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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC4A5 Gene

protein-coding GIFtS: 60
GCID: GC02M074443

solute carrier family 4, sodium bicarbonate cotransporter,...

Explore 3 diseases affiliated with
SLC4A5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 5¹ ²
NBC4¹ ² ³ ⁵
NBCe2² ³
Electrogenic Sodium Bicarbonate Cotransporter 4²
Solute Carrier Family 4 Member 5³

External Ids:	HGNC: 18168¹	Entrez Gene: 57835²	Ensembl: ENSG00000188687⁷	OMIM: 606757⁵	UniProtKB: Q9BY07³

Export aliases for SLC4A5 gene to outside databases

Previous GC identifers: GC02M074576 GC02M074651 GC02M074397 GC02M074414 GC02M074423 GC02M074351 GC02M074360 GC02M074179

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC4A5:

This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter

superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or

electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple

transcript variants encoding different isoforms have been found for this gene, but the biological validity of some

variants has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: S4A5_HUMAN, Q9BY07

Function: Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-)

stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May

play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be

important in protecting the renal paranchyma from alterations in urine pH

Gene Wiki entry for SLC4A5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC4A5 gene promoter:
E2F-4 E2F-3a E2F-5 RREB-1 IRF-1 E2F-2 AP-2gamma E2F E2F-1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC4A5 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC4A5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC4A5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13 Ensembl cytogenetic band: 2p13.1 HGNC cytogenetic band: 2p13.1

SLC4A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC4A5 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M074443: view genomic region (about GC identifiers)

Start:	74,443,369 bp from pter	End:	74,570,541 bp from pter
Size:	127,173 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S4A5_HUMAN, Q9BY07 (See protein sequence)

Recommended Name: Electrogenic sodium bicarbonate cotransporter 4

Size: 1137 amino acids; 126255 Da

Subcellular location: Apical cell membrane; Multi-pass membrane protein. Note=Expressed in the apical plasma membrane

domain of a subset of collecting ducts in the renal medulla

Sequence caution: Sequence=AAG18492.1; Type=Frameshift; Positions=1047; Sequence=AAL50802.1; Type=Frameshift;

Positions=760, 925, 1047; Sequence=EAW99691.1; Type=Frameshift; Positions=1047;

Secondary accessions: Q32MA7 Q59EQ9 Q8WXD3 Q8WXD7 Q96DS7 Q96DS8 Q9HBU5

Alternative splicing: 8 isoforms: Q9BY07-1 Q9BY07-2 Q9BY07-3 Q9BY07-4 Q9BY07-5 Q9BY07-6 Q9BY07-7 Q9BY07-8

(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC4A5: NX_Q9BY07

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BY07

SLC4A5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_067019.3 NP_597812.1

ENSEMBL proteins:

ENSP00000377587 ENSP00000351513 ENSP00000366859 ENSP00000366861 ENSP00000405678

ENSP00000414162 ENSP00000407550 ENSP00000399319 ENSP00000251768 ENSP00000352461

ENSP00000350475 ENSP00000395804

Reactome Protein details: Q9BY07
Human Recombinant Protein Products:

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	Uscn Proteins for SLC4A5

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	NAS	10978526
GO:0016324	apical plasma membrane	IEA	--

SLC4A5 for ontologies About GeneDecksing

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Assay Products for SLC4A5:

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	Uscn ELISAs and CLIAs for SLC4A5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC4A5 for domains About GeneDecksing

5 InterPro domains/families:

IPR011531 HCO3_transpt_C

IPR003020 HCO3_transpt_euk

IPR016152 PTrfase/Anion_transptr

IPR003024 Na/HCO3_transpt

IPR013769 HCO3_transpt_cyt

Graphical View of Domain Structure for InterPro Entry Q9BY07

ProtoNet protein and cluster: Q9BY07

2 Blocks protein families:

IPB003024 Na+/HCO3- co-transporter signature

IPB013769 HCO3- transporter

UniProtKB/Swiss-Prot: S4A5_HUMAN, Q9BY07

Similarity: Belongs to the anion exchanger (TC 2.A.31) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: S4A5_HUMAN, Q9BY07

Function: Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-)

stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May

play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be

important in protecting the renal paranchyma from alterations in urine pH

Enzyme regulation: Activity is inhibited by 4,4'-di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of

several anion channels and transporters)

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC4A5

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005452	inorganic anion exchanger activity	IEA	--
GO:0008509	anion transmembrane transporter activity	--	--
GO:0008510	sodium:bicarbonate symporter activity	NAS	10978526

SLC4A5 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SLC4A5:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Slc4a5^tm1.1Boet for SLC4A5
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Slc4a5):

cardiovascular system	endocrine/exocrine gland	homeostasis/metabolism	nervous system	no phenotypic analysis
renal/urinary system

SLC4A5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Bicarbonate transporters

Bicarbonate transporters

1.00

Bile secretion

Bile secretion

1.00

Amino acid and oligopeptide SLC transporters

Transport of inorganic cations/anions and amino acids/oligopeptides

0.52

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for SLC4A5

	Bicarbonate transporters
	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transport of inorganic cations/anions and amino acids/oligopeptides

1 Kegg Pathway (Kegg details for SLC4A5):

Bile secretion

SLC4A5 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC4A5

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5/67 Interacting proteins for SLC4A5 (Q9BY07² ENSP00000350475⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 67)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AGO2	Q9UKV8², ENSP00000220592⁴	MINT-6489355 STRING: ENSP00000220592
ATP5C1	P36542²	MINT-6489355
CMSS1	Q9BQ75²	MINT-6489355
COPA	P53621²	MINT-6489355
DDOST	P39656²	MINT-6489355

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	TAS	--
GO:0015701	bicarbonate transport	TAS	--
GO:0055085	transmembrane transport	TAS	--

SLC4A5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC4A5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC4A5

2 HMDB Compounds for SLC4A5 About this table

Compound	Synonyms	CAS #	PubMed Ids
Hydrogen carbonate	Bicarbonate (see all 19)	71-52-3	--
Sodium	Sodium (see all 2)	7440-23-5	--

1 DrugBank Compound for SLC4A5 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Sodium bicarbonate	Bicarbonate of soda (see all 6)	144-55-8	transporter	substrate	15014910 17071329 12847417 12027220

2 Novoseek chemical compound relationships for SLC4A5 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sodium bicarbonate	68.7	5	11087115 (2), 10978526 (2), 15014910 (1)
bicarbonate	64.7	2	15014910 (2)

Search CenterWatch for drugs/clinical trials and news about SLC4A5 / S4A5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC4A5 gene (4 alternative transcripts):

NM_021196.3 NM_133478.2 NM_033323.2 NM_133479.1

Unigene Cluster for SLC4A5:

Solute carrier family 4, sodium bicarbonate cotransporter, member 5

Hs.744095 [show with all ESTs]

Unigene Representative Sequence: NM_133478

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000483195 ENST00000394019(uc002skn.3) ENST00000480696 ENST00000358683

ENST00000377632 ENST00000377634 ENST00000425249 ENST00000479776 ENST00000432728

ENST00000444570 ENST00000436454 ENST00000346834(uc010ffc.1) ENST00000359484(uc002skp.1)

ENST00000357822(uc002sko.1) ENST00000423644

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		hsa-miR-345 hsa-miR-148b* hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-183* hsa-miR-141* hsa-miR-593* hsa-miR-573

		SwitchGear 3'UTR luciferase reporter plasmid: SLC4A5 3' UTR sequence

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Additional cDNA sequence:

AF243499.2 AF293337.2 AF293338.2 AF452248.1 AF453528.1 BC109221.2

9 DOTS entries:

DT.109844 DT.95165633 DT.120983579 DT.97803493 DT.120983680 DT.92460179 DT.95200978 DT.86838840

DT.100775606

24/565 AceView cDNA sequences (see all 565):

BM449545 BP366042 CA393292 CB154396 AW084273 T32934 CB127373 AL039311

BU682720 BC013978 BI224537 BQ061695 CB156579 BQ690075 CF125009 BQ895029

AL698722 BQ719068 AI095879 CA447915 NM_133478 BU726337 AJ709213 BM699997

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A5 (see all 9) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19	^	20	^	21	^
SP1:
SP2:
SP3:
SP4:
SP5:							-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	22	^	23a	·	23b	·	23c	^	24a	·	24b	^	25	^	26	^	27	^	28a	·	28b	^	29	^	30	^	31	^	32
SP1:									-
SP2:									-
SP3:
SP4:
SP5:	-		-

ECgene alternative splicing isoforms for SLC4A5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC4A5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGTAAGTCA

About this image

SLC4A5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Mature Choroid Plexus Cells

Selective marker (cell-identifying gene)

Choroid Plexus

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC4A5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC4A5

SOURCE GeneReport for Unigene cluster: Hs.744095

UniProtKB/Swiss-Prot: S4A5_HUMAN, Q9BY07

Tissue specificity: Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus,

hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart,

pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood

lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC4A5 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC4A5¹	solute carrier family 4, sodium bicarbonate cotransporter, more	78.3(n) 82.44(a)		426127 XM_423797.3 XP_423797.3
lizard (Anolis carolinensis)	Reptilia	SLC4A3⁶ SLC4A5⁶	--	83(a) 72(a)	1 ↔ 1 possible ortholog	GL343662.1(285385-298701) GL343968.1(111086-120046)
zebrafish (Danio rerio)	Actinopterygii	LOC559268¹	novel protein similar to vertebrate solute carrier more	70.68(n) 74.68(a)		559268 XM_682596.5 XP_687688.5
fruit fly (Drosophila melanogaster)	Insecta	Ndae1³	sodium:bicarbonate cotransporter	44(a)		27E6 --
worm (Caenorhabditis elegans)	Secernentea	F52B5.1³	anion exchange protein	42(a)		I(8305353-8315575) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G32510⁶ BOR5⁶ (see all 7)	putative boron transporter 5 (see all 7)	21(a) 20(a) (see all 7)	possible ortholog possible ortholog (see all 7)	4(15685903-15688811) 1(28108474-28111534)
rice (Oryza sativa)	Liliopsida	BOR3⁶ BOR4⁶ (see all 3)	boron transporter protein, putative, expressed (see all 3)	21(a) 20(a) (see all 3)	possible ortholog possible ortholog (see all 3)	1(3877069-3899085) 5(4600956-4607390)

ENSEMBL Gene Tree for SLC4A5 (if available)
TreeFam Gene Tree for SLC4A5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC4A5 gene

SLC4A4² SLC4A10² SLC4A7² SLC4A1² SLC4A11² SLC4A8² SLC4A2² SLC4A3²

SLC4A9²

12 SIMAP similar genes for SLC4A5 using alignment to 9 protein entries: S4A5_HUMAN (see all proteins):

DKFZp781H1314 SLC4A4 NBC SLC4A10 SLC4A8 SLC4A3

SLC4A7 SLC4A9 SLC4A2 SLC4A1 AE AE1

SLC4A5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs57421736^1,2	C,	--	74179700(+)	`ACTGCA/GTGGAG`	1	--	ut3¹		2		WA	120
rs1051837^1,2		--	74179876(+)	`ATAGCA/GTTTCT`	1	--	ut3¹		0	--	--	--	--
rs60438577^1,2	C,	--	74180249(+)	`CCCCCC/TACCTC`	1	--	ut3¹		3		WA	122
rs74932250^1,2	C,F,	--	74180495(+)	`AGAGGC/TAATTA`	1	--	ut3¹		1		WA	118
rs56067994^1,2	C,F,	--	74180567(+)	`TGCATT/GTGTCA`	1	--	ut3¹		3		WA CSA	122
rs200547223^1,2	C	--	74180677(+)	`GGCTGG/TCAGGG`	1	--	ut3¹		0	--	--	--	--
rs11888707^1,2	C,F,H	--	74180926(+)	`TTTGGG/TAATAA`	1	--	ut3¹		3		NS NA	232
rs180854276^1,2	C,	--	74181599(+)	`TTCCAA/GAGATG`	1	--	ut3¹		0	--	--	--	--
rs182280269^1,2	C,	--	74182052(+)	`TCTTCA/GGTATT`	1	--	ut3¹		0	--	--	--	--
rs62147685^1,2		--	74182169(+)	`TATTTC/TGAAGT`	1	--	ut3¹		1		NA	2

HapMap Linkage Disequilibrium report for SLC4A5 (74443369 - 74570541 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for SLC4A5
2 CNVs: 97887 3366
5 Indels: 46038 60303 61778 60304 43072

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SLC4A5 for disorders           About GeneDecksing

OMIM gene information: 606757    OMIM disorders: --

3 diseases for SLC4A5:    About MalaCards

alstrom syndrome choroiditis neuronitis

1 Novoseek disease relationship for SLC4A5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alstrom syndrome	89.4	2	11087115 (1), 10978526 (1)

Human Genome Epidemiology (HuGE) Navigator: SLC4A5 (9 documents)

Export disorders for SLC4A5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLC4A5 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with SLC4A5)

Utopia: connect your pdf to the dynamic
world of online information

Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family. (PubMed id 10978526)^{1, 2, 3, 9} Pushkin A.... Kurtz I. (2000)
Two C-terminal variants of NBC4, a new member of the sodium bicarbonate cotransporter family: cloning, characterization, and localization. (PubMed id 11087115)^{1, 2, 3, 9} Pushkin A.... Kurtz I. (2000)
Expression of the Na+-HCO-3 cotransporter NBC4 in rat kidney and characterization of a novel NBC4 variant. (PubMed id 12388414)^{1, 2, 9} Xu J.... Soleimani M. (2003)
Functional characterization of NBC4: a new electrogenic sodium- bicarbonate cotransporter. (PubMed id 11788353)^{1, 2, 9} Sassani P.... Kurtz I. (2002)
Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150(Glued). (PubMed id 12063394)^{1, 2} Pushkin A.... Kurtz I. (2001)
Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. (PubMed id 15014910)^{7, 9} Kurtz I....Tatishchev S. (2004)
Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. (PubMed id 12027220)^{7, 9} Soleimani M. (2002)
Gene-environment effects of SLC4A5 and skin color on b lood pressure among African American women. (PubMed id 22764636)¹ Taylor J.Y....Jackson J.S. (2012)
Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter. (PubMed id 22987918)¹ Carey R.M....Felder R.A. (2012)
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)¹ Kennedy R.B....Poland G.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57835	HGNC: 18168	AceView: DCTN1andSLC4A5	Ensembl:ENSG00000188687	euGenes: HUgn57835
ECgene: SLC4A5	Kegg: 57835	H-InvDB: SLC4A5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SLC4A5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC4A5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC4A5 gene:
Search GeneIP for patents involving SLC4A5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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