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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC4A1AP Gene

protein-coding   GIFtS: 45
GCID: GC02P027886

solute carrier family 4 (anion exchanger), member 1, adaptor...

(Previous names: solute carrier family 4 (anion exchanger), member 1, adapter...)
 Explore 2 diseases affiliated with
SLC4A1AP via our new
 Human Malady Compendium 
Biological research products
for SLC4A1AP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Solute Carrier Family 4 (Anion Exchanger), Member 1, Adaptor Protein1 2     Solute Carrier Family 4 Anion Exchanger Member 1 Adapter Protein2 3
Kanadaptin1     HLC-32 3
Solute Carrier Family 4 (Anion Exchanger), Member 1, Adapter Protein1 2     HLC31
Human Lung Cancer Oncogene 3 Protein2 3     Kidney Anion Exchanger Adaptor Protein2
Kidney Anion Exchanger Adapter Protein2 3     Lung Cancer Oncogene 32

External Ids:    HGNC: 138131   Entrez Gene: 229502   Ensembl: ENSG000001637987   OMIM: 6026555   UniProtKB: Q9BWU03   

Export aliases for SLC4A1AP gene to outside databases

Previous GC identifers: GC02P027807 GC02P027978 GC02P027844 GC02P027861 GC02P027862 GC02P027797 GC02P027739 GC02P027627


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC4A1AP gene promoter:
         TBP   Spz1   Elk-1   STAT5A   PPAR-alpha   TFIID   STAT3   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC4A1AP promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC4A1AP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC4A1AP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

SLC4A1AP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC4A1AP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P027886:  view genomic region     (about GC identifiers)

Start:
27,886,338 bp from pter      End:
27,917,847 bp from pter
Size:
31,510 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NADAP_HUMAN, Q9BWU0 (See protein sequence)
Recommended Name: Kanadaptin  
Size: 796 amino acids; 88814 Da
Subcellular location: Nucleus. Cytoplasm. Note=Mainly nuclear. Small amounts are found in the cytoplasm
Caution: PubMed:15764369 initially suggested a role in targeting SLC4A1 (kidney anion exchanger 1) to the plasma
membrane; it does not seem to do so as it does not interact with SLC4A1 and has no effect on SLC4A1 trafficking
Sequence caution: Sequence=AAN12269.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SLC4A1AP:
4H87 (3D)    
Secondary accessions: A6NJ39 Q4KMT1 Q4KMX0 Q7Z5Q9 Q9NVN2

Explore the universe of human proteins at neXtProt for SLC4A1AP: NX_Q9BWU0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BWU0

  • SLC4A1AP Protein expression data from MOPED and PaxDb:    About this image 
    SLC4A1AP Protein Expression
    REFSEQ proteins: NP_060628.2  
    ENSEMBL proteins: 
     ENSP00000323837   ENSP00000404129  

    Human Recombinant Protein Products for SLC4A1AP: 
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    Novus Biologicals SLC4A1AP Proteins
    Novus Biologicals SLC4A1AP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IEA--

    SLC4A1AP for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC4A1AP for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001159 Ds-RNA-bd
     IPR008984 SMAD_FHA_domain
     IPR000253 FHA_dom

    Graphical View of Domain Structure for InterPro Entry Q9BWU0

    ProtoNet protein and cluster: Q9BWU0

    1 Blocks protein family: IPB000253 Forkhead-associated (FHA)

    UniProtKB/Swiss-Prot: NADAP_HUMAN, Q9BWU0
    Similarity: Contains 1 FHA domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding IEA--
    GO:0005515protein binding IPI17553790
         
    SLC4A1AP for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Slc4a1ap (no phenotypes)

    SLC4A1AP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC4A1AP 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSLC4A1AP 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC4A1AP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC4A1AP

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/7 Interacting proteins for SLC4A1AP (Q9BWU01, 3 ENSP000003238374) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ILKQ134181, 3, ENSP000002994214EBI-1999704,EBI-747644 I2D: score=1 STRING: ENSP00000299421
    SLC4A1P027303, ENSP000002624184I2D: score=2 STRING: ENSP00000262418
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    PSMC6P623333I2D: score=1 
    RBL1P287493I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC4A1AP
    Search CenterWatch for drugs/clinical trials and news about SLC4A1AP / NADAP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC4A1AP gene: 
    NM_018158.2  

    Unigene Cluster for SLC4A1AP:

    Solute carrier family 4 (anion exchanger), member 1, adaptor protein
    Hs.306000  [show with all ESTs]
    Unigene Representative Sequence: NM_018158
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326019(uc002rlk.4) ENST00000427424 ENST00000492196

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC4A1AP:
    hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidSLC4A1AP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC4A1AP (see all 7)
    OriGene shRNA RFP: SLC4A1AP
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC4A1AP
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    Additional cDNA sequence: 

    AK001486.1 AK300958.1 AY028435.1 AY117688.1 BC098302.1 BC098358.1 BC099711.1 BC099739.1 
    DQ786283.1 U38432.1 

    12 DOTS entries:

    DT.100675496  DT.100703335  DT.95149029  DT.411112  DT.100826887  DT.92444493  DT.99936021  DT.121010651 
    DT.92444487  DT.95231044  DT.436333  DT.92444491 

    24/203 AceView cDNA sequences (see all 203):

    BE328256 AU146606 AY028435 CA446643 N26833 BM015979 BF197202 AI292134 
    U38432 AA748416 AI421543 AU120573 BU178379 AW991229 AL698208 AL597506 
    BQ029054 CB054194 AI027674 AI362266 AI208150 CB851587 AI123425 BQ021685 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A1AP (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                      -                                                                                       
    SP2:        -     -                       -                                                                                       
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for SLC4A1AP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC4A1AP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATCCTATTAA
    SLC4A1AP Expression
    About this image
    See SLC4A1AP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC4A1AP

    SOURCE GeneReport for Unigene cluster: Hs.306000

    UniProtKB/Swiss-Prot: NADAP_HUMAN, Q9BWU0
    Tissue specificity: Ubiquitously expressed

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC4A1AP gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SLC4A1AP1 solute carrier family 4 (anion exchanger), member 1, more 67.96(n)
    65.17(a)
      421420  XM_419473.3  XP_419473.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC4A1AP6
    --
    59(a)
    1 ↔ 1
    2(125217669-125238759)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.116012 Transcribed sequence with weak similarity to protein more 73.59(n)    BX717637.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.117622 Transcribed sequence with weak similarity to protein more 78.06(n)    AI878160.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG77061 , 3 anion exchanger adaptor3
    CG77061
    36(a)3
    47.99(n)1
    40.15(a)1
      91C13
    422441  NM_142485.21  NP_650742.21 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK632.21 , 3 Coiled coil protein3
    Protein ZK632.21
    33(a)3
    47.25(n)1
    36.01(a)1
      III(9870825-9873999)3
    1763861  NM_066771.31  NP_499172.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G388401 SMAD/FHA domain-containing protein 44.53(n)
    32.67(a)
      833875  NM_123245.3  NP_198700.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g02759001 hypothetical protein 43.82(n)
    34.11(a)
      4340752  NM_001063918.1  NP_001057383.1 


    ENSEMBL Gene Tree for SLC4A1AP (if available)
    TreeFam Gene Tree for SLC4A1AP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC4A1AP gene
    SNIP12  

    SLC4A1AP for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SLC4A1AP
    PGOHUM00000245127 PGOHUM00000236000


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/520 NCBI SNPs in SLC4A1AP are shown (see all 520    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503009461,2
    C,F--27886669(+) TTCACC/TATCGC 2 P L mis11Minor allele frequency- T:0.00NA 4550
    rs1490668671,2
    C,F--27886701(+) GCTTGG/AGAGAG 2 /R /G mis12Minor allele frequency- A:0.00NA EU 5871
    rs1392878061,2
    C,F--27886725(+) GGAACG/CTAAAG 2 /L /V mis12Minor allele frequency- C:0.00NA EU 5871
    rs1165169531,2
    C,F--27886743(+) GGTGGG/TTTTCG 2 V F mis11Minor allele frequency- T:0.01WA 216
    rs1385674411,2
    C,F--27886778(+) CGGTTG/CAGGAT 2 /F /L mis11Minor allele frequency- C:0.00NA 4552
    rs2017549951,2
    --27886800(+) TCTCTC/GAGTCA 2 Q E mis10--------
    rs1396894831,2
    C,F--27886811(+) GAGACC/TCTGGC 2 T syn11Minor allele frequency- T:0.00NA 4552
    rs581067411,2
    C,F--27886820(+) GCGTCG/TCAAGA 2 S syn110Minor allele frequency- T:0.07NS CSA NA WA EU 6751
    rs617449251,2
    C,F--27886835(+) AGTGGG/TGACTT 2 G syn14Minor allele frequency- T:0.00NS WA NA 5052
    rs1909431801,2
    C--27886852(+) GCCAGC/TTCTGC 2 A V mis10--------

    HapMap Linkage Disequilibrium report for SLC4A1AP (27886338 - 27917847 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC4A1AP: --

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC4A1AP
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC4A1AP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC4A1AP for disorders           About GeneDecksing

    OMIM gene information: 602655    OMIM disorders: --

    2 diseases for SLC4A1AP:    About MalaCards
    lung cancer    renal tubular acidosis


    Export disorders for SLC4A1AP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC4A1AP gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with SLC4A1AP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human kanadaptin and kidney anion exchanger 1 (kAE1) do not interact in transfected HEK 293 cells. (PubMed id 15764369)1, 2, 9 Kittanakom S.... Reithmeier R.A.F. (2004)
    2. Kanadaptin is a protein that interacts with the kidney but not the erythroid form of band 3. (PubMed id 9422766)1, 3, 9 Chen J....Al-Awqati Q. (1998)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Genetic variants associated with breast size also infl uence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (2012)
    9. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere s hortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22950 HGNC: 13813 AceView: SLC4A1AP Ensembl:ENSG00000163798 euGenes: HUgn22950
    ECgene: SLC4A1AP H-InvDB: SLC4A1AP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC4A1AP Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Band_3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC4A1AP gene:
    Search GeneIP for patents involving SLC4A1AP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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