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Aliases for SLC4A5 Gene

Aliases for SLC4A5 Gene

  • Solute Carrier Family 4 (Sodium Bicarbonate Cotransporter), Member 5 2 3
  • NBC4 3 4 6
  • NBCe2 3 4
  • Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 5 2
  • Electrogenic Sodium Bicarbonate Cotransporter 4 3
  • Solute Carrier Family 4 Member 5 4

External Ids for SLC4A5 Gene

Previous GeneCards Identifiers for SLC4A5 Gene

  • GC02M074576
  • GC02M074651
  • GC02M074397
  • GC02M074414
  • GC02M074423
  • GC02M074351
  • GC02M074360
  • GC02M074443
  • GC02M074179

Summaries for SLC4A5 Gene

Entrez Gene Summary for SLC4A5 Gene

  • This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC4A5 Gene

SLC4A5 (Solute Carrier Family 4 (Sodium Bicarbonate Cotransporter), Member 5) is a Protein Coding gene. Diseases associated with SLC4A5 include renal tubular acidosis, proximal, with ocular abnormalities and alstrom syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Bile secretion. GO annotations related to this gene include inorganic anion exchanger activity and sodium:bicarbonate symporter activity. An important paralog of this gene is SLC4A8.

UniProtKB/Swiss-Prot for SLC4A5 Gene

  • Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.

Gene Wiki entry for SLC4A5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A5 Gene

Genomics for SLC4A5 Gene

Regulatory Elements for SLC4A5 Gene

Genomic Location for SLC4A5 Gene

Start:
74,216,242 bp from pter
End:
74,343,414 bp from pter
Size:
127,173 bases
Orientation:
Minus strand

Genomic View for SLC4A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC4A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A5 Gene

Proteins for SLC4A5 Gene

  • Protein details for SLC4A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY07-S4A5_HUMAN
    Recommended name:
    Electrogenic sodium bicarbonate cotransporter 4
    Protein Accession:
    Q9BY07
    Secondary Accessions:
    • Q32MA7
    • Q59EQ9
    • Q8WXD3
    • Q8WXD7
    • Q96DS7
    • Q96DS8
    • Q9HBU5

    Protein attributes for SLC4A5 Gene

    Size:
    1137 amino acids
    Molecular mass:
    126255 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG18492.1; Type=Frameshift; Positions=1047; Evidence={ECO:0000305}; Sequence=AAL50802.1; Type=Frameshift; Positions=760, 925, 1047; Evidence={ECO:0000305}; Sequence=EAW99691.1; Type=Frameshift; Positions=1047; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC4A5 Gene

neXtProt entry for SLC4A5 Gene

Proteomics data for SLC4A5 Gene at MOPED

Post-translational modifications for SLC4A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC4A5 Gene

Domains for SLC4A5 Gene

Suggested Antigen Peptide Sequences for SLC4A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BY07

UniProtKB/Swiss-Prot:

S4A5_HUMAN :
  • Q9BY07
Family:
  • Belongs to the anion exchanger (TC 2.A.31) family.
genes like me logo Genes that share domains with SLC4A5: view

Function for SLC4A5 Gene

Molecular function for SLC4A5 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Activity is inhibited by 4,4-di-isothiocyanatostilbene-2,2-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters)
UniProtKB/Swiss-Prot Function: Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.

Gene Ontology (GO) - Molecular Function for SLC4A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005452 inorganic anion exchanger activity IEA --
GO:0008509 anion transmembrane transporter activity --
GO:0008510 sodium:bicarbonate symporter activity NAS 10978526
genes like me logo Genes that share ontologies with SLC4A5: view
genes like me logo Genes that share phenotypes with SLC4A5: view

Animal Models for SLC4A5 Gene

MGI Knock Outs for SLC4A5:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC4A5 Gene

Localization for SLC4A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A5 Gene

Apical cell membrane; Multi-pass membrane protein. Note=Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla. {ECO:0000269 PubMed:17715183}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC4A5 Gene COMPARTMENTS Subcellular localization image for SLC4A5 gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC4A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 10978526
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC4A5: view

Pathways for SLC4A5 Gene

genes like me logo Genes that share pathways with SLC4A5: view

Interacting Proteins for SLC4A5 Gene

Selected Interacting proteins: Q9BY07-S4A5_HUMAN for SLC4A5 Gene via MINT

Gene Ontology (GO) - Biological Process for SLC4A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002064 epithelial cell development IEA --
GO:0003014 renal system process IBA --
GO:0003073 regulation of systemic arterial blood pressure IEA --
GO:0006810 transport --
GO:0006811 ion transport TAS --
genes like me logo Genes that share ontologies with SLC4A5: view

Compounds for SLC4A5 Gene

(2) HMDB Compounds for SLC4A5 Gene

Compound Synonyms Cas Number PubMed IDs
Hydrogen carbonate
  • Bicarbonate
71-52-3
Sodium
  • Sodium
7440-23-5

(1) Drugbank Compounds for SLC4A5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Sodium bicarbonate
  • Bicarbonate of soda
144-55-8 transporter substrate

(2) Novoseek inferred chemical compound relationships for SLC4A5 Gene

Compound -log(P) Hits PubMed IDs
sodium bicarbonate 68.7 5
bicarbonate 64.7 2
genes like me logo Genes that share compounds with SLC4A5: view

Transcripts for SLC4A5 Gene

Unigene Clusters for SLC4A5 Gene

Solute carrier family 4, sodium bicarbonate cotransporter, member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC4A5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC4A5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^
SP1:
SP2:
SP3:
SP4:
SP5: - - - - - - - - - - - - - - - - - - - - - - -
SP6:
SP7:
SP8:
SP9: - - - - - - - - - - -

ExUns: 22 ^ 23a · 23b · 23c ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32
SP1: -
SP2: -
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9: - - - - - - - - - -

Relevant External Links for SLC4A5 Gene

GeneLoc Exon Structure for
SLC4A5
ECgene alternative splicing isoforms for
SLC4A5

Expression for SLC4A5 Gene

mRNA expression in normal human tissues for SLC4A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC4A5 Gene

This gene is overexpressed in Thyroid (22.7) and Testis (5.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC4A5 Gene

SOURCE GeneReport for Unigene cluster for SLC4A5 Gene Hs.594099

mRNA Expression by UniProt/SwissProt for SLC4A5 Gene

Q9BY07-S4A5_HUMAN
Tissue specificity: Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle.
genes like me logo Genes that share expressions with SLC4A5: view

In Situ Assay Products

Orthologs for SLC4A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC4A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC4A5 35
  • 99.82 (n)
  • 99.82 (a)
SLC4A5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC4A5 35
  • 89.37 (n)
  • 91.42 (a)
SLC4A5 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC4A5 35
  • 90.87 (n)
  • 93.17 (a)
SLC4A5 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc4a5 35
  • 88.44 (n)
  • 92.99 (a)
Slc4a5 16
Slc4a5 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC4A5 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC4A5 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc4a5 35
  • 87.4 (n)
  • 89.92 (a)
chicken
(Gallus gallus)
Aves SLC4A5 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC4A5 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc4a5 35
  • 71.9 (n)
  • 78.37 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-48m9.1 35
  • 71.08 (n)
  • 75.62 (a)
slc4a5 36
  • 71 (a)
OneToMany
SLC4A5 (1 of 2) 36
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ndae1 36
  • 39 (a)
OneToMany
Ndae1 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea abts-1 36
  • 37 (a)
OneToMany
F52B5.1 37
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for SLC4A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC4A5 Gene

ENSEMBL:
Gene Tree for SLC4A5 (if available)
TreeFam:
Gene Tree for SLC4A5 (if available)

Paralogs for SLC4A5 Gene

Paralogs for SLC4A5 Gene

genes like me logo Genes that share paralogs with SLC4A5: view

Variants for SLC4A5 Gene

Sequence variations from dbSNP and Humsavar for SLC4A5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs702462 -- 74,217,304(-) TGATT(A/T)AATGC utr-variant-3-prime
rs758699 -- 74,287,540(-) CCTGG(A/G)TGTGG intron-variant
rs828862 -- 74,231,106(-) GTCTT(A/G)GCCGG intron-variant
rs828863 -- 74,225,132(-) GCTTC(A/G)AGACG intron-variant
rs828902 -- 74,243,007(-) AGATA(C/T)CAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC4A5 Gene

Variant ID Type Subtype PubMed ID
nsv834261 CNV Loss 17160897
dgv1198e1 CNV Complex 17122850
dgv1199e1 CNV Complex 17122850
nsv2783 CNV Loss 18451855
esv2466904 CNV Deletion 19546169
esv4660 CNV Deletion 18987735
esv2123407 CNV Deletion 18987734
esv2720210 CNV Deletion 23290073
esv7786 CNV Loss 19470904
nsv874287 CNV Loss 21882294
esv2660222 CNV Deletion 23128226
dgv636n67 CNV Loss 20364138
esv2720211 CNV Deletion 23290073
esv2720212 CNV Deletion 23290073

Relevant External Links for SLC4A5 Gene

HapMap Linkage Disequilibrium report
SLC4A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A5 Gene

Disorders for SLC4A5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SLC4A5 Gene including...

Search for SLC4A5 Gene in MalaCards »

(1) Novoseek inferred disease relationships for SLC4A5 Gene

Disease -log(P) Hits PubMed IDs
alstrom syndrome 89.4 2

Relevant External Links for SLC4A5

Genetic Association Database (GAD)
SLC4A5
Human Genome Epidemiology (HuGE) Navigator
SLC4A5
genes like me logo Genes that share disorders with SLC4A5: view

No data available for UniProtKB/Swiss-Prot for SLC4A5 Gene

Publications for SLC4A5 Gene

  1. Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family. (PMID: 10978526) Pushkin A. … Kurtz I. (Biochim. Biophys. Acta 2000) 2 3 4 23
  2. Two C-terminal variants of NBC4, a new member of the sodium bicarbonate cotransporter family: cloning, characterization, and localization. (PMID: 11087115) Pushkin A. … Kurtz I. (IUBMB Life 2000) 2 3 4 23
  3. Functional characterization of NBC4: a new electrogenic sodium- bicarbonate cotransporter. (PMID: 11788353) Sassani P. … Kurtz I. (Am. J. Physiol. 2002) 3 4 23
  4. Expression of the Na+-HCO-3 cotransporter NBC4 in rat kidney and characterization of a novel NBC4 variant. (PMID: 12388414) Xu J. … Soleimani M. (Am. J. Physiol. 2003) 3 4 23
  5. Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150(Glued). (PMID: 12063394) Pushkin A. … Kurtz I. (Cytogenet. Cell Genet. 2001) 3 4

Products for SLC4A5 Gene

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Sources for SLC4A5 Gene

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