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Aliases for SLC5A1 Gene

Aliases for SLC5A1 Gene

  • Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 1 2 3
  • SGLT1 3 4 6
  • High Affinity Sodium-Glucose Cotransporter 3 4
  • Sodium/Glucose Cotransporter 1 2 3
  • NAGT 3 4
  • Solute Carrier Family 5 Member 1 4
  • Na(+)/Glucose Cotransporter 1 4
  • Na+/Glucose Cotransporter 1 3
  • D22S675 3

External Ids for SLC5A1 Gene

Previous HGNC Symbols for SLC5A1 Gene

  • SGLT1

Previous GeneCards Identifiers for SLC5A1 Gene

  • GC22P029135
  • GC22P030763
  • GC22P030769
  • GC22P032439
  • GC22P015394

Summaries for SLC5A1 Gene

Entrez Gene Summary for SLC5A1 Gene

  • This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for SLC5A1 Gene

SLC5A1 (Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 1) is a Protein Coding gene. Diseases associated with SLC5A1 include glucose/galactose malabsorption and renal glucosuria. Among its related pathways are Metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include glucose:sodium symporter activity. An important paralog of this gene is SLC5A10.

UniProtKB/Swiss-Prot for SLC5A1 Gene

  • Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules

Gene Wiki entry for SLC5A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC5A1 Gene

Genomics for SLC5A1 Gene

Regulatory Elements for SLC5A1 Gene

Genomic Location for SLC5A1 Gene

Start:
32,043,032 bp from pter
End:
32,113,029 bp from pter
Size:
69,998 bases
Orientation:
Plus strand

Genomic View for SLC5A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC5A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC5A1 Gene

Proteins for SLC5A1 Gene

  • Protein details for SLC5A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13866-SC5A1_HUMAN
    Recommended name:
    Sodium/glucose cotransporter 1
    Protein Accession:
    P13866
    Secondary Accessions:
    • B2R7E2
    • B7Z4Q9
    • B7ZA69

    Protein attributes for SLC5A1 Gene

    Size:
    664 amino acids
    Molecular mass:
    73498 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC5A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC5A1 Gene

Proteomics data for SLC5A1 Gene at MOPED

Post-translational modifications for SLC5A1 Gene

Other Protein References for SLC5A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SLC5A1 (SLC5A1)

No data available for DME Specific Peptides for SLC5A1 Gene

Domains for SLC5A1 Gene

Gene Families for SLC5A1 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC5A1 Gene

Graphical View of Domain Structure for InterPro Entry

P13866

UniProtKB/Swiss-Prot:

SC5A1_HUMAN :
  • P13866
Family:
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
genes like me logo Genes that share domains with SLC5A1: view

Function for SLC5A1 Gene

Molecular function for SLC5A1 Gene

GENATLAS Biochemistry: solute carrier family 5 (sodium/glucose cotransporter),member 1
UniProtKB/Swiss-Prot Function: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules

Gene Ontology (GO) - Molecular Function for SLC5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005355 glucose transmembrane transporter activity --
GO:0005412 glucose:sodium symporter activity IDA 8563765
GO:0005515 protein binding IPI 18455122
genes like me logo Genes that share ontologies with SLC5A1: view
genes like me logo Genes that share phenotypes with SLC5A1: view

Animal Models for SLC5A1 Gene

MGI Knock Outs for SLC5A1:

Animal Model Products

CRISPR Products

miRNA for SLC5A1 Gene

miRTarBase miRNAs that target SLC5A1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC5A1 Gene

Localization for SLC5A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC5A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC5A1 Gene COMPARTMENTS Subcellular localization image for SLC5A1 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8563765
GO:0005903 brush border --
GO:0005911 cell-cell junction IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SLC5A1: view

Pathways for SLC5A1 Gene

genes like me logo Genes that share pathways with SLC5A1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SLC5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001656 metanephros development IEA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006810 transport --
GO:0006814 sodium ion transport IEA --
GO:0008645 hexose transport TAS --
genes like me logo Genes that share ontologies with SLC5A1: view

Compounds for SLC5A1 Gene

(1) HMDB Compounds for SLC5A1 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(5) IUPHAR Ligand for SLC5A1 Gene

Ligand Type Action Affinity Pubmed IDs
canagliflozin Inhibitor Inhibition 6.4
dapagliflozin Inhibitor Inhibition 5.9
remogliflozin Inhibitor Inhibition 5.4
empagliflozin Inhibitor Inhibition 5.1
sergliflozin Inhibitor Inhibition 5.1

(34) Novoseek inferred chemical compound relationships for SLC5A1 Gene

Compound -log(P) Hits PubMed IDs
phlorizin 92.3 26
methyl alpha-d-glucopyranoside 81.9 3
glucose 77 156
galactose 69 15
sodium 51 20
genes like me logo Genes that share compounds with SLC5A1: view

Transcripts for SLC5A1 Gene

Unigene Clusters for SLC5A1 Gene

Solute carrier family 5 (sodium/glucose cotransporter), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC5A1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC5A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A1 Gene

No ASD Table

Relevant External Links for SLC5A1 Gene

GeneLoc Exon Structure for
SLC5A1
ECgene alternative splicing isoforms for
SLC5A1

Expression for SLC5A1 Gene

mRNA expression in normal human tissues for SLC5A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC5A1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (17.5), Heart - Left Ventricle (16.0), and Heart - Atrial Appendage (5.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC5A1 Gene

SOURCE GeneReport for Unigene cluster for SLC5A1 Gene Hs.1964

mRNA Expression by UniProt/SwissProt for SLC5A1 Gene

P13866-SC5A1_HUMAN
Tissue specificity: Expressed mainly in intestine and kidney
genes like me logo Genes that share expressions with SLC5A1: view

In Situ Assay Products

Orthologs for SLC5A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC5A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC5A1 35
  • 99.25 (n)
  • 98.8 (a)
SLC5A1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SGLT1 36
  • 86 (a)
OneToOne
SLC5A1 35
  • 87.1 (n)
  • 85.84 (a)
dog
(Canis familiaris)
Mammalia SLC5A1 35
  • 87.06 (n)
  • 87.16 (a)
SLC5A1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc5a1 35
  • 85.09 (n)
  • 88.1 (a)
Slc5a1 16
Slc5a1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC5A1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC5A1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc5a1 35
  • 84.54 (n)
  • 87.95 (a)
chicken
(Gallus gallus)
Aves SLC5A1 35
  • 74.82 (n)
  • 80.56 (a)
SLC5A1 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC5A1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493915 35
  • 72.08 (n)
  • 75.87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12162 35
zebrafish
(Danio rerio)
Actinopterygii slc5a1 35
  • 72.06 (n)
  • 75.16 (a)
slc5a1 36
  • 71 (a)
OneToOne
zgc66074 35
fruit fly
(Drosophila melanogaster)
Insecta CG2187 36
  • 17 (a)
ManyToMany
CG31262 36
  • 16 (a)
ManyToMany
CG31668 36
  • 17 (a)
ManyToMany
CG33124 36
  • 19 (a)
ManyToMany
CG42235 36
  • 14 (a)
ManyToMany
CG5687 36
  • 16 (a)
ManyToMany
CG6723 36
  • 17 (a)
ManyToMany
CG7720 36
  • 16 (a)
ManyToMany
CG8451 36
  • 17 (a)
ManyToMany
CG9657 36
  • 17 (a)
ManyToMany
salt 36
  • 18 (a)
ManyToMany
Smvt 36
  • 17 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F52H2.4 36
  • 16 (a)
ManyToMany
ZK822.5 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14066 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
OneToOne
Species with no ortholog for SLC5A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC5A1 Gene

ENSEMBL:
Gene Tree for SLC5A1 (if available)
TreeFam:
Gene Tree for SLC5A1 (if available)

Paralogs for SLC5A1 Gene

Selected SIMAP similar genes for SLC5A1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SLC5A1 Gene

genes like me logo Genes that share paralogs with SLC5A1: view

Variants for SLC5A1 Gene

Sequence variations from dbSNP and Humsavar for SLC5A1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs93108 -- 32,067,623(-) TATGA(C/T)GACTA intron-variant
rs130263 -- 32,046,369(+) TTTTT(-/T)AAGTT intron-variant
rs130264 -- 32,048,230(+) TGTTC(A/G)CTGAG intron-variant
rs130265 -- 32,049,415(+) TTTTT(-/T)GAGAT intron-variant
rs130266 -- 32,054,375(+) ATATA(C/T)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC5A1 Gene

Variant ID Type Subtype PubMed ID
nsv834177 CNV Gain 17160897
esv2422247 CNV Duplication 17116639
nsv834178 CNV Loss 17160897
nsv3596 CNV Loss 18451855

Relevant External Links for SLC5A1 Gene

HapMap Linkage Disequilibrium report
SLC5A1
Human Gene Mutation Database (HGMD)
SLC5A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC5A1 Gene

Disorders for SLC5A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SLC5A1 Gene including...

Search for SLC5A1 Gene in MalaCards »

(1) OMIM Diseases for SLC5A1 Gene (182380)

UniProtKB/Swiss-Prot

SC5A1_HUMAN
  • Congenital glucose/galactose malabsorption (GGM) [MIM:606824]: Intestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and galactose are eliminated from the diet. {ECO:0000269 PubMed:10036327, ECO:0000269 PubMed:11406349, ECO:0000269 PubMed:2008213, ECO:0000269 PubMed:8195156}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for SLC5A1 Gene

(5) Novoseek inferred disease relationships for SLC5A1 Gene

Disease -log(P) Hits PubMed IDs
malabsorption 69.7 14
hyperglycemia 12.9 1
atrophy 0 1
obesity 0 2
cancer 0 2

Genatlas disease for SLC5A1 Gene

glucose-galactose malabsorption

Relevant External Links for SLC5A1

Genetic Association Database (GAD)
SLC5A1
Human Genome Epidemiology (HuGE) Navigator
SLC5A1
genes like me logo Genes that share disorders with SLC5A1: view

Publications for SLC5A1 Gene

  1. Structure of the human Na+/glucose cotransporter gene SGLT1. (PMID: 8195156) Turk E. … Wright E.M. (J. Biol. Chem. 1994) 2 3 4 23
  2. Missense mutations in SGLT1 cause glucose-galactose malabsorption by trafficking defects. (PMID: 10036327) Lam J.T. … Wright E.M. (Biochim. Biophys. Acta 1999) 3 4 23
  3. Membrane topology of the human Na+/glucose cotransporter SGLT1. (PMID: 8567640) Turk E. … Wright E.M. (J. Biol. Chem. 1996) 3 4 23
  4. Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter. (PMID: 2008213) Turk E. … Wright E.M. (Nature 1991) 3 4 23
  5. Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption. (PMID: 8563765) MartA-n M.G. … Wright E.M. (Nat. Genet. 1996) 3 23

Products for SLC5A1 Gene

Sources for SLC5A1 Gene

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