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Aliases for SLC4A9 Gene

Aliases for SLC4A9 Gene

  • Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 9 2 3
  • Sodium Bicarbonate Cotransporter 5 3 4
  • Anion Exchanger 4 3 4
  • AE4 3 4
  • Solute Carrier Family 4, Sodium Bicarbonate Cotransporter-Like, Member 9 3
  • Solute Carrier Family 4 Member 9 4
  • Anion Exchange Protein 4 3
  • AE 4 4
  • SBC5 4

External Ids for SLC4A9 Gene

Previous GeneCards Identifiers for SLC4A9 Gene

  • GC05P139556
  • GC05P140322
  • GC05P139722
  • GC05P139768
  • GC05P139719
  • GC05P134884

Summaries for SLC4A9 Gene

Entrez Gene Summary for SLC4A9 Gene

  • The protein encoded by this gene is a membrane protein involved in anion exchange. Expression of this gene is mostly limited to the kidney. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for SLC4A9 Gene

SLC4A9 (Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 9) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include inorganic anion exchanger activity. An important paralog of this gene is SLC4A8.

UniProtKB/Swiss-Prot for SLC4A9 Gene

  • Probable apical anion exchanger of the kidney cortex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A9 Gene

Genomics for SLC4A9 Gene

Regulatory Elements for SLC4A9 Gene

Genomic Location for SLC4A9 Gene

Start:
140,360,202 bp from pter
End:
140,375,143 bp from pter
Size:
14,942 bases
Orientation:
Plus strand

Genomic View for SLC4A9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC4A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A9 Gene

Proteins for SLC4A9 Gene

  • Protein details for SLC4A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96Q91-B3A4_HUMAN
    Recommended name:
    Anion exchange protein 4
    Protein Accession:
    Q96Q91
    Secondary Accessions:
    • B7ZL63
    • D3DQD4
    • D3DQD5
    • D3DQD6
    • E9PDK1
    • Q96RM5
    • Q9BXF2
    • Q9BXN3

    Protein attributes for SLC4A9 Gene

    Size:
    983 amino acids
    Molecular mass:
    108248 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK28832.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC4A9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC4A9 Gene

Proteomics data for SLC4A9 Gene at MOPED

Post-translational modifications for SLC4A9 Gene

  • Glycosylation at Asn576 and Asn600
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC4A9 Gene

No data available for DME Specific Peptides for SLC4A9 Gene

Domains for SLC4A9 Gene

Gene Families for SLC4A9 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Suggested Antigen Peptide Sequences for SLC4A9 Gene

Graphical View of Domain Structure for InterPro Entry

Q96Q91

UniProtKB/Swiss-Prot:

B3A4_HUMAN :
  • Q96Q91
Family:
  • Belongs to the anion exchanger (TC 2.A.31) family.
genes like me logo Genes that share domains with SLC4A9: view

Function for SLC4A9 Gene

Molecular function for SLC4A9 Gene

UniProtKB/Swiss-Prot Function: Probable apical anion exchanger of the kidney cortex.

Gene Ontology (GO) - Molecular Function for SLC4A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005452 inorganic anion exchanger activity IEA --
GO:0008509 anion transmembrane transporter activity --
GO:0008510 sodium:bicarbonate symporter activity IBA --
genes like me logo Genes that share ontologies with SLC4A9: view

Phenotypes for SLC4A9 Gene

genes like me logo Genes that share phenotypes with SLC4A9: view

Animal Models for SLC4A9 Gene

MGI Knock Outs for SLC4A9:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC4A9 Gene

Localization for SLC4A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC4A9 Gene COMPARTMENTS Subcellular localization image for SLC4A9 gene
Compartment Confidence
plasma membrane 4
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC4A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0045177 apical part of cell IEA --
genes like me logo Genes that share ontologies with SLC4A9: view

Pathways for SLC4A9 Gene

genes like me logo Genes that share pathways with SLC4A9: view

Interacting Proteins for SLC4A9 Gene

Gene Ontology (GO) - Biological Process for SLC4A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport TAS --
GO:0006820 anion transport --
GO:0015701 bicarbonate transport TAS --
GO:0035725 sodium ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC4A9: view

Compounds for SLC4A9 Gene

(2) Novoseek inferred chemical compound relationships for SLC4A9 Gene

Compound -log(P) Hits PubMed IDs
sodium bicarbonate 69.9 1
bicarbonate 68.2 2
genes like me logo Genes that share compounds with SLC4A9: view

Transcripts for SLC4A9 Gene

Unigene Clusters for SLC4A9 Gene

Solute carrier family 4, sodium bicarbonate cotransporter, member 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC4A9

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC4A9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A9 Gene

No ASD Table

Relevant External Links for SLC4A9 Gene

GeneLoc Exon Structure for
SLC4A9
ECgene alternative splicing isoforms for
SLC4A9

Expression for SLC4A9 Gene

mRNA expression in normal human tissues for SLC4A9 Gene

mRNA differential expression in normal tissues according to GTEx for SLC4A9 Gene

This gene is overexpressed in Kidney - Cortex (41.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC4A9 Gene

SOURCE GeneReport for Unigene cluster for SLC4A9 Gene Hs.550313

mRNA Expression by UniProt/SwissProt for SLC4A9 Gene

Q96Q91-B3A4_HUMAN
Tissue specificity: Kidney specific.
genes like me logo Genes that share expressions with SLC4A9: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC4A9 Gene

Orthologs for SLC4A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC4A9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC4A9 35
  • 99.53 (n)
  • 99.39 (a)
SLC4A9 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC4A9 35
  • 87.64 (n)
  • 86.6 (a)
SLC4A9 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC4A9 35
  • 87.25 (n)
  • 86.69 (a)
SLC4A9 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc4a9 35
  • 83.82 (n)
  • 83.26 (a)
Slc4a9 16
Slc4a9 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC4A9 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC4A9 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc4a9 35
  • 84.78 (n)
  • 83.32 (a)
chicken
(Gallus gallus)
Aves SLC4A9 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC4A9 36
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ndae1 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea abts-1 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for SLC4A9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC4A9 Gene

ENSEMBL:
Gene Tree for SLC4A9 (if available)
TreeFam:
Gene Tree for SLC4A9 (if available)

Paralogs for SLC4A9 Gene

Paralogs for SLC4A9 Gene

Selected SIMAP similar genes for SLC4A9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC4A9: view

Variants for SLC4A9 Gene

Sequence variations from dbSNP and Humsavar for SLC4A9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs717097 -- 140,361,785(+) TTAAT(A/C)ACTGC intron-variant
rs2112259 -- 140,364,805(+) AGGCC(C/T)GATAT intron-variant
rs6860077 -- 140,365,569(+) GACAT(C/T)GTAAG synonymous-codon, reference
rs6865864 -- 140,362,200(+) GGAGT(C/T)AGGGA intron-variant
rs6878367 -- 140,367,168(+) CTTCT(C/G)TTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC4A9 Gene

Variant ID Type Subtype PubMed ID
nsv509090 CNV Insertion 20534489
esv2659425 CNV Deletion 23128226

Relevant External Links for SLC4A9 Gene

HapMap Linkage Disequilibrium report
SLC4A9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A9 Gene

Disorders for SLC4A9 Gene

No disorders were found for SLC4A9 Gene.

No data available for UniProtKB/Swiss-Prot for SLC4A9 Gene

Publications for SLC4A9 Gene

  1. A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9 at 5q31. (PMID: 11305939) Lipovich L. … King M.-C. (Genome Biol. 2001) 2 3 4 23
  2. Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney. (PMID: 11302728) Parker M.D. … Tanner M.J.A. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  3. Na+:HCO(3-) cotransporters (NBC): cloning and characterization. (PMID: 11562789) Soleimani M. … Burnham C.E. (J. Membr. Biol. 2001) 23
  4. Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. (PMID: 12027220) Soleimani M. (J. Nephrol. 2002) 23
  5. Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). (PMID: 12847417) Soleimani M. (Minerva Urol Nefrol 2003) 23

Products for SLC4A9 Gene

Sources for SLC4A9 Gene

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