Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC50A1 Gene

Aliases for SLC50A1 Gene

  • Solute Carrier Family 50 (Sugar Efflux Transporter), Member 1 2 3
  • Stromal Cell Protein 2 3 4
  • RAG1AP1 3 4 6
  • Recombination Activating Gene 1 Activating Protein 1 2 3
  • Solute Carrier Family 50 Member 1 3 4
  • RAG1-Activating Protein 1 3 4
  • HsSWEET1 3 4
  • SCP 3 4
  • Solute Carrier Family 50 (Sugar Transporter), Member 1 3
  • Probable Sugar Transporter RAG1AP1 3
  • Sugar Transporter SWEET1 3
  • RP11-540D14.5 3
  • RZPDo834D038D 3
  • SWEET1 3
  • Slv 3

External Ids for SLC50A1 Gene

Previous HGNC Symbols for SLC50A1 Gene

  • RAG1AP1

Previous GeneCards Identifiers for SLC50A1 Gene

  • GC01P155110

Summaries for SLC50A1 Gene

GeneCards Summary for SLC50A1 Gene

SLC50A1 (Solute Carrier Family 50 (Sugar Efflux Transporter), Member 1) is a Protein Coding gene. GO annotations related to this gene include glucoside transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC50A1 Gene

  • Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC50A1 Gene

Genomics for SLC50A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC50A1 Gene

Start:
155,135,344 bp from pter
End:
155,138,858 bp from pter
Size:
3,515 bases
Orientation:
Plus strand

Genomic View for SLC50A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC50A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC50A1 Gene

No data available for Regulatory Elements for SLC50A1 Gene

Proteins for SLC50A1 Gene

  • Protein details for SLC50A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRV3-SWET1_HUMAN
    Recommended name:
    Sugar transporter SWEET1
    Protein Accession:
    Q9BRV3
    Secondary Accessions:
    • Q5SR64
    • Q6IAK6
    • Q96DC5
    • Q9UHQ2
    • Q9UHQ3

    Protein attributes for SLC50A1 Gene

    Size:
    221 amino acids
    Molecular mass:
    25030 Da
    Quaternary structure:
    • Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation.

    Alternative splice isoforms for SLC50A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC50A1 Gene

Proteomics data for SLC50A1 Gene at MOPED

Post-translational modifications for SLC50A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC50A1 Gene

Domains for SLC50A1 Gene

Gene Families for SLC50A1 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC50A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC50A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRV3

UniProtKB/Swiss-Prot:

SWET1_HUMAN :
  • Q9BRV3
Domain:
  • Contains 2 MtN3/slv domains.
Family:
  • Belongs to the SWEET sugar transporter family.
genes like me logo Genes that share domains with SLC50A1: view

Function for SLC50A1 Gene

Molecular function for SLC50A1 Gene

UniProtKB/Swiss-Prot Function: Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1.

Gene Ontology (GO) - Molecular Function for SLC50A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042947 glucoside transmembrane transporter activity IDA 21107422
genes like me logo Genes that share ontologies with SLC50A1: view

Phenotypes for SLC50A1 Gene

genes like me logo Genes that share phenotypes with SLC50A1: view

Animal Model Products

CRISPR Products

miRNA for SLC50A1 Gene

miRTarBase miRNAs that target SLC50A1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC50A1 Gene

Localization for SLC50A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC50A1 Gene

Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=May also localize to the endoplasmic reticulum. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for SLC50A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IC 8630032
GO:0005794 Golgi apparatus IDA 21107422
GO:0005886 plasma membrane IDA 21107422
GO:0012505 endomembrane system ISS --
genes like me logo Genes that share ontologies with SLC50A1: view

No data available for Subcellular locations from COMPARTMENTS for SLC50A1 Gene

Pathways for SLC50A1 Gene

SuperPathways for SLC50A1 Gene

No Data Available

Interacting Proteins for SLC50A1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357389%0d%0a9606.ENSP00000342222%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000357389 Q9BRV3-SWET1_HUMAN for SLC50A1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC50A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006310 DNA recombination IEA --
GO:0008643 carbohydrate transport IEA --
GO:0042946 glucoside transport IDA 21107422
GO:0045815 positive regulation of gene expression, epigenetic ISS 8630032
genes like me logo Genes that share ontologies with SLC50A1: view

No data available for Pathways by source for SLC50A1 Gene

Transcripts for SLC50A1 Gene

Unigene Clusters for SLC50A1 Gene

Solute carrier family 50 (sugar transporter), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC50A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC50A1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - -
SP6:
SP7:

Relevant External Links for SLC50A1 Gene

GeneLoc Exon Structure for
SLC50A1
ECgene alternative splicing isoforms for
SLC50A1

Expression for SLC50A1 Gene

mRNA expression in normal human tissues for SLC50A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC50A1 Gene

SOURCE GeneReport for Unigene cluster for SLC50A1 Gene Hs.292154

mRNA Expression by UniProt/SwissProt for SLC50A1 Gene

Q9BRV3-SWET1_HUMAN
Tissue specificity: Ubiquitously expressed with highest expression in oviduct, epididymis and intestine.
genes like me logo Genes that share expressions with SLC50A1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC50A1 Gene

Orthologs for SLC50A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC50A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC50A1 35
  • 100 (n)
  • 100 (a)
SLC50A1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC50A1 35
  • 87.33 (n)
  • 83.26 (a)
SLC50A1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAG1AP1 36
  • 81 (a)
OneToOne
SLC50A1 35
  • 85.82 (n)
  • 81 (a)
mouse
(Mus musculus)
Mammalia Slc50a1 35
  • 82.96 (n)
  • 79.64 (a)
Slc50a1 16
Slc50a1 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC50A1 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc50a1 35
  • 84.01 (n)
  • 79.64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5895 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc50a1 35
  • 66.67 (n)
  • 65.02 (a)
zebrafish
(Danio rerio)
Actinopterygii slc50a1 35
  • 59.82 (n)
  • 61.08 (a)
slc50a1 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005236 35
  • 43.7 (n)
  • 29.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta slv 35
  • 42.41 (n)
  • 28.71 (a)
slv 36
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea swt-1 35
  • 42.86 (n)
  • 31.12 (a)
swt-1 36
  • 20 (a)
OneToMany
swt-2 36
  • 21 (a)
OneToMany
swt-3 36
  • 17 (a)
OneToMany
swt-4 36
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G50790 35
  • 42.34 (n)
  • 28.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10502 36
  • 33 (a)
OneToOne
Species with no ortholog for SLC50A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC50A1 Gene

ENSEMBL:
Gene Tree for SLC50A1 (if available)
TreeFam:
Gene Tree for SLC50A1 (if available)

Paralogs for SLC50A1 Gene

No data available for Paralogs for SLC50A1 Gene

Variants for SLC50A1 Gene

Sequence variations from dbSNP and Humsavar for SLC50A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1132234 -- 155,138,677(+) aaatt(A/G)gccag utr-variant-3-prime
rs11264333 -- 155,135,811(+) CGAGT(A/G)CGCGG upstream-variant-2KB, intron-variant
rs12726330 -- 155,135,691(+) GACCA(A/G)GGTAC upstream-variant-2KB, intron-variant
rs34257430 -- 155,137,411(+) AAGTT(-/T)GGTGG intron-variant
rs34716297 -- 155,137,648(+) CTGAG(-/G)CCCGG frameshift-variant, reference, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC50A1 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv464084 CNV Loss 19166990
dgv3n68 CNV Loss 17160897
dgv132e1 CNV Complex 17122850

Relevant External Links for SLC50A1 Gene

HapMap Linkage Disequilibrium report
SLC50A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC50A1 Gene

Disorders for SLC50A1 Gene

No disorders were found for SLC50A1 Gene.

No data available for UniProtKB/Swiss-Prot for SLC50A1 Gene

Publications for SLC50A1 Gene

  1. Sugar transporters for intercellular exchange and nutrition of pathogens. (PMID: 21107422) Chen L.-Q. … Frommer W.B. (Nature 2010) 2 3 4
  2. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N. … Foroud T. (Ann. Neurol. 2012) 3
  3. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for SLC50A1 Gene

Sources for SLC50A1 Gene

Back to Top

Content