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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC51B Gene

protein-coding   GIFtS: 38
GCID: GC15P065420

Solute Carrier Family 51, Beta Subunit

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 51, Beta Subunit1 2     OST-beta2 3
OSTB2 3 5     OSTBETA2
Organic Solute Transporter Beta Subunit1 2     Organic Solute Transporter Subunit Beta2
Solute Carrier Family 51 Subunit Beta2 3     

External Ids:    HGNC: 299561   Entrez Gene: 1232642   Ensembl: ENSG000001861987   OMIM: 6120855   UniProtKB: Q86UW23   

Export aliases for SLC51B gene to outside databases

Previous GC identifer: GC15P065338


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC51B Gene: 
SLC51B (solute carrier family 51, beta subunit) is a protein-coding gene. Diseases associated with SLC51B include extrahepatic cholestasis, and biliary atresia. GO annotations related to this gene include transporter activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot: OSTB_HUMAN, Q86UW2
Function: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal
basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently
transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability
activities

Gene Wiki entry for SLC51B (OSTbeta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SLC51B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SLC51B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC51B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.31

SLC51B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC51B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P065420:  view genomic region     (about GC identifiers)

Start:
65,337,708 bp from pter      End:
65,345,734 bp from pter
Size:
8,027 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OSTB_HUMAN, Q86UW2 (See protein sequence)
Recommended Name: Organic solute transporter subunit beta  
Size: 128 amino acids; 14346 Da
Subunit: Interacts with SLC51A. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and
beta (SLC51B) subunit; induces the transport of SLC51A from the reticulum endoplasmic to the plasma membrane (By
similarity)
Subcellular location: Cell membrane; Single-pass membrane protein. Note=Mainly restricted to the lateral and basal
membranes of ileal enterocytes
Secondary accessions: Q3SYF5

Explore the universe of human proteins at neXtProt for SLC51B: NX_Q86UW2

Explore proteomics data for SLC51B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UW2

  • SLC51B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC51B Protein Expression
    REFSEQ proteins: NP_849190.2  
    ENSEMBL proteins: 
     ENSP00000335292  

    Human Recombinant Protein Products for SLC51B: 
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    Novus Biologicals SLC51B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA12719432
    GO:0016021integral to membrane ISS--
    GO:0043234protein complex ISS--

    SLC51B for ontologies           About GeneDecksing



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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: OST&beta 
    SLC51 family of steroid-derived molecule transporters

    ProtoNet protein and cluster: Q86UW2

    UniProtKB/Swiss-Prot: OSTB_HUMAN, Q86UW2
    Domain: The transmembrane domain (TM) is the major site of interaction with SLC51A. The extracellular-membrane
    interface is absolutely required for transport activity. The intracellular-membrane interface is necessary for
    establishing the correct membrane orientation that is essential for the heterodimer Ost-alpha/Ost-beta complex
    formation and transport activity at the cell membrane surface (By similarity)
    Similarity: Belongs to the OST-beta family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSTB_HUMAN, Q86UW2
    Function: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal
    basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently
    transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability
    activities
    Induction: Positively regulated via NR1H4/FXR

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ISS--
         
    SLC51B for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC51B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Drug Induction of Bile Acid Pathway
    Drug Induction of Bile Acid Pathway
    2Bile secretion
    Bile secretion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SLC51B
        Drug Induction of Bile Acid Pathway


    1         Kegg Pathway  (Kegg details for SLC51B):
        Bile secretion


    SLC51B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC51B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC51B (ENSP000003352924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC51AENSP000002963274STRING: ENSP00000296327
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0015721bile acid and bile salt transport ISS--
    GO:0031647regulation of protein stability ISS--
    GO:0060050positive regulation of protein glycosylation ISS--
    GO:0070863positive regulation of protein exit from endoplasmic reticulum ISS--

    SLC51B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC51B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC51B (OSTB)

    5 Novoseek inferred chemical compound relationships for SLC51B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrone sulfate 69.5 1 16246895 (1)
    taurocholate 67 1 16246895 (1)
    chenodeoxycholic acid 66.8 2 16251721 (1), 16423920 (1)
    digoxin 50.4 1 16246895 (1)
    pge2 31.2 1 16246895 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC51B / OSTB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC51B gene: 
    NM_178859.3  

    Unigene Cluster for SLC51B:

    Solute carrier family 51, beta subunit
    Hs.534533  [show with all ESTs]
    Unigene Representative Sequence: NM_178859
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000334287(uc002aog.3)
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC51B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC51B
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC51B

    Additional mRNA sequence: 

    AK129601.1 AY194242.1 BC103842.1 BC103843.1 BC103844.1 

    2 DOTS entries:

    DT.208377  DT.100750245 

    20 AceView cDNA sequences:

    AA927993 AW080000 AI479168 AI733180 AA746188 AW271603 AW304143 AW299821 
    AI935649 AI793107 AW291210 AK129601 NM_178859 AV698921 AI138844 AY194242 
    AA863359 BX095738 AA156475 AA156136 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC51B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC51B Expression
    About this image


    See SLC51B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC51B

    SOURCE GeneReport for Unigene cluster: Hs.534533

    UniProtKB/Swiss-Prot: OSTB_HUMAN, Q86UW2
    Tissue specificity: Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small
    intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland,
    uterus, prostate, mammary gland and fat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC51B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for SLC51B gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc51b5
    Ostb1
    organic solute transporter beta1, 5 76.46(n)1
    64.29(a)1
      9 (35.29 cM)5
    3309621  NM_178933.21  NP_849264.11 
     654127535 


    ENSEMBL Gene Tree for SLC51B (if available)
    TreeFam Gene Tree for SLC51B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/199 SNPs in SLC51B are shown (see all 199)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906934951,2
    --65335725(+) TTCCAC/GCCAGC 1 -- us2k10--------
    rs1420864591,2
    --65335756(+) AATGTC/TAATTA 1 -- us2k10--------
    rs1155273461,2
    F--65335853(+) GCCCAC/ACATGA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs80310501,2
    C,F,H--65335863(+) aggagT/Gggata 1 -- us2k121Minor allele frequency- G:0.45NS EA NA WA CSA 2346
    rs1826182161,2
    --65335871(+) ATACTC/TCTGTC 1 -- us2k10--------
    rs1858082691,2
    --65335887(+) TCTGAC/TTTTAT 1 -- us2k10--------
    rs350642511,2
    C--65336011(+) TTTTT-/TCTGAG 1 -- us2k10--------
    rs29466731,2
    C,F,A,H--65336045(+) tgttgC/Tccagg 1 -- us2k12Minor allele frequency- T:0.33NA WA 6
    rs1392535581,2
    --65336230(+) GAACTC/TCTGAC 1 -- us2k10--------
    rs1418076981,2
    --65336450(+) CTGCTA/GTAATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC51B (65337708 - 65345734 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC51B: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC51B
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC51B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612085    OMIM disorders: --

    6 diseases for SLC51B:    About MalaCards
    extrahepatic cholestasis    biliary atresia    cholestasis    obesity
    thyroiditis    prostatitis


    SLC51B for disorders           About GeneDecksing


    Export disorders for SLC51B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC51B gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with SLC51B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. (PubMed id 12719432)1, 2, 3, 9 Seward D.J.... Ballatori N. (2003)
    2. FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. (PubMed id 16251721)1, 2, 9 Lee H.... Edwards P.A. (2006)
    3. The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. (PubMed id 16269519)1, 2, 9 Landrier J.-F.... Kullak-Ublick G.A. (2006)
    4. Getting the mOST from OST: Role of organic solute tran sporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism. (PubMed id 20538072)1, 3 Dawson P.A....Rao A. (2010)
    5. OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. (PubMed id 16317684)1, 2 Ballatori N.... Li N. (2005)
    6. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. (PubMed id 16423920)1, 9 Boyer J.L....Ballatori N. (2006)
    7. b-Subunit of the Osta-Ostb organic solute transporter is required not only for heterodimerization and trafficking but also for functio n. (PubMed id 22535958)1 Christian W.V....Ballatori N. (2012)
    8. Pleiotropic functions of the organic solute transport er OstI+-OstI^. (PubMed id 21691099)1 Ballatori N. (2011)
    9. Neurosteroid transport by the organic solute transpor ter OSTI+-OSTI^. (PubMed id 20649839)1 Fang F....Ballatori N. (2010)
    10. Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease. (PubMed id 18469300)1 Renner O....Stange E.F. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 123264 HGNC: 29956 AceView: OSTbeta Ensembl:ENSG00000186198 euGenes: HUgn123264
    ECgene: SLC51B Kegg: 123264 H-InvDB: SLC51B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC51B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC51B gene:
    Search GeneIP for patents involving SLC51B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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