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Aliases for SLC4A3 Gene

Aliases for SLC4A3 Gene

  • Solute Carrier Family 4 Member 3 2 3 4
  • Solute Carrier Family 4 (Anion Exchanger), Member 3 2 3 5
  • Cardiac/Brain Band 3-Like Protein 3 4
  • Neuronal Band 3-Like Protein 3 4
  • Anion Exchanger 3 2 4
  • CAE3/BAE3 3 4
  • AE 3 3 4
  • AE3 3 4
  • Solute Carrier Family 4, Anion Exchanger, Member 3 2
  • Anion Exchanger 3 Cardiac Isoform 3
  • Anion Exchanger 3, Neuronal 3
  • Neuronal 2
  • SLC2C 3

External Ids for SLC4A3 Gene

Previous GeneCards Identifiers for SLC4A3 Gene

  • GC02P218515
  • GC02P219214
  • GC02P220456
  • GC02P220695
  • GC02P220694
  • GC02P220317
  • GC02P220200
  • GC02P220492
  • GC02P212345

Summaries for SLC4A3 Gene

GeneCards Summary for SLC4A3 Gene

SLC4A3 (Solute Carrier Family 4 Member 3) is a Protein Coding gene. Diseases associated with SLC4A3 include epithelial malignant thymoma and dendritic cell thymoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Hepatic ABC Transporters. GO annotations related to this gene include transporter activity and anion transmembrane transporter activity. An important paralog of this gene is SLC4A8.

UniProtKB/Swiss-Prot for SLC4A3 Gene

  • Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-).

Gene Wiki entry for SLC4A3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A3 Gene

Genomics for SLC4A3 Gene

Regulatory Elements for SLC4A3 Gene

Promoters for SLC4A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC4A3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SLC4A3 gene promoter:

Genomic Location for SLC4A3 Gene

Chromosome:
2
Start:
219,627,327 bp from pter
End:
219,641,980 bp from pter
Size:
14,654 bases
Orientation:
Plus strand

Genomic View for SLC4A3 Gene

Genes around SLC4A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC4A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC4A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A3 Gene

Proteins for SLC4A3 Gene

  • Protein details for SLC4A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48751-B3A3_HUMAN
    Recommended name:
    Anion exchange protein 3
    Protein Accession:
    P48751
    Secondary Accessions:
    • A6H8L2
    • A8K1Q9
    • B7ZVX6
    • B9EGD1
    • Q6YIQ9

    Protein attributes for SLC4A3 Gene

    Size:
    1232 amino acids
    Molecular mass:
    135791 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC4A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC4A3 Gene

Proteomics data for SLC4A3 Gene at MOPED

Post-translational modifications for SLC4A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC4A3 Gene

Domains & Families for SLC4A3 Gene

Gene Families for SLC4A3 Gene

Suggested Antigen Peptide Sequences for SLC4A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48751

UniProtKB/Swiss-Prot:

B3A3_HUMAN :
  • Belongs to the anion exchanger (TC 2.A.31) family.
Family:
  • Belongs to the anion exchanger (TC 2.A.31) family.
genes like me logo Genes that share domains with SLC4A3: view

Function for SLC4A3 Gene

Molecular function for SLC4A3 Gene

GENATLAS Biochemistry:
solute carrier family 4 (chloride-bicarbonate,anion exchange),member 3,expressed in human heart,isoform 3c in brain and stomach,containing an intronic CGG repeat
UniProtKB/Swiss-Prot Function:
Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-).
genes like me logo Genes that share phenotypes with SLC4A3: view

Animal Models for SLC4A3 Gene

MGI Knock Outs for SLC4A3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC4A3 Gene

Localization for SLC4A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC4A3 Gene COMPARTMENTS Subcellular localization image for SLC4A3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SLC4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,TAS 7923606
genes like me logo Genes that share ontologies with SLC4A3: view

Pathways & Interactions for SLC4A3 Gene

genes like me logo Genes that share pathways with SLC4A3: view

Gene Ontology (GO) - Biological Process for SLC4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015701 bicarbonate transport TAS --
GO:0051453 regulation of intracellular pH IEA,IBA --
GO:0055085 transmembrane transport TAS --
GO:0098656 anion transmembrane transport IEA --
GO:1902476 chloride transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC4A3: view

No data available for SIGNOR curated interactions for SLC4A3 Gene

Drugs & Compounds for SLC4A3 Gene

(2) Additional Compounds for SLC4A3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC4A3: view

Transcripts for SLC4A3 Gene

Unigene Clusters for SLC4A3 Gene

Solute carrier family 4, anion exchanger, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A3 Gene

No ASD Table

Relevant External Links for SLC4A3 Gene

GeneLoc Exon Structure for
SLC4A3
ECgene alternative splicing isoforms for
SLC4A3

Expression for SLC4A3 Gene

mRNA expression in normal human tissues for SLC4A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC4A3 Gene

This gene is overexpressed in Heart - Left Ventricle (x11.1), Heart - Atrial Appendage (x7.9), and Ovary (x5.8).

Protein differential expression in normal tissues from HIPED for SLC4A3 Gene

This gene is overexpressed in Heart (43.2) and Retina (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC4A3 Gene



SOURCE GeneReport for Unigene cluster for SLC4A3 Gene Hs.1176

mRNA Expression by UniProt/SwissProt for SLC4A3 Gene

P48751-B3A3_HUMAN
Tissue specificity: Both BAE3 and CAE3 are expressed in failing ventricle.
genes like me logo Genes that share expression patterns with SLC4A3: view

Protein tissue co-expression partners for SLC4A3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC4A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC4A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC4A3 35
  • 99.36 (n)
  • 99.76 (a)
SLC4A3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC4A3 36
  • 96 (a)
OneToOne
SLC4A3 35
  • 89.09 (n)
  • 94.33 (a)
dog
(Canis familiaris)
Mammalia SLC4A3 35
  • 89.94 (n)
  • 94.98 (a)
SLC4A3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc4a3 36
  • 96 (a)
OneToOne
Slc4a3 16
Slc4a3 35
  • 88.18 (n)
  • 96.17 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC4A3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC4A3 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc4a3 35
  • 88.24 (n)
  • 95.93 (a)
chicken
(Gallus gallus)
Aves SLC4A3 36
  • 69 (a)
OneToOne
SLC4A3 35
  • 70.77 (n)
  • 72.3 (a)
lizard
(Anolis carolinensis)
Reptilia SLC4A3 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495394 35
  • 68.88 (n)
  • 71.1 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100333073 35
  • 64.3 (n)
  • 65.89 (a)
SLC4A3 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8177 36
  • 38 (a)
OneToMany
CG8177 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea R03E9.3 37
  • 26 (a)
abts-4 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BOR1 36
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons BOR1 35
  • 44.55 (n)
  • 33.64 (a)
rice
(Oryza sativa)
Liliopsida Os12g0566000 35
  • 45.88 (n)
  • 29.84 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for SLC4A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC4A3 Gene

ENSEMBL:
Gene Tree for SLC4A3 (if available)
TreeFam:
Gene Tree for SLC4A3 (if available)

Paralogs for SLC4A3 Gene

Paralogs for SLC4A3 Gene

(13) SIMAP similar genes for SLC4A3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC4A3: view

Variants for SLC4A3 Gene

Sequence variations from dbSNP and Humsavar for SLC4A3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs36068948 - 219,630,218(+) CCCAT(C/G/T)GGCCA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs597306 - 219,629,396(+) CCCCC(A/C/G/T)CTCAG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs635311 - 219,637,645(+) CCTGG(A/C/T)TGCTG nc-transcript-variant, reference, missense
rs639214 -- 219,635,704(-) GGGGT(C/T)GCTTC nc-transcript-variant, reference, synonymous-codon
rs612078 -- 219,630,445(+) CTGCT(A/C)AGGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC4A3 Gene

Variant ID Type Subtype PubMed ID
dgv4438n71 CNV Loss 21882294
nsv875876 CNV Loss 21882294
esv1005415 CNV Deletion 20482838

Variation tolerance for SLC4A3 Gene

Residual Variation Intolerance Score: 30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC4A3 Gene

HapMap Linkage Disequilibrium report
SLC4A3
Human Gene Mutation Database (HGMD)
SLC4A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A3 Gene

Disorders for SLC4A3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC4A3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
epithelial malignant thymoma
  • squamoid thymoma
dendritic cell thymoma
  • epithelioid thymoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC4A3

Genetic Association Database (GAD)
SLC4A3
Human Genome Epidemiology (HuGE) Navigator
SLC4A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC4A3
genes like me logo Genes that share disorders with SLC4A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC4A3 Gene

Publications for SLC4A3 Gene

  1. Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36. (PMID: 8001971) Su Y.R. … Menon A.G. (Genomics 1994) 2 3 23 67
  2. Characterization of an epilepsy-associated variant of the human Cl-/HCO3(-) exchanger AE3. (PMID: 19605733) Vilas G.L. … Casey J.R. (Am. J. Physiol., Cell Physiol. 2009) 3 23
  3. Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization. (PMID: 11248201) Alrefai W.A. … Dudeja P.K. (Biochim. Biophys. Acta 2001) 3 23
  4. Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart. (PMID: 7923606) Yannoukakos D. … Alper S.L. (Circ. Res. 1994) 3 23
  5. Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients. (PMID: 24811271) Kennedy R.B. … Poland G.A. (Immunogenetics 2014) 3

Products for SLC4A3 Gene

Sources for SLC4A3 Gene

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