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Aliases for SLC4A3 Gene

Aliases for SLC4A3 Gene

  • Solute Carrier Family 4 Member 3 2 3 4 5
  • Solute Carrier Family 4 (Anion Exchanger), Member 3 2 3
  • Cardiac/Brain Band 3-Like Protein 3 4
  • Neuronal Band 3-Like Protein 3 4
  • Anion Exchanger 3, Neuronal 2 3
  • CAE3/BAE3 3 4
  • AE3 3 4
  • Solute Carrier Family 4, Anion Exchanger, Member 3 2
  • Anion Exchanger 3 Cardiac Isoform 3
  • Anion Exchange Protein 3 3
  • Anion Exchanger 3 4
  • SLC2C 3
  • AE 3 4

External Ids for SLC4A3 Gene

Previous GeneCards Identifiers for SLC4A3 Gene

  • GC02P218515
  • GC02P219214
  • GC02P220456
  • GC02P220695
  • GC02P220694
  • GC02P220317
  • GC02P220200
  • GC02P220492
  • GC02P212345

Summaries for SLC4A3 Gene

Entrez Gene Summary for SLC4A3 Gene

  • The protein encoded by this gene is a plasma membrane anion exchange protein. The encoded protein has been found in brain, heart, kidney, small intestine, and lung. [provided by RefSeq, May 2016]

GeneCards Summary for SLC4A3 Gene

SLC4A3 (Solute Carrier Family 4 Member 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Hepatic ABC Transporters. GO annotations related to this gene include transporter activity and anion transmembrane transporter activity. An important paralog of this gene is SLC4A2.

UniProtKB/Swiss-Prot for SLC4A3 Gene

  • Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-).

Gene Wiki entry for SLC4A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A3 Gene

Genomics for SLC4A3 Gene

Regulatory Elements for SLC4A3 Gene

Enhancers for SLC4A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F219574 1.3 Ensembl ENCODE 11.4 -51.0 -50995 3.6 ATF1 MLX ARID4B DMAP1 ZNF48 ZNF2 YY1 SLC30A9 SP5 MXD4 INHA CHPF TMEM198 SLC4A3 ENSG00000228973 OBSL1 ASIC4 GMPPA RN7SKP213
GH02F219683 1.2 Ensembl ENCODE 11.4 +60.3 60349 7.4 PKNOX1 ATF1 ARID4B ZNF143 ZNF263 SP3 GTF2B NFYC REST ZNF592 OBSL1 CHPF TMEM198 SLC4A3 ENSG00000228973 DNPEP DNAJB2 ATG9A LOC105373886 RPL23P4
GH02F219660 1.1 Ensembl ENCODE 11.3 +34.9 34909 3.1 PKNOX1 CBX3 CBX5 ZNF280D CEBPB KLF16 SMARCA4 PBX2 IKZF1 HMBOX1 SLC4A3 ENSG00000228973 ENSG00000267919 GC02M219685
GH02F219578 0.9 Ensembl ENCODE 11.5 -48.2 -48216 1.3 SOX13 GATAD2A CEBPB CEBPG E2F4 EP300 GATA3 CEBPA PRDM10 SMAD4 CHPF TMEM198 ENSG00000228973 SLC4A3 ASIC4 OBSL1 RN7SKP213
GH02F219655 0.7 ENCODE 12.3 +29.2 29156 1.4 SMARCE1 ZNF362 MAFG RAD51 ZNF316 SMARCA4 IKZF1 TRIM24 FOS NFE2 ENSG00000228973 SLC4A3 RESP18 ENSG00000267919 GC02M219685
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC4A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC4A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001832717 473 1201 CTCF KLF1 MAZ ESRRA SP3 UBTF ZIC2 ZFHX2 GLIS2 POLR2A

Transcription factor binding sites by QIAGEN in the SLC4A3 gene promoter:

Genomic Location for SLC4A3 Gene

Chromosome:
2
Start:
219,627,327 bp from pter
End:
219,641,980 bp from pter
Size:
14,654 bases
Orientation:
Plus strand

Genomic View for SLC4A3 Gene

Genes around SLC4A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC4A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC4A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A3 Gene

Proteins for SLC4A3 Gene

  • Protein details for SLC4A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48751-B3A3_HUMAN
    Recommended name:
    Anion exchange protein 3
    Protein Accession:
    P48751
    Secondary Accessions:
    • A6H8L2
    • A8K1Q9
    • B7ZVX6
    • B9EGD1
    • Q6YIQ9

    Protein attributes for SLC4A3 Gene

    Size:
    1232 amino acids
    Molecular mass:
    135791 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC4A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC4A3 Gene

Post-translational modifications for SLC4A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC4A3 Gene

Domains & Families for SLC4A3 Gene

Gene Families for SLC4A3 Gene

Suggested Antigen Peptide Sequences for SLC4A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48751

UniProtKB/Swiss-Prot:

B3A3_HUMAN :
  • Belongs to the anion exchanger (TC 2.A.31) family.
Family:
  • Belongs to the anion exchanger (TC 2.A.31) family.
genes like me logo Genes that share domains with SLC4A3: view

Function for SLC4A3 Gene

Molecular function for SLC4A3 Gene

GENATLAS Biochemistry:
solute carrier family 4 (chloride-bicarbonate,anion exchange),member 3,expressed in human heart,isoform 3c in brain and stomach,containing an intronic CGG repeat
UniProtKB/Swiss-Prot Function:
Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-).

Gene Ontology (GO) - Molecular Function for SLC4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IEA,TAS --
GO:0008509 anion transmembrane transporter activity IEA --
GO:0015297 antiporter activity IEA --
GO:0015301 anion:anion antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC4A3: view
genes like me logo Genes that share phenotypes with SLC4A3: view

Animal Models for SLC4A3 Gene

MGI Knock Outs for SLC4A3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC4A3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC4A3 Gene

Localization for SLC4A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC4A3 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for SLC4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7923606
GO:0016020 membrane IEA,TAS 7923606
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC4A3: view

Pathways & Interactions for SLC4A3 Gene

genes like me logo Genes that share pathways with SLC4A3: view

Gene Ontology (GO) - Biological Process for SLC4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA,TAS 7923606
GO:0006811 ion transport IEA --
GO:0006820 anion transport IEA --
GO:0015698 inorganic anion transport IEA --
GO:0015701 bicarbonate transport TAS --
genes like me logo Genes that share ontologies with SLC4A3: view

No data available for SIGNOR curated interactions for SLC4A3 Gene

Drugs & Compounds for SLC4A3 Gene

(2) Additional Compounds for SLC4A3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC4A3: view

Transcripts for SLC4A3 Gene

Unigene Clusters for SLC4A3 Gene

Solute carrier family 4, anion exchanger, member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A3 Gene

No ASD Table

Relevant External Links for SLC4A3 Gene

GeneLoc Exon Structure for
SLC4A3
ECgene alternative splicing isoforms for
SLC4A3

Expression for SLC4A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC4A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC4A3 Gene

This gene is overexpressed in Heart - Left Ventricle (x11.1), Heart - Atrial Appendage (x7.9), and Ovary (x5.8).

Protein differential expression in normal tissues from HIPED for SLC4A3 Gene

This gene is overexpressed in Heart (43.2) and Retina (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC4A3 Gene



Protein tissue co-expression partners for SLC4A3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC4A3 Gene:

SLC4A3

SOURCE GeneReport for Unigene cluster for SLC4A3 Gene:

Hs.1176

mRNA Expression by UniProt/SwissProt for SLC4A3 Gene:

P48751-B3A3_HUMAN
Tissue specificity: Both BAE3 and CAE3 are expressed in failing ventricle.
genes like me logo Genes that share expression patterns with SLC4A3: view

Primer Products

Orthologs for SLC4A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC4A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC4A3 34 35
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia SLC4A3 34 35
  • 89.94 (n)
cow
(Bos Taurus)
Mammalia SLC4A3 34 35
  • 89.09 (n)
rat
(Rattus norvegicus)
Mammalia Slc4a3 34
  • 88.24 (n)
mouse
(Mus musculus)
Mammalia Slc4a3 34 16 35
  • 88.18 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC4A3 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC4A3 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC4A3 34 35
  • 70.77 (n)
lizard
(Anolis carolinensis)
Reptilia SLC4A3 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495394 34
  • 68.88 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100333073 34
  • 64.3 (n)
SLC4A3 35
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8177 36 35
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea abts-4 35
  • 29 (a)
OneToMany
R03E9.3 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BOR1 35
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons BOR1 34
  • 44.55 (n)
rice
(Oryza sativa)
Liliopsida Os12g0566000 34
  • 45.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for SLC4A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC4A3 Gene

ENSEMBL:
Gene Tree for SLC4A3 (if available)
TreeFam:
Gene Tree for SLC4A3 (if available)

Paralogs for SLC4A3 Gene

Paralogs for SLC4A3 Gene

(13) SIMAP similar genes for SLC4A3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC4A3: view

Variants for SLC4A3 Gene

Sequence variations from dbSNP and Humsavar for SLC4A3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs376572581 Uncertain significance 219,639,524(+) GGCTC(C/T)GGTTT nc-transcript-variant, reference, synonymous-codon
rs387907529 Uncertain significance 219,628,499(+) TGGGG(A/G)CCTCA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs387907530 Uncertain significance 219,630,205(+) GCCGG(A/C)CCTGG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs387907531 Uncertain significance 219,629,297(+) GACCC(C/T)TCCCA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs387907532 Uncertain significance 219,630,222(+) TCGGC(C/T)AGTTA nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SLC4A3 Gene

Variant ID Type Subtype PubMed ID
esv1005415 CNV deletion 20482838

Variation tolerance for SLC4A3 Gene

Residual Variation Intolerance Score: 30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC4A3 Gene

Human Gene Mutation Database (HGMD)
SLC4A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC4A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A3 Gene

Disorders for SLC4A3 Gene

Relevant External Links for SLC4A3

Genetic Association Database (GAD)
SLC4A3
Human Genome Epidemiology (HuGE) Navigator
SLC4A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC4A3

No disorders were found for SLC4A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC4A3 Gene

Publications for SLC4A3 Gene

  1. Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36. (PMID: 8001971) Su Y.R. … Menon A.G. (Genomics 1994) 2 3 22 64
  2. Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart. (PMID: 7923606) Yannoukakos D. … Alper S.L. (Circ. Res. 1994) 3 4 22 64
  3. Genetic susceptibility to febrile seizures: case-control association studies. (PMID: 19854014) Kira R. … Hara T. (Brain Dev. 2010) 3 46 64
  4. Characterization of an epilepsy-associated variant of the human Cl-/HCO3(-) exchanger AE3. (PMID: 19605733) Vilas G.L. … Casey J.R. (Am. J. Physiol., Cell Physiol. 2009) 3 22 64
  5. Association of the 867Asp variant of the human anion exchanger 3 gene with common subtypes of idiopathic generalized epilepsy. (PMID: 12399075) Sander T. … NA1rnberg P. (Epilepsy Res. 2002) 22 46 64

Products for SLC4A3 Gene

Sources for SLC4A3 Gene

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