Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC4A2 Gene

protein-coding   GIFtS: 65
GCID: GC07P150754

Solute Carrier Family 4 (Anion Exchanger), Member 2

(Previous names: erythrocyte membrane protein band 3-like 1, solute carrier...)
(Previous symbols: EPB3L1, AE2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 4 (Anion Exchanger), Member 21 2     BND3L2 3
AE21 2 3 5     HKB32 3
EPB3L11 2 3 5     AE 22 3
Erythrocyte Membrane Protein Band 3-Like 11 2     Solute Carrier Family 4, Anion Exchanger, Member 2 (Erythrocyte Membrane
Protein Band 3-Like 1)1
Anion Exchanger 2 Type A1 2     NBND32
Anion Exchanger 2 Type B11 2     Anion Exchange Protein 22
Anion Exchanger 2 Type B21 2     MPB3L3
Non-Erythroid Band 3-Like Protein2 3     Anion Exchanger 23
Solute Carrier Family 4 Member 22 3     

External Ids:    HGNC: 110281   Entrez Gene: 65222   Ensembl: ENSG000001648897   OMIM: 1092805   UniProtKB: P049203   

Export aliases for SLC4A2 gene to outside databases

Previous GC identifers: GC07P149003 GC07P150072 GC07P150148 GC07P150194 GC07P150387 GC07P144569


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC4A2 Gene: 
SLC4A2 (solute carrier family 4 (anion exchanger), member 2) is a protein-coding gene. Diseases associated with SLC4A2 include primary biliary cirrhosis, and renal tubular acidosis, and among its related super-pathways are Transmembrane transport of small molecules and Salivary secretion. GO annotations related to this gene include anion transmembrane transporter activity and inorganic anion exchanger activity. An important paralog of this gene is SLC4A10.

UniProtKB/Swiss-Prot: B3A2_HUMAN, P04920
Function: Plasma membrane anion exchange protein of wide distribution

Gene Wiki entry for SLC4A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007914.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC4A2 gene promoter:
         E2F-4   E2F-3a   E2F-5   p53   p300   E2F-2   E2F   E2F-1   HOXA5   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): SLC4A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC4A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC4A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

SLC4A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC4A2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P150754:  view genomic region     (about GC identifiers)

Start:
150,754,297 bp from pter      End:
150,773,614 bp from pter
Size:
19,318 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 150,084,838-150,103,154     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: B3A2_HUMAN, P04920 (See protein sequence)
Recommended Name: Anion exchange protein 2  
Size: 1241 amino acids; 137009 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B2R6T0 B4DIT0 D3DX05 F8W682 Q45EY5 Q969L3
Alternative splicing: 3 isoforms:  P04920-1   P04920-2   P04920-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC4A2: NX_P04920

Explore proteomics data for SLC4A2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04920

  • SLC4A2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC4A2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001186621.1  NP_001186622.1  NP_001186623.1  NP_003031.3  

    ENSEMBL proteins: 
     ENSP00000417808   ENSP00000419412   ENSP00000405600   ENSP00000418114   ENSP00000419379  
     ENSP00000418584   ENSP00000417221   ENSP00000376571   ENSP00000419164   ENSP00000311402  
    Reactome Protein details: P04920
    Human Recombinant Protein Products for SLC4A2: 
    EMD Millipore Purified and/or Recombinant SLC4A2 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SLC4A2
    GenScript Custom Purified and Recombinant Proteins Services for SLC4A2
    Novus Biologicals SLC4A2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane TAS3015590
    GO:0016021integral to membrane IEA--
    GO:0016323basolateral plasma membrane IEA--

    SLC4A2 for ontologies           About GeneDecksing



    SLC4A2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC4A2
    GenScript Custom Superior Antibodies Services for SLC4A2
    Novus Biologicals SLC4A2 Antibodies
    Abcam antibodies for SLC4A2
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for SLC4A2
    LSBio Antibodies in human, mouse, rat for SLC4A2 

    Assay Products for SLC4A2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC4A2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC4A2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Anion exchange protein 2 
    Anion exchangers

    5/7 InterPro protein domains (see all 7):
     IPR001717 Anion_exchange
     IPR011531 HCO3_transpt_C
     IPR003020 HCO3_transpt_euk
     IPR016152 PTrfase/Anion_transptr
     IPR018241 Anion_exchange_CS

    Graphical View of Domain Structure for InterPro Entry P04920

    ProtoNet protein and cluster: P04920

    3 Blocks protein domains:
    IPB001717 Anion exchange protein
    IPB002978 Anion exchanger isoform 2 signature
    IPB013769 HCO3- transporter


    UniProtKB/Swiss-Prot: B3A2_HUMAN, P04920
    Similarity: Belongs to the anion exchanger (TC 2.A.31) family


    SLC4A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: B3A2_HUMAN, P04920
    Function: Plasma membrane anion exchange protein of wide distribution

         Genatlas biochemistry entry for SLC4A2:
    solute carrier family 4 (chloride-bicarbonate,anion exchange),member 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005452inorganic anion exchanger activity IEA--
    GO:0008509anion transmembrane transporter activity TAS3015590
    GO:0015108chloride transmembrane transporter activity IEA--
         
    SLC4A2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC4A2:
     Small cells 

         14 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Slc4a2):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  normal  reproductive system  skeleton 

    SLC4A2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SLC4A2: Slc4a2tm1Jmed Slc4a2tm1Ges

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC4A2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC4A2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC4A2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC4A2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC4A2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SLC4A2:
    hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidSLC4A2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC4A2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC4A2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC4A2
    Sirion Biotech Customized adenovirus for overexpression of SLC4A2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SLC4A2 (see all 7)
    OriGene ORF clones in mouse, rat for SLC4A2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SLC4A2 (NM_001199694)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC4A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC4A2
    Sirion Biotech Customized lentivirus for stable overexpression of SLC4A2 
                         Customized lentivirus expression plasmids for stable overexpression of SLC4A2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC4A2
    LifeMap BioReagents: cell line associated with SLC4A2: PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC4A2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC4A2 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    2Gastric acid secretion
    Gastric acid secretion0.34
    Salivary secretion0.34
    3Amino acid and oligopeptide SLC transporters
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    4Selected targets of HNF1
    Selected targets of HNF1
    5Selected targets of GCR-alpha
    Selected targets of GCR-alpha

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for SLC4A2
        Selected targets of GCR-alpha
    Selected targets of HNF1


    4        Reactome Pathways for SLC4A2
        Bicarbonate transporters
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of inorganic cations/anions and amino acids/oligopeptides


    4         Kegg Pathways  (Kegg details for SLC4A2):
        Salivary secretion
    Gastric acid secretion
    Pancreatic secretion
    Bile secretion


    SLC4A2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC4A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SLC4A2 (P049203 ENSP000003114024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CA2P009183, ENSP000002853794I2D: score=2 STRING: ENSP00000285379
    EPB42P164523, ENSP000003002154I2D: score=1 STRING: ENSP00000300215
    LIN54Q6MZP73, ENSP000003419474I2D: score=1 STRING: ENSP00000341947
    SLC26A7ENSP000003095044STRING: ENSP00000309504
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006811ion transport TAS--
    GO:0006820anion transport TAS3015590
    GO:0006821chloride transport ----
    GO:0015701bicarbonate transport TAS--

    SLC4A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC4A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC4A2 (B3A2)

    10/14 Novoseek inferred chemical compound relationships for SLC4A2 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bicarbonate 80 28 12791678 (3), 8188169 (2), 19157624 (1), 9587054 (1) (see all 19)
    dids 78.8 4 16911539 (1), 20180022 (1), 17018029 (1)
    stilbene 55.4 4 8458871 (1), 12791678 (1), 7744759 (1)
    chloride 53.9 6 8188169 (1), 11248201 (1), 11006093 (1), 14673180 (1) (see all 5)
    calmidazolium 52.1 3 12529246 (2)
    amiloride 48.4 1 7840148 (1)
    ammonium 31.7 5 9142848 (2), 12027221 (1)
    sulfate 28.3 8 7499397 (2), 7744759 (2), 10452823 (1)
    arsenite 25.7 8 16911539 (3), 17018029 (3)
    glyceraldehyde 3-phosphate 20.2 2 10362722 (1), 11875273 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC4A2 / B3A2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC4A2 gene (4 alternative transcripts): 
    NM_001199692.1  NM_001199693.1  NM_001199694.1  NM_003040.3  

    Unigene Cluster for SLC4A2:

    Solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
    Hs.647069  [show with all ESTs]
    Unigene Representative Sequence: NM_001199692
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000483786 ENST00000466368 ENST00000485713(uc022apz.1) ENST00000413384(uc003wit.4)
    ENST00000494125 ENST00000490898 ENST00000482950 ENST00000463414 ENST00000488420
    ENST00000392826(uc011kve.2) ENST00000461735(uc003wiu.4) ENST00000469355
    ENST00000494298 ENST00000480107 ENST00000493040 ENST00000460010 ENST00000482697
    ENST00000472204
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC4A2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SLC4A2:
    hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidSLC4A2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC4A2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC4A2
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC4A2 (see all 7)
    OriGene ORF clones in mouse, rat for SLC4A2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SLC4A2 (NM_001199694)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC4A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC4A2
    Sirion Biotech Customized lentivirus for stable overexpression of SLC4A2 
                         Customized lentivirus expression plasmids for stable overexpression of SLC4A2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC4A2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC4A2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC4A2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC4A2

    Additional mRNA sequence: 

    AB209158.1 AK295767.1 AK296065.1 AK312699.1 AY927498.1 BC004893.2 BC009386.2 BC009434.1 
    BC010069.2 BC028601.2 U62531.1 X03918.1 X62137.1 

    24/27 DOTS entries (see all 27):

    DT.101958385  DT.314587  DT.100811691  DT.101982432  DT.100811689  DT.100811688  DT.92451257  DT.100811695 
    DT.121074402  DT.121074494  DT.100803372  DT.75103240  DT.121074407  DT.429193  DT.100030864  DT.100811683 
    DT.100811692  DT.100811696  DT.100837807  DT.121074451  DT.121074472  DT.92018572  DT.95157114  DT.95157121 

    24/346 AceView cDNA sequences (see all 346):

    AI934687 BU155246 BE259443 BM141907 BQ881981 CA489368 BF002399 BC009434 
    BF526005 AA078435 BG775132 BM668845 BU154030 BM807054 BU168753 AU124868 
    BU169083 BX473401 AL555662 BE408741 CB217055 CD616179 CR602751 CB153444 

    GeneLoc Exon Structure

    5/19 Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A2 (see all 19)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
    SP1:        -     -     -     -     -     -     -           -     -     -                                                                       -     -         
    SP2:                    -     -     -     -     -           -     -     -                                                                       -     -         
    SP3:                    -     -     -     -     -           -     -     -                       -     -     -     -                             -     -         
    SP4:                                                                                                                                            -     -         
    SP5:                                            -           -     -     -     -     -     -                                                     -     -         

    ExUns: 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b · 25c ^ 26a · 26b ^ 27 ^ 28a · 28b · 28c ^ 29a · 29b ^
    SP1:                                                              -                             -                                                               
    SP2:                                                              -                             -                                                               
    SP3:                                                              -                             -                                                               
    SP4:                                                              -                             -                                                               
    SP5:                                                              -                             -                                                               

    ExUns: 30a · 30b ^ 31 ^ 32
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SLC4A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC4A2 expression in normal human tissues (normalized intensities)      SLC4A2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCTCCCTC
    SLC4A2 Expression
    About this image


    SLC4A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Epithelium
             oral mucosa ; squamous epithelial cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 3 entries
             small intestine ; glandular cells   
             SMALL INTESTINE   
     
     Breast
             breast ; myoepithelial cells   

    See SLC4A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC4A2

    SOURCE GeneReport for Unigene cluster: Hs.647069
        SABiosciences Custom PCR Arrays for SLC4A2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC4A2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC4A2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC4A2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC4A2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC4A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC4A2 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc4a21 , 5 solute carrier family 4 (anion exchanger), member 21, 5 87.68(n)1
    94.89(a)1
      5 (11.74 cM)5
    205351  NM_009207.31  NP_033233.21 
     244238375 
    chicken
    (Gallus gallus)
    Aves SLC4A21 solute carrier family 4, anion exchanger, member 2 more 77.71(n)
    80.45(a)
      395809  NM_204963.1  NP_990294.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC4A26
    --
    Uncharacterized protein
    57(a)
    34(a)
    1 ↔ 1
    possible ortholog
    GL344454.1(2048-21154)
    GL343662.1(284742-298701)
    zebrafish
    (Danio rerio)
    Actinopterygii slc4a2b1 solute carrier family 4, anion exchanger, member 2b 67.63(n)
    70.98(a)
      570716  NM_001114440.1  NP_001107912.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81771 , 3 anion exchanger3
    CG81771
    44(a)3
    53.92(n)1
    46.95(a)1
      391471  NM_206312.11  NP_996034.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R03E9.33 anion exchange protein 26(a)   X(6782894-6795730)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BOR16
    Boron efflux transporter of the plasma membrane; b...
    25(a)
    1 → many
    XIV(119268-120998)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G064501 putative boron transporter 3 42.88(n)
    30.22(a)
      819821  NM_001125118.1  NP_001118590.1 


    ENSEMBL Gene Tree for SLC4A2 (if available)
    TreeFam Gene Tree for SLC4A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC4A2 gene
    SLC4A102  SLC4A72  SLC4A42  SLC4A112  SLC4A12  SLC4A52  SLC4A82  SLC4A92  
    SLC4A32  
    13 SIMAP similar genes for SLC4A2 using alignment to 13 protein entries:     B3A2_HUMAN (see all proteins):
    EPB3    AE1    DKFZp781H1314    AE    SLC4A1    SLC4A3
    NBC    SLC4A4    SLC4A10    SLC4A8    SLC4A7    SLC4A5
    SLC4A9

    SLC4A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/411 SNPs in SLC4A2 are shown (see all 411)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0251714
    ----see VAR_0251712 L F mis40--------
    rs38348721,2
    C,F--150757231(-) GGGGGC/-CCCGG 2 -- int15Minor allele frequency- -:0.04NS 170
    rs346067131,2
    C,F--150757236(+) GGGGCC/TCCCAT 2 -- int16Minor allele frequency- T:0.05NS WA 294
    rs1885395191,2
    --150757312(+) TCAGAC/GAGAAG 2 -- int10--------
    rs64641201,2
    C,F,H--150757397(+) GCGGGG/AAGTTC 2 -- int122Minor allele frequency- A:0.09MN NS NA WA CSA EA 962
    rs344118531,2
    F--150757817(+) CCACCC/GGCCCT 4 -- int1 us2k15Minor allele frequency- G:0.01NS 186
    rs1160221961,2
    C,F--150757933(+) CTATAT/CTGTTT 4 -- int1 us2k11Minor allele frequency- C:0.02WA 118
    rs1918562031,2
    --150757941(+) TTTGAC/TGCTAC 4 -- int1 us2k10--------
    rs340266161,2
    C,F,H--150758022(+) GTACCG/ATCACT 4 -- int1 us2k118Minor allele frequency- A:0.08EA NS NA WA 1824
    rs1408063821,2
    --150758188(+) CCACTC/TAGATT 4 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for SLC4A2 (150754297 - 150773614 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for SLC4A2 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6004CNV Insertion18451855
    nsv517508CNV Loss19592680
    dgv7547n71CNV Loss21882294
    dgv7546n71CNV Loss21882294
    dgv7548n71CNV Loss21882294
    nsv889477CNV Loss21882294
    nsv465215CNV Loss19166990
    nsv889465CNV Loss21882294
    nsv526410CNV Loss19592680
    dgv7545n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SLC4A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC4A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 109280    OMIM disorders: --

    20 diseases for SLC4A2:    About MalaCards
    primary biliary cirrhosis    renal tubular acidosis    hereditary elliptocytosis    intrahepatic cholestasis of pregnancy
    intrahepatic cholestasis    cholestasis    osteopetrosis    polycystic kidney disease
    kidney disease    colon adenocarcinoma    choroiditis    liver disease
    hyperparathyroidism    cervical cancer    cervicitis    hepatocellular carcinoma
    gastric cancer    adenocarcinoma    pancreatitis    lung cancer

    4 diseases from the University of Copenhagen DISEASES database for SLC4A2:
    Primary biliary cirrhosis     Osteopetrosis     Renal tubular acidosis     Hereditary elliptocytosis

    SLC4A2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for SLC4A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    biliary cirrhosis primary 63.5 4 19157624 (1), 8985258 (1), 18471521 (1)
    cholestasis 39.1 1 19882051 (1)
    liver diseases 21.4 2 18930330 (1), 8335211 (1)
    epilepsy 0 1 17008177 (1)

    Genetic Association Database (GAD): SLC4A2
    Human Genome Epidemiology (HuGE) Navigator: SLC4A2 (13 documents)

    Export disorders for SLC4A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC4A2 gene, integrated from 9 sources (see all 132):
    (articles sorted by number of sources associating them with SLC4A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic factors of susceptibility and of severity in primary biliary cirrhosis. (PubMed id 18930330)1, 4, 9 Poupon R....Barbu V. (2008)
    2. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    3. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Common genetic variation and haplotypes of the anion exchanger SLC4A2 in primary biliary cirrhosis. (PubMed id 19491853)1, 4 Juran B.D....Lazaridis K.N. (2009)
    7. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
    8. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
    9. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6522 HGNC: 11028 AceView: SLC4A2 Ensembl:ENSG00000164889 euGenes: HUgn6522
    ECgene: SLC4A2 Kegg: 6522 H-InvDB: SLC4A2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC4A2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/slc4a2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC4A2 gene:
    Search GeneIP for patents involving SLC4A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Purified and/or Recombinant SLC4A2 Protein
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC4A2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC4A2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC4A2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC4A2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC4A2   OriGene Custom Protein Services for SLC4A2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC4A2
     QIAGEN SeqTarget long-range PCR primers for resequencing SLC4A2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC4A2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC4A2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC4A2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC4A2
     GenScript Custom Purified and Recombinant Proteins Services for SLC4A2 GenScript cDNA clones with any tag delivered in your preferred vector for SLC4A2
     GenScript Custom Assay Services for SLC4A2 GenScript Custom Superior Antibodies Services for SLC4A2
     GenScript Custom overexpressing Cell Line Services for SLC4A2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC4A2 promoter
     Search Chromatin IP Primers for SLC4A2
     RT2 qPCR Primer Assay in human, mouse, rat SLC4A2
     GNC Network for SLC4A2
     SABiosciences Custom PCR Arrays for SLC4A2
     Search Tocris compounds for SLC4A2 (B3A2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC4A2 antibodies
     SLC4A2 proteins
     Antibodies for SLC4A2
     See all of Abcam's Antibodies, Kits and Proteins for SLC4A2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Cell Line associated with SLC4A2: PureStem ES-210, Ecto-ntu Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC4A2
     SwitchGear 3'UTR luciferase reporter plasmids for SLC4A2
     SwitchGear Promoter luciferase reporter plasmids for SLC4A2
     ThermoFisher Antibodies for SLC4A2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC4A2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC4A2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC4A2
    Customized:
     lentivirus for stable overexpression of SLC4A2
     lentivirus expression plasmids for stable overexpression of SLC4A2
     adenovirus for overexpression of SLC4A2
     LSBio Antibodies in human, mouse, rat for SLC4A2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC4A2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4