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Aliases for SLC4A1AP Gene

Aliases for SLC4A1AP Gene

  • Solute Carrier Family 4 (Anion Exchanger), Member 1, Adaptor Protein 2 3
  • Solute Carrier Family 4 (Anion Exchanger), Member 1, Adapter Protein 2 3
  • Solute Carrier Family 4 Anion Exchanger Member 1 Adapter Protein 3 4
  • Kidney Anion Exchanger Adapter Protein 3 4
  • Human Lung Cancer Oncogene 3 Protein 3 4
  • Lung Cancer Oncogene 3 2 3
  • HLC-3 3 4
  • Kidney Anion Exchanger Adaptor Protein 3
  • Kanadaptin 3
  • HLC3 3

External Ids for SLC4A1AP Gene

Previous GeneCards Identifiers for SLC4A1AP Gene

  • GC02P027807
  • GC02P027978
  • GC02P027844
  • GC02P027861
  • GC02P027862
  • GC02P027797
  • GC02P027739
  • GC02P027886
  • GC02P027627

Summaries for SLC4A1AP Gene

GeneCards Summary for SLC4A1AP Gene

SLC4A1AP (Solute Carrier Family 4 (Anion Exchanger), Member 1, Adaptor Protein) is a Protein Coding gene. Diseases associated with SLC4A1AP include lung cancer. An important paralog of this gene is PPP1R8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A1AP Gene

Genomics for SLC4A1AP Gene

Regulatory Elements for SLC4A1AP Gene

Genomic Location for SLC4A1AP Gene

Start:
27,663,471 bp from pter
End:
27,694,980 bp from pter
Size:
31,510 bases
Orientation:
Plus strand

Genomic View for SLC4A1AP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC4A1AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A1AP Gene

Proteins for SLC4A1AP Gene

  • Protein details for SLC4A1AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWU0-NADAP_HUMAN
    Recommended name:
    Kanadaptin
    Protein Accession:
    Q9BWU0
    Secondary Accessions:
    • A6NJ39
    • Q4KMT1
    • Q4KMX0
    • Q7Z5Q9
    • Q9NVN2

    Protein attributes for SLC4A1AP Gene

    Size:
    796 amino acids
    Molecular mass:
    88814 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAN12269.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLC4A1AP Gene

neXtProt entry for SLC4A1AP Gene

Proteomics data for SLC4A1AP Gene at MOPED

Post-translational modifications for SLC4A1AP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC4A1AP Gene

No data available for DME Specific Peptides for SLC4A1AP Gene

Domains for SLC4A1AP Gene

Protein Domains for SLC4A1AP Gene

Suggested Antigen Peptide Sequences for SLC4A1AP Gene

Graphical View of Domain Structure for InterPro Entry

Q9BWU0

UniProtKB/Swiss-Prot:

NADAP_HUMAN :
  • Q9BWU0
Domain:
  • Contains 1 FHA domain.
genes like me logo Genes that share domains with SLC4A1AP: view

No data available for Gene Families for SLC4A1AP Gene

Function for SLC4A1AP Gene

Gene Ontology (GO) - Molecular Function for SLC4A1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17553790
genes like me logo Genes that share ontologies with SLC4A1AP: view

miRNA for SLC4A1AP Gene

miRTarBase miRNAs that target SLC4A1AP

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC4A1AP Gene

Localization for SLC4A1AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A1AP Gene

Nucleus. Cytoplasm. Note=Mainly nuclear. Small amounts are found in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC4A1AP Gene COMPARTMENTS Subcellular localization image for SLC4A1AP gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC4A1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SLC4A1AP: view

Pathways for SLC4A1AP Gene

SuperPathways for SLC4A1AP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC4A1AP Gene

None

No data available for Pathways by source for SLC4A1AP Gene

Transcripts for SLC4A1AP Gene

Unigene Clusters for SLC4A1AP Gene

Solute carrier family 4 (anion exchanger), member 1, adaptor protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A1AP Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: - - -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for SLC4A1AP Gene

GeneLoc Exon Structure for
SLC4A1AP
ECgene alternative splicing isoforms for
SLC4A1AP

Expression for SLC4A1AP Gene

mRNA expression in normal human tissues for SLC4A1AP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC4A1AP Gene

SOURCE GeneReport for Unigene cluster for SLC4A1AP Gene Hs.306000

mRNA Expression by UniProt/SwissProt for SLC4A1AP Gene

Q9BWU0-NADAP_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with SLC4A1AP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC4A1AP Gene

Orthologs for SLC4A1AP Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC4A1AP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC4A1AP 35
  • 99.58 (n)
  • 99.37 (a)
SLC4A1AP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
SLC4A1AP 35
  • 86.98 (n)
  • 84.59 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
SLC4A1AP 35
  • 88.24 (n)
  • 86.22 (a)
mouse
(Mus musculus)
Mammalia Slc4a1ap 35
  • 82.35 (n)
  • 79.97 (a)
Slc4a1ap 16
Slc4a1ap 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC4A1AP 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC4A1AP 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc4a1ap 35
  • 82.61 (n)
  • 81.72 (a)
chicken
(Gallus gallus)
Aves SLC4A1AP 35
  • 72.59 (n)
  • 72.86 (a)
SLC4A1AP 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC4A1AP 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc4a1ap 35
  • 65.99 (n)
  • 68.48 (a)
Str.11601 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11762 35
slc4a1ap 35
  • 62.3 (n)
  • 60.48 (a)
slc4a1ap 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004588 35
  • 49.07 (n)
  • 41.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7706 35
  • 49.3 (n)
  • 42.16 (a)
CG7706 36
  • 33 (a)
OneToOne
CG7706 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK632.2 36
  • 29 (a)
OneToOne
ZK632.2 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for SLC4A1AP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC4A1AP Gene

ENSEMBL:
Gene Tree for SLC4A1AP (if available)
TreeFam:
Gene Tree for SLC4A1AP (if available)

Paralogs for SLC4A1AP Gene

Paralogs for SLC4A1AP Gene

Pseudogenes.org Pseudogenes for SLC4A1AP Gene

genes like me logo Genes that share paralogs with SLC4A1AP: view

Variants for SLC4A1AP Gene

Sequence variations from dbSNP and Humsavar for SLC4A1AP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1919130 -- 27,690,695(-) cccgg(A/G)caaca intron-variant
rs2178198 -- 27,672,206(+) GTTTT(C/T)TGCAA intron-variant
rs2272406 -- 27,669,156(+) CATCT(A/T)AAAAA intron-variant
rs3039811 -- 27,686,499(+) gctgc(-/TC)acgcc intron-variant
rs6737034 -- 27,671,385(+) ttttc(C/T)taagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC4A1AP Gene

Variant ID Type Subtype PubMed ID
esv2660490 CNV Deletion 23128226

Relevant External Links for SLC4A1AP Gene

HapMap Linkage Disequilibrium report
SLC4A1AP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A1AP Gene

Disorders for SLC4A1AP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC4A1AP Gene including...

Search for SLC4A1AP Gene in MalaCards »

Relevant External Links for SLC4A1AP

Genetic Association Database (GAD)
SLC4A1AP
genes like me logo Genes that share disorders with SLC4A1AP: view

No data available for UniProtKB/Swiss-Prot for SLC4A1AP Gene

Publications for SLC4A1AP Gene

  1. Kanadaptin is a protein that interacts with the kidney but not the erythroid form of band 3. (PMID: 9422766) Chen J. … Al-Awqati Q. (J. Biol. Chem. 1998) 2 3 23
  2. Human kanadaptin and kidney anion exchanger 1 (kAE1) do not interact in transfected HEK 293 cells. (PMID: 15764369) Kittanakom S. … Reithmeier R.A.F. (Mol. Membr. Biol. 2004) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for SLC4A1AP Gene

Sources for SLC4A1AP Gene

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