1

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/6 Interacting proteins for SLC5A1 (P13866^{1, 3} ENSP00000266088⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EGFR	P00533¹^,³, ENSP00000275493⁴	EBI-1772443,EBI-297353 I2D: score=1 STRING: ENSP00000275493
HSPA1A	P08107³, ENSP00000364802⁴	I2D: score=2 STRING: ENSP00000364802
HSPA1B	P08107³	I2D: score=2
PAWR	Q96IZ0³, ENSP00000328088⁴	I2D: score=1 STRING: ENSP00000328088
ATP1A1	P05023³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0008645	hexose transport	TAS	--
GO:0015758	glucose transport	IMP	8563765
GO:0044281	small molecule metabolic process	TAS	--
GO:0050892	intestinal absorption	IEA	--

SLC5A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC5A1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC5A1

1 HMDB Compound for SLC5A1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Sodium	Sodium (see all 2)	7440-23-5	--

10/34 Novoseek chemical compound relationships for SLC5A1 gene (see all 34) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phlorizin	92.3	36	15904891 (2), 10373701 (2), 15081894 (2), 12755613 (2) (see all 22)
methyl alpha-d-glucopyranoside	81.9	3	9252334 (1), 11562363 (1), 17686765 (1)
glucose	77	294	14659592 (4), 8631815 (3), 8764205 (3), 14505350 (3) (see all 99)
galactose	69	20	11602601 (2), 14642859 (2), 8844006 (1), 10997927 (1) (see all 13)
sodium	51	27	9073126 (2), 10441667 (1), 11193601 (1), 11131365 (1) (see all 19)
fructose	50	9	11877642 (1), 9073126 (1), 12221236 (1), 11531215 (1) (see all 7)
3-o-methylglucose	47.4	4	11531215 (1), 11871739 (1)
hmba	44.9	5	9573543 (2), 7544792 (1)
monosaccharide	41.6	3	9468325 (1), 9729444 (1)
2-deoxyglucose	32.5	6	11848285 (1), 17153597 (1), 17686765 (1)

Search CenterWatch for drugs/clinical trials and news about SLC5A1 / SC5A1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC5A1 gene (2 alternative transcripts):

NM_000343.3 NM_001256314.1

Unigene Cluster for SLC5A1:

Solute carrier family 5 (sodium/glucose cotransporter), member 1

Hs.1964 [show with all ESTs]

Unigene Representative Sequence: NM_000343

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000266088(uc003amc.3 uc011alz.2) ENST00000486394 ENST00000477969

ENST00000543737

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		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC5A1 (see all 16):
		hsa-miR-485-5p hsa-miR-607 hsa-miR-892b hsa-miR-3653 hsa-miR-105 hsa-miR-1184 hsa-miR-641 hsa-miR-3658

		SwitchGear 3'UTR luciferase reporter plasmid: SLC5A1 3' UTR sequence

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Additional cDNA sequence:

AK297665.1 AK312948.1 AK316184.1 BC139838.1 BC139839.1 CR456579.1 DQ656053.2 M24847.1

3 DOTS entries:

DT.108277 DT.40291552 DT.97808082

24/29 AceView cDNA sequences (see all 29):

NM_000343 W95803 BF114994 BG742097 CR456579 AI628117 BX106912 M24847

BX483563 AL693702 AA639744 BX113277 BX487722 AI376528 AI889071 AW084574

BX503206 BU584759 AI078794 BU584595 AA433832 BX482441 AL599996 AA669064

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC5A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTATATATA

About this image

SLC5A1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Proximal Tubule

Proximal Tubule Cells

Selective marker (cell-identifying gene)

Kidney

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Gut Tube

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC5A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC5A1

SOURCE GeneReport for Unigene cluster: Hs.1964

UniProtKB/Swiss-Prot: SC5A1_HUMAN, P13866

Tissue specificity: Expressed mainly in intestine and kidney

SABiosciences Expression via Pathway-Focused PCR Array including SLC5A1:

Drug Transporters in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SLC5A1 gene from 4/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC5A1¹	solute carrier family 5 (sodium/glucose cotransporter), more	74.82(n) 80.56(a)		395496 XM_415247.3 XP_415247.3
lizard (Anolis carolinensis)	Reptilia	-- --	--	80(a) 71(a)	many ↔ many many ↔ many	GL344191.1(87618-96791) AAWZ02037698(10042-14759)
zebrafish (Danio rerio)	Actinopterygii	zgc66074²	hypothetical protein MGC66074	77.24(n)		393654 BC058316.1
E. coli (Escherichia coli)	Gamma proteobacteria	yidK⁶ putP⁶ (see all 3)	proline:sodium symporter (see all 3)	23(a) 18(a) (see all 3)	1 ↔ many possible ortholog (see all 3)	Chromosome(3856424-3858139) Chromosome(1078528-1080036)

ENSEMBL Gene Tree for SLC5A1 (if available)
TreeFam Gene Tree for SLC5A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC5A1 gene

SLC5A8² SLC5A4² SLC5A5² SLC5A11² SLC5A9² SLC5A3² SLC5A10² SLC5A2²

SLC5A6² SLC5A12² SLC5A7²

6 SIMAP similar genes for SLC5A1 using alignment to 2 protein entries: SC5A1_HUMAN (see all proteins):

SLC5A4 SLC5A10 SLC5A2 SLC5A9 SLC5A11 SLC5A3

SLC5A1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for SLC5A1
PGOHUM00000259273 PGOHUM00000246527

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5998218^1,2	H	--	15392922(+)	`CCCCAG/CGTTGA`	1	--	us2k¹		4		NS EA	414
rs62240632^1,2		--	15393098(+)	`GGGTCG/AGTACA`	1	--	us2k¹		1		NA	2
rs78239262^1,2	C,F,	--	15394030(+)	`GGGCTG/TCAGGG`	1	--	us2k¹		1		WA	118
rs7291826^1,2	C,F,H,	--	15394526(+)	`ATTTTA/CCAAGC`	1	--	us2k¹		14		NS EA NA WA	1790
rs61253698^1,2		--	15394671(+)	`GGTGGC/TGCTGC`	1	--	us2k¹		0	--	--	--	--
rs5998219^1,2	H,	--	15394694(+)	`TGGGAG/ATACAG`	1	--	us2k¹		4		NS EA	418
rs111361054^1,2	C,F,	--	15394718(+)	`CAGGCG/AGGCAC`	1	--	us2k¹		3		WA CSA	122
rs200443129^1,2	C,	--	15394978(+)	`AAGGAC/TGCAAC`	1	--	ut5¹		0	--	--	--	--
rs33973317^1,2	C,F,	--	15394998(+)	`ATGGAC/TAGTAG`	2	D	syn¹		6		NS NA EU	6877
rs33994397^1,2	C,F	--	15395010(+)	`ACCTGG/AAGCCC`	2	/* /W	stg¹		2		--	1104

HapMap Linkage Disequilibrium report for SLC5A1 (32439019 - 32509016 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC5A1
1 CNV: 5358
Human Gene Mutation Database (HGMD): SLC5A1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC5A1 for disorders           About GeneDecksing

OMIM gene information: 182380
OMIM disorders: 606824
UniProtKB/Swiss-Prot: SC5A1_HUMAN, P13866

Defects in SLC5A1 are the cause of congenital glucose/galactose malabsorption (GGM) [MIM:606824]. GGM is an

intestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the

first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and

galactose are eliminated from the diet

19 diseases for SLC5A1: About MalaCards

glucose/galactose malabsorption renal glucosuria renal glycosuria nephrocalcinosis

cystic fibrosis hyperglycemia stomatitis diarrhea

fibrosis peritonitis pancreatic cancer lung cancer

prostate cancer pancreatitis cholesterol hypoxia

prostatitis thyroiditis neuronitis

2 diseases from the University of Copenhagen DISEASES database for SLC5A1:

Renal glycosuria Hartnup disease

5 Novoseek disease relationships for SLC5A1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
malabsorption	69.7	15	9098004 (2), 8563765 (2), 10036327 (2), 20421923 (1) (see all 11)
hyperglycemia	12.9	1	17531273 (1)
atrophy	0	1	9274472 (1)
obesity	0	2	15166308 (1), 16788147 (1)
cancer	0	1	11509120 (1), 18455122 (1)

Genatlas disease: SLC5A1

glucose-galactose malabsorption

Human Genome Epidemiology (HuGE) Navigator: SLC5A1 (4 documents)

Export disorders for SLC5A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC5A1 gene, integrated from 9 sources (see all 220):
(articles sorted by number of sources associating them with SLC5A1)

Utopia: connect your pdf to the dynamic
world of online information

Structure of the human Na+/glucose cotransporter gene SGLT1. (PubMed id 8195156)^{1, 2, 3, 9} Turk E.... Wright E.M. (1994)
Missense mutations in SGLT1 cause glucose-galactose malabsorption by trafficking defects. (PubMed id 10036327)^{1, 2, 9} Lam J.T.... Wright E.M. (1999)
Membrane topology of the human Na+/glucose cotransporter SGLT1. (PubMed id 8567640)^{1, 2, 9} Turk E.... Wright E.M. (1996)
Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter. (PubMed id 2008213)^{1, 2, 9} Turk E.... Wright E.M. (1991)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
A missense mutation in the Na(+)/glucose cotransporter gene SGLT1 in a patient with congenital glucose-galactose malabsorption: normal trafficking but inactivation of the mutant protein. (PubMed id 11406349)^{1, 2} Kasahara M.... Abe T. (2001)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Homology of the human intestinal Na+/glucose and Escherichia coli Na+/proline cotransporters. (PubMed id 2490366)^{1, 2} Hediger M.A.... Wright E.M. (1989)
More than apical: Distribution of SGLT1 in Caco-2 cells. (PubMed id 12773314)^{1, 9} Kipp H....Kinne R.K. (2003)
SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states. (PubMed id 19509029)^{1, 9} Banerjee S.K....Ahmad F. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6523	HGNC: 11036	AceView: SLC5A1	Ensembl:ENSG00000100170	euGenes: HUgn6523
ECgene: SLC5A1	Kegg: 6523	H-InvDB: SLC5A1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC5A1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC5A1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SLC5A1 gene:
Search GeneIP for patents involving SLC5A1

GeneCards and IP:
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