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Aliases for SLC4A9 Gene

Aliases for SLC4A9 Gene

  • Solute Carrier Family 4 Member 9 2 3 4 5
  • Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 9 2 3
  • Sodium Bicarbonate Cotransporter 5 3 4
  • Anion Exchanger 4 3 4
  • AE4 3 4
  • Anion Exchange Protein 4 3
  • AE 4 4
  • SBC5 4

External Ids for SLC4A9 Gene

Previous GeneCards Identifiers for SLC4A9 Gene

  • GC05P139556
  • GC05P140322
  • GC05P139722
  • GC05P139768
  • GC05P139719
  • GC05P134884
  • GC05P140464
  • GC05P140469
  • GC05P140477
  • GC05P140486
  • GC05P140492
  • GC05P140500

Summaries for SLC4A9 Gene

Entrez Gene Summary for SLC4A9 Gene

  • The protein encoded by this gene is a membrane protein involved in anion exchange. Expression of this gene is mostly limited to the kidney. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for SLC4A9 Gene

SLC4A9 (Solute Carrier Family 4 Member 9) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and anion transmembrane transporter activity. An important paralog of this gene is SLC4A4.

UniProtKB/Swiss-Prot for SLC4A9 Gene

  • Probable apical anion exchanger of the kidney cortex.

Additional gene information for SLC4A9 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A9 Gene

Genomics for SLC4A9 Gene

Regulatory Elements for SLC4A9 Gene

Enhancers for SLC4A9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H140257 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -98.4 -98422 5.5 PKNOX1 FOXA2 ATF1 FEZF1 YY1 ELK1 ZNF548 FOS ATF7 NCOA1 PFDN1 HBEGF ANKHD1 APBB3 HARS2 CD14 SLC4A9 ENSG00000253965 WDR55 SRA1
GH05H140309 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -46.6 -46550 4.7 TBP PKNOX1 ATF1 ZNF2 ZNF766 GATA2 FOS ATF7 CEBPB ZNF592 PFDN1 HBEGF SLC4A9 ENSG00000253965 CYSTM1 APBB3
GH05H140327 1.2 Ensembl ENCODE dbSUPER 12.3 -30.7 -30734 0.8 FOXA2 INSM2 CEBPG EBF1 RELA ZNF121 TEAD1 ZNF10 NR2F1 FOXA3 PFDN1 ENSG00000253965 SLC4A9 CYSTM1 HBEGF
GH05H140301 1.3 ENCODE dbSUPER 11.3 -55.7 -55736 2.2 PKNOX1 ATF1 ARNT ARID4B YBX1 ZNF2 YY1 GLIS2 GATA2 ZNF143 PFDN1 CYSTM1 HBEGF ENSG00000253965 SLC4A9 EIF4EBP3 SLC35A4 GC05M140174
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC4A9 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC4A9 Gene

Genomic Locations for SLC4A9 Gene
16,585 bases
Plus strand

Genomic View for SLC4A9 Gene

Genes around SLC4A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC4A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC4A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A9 Gene

Proteins for SLC4A9 Gene

  • Protein details for SLC4A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Anion exchange protein 4
    Protein Accession:
    Secondary Accessions:
    • B7ZL63
    • D3DQD4
    • D3DQD5
    • D3DQD6
    • E9PDK1
    • Q96RM5
    • Q9BXF2
    • Q9BXN3

    Protein attributes for SLC4A9 Gene

    983 amino acids
    Molecular mass:
    108248 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK28832.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC4A9 Gene


neXtProt entry for SLC4A9 Gene

Post-translational modifications for SLC4A9 Gene

  • Glycosylation at isoforms=2, 3, 4576 and Asn600
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC4A9 Gene

Domains & Families for SLC4A9 Gene

Gene Families for SLC4A9 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC4A9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the anion exchanger (TC 2.A.31) family.
  • Belongs to the anion exchanger (TC 2.A.31) family.
genes like me logo Genes that share domains with SLC4A9: view

Function for SLC4A9 Gene

Molecular function for SLC4A9 Gene

UniProtKB/Swiss-Prot Function:
Probable apical anion exchanger of the kidney cortex.

Phenotypes From GWAS Catalog for SLC4A9 Gene

Gene Ontology (GO) - Molecular Function for SLC4A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IEA --
GO:0008509 anion transmembrane transporter activity IEA --
GO:0008510 sodium:bicarbonate symporter activity TAS --
GO:0015297 antiporter activity IEA --
GO:0015301 anion:anion antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC4A9: view
genes like me logo Genes that share phenotypes with SLC4A9: view

Animal Models for SLC4A9 Gene

MGI Knock Outs for SLC4A9:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC4A9 Gene

Localization for SLC4A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC4A9 gene
Compartment Confidence
plasma membrane 5
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC4A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0045177 apical part of cell IEA --
genes like me logo Genes that share ontologies with SLC4A9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC4A9 Gene

Pathways & Interactions for SLC4A9 Gene

genes like me logo Genes that share pathways with SLC4A9: view

Interacting Proteins for SLC4A9 Gene

Gene Ontology (GO) - Biological Process for SLC4A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006820 anion transport IEA --
GO:0015698 inorganic anion transport IEA --
GO:0015701 bicarbonate transport TAS --
genes like me logo Genes that share ontologies with SLC4A9: view

No data available for SIGNOR curated interactions for SLC4A9 Gene

Drugs & Compounds for SLC4A9 Gene

(1) Drugs for SLC4A9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SLC4A9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC4A9: view

Transcripts for SLC4A9 Gene

Unigene Clusters for SLC4A9 Gene

Solute carrier family 4, sodium bicarbonate cotransporter, member 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A9 Gene

No ASD Table

Relevant External Links for SLC4A9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC4A9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC4A9 Gene

mRNA differential expression in normal tissues according to GTEx for SLC4A9 Gene

This gene is overexpressed in Kidney - Cortex (x41.5).

Protein differential expression in normal tissues from HIPED for SLC4A9 Gene

This gene is overexpressed in Heart (36.6) and Synovial fluid (32.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC4A9 Gene

Protein tissue co-expression partners for SLC4A9 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC4A9 Gene:


SOURCE GeneReport for Unigene cluster for SLC4A9 Gene:


mRNA Expression by UniProt/SwissProt for SLC4A9 Gene:

Tissue specificity: Kidney specific.

Evidence on tissue expression from TISSUES for SLC4A9 Gene

  • Kidney(4.4)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with SLC4A9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC4A9 Gene

Orthologs for SLC4A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC4A9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC4A9 33 34
  • 99.53 (n)
(Bos Taurus)
Mammalia SLC4A9 33 34
  • 87.64 (n)
(Canis familiaris)
Mammalia SLC4A9 33 34
  • 87.25 (n)
(Rattus norvegicus)
Mammalia Slc4a9 33
  • 84.78 (n)
(Mus musculus)
Mammalia Slc4a9 33 16 34
  • 83.82 (n)
(Ornithorhynchus anatinus)
Mammalia SLC4A9 34
  • 69 (a)
(Monodelphis domestica)
Mammalia SLC4A9 34
  • 52 (a)
(Gallus gallus)
Aves SLC4A9 34
  • 52 (a)
(Anolis carolinensis)
Reptilia SLC4A9 34
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ndae1 34
  • 34 (a)
(Caenorhabditis elegans)
Secernentea abts-1 34
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for SLC4A9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC4A9 Gene

Gene Tree for SLC4A9 (if available)
Gene Tree for SLC4A9 (if available)

Paralogs for SLC4A9 Gene

Paralogs for SLC4A9 Gene

(9) SIMAP similar genes for SLC4A9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC4A9: view

Variants for SLC4A9 Gene

Sequence variations from dbSNP and Humsavar for SLC4A9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000018389 -- 140,372,097(+) TTTAT(C/T)CTATC intron-variant
rs1000365383 -- 140,358,518(+) ACAGA(C/T)TGTCA upstream-variant-2KB
rs1000396454 -- 140,357,873(+) GTATG(C/T)TCTCA upstream-variant-2KB
rs1000732942 -- 140,359,801(+) TGTGG(A/C)CCCAG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000778573 -- 140,367,306(+) ACTAG(C/T)ATCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC4A9 Gene

Variant ID Type Subtype PubMed ID
nsv509090 CNV insertion 20534489
nsv1020011 CNV gain 25217958
esv3606949 CNV loss 21293372
esv3434218 CNV duplication 20981092
esv2659425 CNV deletion 23128226

Variation tolerance for SLC4A9 Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.70; 57.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC4A9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A9 Gene

Disorders for SLC4A9 Gene

Relevant External Links for SLC4A9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC4A9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC4A9 Gene

Publications for SLC4A9 Gene

  1. A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9 at 5q31. (PMID: 11305939) Lipovich L … King MC (Genome biology 2001) 2 3 4 22 60
  2. Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney. (PMID: 11302728) Parker MD … Tanner MJ (Biochemical and biophysical research communications 2001) 3 4 22 60
  3. Ae4 (Slc4a9) is an electroneutral monovalent cation-dependent Cl-/HCO3- exchanger. (PMID: 27114614) Peña-Münzenmayer G … Catalán MA (The Journal of general physiology 2016) 3 60
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for SLC4A9 Gene

Sources for SLC4A9 Gene

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