SLC50A1 Gene
protein-coding GIFtS : 45
GCID: GC01 P155110
solute carrier family 50 (sugar transporter), member 1 (Previous name: recombination activating gene 1 activating protein 1 ) (Previous symbol: RAG1AP1 )
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Aliasesfor SLC50A1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Solute Carrier Family 50 (Sugar Transporter), Member 1 1 2 Slv1 RAG1AP11 2 3 5 Solute Carrier Family 50 Member 12 3 HsSWEET11 2 3 Stromal Cell Protein2 3 SCP1 2 3 RAG1-Activating Protein 12 3 RZPDo834D038D1 2 RP11-540D14.51 SWEET11 2 Probable Sugar Transporter RAG1AP12 Recombination Activating Gene 1 Activating Protein 11 2 Sugar Transporter SWEET12
Export aliases for SLC50A1 gene to outside databases
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Summariesfor SLC50A1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: SWET1_HUMAN, Q9BRV3 Function : Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1
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Genomic Viewsfor SLC50A1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004487.19 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for SLC50A1 Other transcription factors Search SABiosciences Chromatin IP Primers for SLC50A1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SLC50A1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q22 SLC50A1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P155110: view genomic region
(about GC identifiers )
Start:
155,107,820 bp from pter
End:
155,111,334 bp from pter
Size:
3,515 bases
Orientation:
plus strand
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Proteinsfor SLC50A1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SWET1_HUMAN, Q9BRV3 (See
protein sequence )Recommended Name: Sugar transporter SWEET1 Size : 221 amino acids; 25030 Da
Subunit : Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation (Bysimilarity)
Subcellular location : Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membraneprotein. Note=May also localize to the endoplasmic reticulum (By similarity)
Secondary accessions : Q5SR64 Q6IAK6 Q96DC5 Q9UHQ2 Q9UHQ3Alternative splicing : 3 isoforms : Q9BRV3-1 Q9BRV3-2 Q9BRV3-3 (Ref.1 (AAF17233) sequence differs from that shown due to frameshifts in positions 29 and 30)Explore the universe of human proteins at neXtProt for SLC50A1: NX_Q9BRV3 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9BRV3 SLC50A1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001116309.1 NP_001116311.1 NP_061333.2 ENSEMBL proteins: ENSP00000420189 ENSP00000306146 ENSP00000357389 ENSP00000357386 Human Recombinant Protein Products: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
SLC50A1 for ontologies About GeneDecksing SLC50A1 Antibody Products: Assay Products for SLC50A1:
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Protein
Domains / Familiesfor SLC50A1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SLC50A1 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9BRV3 ProtoNet protein and cluster: Q9BRV3
UniProtKB/Swiss-Prot: SWET1_HUMAN, Q9BRV3 Similarity : Belongs to the SWEET sugar transporter familySimilarity : Contains 2 MtN3/slv domains
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Functionfor SLC50A1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SWET1_HUMAN, Q9BRV3 Function : Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC50A1 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC50A1 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): SLC50A1 (NM_018845 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC50A1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC50A1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC50A1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0042947 glucoside transmembrane transporter activity
IDA --
SLC50A1 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for SLC50A1 :
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Pathways & Interactionsfor SLC50A1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC50A1 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)3 Interacting proteins for SLC50A1 (Q9BRV3 3 ENSP00000357389 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 4 biological process terms (GO ID links to tree view) : About this table
SLC50A1 for ontologies About GeneDecksing
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Drugs & Compoundsfor SLC50A1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SLC50A1 Search CenterWatch for drugs/clinical trials and news about SLC50A1 / SWET1
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Transcriptsfor SLC50A1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SLC50A1 gene (3 alternative transcripts): NM_001122837.1 NM_001122839.1 NM_018845.3 Unigene Cluster for SLC50A1:
Solute carrier family 50 (sugar transporter), member 1 Hs.292154 [show with all ESTs ] Unigene Representative Sequence: NM_018845 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000484157 ENST00000490770 ENST00000475824 ENST00000465546 ENST00000490276 ENST00000303343 ENST00000368404 (uc001fhj.4 uc001fhk.4 uc001fhl.4 )ENST00000368401 ENST00000368405 ENST00000488609 ENST00000484027 ENST00000479579 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC50A1 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC50A1 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): SLC50A1 (NM_018845 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC50A1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC50A1
Additional cDNA sequence: AF126023.1 AF126024.1 AK289551.1 BC005943.1 BC009621.1 BC010869.1 BC012378.1 CR457148.1
13 DOTS entries : DT.40133174 DT.102825193
DT.102825194 DT.100788686 DT.100028785 DT.100788697 DT.103111 DT.121454568 DT.95278881 DT.100650128 DT.91708989 DT.92431454 DT.95278875 24/133 AceView cDNA sequences (see all 133 ):
BC010869 BM509105 BU160680 CK431206 BM468975 BI710945 BG747111 CA435891 BC009621 BM509335 X84712 BM756497 BM565496 BU782567 AW674083 AA236039 CB126002 BC069245 BU789675 BM806886 BM820275 BQ686109 BU069059 BU164123 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SLC50A1 (see all 7 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e SP1 :             -           -           SP2 :   -   -   -     -   -     -                 SP3 :           -   -   -         -           SP4 :           -   -                     SP5 :           -   -   -   -   -     -          
ECgene alternative splicing isoforms for SLC50A1
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Expression for SLC50A1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SLC50A1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TACCTCTCAC
About this image See SLC50A1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SLC50A1 SOURCE GeneReport for Unigene cluster: Hs.292154 UniProtKB/Swiss-Prot: SWET1_HUMAN, Q9BRV3 Tissue specificity : Ubiquitously expressed with highest expression in oviduct, epididymis and intestine SABiosciences Custom PCR Arrays for SLC50A1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SLC50A1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SLC50A1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SLC50A1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SLC50A1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC50A1
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Orthologsfor SLC50A1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC50A1 gene from 7/21 species (see all 21 ) About this table
ENSEMBL Gene Tree for SLC50A1 (if available)TreeFam Gene Tree for SLC50A1 (if available)
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Paralogsfor SLC50A1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor SLC50A1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SLC50A1 (155107820 - 155111334 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SLC50A1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SLC50A1
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Disorders
/ Diseasesfor SLC50A1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SLC50A1 for disorders About GeneDecksing
OMIM gene information: 613683
OMIM disorders : --1 disease for SLC50A1 : About MalaCards prostatitis Export disorders for SLC50A1 gene to outside databases
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Publicationsfor SLC50A1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SLC50A1 gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with SLC50A1) Utopia : connect your pdf to the dynamic world of online information
Sugar transporters for intercellular exchange and nut rition of pathogens. (PubMed id 21107422) 1 , 2 , 3 Chen L.Q....Frommer W.B. (2010) Meta-analysis of Parkinson's disease: identification o f a novel locus, RIT2. (PubMed id 22451204) 1 Pankratz N....Foroud T. (2012) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) RGA protein associates with a TRPV ion channel during biosynthesis and trafficking. (PubMed id 14991772) 1 Barnhill J.C....Turner H. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946) 2 Hu R.-M.... Chen J.-L. (2000)
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External Searches for SLC50A1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SLC50A1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SLC50A1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SLC50A1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SLC50A1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SLC50A1 gene: Search GeneIP for patents involving SLC50A1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SLC50A1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SLC50A1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SLC50A1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SLC50A1 OriGene Protein Over-expression Lysate for SLC50A1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SLC50A1 OriGene 3'-UTR Clone for SLC50A1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC50A1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC50A1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SLC50A1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SLC50A1 OriGene Custom Protein Services for SLC50A1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC50A1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SLC50A1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SLC50A1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SLC50A1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SLC50A1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SLC50A1
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SLC50A1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC50A1
Search ThermoFisher Antibodies for SLC50A1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC50A1
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Aliases for SLC50A1
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Disorders / Diseases for SLC50A1
Domains / Families for SLC50A1
Drugs / Compounds for SLC50A1
Expression for SLC50A1
Function for SLC50A1
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Orthologs for SLC50A1
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