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Aliases for SLC4A1AP Gene

Aliases for SLC4A1AP Gene

  • Solute Carrier Family 4 Member 1 Adaptor Protein 2 3 5
  • Solute Carrier Family 4 (Anion Exchanger), Member 1, Adapter Protein 2 3
  • Solute Carrier Family 4 (Anion Exchanger), Member 1, Adaptor Protein 2 3
  • Solute Carrier Family 4 Anion Exchanger Member 1 Adapter Protein 3 4
  • Kidney Anion Exchanger Adapter Protein 3 4
  • Human Lung Cancer Oncogene 3 Protein 3 4
  • Lung Cancer Oncogene 3 2 3
  • HLC-3 3 4
  • Kidney Anion Exchanger Adaptor Protein 3
  • Kanadaptin 3
  • HLC3 3

External Ids for SLC4A1AP Gene

Previous GeneCards Identifiers for SLC4A1AP Gene

  • GC02P027807
  • GC02P027978
  • GC02P027844
  • GC02P027861
  • GC02P027862
  • GC02P027797
  • GC02P027739
  • GC02P027886
  • GC02P027627

Summaries for SLC4A1AP Gene

GeneCards Summary for SLC4A1AP Gene

SLC4A1AP (Solute Carrier Family 4 Member 1 Adaptor Protein) is a Protein Coding gene. An important paralog of this gene is PPP1R8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A1AP Gene

Genomics for SLC4A1AP Gene

Regulatory Elements for SLC4A1AP Gene

Enhancers for SLC4A1AP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F027684 0.8 ENCODE 21.1 +22.3 22338 2.7 FOSL1 ZNF316 HINFP ZNF512 FOS MAFK SLC4A1AP SUPT7L LINC01460 CCDC121 GPN1 ZNF512 C2orf16 KRTCAP3 OST4 LOC105374378
GH02F027656 0.7 FANTOM5 12.9 -7.3 -7319 0.3 MAFK SLC4A1AP GPN1 CCDC121 ZNF512 IFT172 NRBP1 KRTCAP3 SLC5A6 SUPT7L GTF3C2
GH02F027662 0.4 ENCODE 12.7 +0.2 175 2.4 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 GPN1 NRBP1 GTF3C2 EMILIN1 ZNF512 SNX17 SLC4A1AP OST4 ENSG00000233438 ENSG00000206731
GH02F027689 0.5 ENCODE 11.9 +26.2 26178 0.2 MAFG SLC4A1AP SUPT7L LINC01460 CCDC121 GPN1 ZNF512 C2orf16 LOC105374378
GH02F027636 1.1 ENCODE 11.6 -25.2 -25246 3.2 MAFG ZNF316 MAFF JUND ZNF512 GLIS1 FOS MAFK EMSY SNX17 SLC4A1AP KRTCAP3 CGREF1 OST4 ENSG00000206731 GC02M027644 CCDC121
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC4A1AP on UCSC Golden Path with GeneCards custom track

Promoters for SLC4A1AP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000012102 329 2001 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for SLC4A1AP Gene

Chromosome:
2
Start:
27,663,471 bp from pter
End:
27,694,980 bp from pter
Size:
31,510 bases
Orientation:
Plus strand

Genomic View for SLC4A1AP Gene

Genes around SLC4A1AP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC4A1AP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC4A1AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A1AP Gene

Proteins for SLC4A1AP Gene

  • Protein details for SLC4A1AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWU0-NADAP_HUMAN
    Recommended name:
    Kanadaptin
    Protein Accession:
    Q9BWU0
    Secondary Accessions:
    • A6NJ39
    • Q4KMT1
    • Q4KMX0
    • Q7Z5Q9
    • Q9NVN2

    Protein attributes for SLC4A1AP Gene

    Size:
    796 amino acids
    Molecular mass:
    88814 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAN12269.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLC4A1AP Gene

neXtProt entry for SLC4A1AP Gene

Post-translational modifications for SLC4A1AP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC4A1AP Gene

No data available for DME Specific Peptides for SLC4A1AP Gene

Domains & Families for SLC4A1AP Gene

Protein Domains for SLC4A1AP Gene

Suggested Antigen Peptide Sequences for SLC4A1AP Gene

Graphical View of Domain Structure for InterPro Entry

Q9BWU0

UniProtKB/Swiss-Prot:

NADAP_HUMAN :
  • Contains 1 FHA domain.
Domain:
  • Contains 1 FHA domain.
genes like me logo Genes that share domains with SLC4A1AP: view

No data available for Gene Families for SLC4A1AP Gene

Function for SLC4A1AP Gene

Gene Ontology (GO) - Molecular Function for SLC4A1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 17553790
genes like me logo Genes that share ontologies with SLC4A1AP: view

Phenotypes for SLC4A1AP Gene

GenomeRNAi human phenotypes for SLC4A1AP:
genes like me logo Genes that share phenotypes with SLC4A1AP: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC4A1AP Gene

Localization for SLC4A1AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A1AP Gene

Nucleus. Cytoplasm. Note=Mainly nuclear. Small amounts are found in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC4A1AP Gene COMPARTMENTS Subcellular localization image for SLC4A1AP gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC4A1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SLC4A1AP: view

Pathways & Interactions for SLC4A1AP Gene

SuperPathways for SLC4A1AP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC4A1AP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC4A1AP Gene

Transcripts for SLC4A1AP Gene

Unigene Clusters for SLC4A1AP Gene

Solute carrier family 4 (anion exchanger), member 1, adaptor protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A1AP Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: - - -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for SLC4A1AP Gene

GeneLoc Exon Structure for
SLC4A1AP
ECgene alternative splicing isoforms for
SLC4A1AP

Expression for SLC4A1AP Gene

mRNA expression in normal human tissues for SLC4A1AP Gene

Protein differential expression in normal tissues from HIPED for SLC4A1AP Gene

This gene is overexpressed in Lung (29.3) and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC4A1AP Gene



Protein tissue co-expression partners for SLC4A1AP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC4A1AP Gene:

SLC4A1AP

SOURCE GeneReport for Unigene cluster for SLC4A1AP Gene:

Hs.306000

mRNA Expression by UniProt/SwissProt for SLC4A1AP Gene:

Q9BWU0-NADAP_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with SLC4A1AP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC4A1AP Gene

Orthologs for SLC4A1AP Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC4A1AP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC4A1AP 34 35
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 90 (a)
OneToMany
SLC4A1AP 34
  • 86.98 (n)
-- 35
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLC4A1AP 34
  • 88.24 (n)
-- 35
  • 81 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc4a1ap 34
  • 82.61 (n)
mouse
(Mus musculus)
Mammalia Slc4a1ap 34 16 35
  • 82.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC4A1AP 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC4A1AP 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC4A1AP 34 35
  • 72.59 (n)
lizard
(Anolis carolinensis)
Reptilia SLC4A1AP 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc4a1ap 34
  • 65.99 (n)
Str.11601 34
zebrafish
(Danio rerio)
Actinopterygii slc4a1ap 34 35
  • 62.3 (n)
Dr.11762 34
fruit fly
(Drosophila melanogaster)
Insecta CG7706 36 34 35
  • 49.3 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004588 34
  • 49.07 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK632.2 36 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToOne
Species where no ortholog for SLC4A1AP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC4A1AP Gene

ENSEMBL:
Gene Tree for SLC4A1AP (if available)
TreeFam:
Gene Tree for SLC4A1AP (if available)

Paralogs for SLC4A1AP Gene

Paralogs for SLC4A1AP Gene

Pseudogenes.org Pseudogenes for SLC4A1AP Gene

genes like me logo Genes that share paralogs with SLC4A1AP: view

Variants for SLC4A1AP Gene

Sequence variations from dbSNP and Humsavar for SLC4A1AP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10175280 -- 27,689,371(+) ttcac(A/G)agagg intron-variant
rs10200094 -- 27,689,935(+) actca(C/T)acctg intron-variant
rs10202366 -- 27,687,042(+) caagc(A/C)atcct intron-variant
rs10207293 -- 27,679,904(+) atatg(A/G)gagtg intron-variant
rs10659481 -- 27,673,302(+) TTCTT(-/TC)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC4A1AP Gene

Variant ID Type Subtype PubMed ID
esv2660490 CNV deletion 23128226
esv3448213 CNV insertion 20981092
esv3590144 CNV loss 21293372
nsv1151664 CNV insertion 26484159

Variation tolerance for SLC4A1AP Gene

Residual Variation Intolerance Score: 15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.90; 79.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC4A1AP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC4A1AP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A1AP Gene

Disorders for SLC4A1AP Gene

Relevant External Links for SLC4A1AP

Genetic Association Database (GAD)
SLC4A1AP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC4A1AP

No disorders were found for SLC4A1AP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC4A1AP Gene

Publications for SLC4A1AP Gene

  1. Human kanadaptin and kidney anion exchanger 1 (kAE1) do not interact in transfected HEK 293 cells. (PMID: 15764369) Kittanakom S. … Reithmeier R.A.F. (Mol. Membr. Biol. 2004) 3 4 22 64
  2. Kanadaptin is a protein that interacts with the kidney but not the erythroid form of band 3. (PMID: 9422766) Chen J. … Al-Awqati Q. (J. Biol. Chem. 1998) 2 3 22 64
  3. A comprehensive genetic association study of Alzheimer disease in African Americans. (PMID: 22159054) Logue M.W. … Farrer L.A. (Arch. Neurol. 2011) 3 46 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64

Products for SLC4A1AP Gene

Sources for SLC4A1AP Gene

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