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Aliases for SLC4A10 Gene

Aliases for SLC4A10 Gene

  • Solute Carrier Family 4 Member 10 2 3 4 5
  • Solute Carrier Family 4, Sodium Bicarbonate Transporter, Member 10 2 3
  • NCBE 3 4
  • Solute Carrier Family 4, Sodium Bicarbonate Cotransporter-Like, Member 10 3
  • Solute Carrier Family 4, Sodium Bicarbonate Transporter-Like, Member 10 2
  • Sodium-Driven Chloride Bicarbonate Exchanger 3
  • NBCn2 3

External Ids for SLC4A10 Gene

Previous GeneCards Identifiers for SLC4A10 Gene

  • GC02P160534
  • GC02P161009
  • GC02P162444
  • GC02P162683
  • GC02P162306
  • GC02P162189
  • GC02P162281
  • GC02P154363

Summaries for SLC4A10 Gene

Entrez Gene Summary for SLC4A10 Gene

  • This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

GeneCards Summary for SLC4A10 Gene

SLC4A10 (Solute Carrier Family 4 Member 10) is a Protein Coding gene. Diseases associated with SLC4A10 include Complex Partial Epilepsy. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and inorganic anion exchanger activity. An important paralog of this gene is SLC4A8.

UniProtKB/Swiss-Prot for SLC4A10 Gene

  • Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A10 Gene

Genomics for SLC4A10 Gene

Regulatory Elements for SLC4A10 Gene

Enhancers for SLC4A10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SLC4A10 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC4A10 Gene

Chromosome:
2
Start:
161,424,332 bp from pter
End:
161,985,282 bp from pter
Size:
560,951 bases
Orientation:
Plus strand

Genomic View for SLC4A10 Gene

Genes around SLC4A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC4A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC4A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A10 Gene

Proteins for SLC4A10 Gene

  • Protein details for SLC4A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6U841-S4A10_HUMAN
    Recommended name:
    Sodium-driven chloride bicarbonate exchanger
    Protein Accession:
    Q6U841
    Secondary Accessions:
    • B7Z1R0
    • B7Z2J0
    • B7ZLC5
    • B9EG69
    • F8W675
    • Q4ZFX6
    • Q8TCP2
    • Q9HCQ6

    Protein attributes for SLC4A10 Gene

    Size:
    1118 amino acids
    Molecular mass:
    125946 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC4A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC4A10 Gene

Post-translational modifications for SLC4A10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC4A10 Gene

No data available for DME Specific Peptides for SLC4A10 Gene

Domains & Families for SLC4A10 Gene

Gene Families for SLC4A10 Gene

Suggested Antigen Peptide Sequences for SLC4A10 Gene

Graphical View of Domain Structure for InterPro Entry

Q6U841

UniProtKB/Swiss-Prot:

S4A10_HUMAN :
  • Belongs to the anion exchanger (TC 2.A.31) family.
Family:
  • Belongs to the anion exchanger (TC 2.A.31) family.
genes like me logo Genes that share domains with SLC4A10: view

Function for SLC4A10 Gene

Molecular function for SLC4A10 Gene

UniProtKB/Swiss-Prot Function:
Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).

Gene Ontology (GO) - Molecular Function for SLC4A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity TAS --
GO:0008509 anion transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
GO:0015301 anion:anion antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC4A10: view
genes like me logo Genes that share phenotypes with SLC4A10: view

Animal Models for SLC4A10 Gene

MGI Knock Outs for SLC4A10:

Animal Model Products

CRISPR Products

miRNA for SLC4A10 Gene

miRTarBase miRNAs that target SLC4A10

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC4A10 Gene

Localization for SLC4A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A10 Gene

Cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC4A10 Gene COMPARTMENTS Subcellular localization image for SLC4A10 gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC4A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane NAS 10993873
GO:0016323 basolateral plasma membrane IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with SLC4A10: view

Pathways & Interactions for SLC4A10 Gene

genes like me logo Genes that share pathways with SLC4A10: view

Interacting Proteins for SLC4A10 Gene

Gene Ontology (GO) - Biological Process for SLC4A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport IEA --
GO:0006821 chloride transport NAS 10993873
GO:0006885 regulation of pH IEA --
GO:0007399 nervous system development IBA --
GO:0009416 response to light stimulus IEA --
genes like me logo Genes that share ontologies with SLC4A10: view

No data available for SIGNOR curated interactions for SLC4A10 Gene

Drugs & Compounds for SLC4A10 Gene

(1) Drugs for SLC4A10 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sodium bicarbonate Approved Pharma Transporter, substrate 0

(3) Additional Compounds for SLC4A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
71-52-3
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC4A10: view

Transcripts for SLC4A10 Gene

Unigene Clusters for SLC4A10 Gene

Solute carrier family 4, sodium bicarbonate transporter, member 10:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A10 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:

Relevant External Links for SLC4A10 Gene

GeneLoc Exon Structure for
SLC4A10
ECgene alternative splicing isoforms for
SLC4A10

Expression for SLC4A10 Gene

mRNA expression in normal human tissues for SLC4A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC4A10 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.5), Brain - Anterior cingulate cortex (BA24) (x8.5), and Brain - Cortex (x6.0).

Protein differential expression in normal tissues from HIPED for SLC4A10 Gene

This gene is overexpressed in Frontal cortex (38.4), Brain (23.0), and Retina (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC4A10 Gene



Protein tissue co-expression partners for SLC4A10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC4A10 Gene:

SLC4A10

SOURCE GeneReport for Unigene cluster for SLC4A10 Gene:

Hs.333958
genes like me logo Genes that share expression patterns with SLC4A10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC4A10 Gene

Orthologs for SLC4A10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC4A10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC4A10 34
  • 94.07 (n)
  • 99.18 (a)
SLC4A10 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC4A10 34
  • 95.67 (n)
  • 99.37 (a)
SLC4A10 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc4a10 34
  • 90.27 (n)
  • 97.74 (a)
Slc4a10 16
Slc4a10 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC4A10 34
  • 99.79 (n)
  • 99.91 (a)
SLC4A10 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc4a10 34
  • 89.43 (n)
  • 97.38 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC4A10 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC4A10 35
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC4A10 34
  • 82.9 (n)
  • 92.95 (a)
SLC4A10 35
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC4A10 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc4a10 34
  • 78.49 (n)
  • 88.49 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19338 34
zebrafish
(Danio rerio)
Actinopterygii LOC557642 34
  • 72.94 (n)
  • 83.35 (a)
SLC4A10 (2 of 2) 35
  • 81 (a)
OneToMany
slc4a10b 35
  • 82 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ndae1 36
  • 53 (a)
Ndae1 35
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F52B5.1 36
  • 47 (a)
R03E9.3 36
  • 23 (a)
abts-1 35
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToMany
Species where no ortholog for SLC4A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC4A10 Gene

ENSEMBL:
Gene Tree for SLC4A10 (if available)
TreeFam:
Gene Tree for SLC4A10 (if available)

Paralogs for SLC4A10 Gene

Paralogs for SLC4A10 Gene

genes like me logo Genes that share paralogs with SLC4A10: view

Variants for SLC4A10 Gene

Sequence variations from dbSNP and Humsavar for SLC4A10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1023835 -- 161,737,463(+) TGTTT(A/G)GTGGA intron-variant
rs1040135 -- 161,692,811(-) ATCGA(A/G)CTTGG intron-variant
rs1158463 -- 161,676,010(+) AAAAC(A/G)CCATT intron-variant
rs2175230 -- 161,641,612(-) AAATA(A/G)AAAGT intron-variant
rs2176135 -- 161,944,944(+) TATTT(A/G)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC4A10 Gene

Variant ID Type Subtype PubMed ID
esv1338019 CNV deletion 17803354
esv2646896 CNV deletion 19546169
esv2721050 CNV deletion 23290073
esv3304328 CNV mobile element insertion 20981092
esv3304423 CNV mobile element insertion 20981092
esv3380375 CNV insertion 20981092
esv3381795 CNV insertion 20981092
esv3584140 CNV loss 25503493
esv3593162 CNV loss 21293372
esv3593163 CNV loss 21293372
esv3593164 CNV loss 21293372
esv3593165 CNV loss 21293372
esv3593168 CNV loss 21293372
esv3593173 CNV loss 21293372
nsv1127776 CNV deletion 24896259
nsv3006 CNV insertion 18451855
nsv3007 CNV deletion 18451855
nsv3008 CNV insertion 18451855
nsv476511 CNV novel sequence insertion 20440878
nsv519410 CNV gain 19592680
nsv819853 CNV gain 19587683
nsv834438 CNV gain 17160897

Variation tolerance for SLC4A10 Gene

Residual Variation Intolerance Score: 6.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC4A10 Gene

Human Gene Mutation Database (HGMD)
SLC4A10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC4A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A10 Gene

Disorders for SLC4A10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC4A10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
complex partial epilepsy
  • complex partial epileptic seizure
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC4A10

Genetic Association Database (GAD)
SLC4A10
Human Genome Epidemiology (HuGE) Navigator
SLC4A10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC4A10
genes like me logo Genes that share disorders with SLC4A10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC4A10 Gene

Publications for SLC4A10 Gene

  1. AQP1 and SLC4A10 as candidate genes for primary open-angle glaucoma. (PMID: 20101282) Liu W. … Allingham R.R. (Mol. Vis. 2010) 3 46 65
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 46 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity. (PMID: 18319254) Parker M.D. … Boron W.F. (J. Biol. Chem. 2008) 2 3 65
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 65

Products for SLC4A10 Gene

Sources for SLC4A10 Gene

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