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Aliases for SLC4A9 Gene

Aliases for SLC4A9 Gene

  • Solute Carrier Family 4 Member 9 2 3 4
  • Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 9 2 3 5
  • Sodium Bicarbonate Cotransporter 5 3 4
  • Anion Exchanger 4 3 4
  • AE4 3 4
  • AE 4 4
  • SBC5 4

External Ids for SLC4A9 Gene

Previous GeneCards Identifiers for SLC4A9 Gene

  • GC05P139556
  • GC05P140322
  • GC05P139722
  • GC05P139768
  • GC05P139719
  • GC05P134884
  • GC05P140464
  • GC05P140469

Summaries for SLC4A9 Gene

Entrez Gene Summary for SLC4A9 Gene

  • The protein encoded by this gene is a membrane protein involved in anion exchange. Expression of this gene is mostly limited to the kidney. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for SLC4A9 Gene

SLC4A9 (Solute Carrier Family 4 Member 9) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and anion transmembrane transporter activity. An important paralog of this gene is SLC4A8.

UniProtKB/Swiss-Prot for SLC4A9 Gene

  • Probable apical anion exchanger of the kidney cortex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A9 Gene

Genomics for SLC4A9 Gene

Regulatory Elements for SLC4A9 Gene

Enhancers for SLC4A9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC4A9 on UCSC Golden Path with GeneCards custom track

Promoters for SLC4A9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC4A9 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC4A9 Gene

140,358,559 bp from pter
140,375,143 bp from pter
16,585 bases
Plus strand

Genomic View for SLC4A9 Gene

Genes around SLC4A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC4A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC4A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A9 Gene

Proteins for SLC4A9 Gene

  • Protein details for SLC4A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Anion exchange protein 4
    Protein Accession:
    Secondary Accessions:
    • B7ZL63
    • D3DQD4
    • D3DQD5
    • D3DQD6
    • E9PDK1
    • Q96RM5
    • Q9BXF2
    • Q9BXN3

    Protein attributes for SLC4A9 Gene

    983 amino acids
    Molecular mass:
    108248 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK28832.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC4A9 Gene


neXtProt entry for SLC4A9 Gene

Proteomics data for SLC4A9 Gene at MOPED

Post-translational modifications for SLC4A9 Gene

  • Glycosylation at Asn 576 and Asn 600
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC4A9 Gene

No data available for DME Specific Peptides for SLC4A9 Gene

Domains & Families for SLC4A9 Gene

Gene Families for SLC4A9 Gene

Suggested Antigen Peptide Sequences for SLC4A9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the anion exchanger (TC 2.A.31) family.
  • Belongs to the anion exchanger (TC 2.A.31) family.
genes like me logo Genes that share domains with SLC4A9: view

Function for SLC4A9 Gene

Molecular function for SLC4A9 Gene

UniProtKB/Swiss-Prot Function:
Probable apical anion exchanger of the kidney cortex.

Gene Ontology (GO) - Molecular Function for SLC4A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008510 sodium:bicarbonate symporter activity TAS --
genes like me logo Genes that share ontologies with SLC4A9: view
genes like me logo Genes that share phenotypes with SLC4A9: view

Animal Models for SLC4A9 Gene

MGI Knock Outs for SLC4A9:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC4A9

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC4A9 Gene

Localization for SLC4A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC4A9 Gene COMPARTMENTS Subcellular localization image for SLC4A9 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC4A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC4A9: view

Pathways & Interactions for SLC4A9 Gene

genes like me logo Genes that share pathways with SLC4A9: view

Interacting Proteins for SLC4A9 Gene

Gene Ontology (GO) - Biological Process for SLC4A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015701 bicarbonate transport TAS --
GO:0035725 sodium ion transmembrane transport TAS --
GO:0051453 regulation of intracellular pH IBA --
GO:0055085 transmembrane transport TAS --
GO:0098656 anion transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC4A9: view

No data available for SIGNOR curated interactions for SLC4A9 Gene

Drugs & Compounds for SLC4A9 Gene

(1) Drugs for SLC4A9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SLC4A9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC4A9: view

Transcripts for SLC4A9 Gene

Unigene Clusters for SLC4A9 Gene

Solute carrier family 4, sodium bicarbonate cotransporter, member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A9 Gene

No ASD Table

Relevant External Links for SLC4A9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC4A9 Gene

mRNA expression in normal human tissues for SLC4A9 Gene

mRNA differential expression in normal tissues according to GTEx for SLC4A9 Gene

This gene is overexpressed in Kidney - Cortex (x41.5).

Protein differential expression in normal tissues from HIPED for SLC4A9 Gene

This gene is overexpressed in Heart (36.6) and Synovial fluid (32.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC4A9 Gene

SOURCE GeneReport for Unigene cluster for SLC4A9 Gene Hs.550313

mRNA Expression by UniProt/SwissProt for SLC4A9 Gene

Tissue specificity: Kidney specific.
genes like me logo Genes that share expression patterns with SLC4A9: view

Protein tissue co-expression partners for SLC4A9 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC4A9 Gene

Orthologs for SLC4A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC4A9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC4A9 35
  • 87.64 (n)
  • 86.6 (a)
SLC4A9 36
  • 86 (a)
(Canis familiaris)
Mammalia SLC4A9 35
  • 87.25 (n)
  • 86.69 (a)
SLC4A9 36
  • 86 (a)
(Mus musculus)
Mammalia Slc4a9 35
  • 83.82 (n)
  • 83.26 (a)
Slc4a9 16
Slc4a9 36
  • 79 (a)
(Pan troglodytes)
Mammalia SLC4A9 35
  • 99.53 (n)
  • 99.39 (a)
SLC4A9 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc4a9 35
  • 84.78 (n)
  • 83.32 (a)
(Monodelphis domestica)
Mammalia SLC4A9 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia SLC4A9 36
  • 69 (a)
(Gallus gallus)
Aves SLC4A9 36
  • 52 (a)
(Anolis carolinensis)
Reptilia SLC4A9 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ndae1 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea abts-1 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for SLC4A9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC4A9 Gene

Gene Tree for SLC4A9 (if available)
Gene Tree for SLC4A9 (if available)

Paralogs for SLC4A9 Gene

Paralogs for SLC4A9 Gene

(9) SIMAP similar genes for SLC4A9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC4A9: view

Variants for SLC4A9 Gene

Sequence variations from dbSNP and Humsavar for SLC4A9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs717097 -- 140,361,785(+) TTAAT(A/C)ACTGC intron-variant
rs6860077 -- 140,365,569(+) GACAT(C/T)GTAAG downstream-variant-500B, reference, synonymous-codon
rs6865864 -- 140,362,200(+) GGAGT(C/T)AGGGA intron-variant
rs6878367 -- 140,367,168(+) CTTCT(C/G)TTCCA intron-variant
rs7718250 -- 140,361,955(+) ATCAT(C/T)TGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC4A9 Gene

Variant ID Type Subtype PubMed ID
nsv509090 CNV Insertion 20534489
esv2659425 CNV Deletion 23128226

Variation tolerance for SLC4A9 Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.70; 57.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC4A9 Gene

Disorders for SLC4A9 Gene

Relevant External Links for SLC4A9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC4A9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC4A9 Gene

Publications for SLC4A9 Gene

  1. A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9 at 5q31. (PMID: 11305939) Lipovich L. … King M.-C. (Genome Biol. 2001) 2 3 4 23 67
  2. Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney. (PMID: 11302728) Parker M.D. … Tanner M.J.A. (Biochem. Biophys. Res. Commun. 2001) 3 23
  3. Ae4 (Slc4a9) is an electroneutral monovalent cation-dependent Cl-/HCO3- exchanger. (PMID: 27114614) PeA+a-MA1nzenmayer G. … CatalA!n M.A. (J. Gen. Physiol. 2016) 3
  4. Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). (PMID: 12847417) Soleimani M. (Minerva Urol Nefrol 2003) 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC4A9 Gene

Sources for SLC4A9 Gene