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SLC4A3 Gene

protein-coding   GIFtS: 59
GCID: GC02P220492

Solute Carrier Family 4 (Anion Exchanger), Member 3

(Previous names: solute carrier family 4, anion exchanger, member 3)
  See SLC4A3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 4 (Anion Exchanger), Member 31 2     AE 32 3
AE32 3 5     SLC2C2 5
Anion Exchanger 31 3     neuronal1
Cardiac/Brain Band 3-Like Protein2 3     Solute Carrier Family 4, Anion Exchanger, Member 31
Neuronal Band 3-Like Protein2 3     Anion Exchange Protein 32
Solute Carrier Family 4 Member 32 3     Anion Exchanger 3 Cardiac Isoform2
CAE3/BAE32 3     Anion Exchanger 3, Neuronal2

External Ids:    HGNC: 110291   Entrez Gene: 65082   Ensembl: ENSG000001149237   OMIM: 1061955   UniProtKB: P487513   

Export aliases for SLC4A3 gene to outside databases

Previous GC identifers: GC02P218515 GC02P219214 GC02P220456 GC02P220695 GC02P220694 GC02P220317 GC02P220200 GC02P212345


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC4A3 Gene:
SLC4A3 (solute carrier family 4 (anion exchanger), member 3) is a protein-coding gene. Diseases associated with SLC4A3 include epithelial malignant thymoma, and thymoma. GO annotations related to this gene include inorganic anion exchanger activity. An important paralog of this gene is SLC4A10.

UniProtKB/Swiss-Prot: B3A3_HUMAN, P48751
Function: Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the
Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-)

Gene Wiki entry for SLC4A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC4A3 gene promoter:
         MyoD   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SLC4A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC4A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

SLC4A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC4A3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P220492:  view genomic region     (about GC identifiers)

Start:
220,492,049 bp from pter      End:
220,506,702 bp from pter
Size:
14,654 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: B3A3_HUMAN, P48751 (See protein sequence)
Recommended Name: Anion exchange protein 3  
Size: 1232 amino acids; 135791 Da
Secondary accessions: A6H8L2 A8K1Q9 B7ZVX6 B9EGD1 Q6YIQ9
Alternative splicing: 3 isoforms:  P48751-1   P48751-2   P48751-3   

Explore the universe of human proteins at neXtProt for SLC4A3: NX_P48751

Explore proteomics data for SLC4A3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC4A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005061.2  NP_963868.2  

    ENSEMBL proteins: 
     ENSP00000350756   ENSP00000362865   ENSP00000273063   ENSP00000396863   ENSP00000314006  
     ENSP00000414722   ENSP00000403160   ENSP00000398628   ENSP00000362867  
    Reactome Protein details: P48751

    SLC4A3 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Anion exchange protein 3
    Anion exchangers

    Selected InterPro protein domains (see all 7):
     IPR001717 Anion_exchange
     IPR003020 HCO3_transpt_euk
     IPR002979 Anion_exchange_3
     IPR011531 HCO3_transpt_C
     IPR016152 PTrfase/Anion_transptr

    Graphical View of Domain Structure for InterPro Entry P48751

    ProtoNet protein and cluster: P48751

    3 Blocks protein domains:
    IPB001717 Anion exchange protein
    IPB002979 Anion exchanger isoform 3 signature
    IPB013769 HCO3- transporter


    UniProtKB/Swiss-Prot: B3A3_HUMAN, P48751
    Similarity: Belongs to the anion exchanger (TC 2.A.31) family


    Find genes that share domains with SLC4A3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: B3A3_HUMAN, P48751
    Function: Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the
    Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-)

         Genatlas biochemistry entry for SLC4A3:
    solute carrier family 4 (chloride-bicarbonate,anion exchange),member 3,expressed in human heart,isoform 3c in
    brain and stomach,containing an intronic CGG repeat

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005452inorganic anion exchanger activity IEA--
    GO:0008509anion transmembrane transporter activity ----
    GO:0015301anion:anion antiporter activity ----
         
    Find genes that share ontologies with SLC4A3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC4A3:
     Increased S DNA content 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc4a3):
     behavior/neurological  cardiovascular system  cellular  homeostasis/metabolism  integument 
     mortality/aging  muscle  nervous system  respiratory system  vision/eye 

    Find genes that share phenotypes with SLC4A3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SLC4A3: Slc4a3tm1Cahb Slc4a3tm1Ges

       genOway: Develop your customized and physiologically relevant rodent model for SLC4A3

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    SwitchGear 3'UTR luciferase reporter plasmidSLC4A3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    B3A3_HUMAN, P48751: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton1
    extracellular1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7923606
    GO:0016020membrane TAS7923606
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SLC4A3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC4A3 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Bicarbonate transporters0.00
    2Hepatic ABC Transporters
    Hepatic ABC Transporters0.41


    Find genes that share SuperPaths with SLC4A3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SLC4A3
        Hepatic ABC Transporters

    1 Reactome Pathway for SLC4A3
        Bicarbonate transporters


        Pathway & Disease-focused RT2 Profiler PCR Array including SLC4A3: 
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC4A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for SLC4A3 (P487513 ENSP000002730634) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANK1P161573, ENSP000002657094I2D: score=3 STRING: ENSP00000265709
    CA2P009183, ENSP000002853794I2D: score=2 STRING: ENSP00000285379
    CA4P227483, ENSP000003009004I2D: score=2 STRING: ENSP00000300900
    PRKCEQ021563, ENSP000003061244I2D: score=1 STRING: ENSP00000306124
    CAPZBP477563I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS7923606
    GO:0006811ion transport TAS--
    GO:0006820anion transport ----
    GO:0015701bicarbonate transport TAS--
    GO:0051453regulation of intracellular pH IEA--

    Find genes that share ontologies with SLC4A3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC4A3 (B3A3)

    2 Novoseek inferred chemical compound relationships for SLC4A3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bicarbonate 59.6 8 17786210 (3), 12399075 (1), 7836397 (1), 19692653 (1)
    chloride 42.6 2 12399075 (1), 17786210 (1)



    Find genes that share compounds with SLC4A3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC4A3 gene (2 alternative transcripts): 
    NM_005070.3  NM_201574.2  

    Unigene Cluster for SLC4A3:

    Solute carrier family 4, anion exchanger, member 3
    Hs.1176  [show with all ESTs]
    Unigene Representative Sequence: AY142112
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358055 ENST00000373760 ENST00000273063(uc002vmo.4) ENST00000425141(uc010fwn.1)
    ENST00000317151 ENST00000497589 ENST00000413743 ENST00000416910 ENST00000444906
    ENST00000373762(uc002vmn.2 uc002vmp.4 uc010fwm.3)
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    hsa-miR-330-5p hsa-miR-326 hsa-miR-330-3p hsa-miR-1827 hsa-miR-3921 hsa-miR-3670
    SwitchGear 3'UTR luciferase reporter plasmidSLC4A3 3' UTR sequence
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    Additional mRNA sequence: 

    AK226122.1 AK289974.1 AK299109.1 AK299595.1 AK309025.1 AK314083.1 AY142112.1 BC136384.1 
    BC146656.1 BC171760.1 NR_048551.1 U05596.1 X70797.1 X87211.1 

    9 DOTS entries:

    DT.410313  DT.97785781  DT.100748192  DT.100642128  DT.100021587  DT.40204957  DT.86857764  DT.91860324 
    DT.99969430 

    Selected AceView cDNA sequences (see all 61):

    CF552946 BM713839 F11813 AI623272 BU738896 BF724427 AL120203 F06947 
    AY142112 AI620529 BQ685936 CN479276 BU185689 BG912926 NM_005070 F09461 
    BG059909 NM_201574 BM680396 BI771288 U05596 CD619760 BF528441 BP376362 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC4A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTAGAGTGG
    SLC4A3 Expression
    About this image


    SLC4A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             ganglion/cranial/vagus X   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
     
     Skeletal Muscle (Muscoskeletal System)
             Extraocular Muscles
     
     Heart (Cardiovascular System)
    SLC4A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC4A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1176

    UniProtKB/Swiss-Prot: B3A3_HUMAN, P48751
    Tissue specificity: Both BAE3 and CAE3 are expressed in failing ventricle

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC4A3: 
              Cardiotoxicity in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC4A3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc4a31 , 5 solute carrier family 4 (anion exchanger), member 31, 5 88.18(n)1
    96.17(a)1
      1 (39.16 cM)5
    205361  NM_009208.31  NP_033234.21 
     755462665 
    chicken
    (Gallus gallus)
    Aves SLC4A31 solute carrier family 4, anion exchanger, member 3 70.77(n)
    72.3(a)
      424194  XM_003641640.2  XP_003641688.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC4A36
    solute carrier family 4 (anion exchanger), member ...
    68(a)
    1 ↔ 1
    1(94335768-94393092)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004953941 anion exchange protein 3-like 68.88(n)
    71.1(a)
      100495394  XM_002942681.2  XP_002942727.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003330731 anion exchange protein 3-like 64.3(n)
    65.89(a)
      100333073  XM_002662268.3  XP_002662314.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81773 anion exchanger 48(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea R03E9.33 anion exchange protein 26(a)   X(6782894-6795730)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BOR16
    Boron efflux transporter of the plasma membrane; b...
    24(a)
    1 → many
    XIV(119268-120998) YNL275W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons BOR11 BOR1 44.55(n)
    33.64(a)
      819329  NM_180138.2  NP_850469.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g05660001 Os12g0566000 45.88(n)
    29.84(a)
      4352546  NM_001073581.1  NP_001067049.1 


    ENSEMBL Gene Tree for SLC4A3 (if available)
    TreeFam Gene Tree for SLC4A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC4A3 gene
    SLC4A102  SLC4A72  SLC4A42  SLC4A112  SLC4A12  SLC4A52  SLC4A82  SLC4A22  
    SLC4A92  
    13 SIMAP similar genes for SLC4A3 using alignment to 5 protein entries:     B3A3_HUMAN (see all proteins):
    AE    DKFZp781H1314    EPB3    AE1    SLC4A2    SLC4A1
    SLC4A5    SLC4A8    NBC    SLC4A4    SLC4A10    SLC4A7
    SLC4A9

    Find genes that share paralogs with SLC4A3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC4A3 (see all 504)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868330171,2
    --219870981(+) GGCTAC/GGCTCT 2 -- us2k10--------
    rs1386030801,2
    C--219871082(+) AAAGCA/GTTCTC 2 -- us2k10--------
    rs1902760061,2
    --219871114(+) AAATTC/TCCCCC 2 -- us2k10--------
    rs1825035481,2
    --219871133(+) ATATAC/TATATA 2 -- us2k10--------
    rs360728751,2
    C--219871140(+) TATATT/ATTTTT 2 -- us2k12Minor allele frequency- A:0.10NA 122
    rs1415956301,2
    --219871142(+) TATTTA/TTTTTT 2 -- us2k10--------
    rs1871355171,2
    --219871372(+) CACCCA/GCCTTG 2 -- us2k10--------
    rs1915755781,2
    --219871390(+) AAAGTA/GCTGGG 2 -- us2k10--------
    rs1827647251,2
    --219871460(+) TAATGA/GATGAG 2 -- us2k10--------
    rs1131352581,2
    C--219871499(+) CGTTAC/TTGCCA 2 -- us2k11Minor allele frequency- T:0.00CSA 1

    HapMap Linkage Disequilibrium report for SLC4A3 (220492049 - 220506702 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC4A3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1005415CNV Deletion20482838
    dgv4438n71CNV Loss21882294
    nsv875876CNV Loss21882294

    Human Gene Mutation Database (HGMD): SLC4A3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC4A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC4A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 106195    OMIM disorders: --

    2 diseases for SLC4A3:    
    About MalaCards
    epithelial malignant thymoma    thymoma

    1 disease from the University of Copenhagen DISEASES database for SLC4A3:
    Epithelial malignant thymoma

    Find genes that share disorders with SLC4A3           About GenesLikeMe

    Genetic Association Database (GAD): SLC4A3
    Human Genome Epidemiology (HuGE) Navigator: SLC4A3 (1 document)

    Export disorders for SLC4A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC4A3 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with SLC4A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36. (PubMed id 8001971)1, 3, 9 Su Y.R....Menon A.G. (Genomics 1994)
    2. Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart. (PubMed id 7923606)1, 2, 9 Yannoukakos D....Alper S.L. (Circ. Res. 1994)
    3. Genetic susceptibility to febrile seizures: case-control association studies. (PubMed id 19854014)1, 4 Kira R....Hara T. (amp 2010)
    4. Characterization of an epilepsy-associated variant of the human Cl-/HCO3(-) exchanger AE3. (PubMed id 19605733)1, 9 Vilas G.L....Casey J.R. (Am. J. Physiol., Cell Physiol. 2009)
    5. Association of the 867Asp variant of the human anion exchanger 3 gene with common subtypes of idiopathic generalized epilepsy. (PubMed id 12399075)4, 9 Sander T....NA1rnberg P. (Epilepsy Res. 2002)
    6. Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization. (PubMed id 11248201)1, 9 Alrefai W.A....Dudeja P.K. (Biochim. Biophys. Acta 2001)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6508 HGNC: 11029 AceView: SLC4A3 Ensembl:ENSG00000114923 euGenes: HUgn6508
    ECgene: SLC4A3 H-InvDB: SLC4A3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC4A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC4A3 gene:
    Search GeneIP for patents involving SLC4A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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