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Aliases for SLC4A2 Gene

Aliases for SLC4A2 Gene

  • Solute Carrier Family 4 (Anion Exchanger), Member 2 2 3
  • EPB3L1 3 4 6
  • AE2 3 4 6
  • Erythrocyte Membrane Protein Band 3-Like 1 2 3
  • Non-Erythroid Band 3-Like Protein 3 4
  • Solute Carrier Family 4 Member 2 3 4
  • Anion Exchanger 2 Type B1 2 3
  • Anion Exchanger 2 Type B2 2 3
  • Anion Exchanger 2 Type A 2 3
  • BND3L 3 4
  • AE 2 3 4
  • HKB3 3 4
  • Solute Carrier Family 4, Anion Exchanger, Member 2 (Erythrocyte Membrane Protein Band 3-Like 1) 2
  • Anion Exchange Protein 2 3
  • Anion Exchanger 2 4
  • NBND3 3
  • MPB3L 4

External Ids for SLC4A2 Gene

Previous HGNC Symbols for SLC4A2 Gene

  • EPB3L1
  • AE2

Previous GeneCards Identifiers for SLC4A2 Gene

  • GC07P149003
  • GC07P150072
  • GC07P150148
  • GC07P150194
  • GC07P150387
  • GC07P150754
  • GC07P144569

Summaries for SLC4A2 Gene

GeneCards Summary for SLC4A2 Gene

SLC4A2 (Solute Carrier Family 4 (Anion Exchanger), Member 2) is a Protein Coding gene. Diseases associated with SLC4A2 include hereditary elliptocytosis and primary biliary cirrhosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Salivary secretion. GO annotations related to this gene include inorganic anion exchanger activity and anion transmembrane transporter activity. An important paralog of this gene is SLC4A8.

UniProtKB/Swiss-Prot for SLC4A2 Gene

  • Plasma membrane anion exchange protein of wide distribution

Gene Wiki entry for SLC4A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A2 Gene

Genomics for SLC4A2 Gene

Regulatory Elements for SLC4A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC4A2 Gene

Start:
151,057,210 bp from pter
End:
151,076,527 bp from pter
Size:
19,318 bases
Orientation:
Plus strand

Genomic View for SLC4A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC4A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A2 Gene

Proteins for SLC4A2 Gene

  • Protein details for SLC4A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04920-B3A2_HUMAN
    Recommended name:
    Anion exchange protein 2
    Protein Accession:
    P04920
    Secondary Accessions:
    • B2R6T0
    • B4DIT0
    • D3DX05
    • F8W682
    • Q45EY5
    • Q969L3

    Protein attributes for SLC4A2 Gene

    Size:
    1241 amino acids
    Molecular mass:
    137009 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC4A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC4A2 Gene

Proteomics data for SLC4A2 Gene at MOPED

Post-translational modifications for SLC4A2 Gene

  • Ubiquitination at Lys658
  • Glycosylation at Asn859, Asn868, and Asn882
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SLC4A2 Gene

Domains for SLC4A2 Gene

Gene Families for SLC4A2 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P04920

UniProtKB/Swiss-Prot:

B3A2_HUMAN :
  • P04920
Family:
  • Belongs to the anion exchanger (TC 2.A.31) family.
genes like me logo Genes that share domains with SLC4A2: view

Function for SLC4A2 Gene

Molecular function for SLC4A2 Gene

GENATLAS Biochemistry:
solute carrier family 4 (chloride-bicarbonate,anion exchange),member 2
UniProtKB/Swiss-Prot Function:
Plasma membrane anion exchange protein of wide distribution

Gene Ontology (GO) - Molecular Function for SLC4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005452 inorganic anion exchanger activity IEA --
GO:0008509 anion transmembrane transporter activity TAS 3015590
GO:0015108 chloride transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC4A2: view
genes like me logo Genes that share phenotypes with SLC4A2: view

Animal Models for SLC4A2 Gene

MGI Knock Outs for SLC4A2:

Animal Model Products

CRISPR Products

miRNA for SLC4A2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC4A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC4A2 Gene

Localization for SLC4A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC4A2 Gene COMPARTMENTS Subcellular localization image for SLC4A2 gene
Compartment Confidence
plasma membrane 4
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC4A2: view

Pathways for SLC4A2 Gene

genes like me logo Genes that share pathways with SLC4A2: view

Gene Ontology (GO) - Biological Process for SLC4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport TAS --
GO:0006820 anion transport TAS 3015590
GO:0006821 chloride transport --
GO:0015701 bicarbonate transport TAS --
genes like me logo Genes that share ontologies with SLC4A2: view

Compounds for SLC4A2 Gene

(14) Novoseek inferred chemical compound relationships for SLC4A2 Gene

Compound -log(P) Hits PubMed IDs
bicarbonate 80 22
dids 78.8 3
stilbene 55.4 3
chloride 53.9 5
calmidazolium 52.1 2
genes like me logo Genes that share compounds with SLC4A2: view

Transcripts for SLC4A2 Gene

Unigene Clusters for SLC4A2 Gene

Solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC4A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - -
SP5: - - - - - - - - -
SP6:
SP7: - - - - - - -
SP8: -
SP9:
SP10: - - - - -
SP11: - - - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: - - -

ExUns: 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b · 25c ^ 26a · 26b ^ 27 ^ 28a · 28b · 28c ^ 29a · 29b ^
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16:
SP17: -
SP18:
SP19:

ExUns: 30a · 30b ^ 31 ^ 32
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for SLC4A2 Gene

GeneLoc Exon Structure for
SLC4A2
ECgene alternative splicing isoforms for
SLC4A2

Expression for SLC4A2 Gene

mRNA expression in normal human tissues for SLC4A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SLC4A2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.6), Stomach (12.1), and Placenta (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC4A2 Gene

SOURCE GeneReport for Unigene cluster for SLC4A2 Gene Hs.647069

genes like me logo Genes that share expressions with SLC4A2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for SLC4A2 Gene

Orthologs for SLC4A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC4A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC4A2 35
  • 89.81 (n)
  • 95.15 (a)
SLC4A2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC4A2 35
  • 90.35 (n)
  • 95.23 (a)
SLC4A2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc4a2 35
  • 87.57 (n)
  • 94.73 (a)
Slc4a2 16
Slc4a2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC4A2 35
  • 99.49 (n)
  • 99.68 (a)
SLC4A2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc4a2 35
  • 87.91 (n)
  • 94.32 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC4A2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 30 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SLC4A2 35
  • 78.09 (n)
  • 81.01 (a)
SLC4A2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC4A2 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc4a2b 35
  • 67.46 (n)
  • 70.78 (a)
slc4a2a 36
  • 65 (a)
OneToMany
slc4a2b 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8177 37
  • 44 (a)
CG8177 35
  • 54.07 (n)
  • 47.83 (a)
CG8177 36
  • 37 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006115 35
  • 57.13 (n)
  • 49.23 (a)
worm
(Caenorhabditis elegans)
Secernentea R03E9.3 37
  • 26 (a)
abts-4 36
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BOR1 36
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G06450 35
  • 42.36 (n)
  • 29.64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for SLC4A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC4A2 Gene

ENSEMBL:
Gene Tree for SLC4A2 (if available)
TreeFam:
Gene Tree for SLC4A2 (if available)

Paralogs for SLC4A2 Gene

Paralogs for SLC4A2 Gene

genes like me logo Genes that share paralogs with SLC4A2: view

Variants for SLC4A2 Gene

Sequence variations from dbSNP and Humsavar for SLC4A2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1050701 -- 151,064,583(+) TCCGG(A/G)TGCAC reference, missense
rs1050702 -- 151,064,593(+) CGCCG(A/C)CGCAA synonymous-codon, reference
rs1050703 -- 151,070,236(+) GCTCC(C/G)TGGGC reference, missense
rs1063531 -- 151,064,673(+) CATTG(A/T)GGAGG reference, missense
rs1131280 -- 151,064,529(+) GTACC(A/G)CCGCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC4A2 Gene

Variant ID Type Subtype PubMed ID
nsv889465 CNV Loss 21882294
nsv526410 CNV Loss 19592680
nsv889476 CNV Loss 21882294
nsv524928 CNV Gain 19592680
nsv889477 CNV Loss 21882294
dgv7545n71 CNV Loss 21882294
nsv831188 CNV Loss 17160897
dgv7546n71 CNV Loss 21882294
nsv517508 CNV Loss 19592680
nsv465215 CNV Loss 19166990
nsv6004 CNV Insertion 18451855
dgv7547n71 CNV Loss 21882294
dgv7548n71 CNV Loss 21882294

Relevant External Links for SLC4A2 Gene

HapMap Linkage Disequilibrium report
SLC4A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A2 Gene

Disorders for SLC4A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC4A2 Gene in MalaCards »

(2) Diseases for SLC4A2 Gene including...

(4) Novoseek inferred disease relationships for SLC4A2 Gene

Disease -log(P) Hits PubMed IDs
biliary cirrhosis primary 63.5 3
cholestasis 39.1 1
liver diseases 21.4 2
epilepsy 0 1

Relevant External Links for SLC4A2

Genetic Association Database (GAD)
SLC4A2
Human Genome Epidemiology (HuGE) Navigator
SLC4A2
genes like me logo Genes that share disorders with SLC4A2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for SLC4A2 Gene

Publications for SLC4A2 Gene

  1. Genetic factors of susceptibility and of severity in primary biliary cirrhosis. (PMID: 18930330) Poupon R. … Barbu V. (J. Hepatol. 2008) 3 23 48
  2. Expression of anion exchanger 2 in human gastric cancer. (PMID: 18438347) Yang Y. … Fu G.H. (Exp. Oncol. 2008) 3 23
  3. Reduction of anion exchanger 2 expression induces apoptosis of human hepatocellular carcinoma cells. (PMID: 19224338) Hwang J.M. … Liu J.Y. (Mol. Cell. Biochem. 2009) 3 23
  4. Overexpression of anion exchanger 2 in human hepatocellular carcinoma. (PMID: 17058451) Wu T.T. … Liu J.Y. (Chin J Physiol 2006) 3 23
  5. Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters. (PMID: 17652430) Morgan P.E. … Casey J.R. (Am. J. Physiol., Cell Physiol. 2007) 3 23

Products for SLC4A2 Gene

Sources for SLC4A2 Gene

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