Aliases for SLC5A1 Gene
External Ids for SLC5A1 Gene
Previous HGNC Symbols for SLC5A1 Gene
Previous GeneCards Identifiers for SLC5A1 Gene
This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for SLC5A1 Gene
SLC5A1 (Solute Carrier Family 5 Member 1) is a Protein Coding gene. Diseases associated with SLC5A1 include Glucose/Galactose Malabsorption and Osmotic Diarrhea. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and glucose:sodium symporter activity. An important paralog of this gene is SLC5A4.
UniProtKB/Swiss-Prot for SLC5A1 Gene
Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.