Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC50A1 Gene

Aliases for SLC50A1 Gene

  • Solute Carrier Family 50 Member 1 2 3 4
  • Solute Carrier Family 50 (Sugar Efflux Transporter), Member 1 2 3 5
  • Stromal Cell Protein 2 3 4
  • Recombination Activating Gene 1 Activating Protein 1 2 3
  • RAG1-Activating Protein 1 3 4
  • HsSWEET1 3 4
  • RAG1AP1 3 4
  • SCP 3 4
  • Solute Carrier Family 50 (Sugar Transporter), Member 1 3
  • Probable Sugar Transporter RAG1AP1 3
  • RP11-540D14.5 3
  • RZPDo834D038D 3
  • SWEET1 3
  • Slv 3

External Ids for SLC50A1 Gene

Previous HGNC Symbols for SLC50A1 Gene

  • RAG1AP1

Previous GeneCards Identifiers for SLC50A1 Gene

  • GC01P155110

Summaries for SLC50A1 Gene

GeneCards Summary for SLC50A1 Gene

SLC50A1 (Solute Carrier Family 50 Member 1) is a Protein Coding gene. Diseases associated with SLC50A1 include Cerebral Palsy, Spastic Quadriplegic, 1. GO annotations related to this gene include glucoside transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC50A1 Gene

  • Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC50A1 Gene

Genomics for SLC50A1 Gene

Regulatory Elements for SLC50A1 Gene

Enhancers for SLC50A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC50A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLC50A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC50A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC50A1 Gene

155,135,344 bp from pter
155,138,858 bp from pter
3,515 bases
Plus strand

Genomic View for SLC50A1 Gene

Genes around SLC50A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC50A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC50A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC50A1 Gene

Proteins for SLC50A1 Gene

  • Protein details for SLC50A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sugar transporter SWEET1
    Protein Accession:
    Secondary Accessions:
    • Q5SR64
    • Q6IAK6
    • Q96DC5
    • Q9UHQ2
    • Q9UHQ3

    Protein attributes for SLC50A1 Gene

    221 amino acids
    Molecular mass:
    25030 Da
    Quaternary structure:
    • Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation.

    Alternative splice isoforms for SLC50A1 Gene


neXtProt entry for SLC50A1 Gene

Proteomics data for SLC50A1 Gene at MOPED

Post-translational modifications for SLC50A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC50A1 Gene

Domains & Families for SLC50A1 Gene

Gene Families for SLC50A1 Gene

Protein Domains for SLC50A1 Gene


Suggested Antigen Peptide Sequences for SLC50A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 MtN3/slv domains.
  • Belongs to the SWEET sugar transporter family.
  • Contains 2 MtN3/slv domains.
  • Belongs to the SWEET sugar transporter family.
genes like me logo Genes that share domains with SLC50A1: view

Function for SLC50A1 Gene

Molecular function for SLC50A1 Gene

UniProtKB/Swiss-Prot Function:
Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1.

Gene Ontology (GO) - Molecular Function for SLC50A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042947 glucoside transmembrane transporter activity IDA 21107422
GO:0051119 sugar transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC50A1: view
genes like me logo Genes that share phenotypes with SLC50A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC50A1

CRISPR Products

miRNA for SLC50A1 Gene

miRTarBase miRNAs that target SLC50A1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC50A1 Gene

Localization for SLC50A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC50A1 Gene

Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=May also localize to the endoplasmic reticulum. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SLC50A1 Gene COMPARTMENTS Subcellular localization image for SLC50A1 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
nucleus 3

Gene Ontology (GO) - Cellular Components for SLC50A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IC 8630032
GO:0005886 plasma membrane IDA 21107422
GO:0012505 endomembrane system ISS --
genes like me logo Genes that share ontologies with SLC50A1: view

Pathways & Interactions for SLC50A1 Gene

SuperPathways for SLC50A1 Gene

No Data Available

Interacting Proteins for SLC50A1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9BRV3-SWET1_HUMAN ENSP00000357389 for SLC50A1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SLC50A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA,IBA --
genes like me logo Genes that share ontologies with SLC50A1: view

No data available for Pathways by source and SIGNOR curated interactions for SLC50A1 Gene

Drugs & Compounds for SLC50A1 Gene

No Compound Related Data Available

Transcripts for SLC50A1 Gene

Unigene Clusters for SLC50A1 Gene

Solute carrier family 50 (sugar transporter), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC50A1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - -

Relevant External Links for SLC50A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC50A1 Gene

mRNA expression in normal human tissues for SLC50A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC50A1 Gene

This gene is overexpressed in Adrenal (32.8) and Platelet (31.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC50A1 Gene

SOURCE GeneReport for Unigene cluster for SLC50A1 Gene Hs.292154

mRNA Expression by UniProt/SwissProt for SLC50A1 Gene

Tissue specificity: Ubiquitously expressed with highest expression in oviduct, epididymis and intestine.
genes like me logo Genes that share expression patterns with SLC50A1: view

Protein tissue co-expression partners for SLC50A1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for SLC50A1 Gene

Orthologs for SLC50A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC50A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC50A1 35
  • 87.33 (n)
  • 83.26 (a)
SLC50A1 36
  • 78 (a)
(Canis familiaris)
Mammalia SLC50A1 35
  • 85.82 (n)
  • 81 (a)
RAG1AP1 36
  • 81 (a)
(Mus musculus)
Mammalia Slc50a1 35
  • 82.96 (n)
  • 79.64 (a)
Slc50a1 16
Slc50a1 36
  • 80 (a)
(Pan troglodytes)
Mammalia SLC50A1 35
  • 100 (n)
  • 100 (a)
SLC50A1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Slc50a1 35
  • 84.01 (n)
  • 79.64 (a)
(Monodelphis domestica)
Mammalia SLC50A1 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc50a1 35
  • 66.67 (n)
  • 65.02 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5895 35
(Danio rerio)
Actinopterygii slc50a1 35
  • 59.82 (n)
  • 61.08 (a)
slc50a1 36
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005236 35
  • 43.7 (n)
  • 29.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta slv 35
  • 42.41 (n)
  • 28.71 (a)
slv 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea swt-1 35
  • 42.86 (n)
  • 31.12 (a)
swt-1 36
  • 20 (a)
swt-2 36
  • 21 (a)
swt-3 36
  • 17 (a)
swt-4 36
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G50790 35
  • 42.34 (n)
  • 28.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10502 36
  • 33 (a)
Species with no ortholog for SLC50A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC50A1 Gene

Gene Tree for SLC50A1 (if available)
Gene Tree for SLC50A1 (if available)

Paralogs for SLC50A1 Gene

No data available for Paralogs for SLC50A1 Gene

Variants for SLC50A1 Gene

Sequence variations from dbSNP and Humsavar for SLC50A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1132234 -- 155,138,677(+) aaatt(A/G)gccag utr-variant-3-prime
rs11264333 -- 155,135,811(+) CGAGT(A/G)CGCGG intron-variant, upstream-variant-2KB
rs12726330 -- 155,135,691(+) GACCA(A/G)GGTAC intron-variant, upstream-variant-2KB
rs34716297 -- 155,137,648(+) CTGAG(-/G)CCCGG intron-variant, reference, frameshift-variant
rs34257430 -- 155,137,411(+) AAGTT(-/T)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC50A1 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv464084 CNV Loss 19166990
dgv3n68 CNV Loss 17160897
dgv132e1 CNV Complex 17122850

Variation tolerance for SLC50A1 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC50A1 Gene

Disorders for SLC50A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC50A1 Gene - From: OMIM

Disorder Aliases PubMed IDs
cerebral palsy, spastic quadriplegic, 1
  • cerebral palsy, spastic quadriplegic 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC50A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC50A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC50A1 Gene

Publications for SLC50A1 Gene

  1. Sugar transporters for intercellular exchange and nutrition of pathogens. (PMID: 21107422) Chen L.-Q. … Frommer W.B. (Nature 2010) 2 3 4 67
  2. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3
  3. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N. … Foroud T. (Ann. Neurol. 2012) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for SLC50A1 Gene

Sources for SLC50A1 Gene