Aliases for SLC52A1 Gene
External Ids for SLC52A1 Gene
Previous HGNC Symbols for SLC52A1 Gene
Previous GeneCards Identifiers for SLC52A1 Gene
Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
GeneCards Summary for SLC52A1 Gene
SLC52A1 (Solute Carrier Family 52 (Riboflavin Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC52A1 include riboflavin deficiency and transient neonatal multiple acyl-coa dehydrogenase deficiency. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include virus receptor activity and riboflavin transporter activity. An important paralog of this gene is SLC52A2.
UniProtKB/Swiss-Prot for SLC52A1 Gene
Riboflavin transporter. Riboflavin transport is Na(+)-independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).