Aliases for SLC4A7 Gene
External Ids for SLC4A7 Gene
Previous Symbols for SLC4A7 Gene
This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
GeneCards Summary for SLC4A7 Gene
SLC4A7 (Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 7) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include inorganic anion exchanger activity and sodium:bicarbonate symporter activity. An important paralog of this gene is SLC4A8.
UniProtKB/Swiss-Prot for SLC4A7 Gene
Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.