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Aliases for SLC51B Gene

Aliases for SLC51B Gene

  • Solute Carrier Family 51 Beta Subunit 2 3 5
  • Organic Solute Transporter Beta Subunit 2 3
  • Solute Carrier Family 51 Subunit Beta 3 4
  • OST-Beta 3 4
  • OSTB 3 4
  • Organic Solute Transporter Subunit Beta 3
  • Solute Carrier Family 51, Beta Subunit 2
  • OSTBETA 3

External Ids for SLC51B Gene

Previous GeneCards Identifiers for SLC51B Gene

  • GC15P065338
  • GC15P065420
  • GC15P065762
  • GC15P065078
  • GC15P065434
  • GC15P065463

Summaries for SLC51B Gene

GeneCards Summary for SLC51B Gene

SLC51B (Solute Carrier Family 51 Beta Subunit) is a Protein Coding gene. Diseases associated with SLC51B include Cholestasis and Bile Duct Disease. Among its related pathways are Drug Induction of Bile Acid Pathway and Bile secretion. GO annotations related to this gene include protein heterodimerization activity and transporter activity.

UniProtKB/Swiss-Prot for SLC51B Gene

  • Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.

Gene Wiki entry for SLC51B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC51B Gene

Genomics for SLC51B Gene

Regulatory Elements for SLC51B Gene

Enhancers for SLC51B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SLC51B on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC51B Gene

Chromosome:
15
Start:
65,045,370 bp from pter
End:
65,053,396 bp from pter
Size:
8,027 bases
Orientation:
Plus strand

Genomic View for SLC51B Gene

Genes around SLC51B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC51B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC51B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC51B Gene

Proteins for SLC51B Gene

  • Protein details for SLC51B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UW2-OSTB_HUMAN
    Recommended name:
    Organic solute transporter subunit beta
    Protein Accession:
    Q86UW2
    Secondary Accessions:
    • Q3SYF5

    Protein attributes for SLC51B Gene

    Size:
    128 amino acids
    Molecular mass:
    14346 Da
    Quaternary structure:
    • Interacts with SLC51A. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit; induces the transport of SLC51A from the reticulum endoplasmic to the plasma membrane (By similarity).

neXtProt entry for SLC51B Gene

Post-translational modifications for SLC51B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC51B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC51B Gene

Domains & Families for SLC51B Gene

Gene Families for SLC51B Gene

Protein Domains for SLC51B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC51B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UW2

UniProtKB/Swiss-Prot:

OSTB_HUMAN :
  • The transmembrane domain (TM) is the major site of interaction with SLC51A. The extracellular-membrane interface is absolutely required for transport activity. The intracellular-membrane interface is necessary for establishing the correct membrane orientation that is essential for the heterodimer Ost-alpha/Ost-beta complex formation and transport activity at the cell membrane surface (By similarity).
  • Belongs to the OST-beta family.
Domain:
  • The transmembrane domain (TM) is the major site of interaction with SLC51A. The extracellular-membrane interface is absolutely required for transport activity. The intracellular-membrane interface is necessary for establishing the correct membrane orientation that is essential for the heterodimer Ost-alpha/Ost-beta complex formation and transport activity at the cell membrane surface (By similarity).
Family:
  • Belongs to the OST-beta family.
genes like me logo Genes that share domains with SLC51B: view

Function for SLC51B Gene

Molecular function for SLC51B Gene

UniProtKB/Swiss-Prot Function:
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.
UniProtKB/Swiss-Prot Induction:
Positively regulated via NR1H4/FXR.

Gene Ontology (GO) - Molecular Function for SLC51B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005515 protein binding IEA --
GO:0046982 protein heterodimerization activity IEA,ISS --
genes like me logo Genes that share ontologies with SLC51B: view
genes like me logo Genes that share phenotypes with SLC51B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC51B Gene

Localization for SLC51B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC51B Gene

Cell membrane; Single-pass membrane protein. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC51B Gene COMPARTMENTS Subcellular localization image for SLC51B gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC51B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IDA 12719432
GO:0016021 integral component of membrane IEA,ISS --
GO:0043234 protein complex IEA,ISS --
genes like me logo Genes that share ontologies with SLC51B: view

Pathways & Interactions for SLC51B Gene

genes like me logo Genes that share pathways with SLC51B: view

Pathways by source for SLC51B Gene

1 BioSystems pathway for SLC51B Gene
1 KEGG pathway for SLC51B Gene

Interacting Proteins for SLC51B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000335292%0d%0a9606.ENSP00000296327%0d%0a
Selected Interacting proteins: ENSP00000335292 Q86UW2-OSTB_HUMAN for SLC51B Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC51B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015721 bile acid and bile salt transport IEA,ISS --
GO:0031647 regulation of protein stability IEA,ISS --
GO:0060050 positive regulation of protein glycosylation IEA,ISS --
GO:0070863 positive regulation of protein exit from endoplasmic reticulum IEA,ISS --
genes like me logo Genes that share ontologies with SLC51B: view

No data available for SIGNOR curated interactions for SLC51B Gene

Drugs & Compounds for SLC51B Gene

(7) Drugs for SLC51B Gene - From: DrugBank, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Digoxin Approved Pharma Transporter, substrate 133
conjugated estrogens Approved Pharma Transporter, substrate 0
Dinoprostone Approved Pharma Transporter, substrate 83
Premarin Approved July of 2003 Pharma 0
Taurocholic acid Experimental Pharma Transporter, substrate 0

(2) Additional Compounds for SLC51B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC51B: view

Transcripts for SLC51B Gene

mRNA/cDNA for SLC51B Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC51B Gene

Solute carrier family 51, beta subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC51B Gene

No ASD Table

Relevant External Links for SLC51B Gene

GeneLoc Exon Structure for
SLC51B
ECgene alternative splicing isoforms for
SLC51B

Expression for SLC51B Gene

mRNA expression in normal human tissues for SLC51B Gene

mRNA differential expression in normal tissues according to GTEx for SLC51B Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x11.3) and Colon - Transverse (x10.6).

NURSA nuclear receptor signaling pathways regulating expression of SLC51B Gene:

SLC51B

SOURCE GeneReport for Unigene cluster for SLC51B Gene:

Hs.534533

mRNA Expression by UniProt/SwissProt for SLC51B Gene:

Q86UW2-OSTB_HUMAN
Tissue specificity: Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.
genes like me logo Genes that share expression patterns with SLC51B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SLC51B Gene

Orthologs for SLC51B Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLC51B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC51B 34
  • 76.04 (n)
  • 63.28 (a)
SLC51B 35
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC51B 34
  • 78.22 (n)
  • 65.35 (a)
SLC51B 35
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc51b 34
  • 76.46 (n)
  • 64.29 (a)
Slc51b 16
Slc51b 35
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC51B 34
  • 99.22 (n)
  • 99.22 (a)
SLC51B 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc51b 34
  • 73.54 (n)
  • 59.52 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC51B 35
  • 37 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC51B 35
  • 37 (a)
OneToOne
Species where no ortholog for SLC51B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC51B Gene

ENSEMBL:
Gene Tree for SLC51B (if available)
TreeFam:
Gene Tree for SLC51B (if available)

Paralogs for SLC51B Gene

No data available for Paralogs for SLC51B Gene

Variants for SLC51B Gene

Sequence variations from dbSNP and Humsavar for SLC51B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2946673 -- 65,043,707(+) tgttg(C/T)ccagg upstream-variant-2KB
rs111497351 -- 65,044,524(+) AGGTC(A/G)GGAGA upstream-variant-2KB
rs141807698 -- 65,044,112(+) CTGCT(A/G)TAATT upstream-variant-2KB
rs142086459 -- 65,043,418(+) AATGT(C/T)AATTA upstream-variant-2KB
rs189824389 -- 65,044,192(+) AGGGC(C/T)CTCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC51B Gene

Variant ID Type Subtype PubMed ID
esv2763104 CNV gain 21179565

Variation tolerance for SLC51B Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC51B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC51B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC51B Gene

Disorders for SLC51B Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC51B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cholestasis
  • bile occlusion
bile duct disease
  • bile duct disorder nos
biliary tract disease
  • biliary tract diseases
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC51B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC51B
genes like me logo Genes that share disorders with SLC51B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC51B Gene

Publications for SLC51B Gene

  1. Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. (PMID: 12719432) Seward D.J. … Ballatori N. (J. Biol. Chem. 2003) 2 3 4 22 65
  2. FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. (PMID: 16251721) Lee H. … Edwards P.A. (J. Lipid Res. 2006) 3 4 22 65
  3. The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. (PMID: 16269519) Landrier J.-F. … Kullak-Ublick G.A. (Am. J. Physiol. 2006) 3 4 22 65
  4. Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism. (PMID: 20538072) Dawson P.A. … Rao A. (Biochim. Biophys. Acta 2010) 2 3 65
  5. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. (PMID: 16423920) Boyer J.L. … Ballatori N. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006) 3 22 65

Products for SLC51B Gene

Sources for SLC51B Gene

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