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SLC51B Gene

protein-coding   GIFtS: 38
GCID: GC15P065762

Solute Carrier Family 51, Beta Subunit

  See SLC51B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 51, Beta Subunit1 2     OST-beta2 3
OSTB2 3 5     OSTBETA2
Organic Solute Transporter Beta Subunit1 2     Organic Solute Transporter Subunit Beta2
Solute Carrier Family 51 Subunit Beta2 3     

External Ids:    HGNC: 299561   Entrez Gene: 1232642   Ensembl: ENSG000001861987   OMIM: 6120855   UniProtKB: Q86UW23   

Export aliases for SLC51B gene to outside databases

Previous GC identifers: GC15P065338 GC15P065420


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC51B Gene:
SLC51B (solute carrier family 51, beta subunit) is a protein-coding gene. Diseases associated with SLC51B include extrahepatic cholestasis. GO annotations related to this gene include transporter activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot: OSTB_HUMAN, Q86UW2
Function: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal
basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently
transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability
activities

Gene Wiki entry for SLC51B (OSTbeta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SLC51B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SLC51B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC51B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.31

SLC51B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC51B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P065762:  view genomic region     (about GC identifiers)

Start:
65,337,708 bp from pter      End:
65,345,734 bp from pter
Size:
8,027 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OSTB_HUMAN, Q86UW2 (See protein sequence)
Recommended Name: Organic solute transporter subunit beta  
Size: 128 amino acids; 14346 Da
Subunit: Interacts with SLC51A. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and
beta (SLC51B) subunit; induces the transport of SLC51A from the reticulum endoplasmic to the plasma membrane (By
similarity)
Secondary accessions: Q3SYF5

Explore the universe of human proteins at neXtProt for SLC51B: NX_Q86UW2

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_849190.2  
    ENSEMBL proteins: 
     ENSP00000335292  

    SLC51B Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for SLC51B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: OSTbeta
    SLC51 family of steroid-derived molecule transporters

    ProtoNet protein and cluster: Q86UW2

    UniProtKB/Swiss-Prot: OSTB_HUMAN, Q86UW2
    Domain: The transmembrane domain (TM) is the major site of interaction with SLC51A. The extracellular-membrane
    interface is absolutely required for transport activity. The intracellular-membrane interface is necessary for
    establishing the correct membrane orientation that is essential for the heterodimer Ost-alpha/Ost-beta complex
    formation and transport activity at the cell membrane surface (By similarity)
    Similarity: Belongs to the OST-beta family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSTB_HUMAN, Q86UW2
    Function: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal
    basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently
    transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability
    activities
    Induction: Positively regulated via NR1H4/FXR

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ISS--
         
    Find genes that share ontologies with SLC51B           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC51B
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OSTB_HUMAN, Q86UW2: Cell membrane; Single-pass membrane protein. Note=Mainly restricted to the lateral and basal
    membranes of ileal enterocytes

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA12719432
    GO:0016021integral component of membrane ISS--
    GO:0043234protein complex ISS--

    Find genes that share ontologies with SLC51B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC51B About    
    See pathways by source

    SuperPathContained pathways About
    1Drug Induction of Bile Acid Pathway
    Drug Induction of Bile Acid Pathway
    2Bile secretion
    Bile secretion


    Find genes that share SuperPaths with SLC51B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SLC51B
        Drug Induction of Bile Acid Pathway


    1 Kegg Pathway  (Kegg details for SLC51B):
        Bile secretion

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC51B
    Interactions:

        Search GeneGlobe Interaction Network for SLC51B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC51B (ENSP000003352924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC51AENSP000002963274STRING: ENSP00000296327
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0015721bile acid and bile salt transport ISS--
    GO:0031647regulation of protein stability ISS--
    GO:0060050positive regulation of protein glycosylation ISS--
    GO:0070863positive regulation of protein exit from endoplasmic reticulum ISS--

    Find genes that share ontologies with SLC51B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC51B (OSTB)

    5 Novoseek inferred chemical compound relationships for SLC51B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrone sulfate 69.5 1 16246895 (1)
    taurocholate 67 1 16246895 (1)
    chenodeoxycholic acid 66.8 2 16251721 (1), 16423920 (1)
    digoxin 50.4 1 16246895 (1)
    pge2 31.2 1 16246895 (1)



    Find genes that share compounds with SLC51B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC51B gene: 
    NM_178859.3  

    Unigene Cluster for SLC51B:

    Solute carrier family 51, beta subunit
    Hs.534533  [show with all ESTs]
    Unigene Representative Sequence: NM_178859
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000334287(uc002aog.3)
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC51B
      QuantiFast Probe-based Assays in human, mouse, rat SLC51B

    Additional mRNA sequence: 

    AK129601.1 AY194242.1 BC103842.1 BC103843.1 BC103844.1 

    2 DOTS entries:

    DT.208377  DT.100750245 

    20 AceView cDNA sequences:

    AI479168 AA927993 AI733180 AA746188 AW080000 AW271603 AW299821 AI138844 
    NM_178859 AI935649 AW304143 AY194242 AK129601 AI793107 AV698921 AW291210 
    BX095738 AA863359 AA156475 AA156136 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC51B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC51B Expression
    About this image

    SLC51B Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.534533

    UniProtKB/Swiss-Prot: OSTB_HUMAN, Q86UW2
    Tissue specificity: Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small
    intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland,
    uterus, prostate, mammary gland and fat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC51B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for SLC51B gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc51b1 , 5 organic solute transporter beta5
    solute carrier family 51, beta subunit1
    76.46(n)1
    64.29(a)1
      9 (35.29 cM)5
    3309621  NM_178933.21  NP_849264.11 
     654127535 


    ENSEMBL Gene Tree for SLC51B (if available)
    TreeFam Gene Tree for SLC51B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC51B (see all 199)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906934951,2
    --65335725(+) TTCCAC/GCCAGC 1 -- us2k10--------
    rs1420864591,2
    --65335756(+) AATGTC/TAATTA 1 -- us2k10--------
    rs1155273461,2
    F--65335853(+) GCCCAC/ACATGA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs80310501,2
    C,F,H--65335863(+) aggagT/Gggata 1 -- us2k121Minor allele frequency- G:0.45NS EA NA WA CSA 2346
    rs1826182161,2
    --65335871(+) ATACTC/TCTGTC 1 -- us2k10--------
    rs1858082691,2
    --65335887(+) TCTGAC/TTTTAT 1 -- us2k10--------
    rs350642511,2
    C--65336011(+) TTTTT-/TCTGAG 1 -- us2k10--------
    rs29466731,2
    C,F,A,H--65336045(+) tgttgC/Tccagg 1 -- us2k12Minor allele frequency- T:0.33NA WA 6
    rs1392535581,2
    --65336230(+) GAACTC/TCTGAC 1 -- us2k10--------
    rs1418076981,2
    --65336450(+) CTGCTA/GTAATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC51B (65337708 - 65345734 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC51B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC51B
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC51B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612085    OMIM disorders: --

    1 disease for SLC51B:    
    About MalaCards
    extrahepatic cholestasis


    Find genes that share disorders with SLC51B           About GenesLikeMe


    Export disorders for SLC51B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC51B gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with SLC51B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. (PubMed id 12719432)1, 2, 3, 9 Seward D.J.... Ballatori N. (J. Biol. Chem. 2003)
    2. FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. (PubMed id 16251721)1, 2, 9 Lee H.... Edwards P.A. (J. Lipid Res. 2006)
    3. The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. (PubMed id 16269519)1, 2, 9 Landrier J.-F.... Kullak-Ublick G.A. (Am. J. Physiol. 2006)
    4. Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism. (PubMed id 20538072)1, 3 Dawson P.A....Rao A. (Biochim. Biophys. Acta 2010)
    5. OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. (PubMed id 16317684)1, 2 Ballatori N.... Li N. (Hepatology 2005)
    6. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. (PubMed id 16423920)1, 9 Boyer J.L....Ballatori N. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006)
    7. A novel RARI+/CAR-mediated mechanism for regulation of human organic solute transporter-I^ gene expression. (PubMed id 24264050)1 Xu S....Suchy F.J. (Am. J. Physiol. Gastrointest. Liver Physiol. 2014)
    8. I^-Subunit of the OstI+-OstI^ organic solute transporter is required not only for heterodimerization and trafficking but also for function. (PubMed id 22535958)1 Christian W.V....Ballatori N. (J. Biol. Chem. 2012)
    9. Pleiotropic functions of the organic solute transporter OstI+-OstI^. (PubMed id 21691099)1 Ballatori N. (Dig Dis 2011)
    10. Neurosteroid transport by the organic solute transporter OSTI+-OSTI^. (PubMed id 20649839)1 Fang F....Ballatori N. (J. Neurochem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 123264 HGNC: 29956 AceView: OSTbeta Ensembl:ENSG00000186198 euGenes: HUgn123264
    ECgene: SLC51B Kegg: 123264 H-InvDB: SLC51B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC51B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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