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Aliases for SLC51A Gene

Aliases for SLC51A Gene

  • Solute Carrier Family 51 Alpha Subunit 2 3 5
  • Solute Carrier Family 51, Alpha Subunit 2 3
  • Solute Carrier Family 51 Subunit Alpha 3 4
  • OST-Alpha 3 4
  • OSTA 3 4
  • Organic Solute Transporter, Alpha Subunit 3
  • Organic Solute Transporter Alpha 3
  • Organic Solute Transporter 2
  • Alpha Subunit 2
  • OSTalpha 3

External Ids for SLC51A Gene

Previous GeneCards Identifiers for SLC51A Gene

  • GC03P195939

Summaries for SLC51A Gene

GeneCards Summary for SLC51A Gene

SLC51A (Solute Carrier Family 51 Alpha Subunit) is a Protein Coding gene. Diseases associated with SLC51A include bone resorption disease. Among its related pathways are Bile secretion and Drug Induction of Bile Acid Pathway. GO annotations related to this gene include protein homodimerization activity and transporter activity.

UniProtKB/Swiss-Prot for SLC51A Gene

  • Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.

Gene Wiki entry for SLC51A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC51A Gene

Genomics for SLC51A Gene

Genomic Location for SLC51A Gene

Chromosome:
3
Start:
196,211,487 bp from pter
End:
196,243,178 bp from pter
Size:
31,692 bases
Orientation:
Plus strand

Genomic View for SLC51A Gene

Genes around SLC51A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC51A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC51A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC51A Gene

No data available for Regulatory Elements for SLC51A Gene

Proteins for SLC51A Gene

  • Protein details for SLC51A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UW1-OSTA_HUMAN
    Recommended name:
    Organic solute transporter subunit alpha
    Protein Accession:
    Q86UW1
    Secondary Accessions:
    • Q6ZMC7

    Protein attributes for SLC51A Gene

    Size:
    340 amino acids
    Molecular mass:
    37735 Da
    Quaternary structure:
    • Interacts with SLC51B. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit (By similarity).

neXtProt entry for SLC51A Gene

Proteomics data for SLC51A Gene at MOPED

Post-translational modifications for SLC51A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC51A Gene

No data available for DME Specific Peptides for SLC51A Gene

Domains & Families for SLC51A Gene

Gene Families for SLC51A Gene

Protein Domains for SLC51A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC51A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UW1

UniProtKB/Swiss-Prot:

OSTA_HUMAN :
  • Belongs to the OST-alpha family.
Family:
  • Belongs to the OST-alpha family.
genes like me logo Genes that share domains with SLC51A: view

Function for SLC51A Gene

Molecular function for SLC51A Gene

UniProtKB/Swiss-Prot Function:
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.
UniProtKB/Swiss-Prot Induction:
Positively regulated via NR1H4/FXR in adrenal gland, kidney and intestine.

Gene Ontology (GO) - Molecular Function for SLC51A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IDA 16317684
genes like me logo Genes that share ontologies with SLC51A: view
genes like me logo Genes that share phenotypes with SLC51A: view

Animal Models for SLC51A Gene

MGI Knock Outs for SLC51A:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC51A

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC51A Gene

Localization for SLC51A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC51A Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B (By similarity). Mainly restricted to the lateral and basal membranes of ileal enterocytes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC51A Gene COMPARTMENTS Subcellular localization image for SLC51A gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC51A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,ISS --
genes like me logo Genes that share ontologies with SLC51A: view

Pathways & Interactions for SLC51A Gene

genes like me logo Genes that share pathways with SLC51A: view

Pathways by source for SLC51A Gene

1 BioSystems pathway for SLC51A Gene
1 KEGG pathway for SLC51A Gene

Interacting Proteins for SLC51A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296327%0d%0a9606.ENSP00000335292%0d%0a9606.ENSP00000244769%0d%0a
Selected Interacting proteins: ENSP00000296327 Q86UW1-OSTA_HUMAN for SLC51A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC51A Gene

None

No data available for SIGNOR curated interactions for SLC51A Gene

Drugs & Compounds for SLC51A Gene

(6) Drugs for SLC51A Gene - From: Novoseek, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Digoxin Approved Pharma Transporter, substrate 128
Conjugated Estrogens Approved Pharma Transporter, substrate 0
Dinoprostone Approved Pharma Transporter, substrate Major endogenous prostanoid 74
Premarin Approved July of 2003 Pharma 0
Taurocholic acid Experimental Pharma Transporter, substrate 0

(3) Additional Compounds for SLC51A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC51A: view

Transcripts for SLC51A Gene

Unigene Clusters for SLC51A Gene

Solute carrier family 51, alpha subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC51A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - - - - - -
SP2:
SP3: - -
SP4: -
SP5: - - - - - -
SP6: -
SP7:

Relevant External Links for SLC51A Gene

GeneLoc Exon Structure for
SLC51A
ECgene alternative splicing isoforms for
SLC51A

Expression for SLC51A Gene

mRNA expression in normal human tissues for SLC51A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC51A Gene

This gene is overexpressed in Liver (x17.6), Whole Blood (x5.7), Small Intestine - Terminal Ileum (x5.5), and Colon - Transverse (x4.4).

Protein differential expression in normal tissues from HIPED for SLC51A Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC51A Gene



SOURCE GeneReport for Unigene cluster for SLC51A Gene Hs.630585

mRNA Expression by UniProt/SwissProt for SLC51A Gene

Q86UW1-OSTA_HUMAN
Tissue specificity: Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.
genes like me logo Genes that share expression patterns with SLC51A: view

Protein tissue co-expression partners for SLC51A Gene

Primer Products

In Situ Assay Products

Orthologs for SLC51A Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC51A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC51A 35
  • 85.79 (n)
  • 82.45 (a)
SLC51A 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC51A 35
  • 86.96 (n)
  • 85.59 (a)
SLC51A 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc51a 35
  • 84.51 (n)
  • 82.65 (a)
Slc51a 16
Slc51a 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC51A 35
  • 99.31 (n)
  • 99.12 (a)
SLC51A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc51a 35
  • 84.31 (n)
  • 82.06 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC51A 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC51A 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC424916 35
  • 67.08 (n)
  • 62.19 (a)
SLC51A 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC51A 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc51a 35
  • 61.3 (n)
  • 52.68 (a)
zebrafish
(Danio rerio)
Actinopterygii slc51a 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 13 (a)
OneToMany
-- 36
  • 20 (a)
OneToMany
Species with no ortholog for SLC51A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC51A Gene

ENSEMBL:
Gene Tree for SLC51A (if available)
TreeFam:
Gene Tree for SLC51A (if available)

Paralogs for SLC51A Gene

(1) SIMAP similar genes for SLC51A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC51A: view

No data available for Paralogs for SLC51A Gene

Variants for SLC51A Gene

Sequence variations from dbSNP and Humsavar for SLC51A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs939885 - 196,228,891(+) TTCTC(A/G)TCCCC reference, missense
rs9343 -- 196,233,354(+) GTTAG(A/G)ATAAA utr-variant-3-prime
rs939884 -- 196,228,877(+) CCTGG(G/T)GGGCC reference, missense
rs1045399 -- 196,228,115(+) CCCAG(G/T)TTTTA reference, synonymous-codon
rs1052845 -- 196,232,073(-) TCTAG(A/C)TCAAG intron-variant

Variation tolerance for SLC51A Gene

Residual Variation Intolerance Score: 53.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.23; 92.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC51A Gene

HapMap Linkage Disequilibrium report
SLC51A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC51A Gene

Disorders for SLC51A Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC51A Gene - From: DISEASES

Disorder Aliases PubMed IDs
bone resorption disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC51A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC51A
genes like me logo Genes that share disorders with SLC51A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC51A Gene

Publications for SLC51A Gene

  1. Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. (PMID: 12719432) Seward D.J. … Ballatori N. (J. Biol. Chem. 2003) 2 3 4 23 25 67
  2. Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism. (PMID: 20538072) Dawson P.A. … Rao A. (Biochim. Biophys. Acta 2010) 2 3
  3. FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. (PMID: 16251721) Lee H. … Edwards P.A. (J. Lipid Res. 2006) 3 23
  4. The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. (PMID: 16269519) Landrier J.-F. … Kullak-Ublick G.A. (Am. J. Physiol. 2006) 3 23
  5. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. (PMID: 16423920) Boyer J.L. … Ballatori N. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006) 3 23

Products for SLC51A Gene

Sources for SLC51A Gene

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