Aliases for SLC4A10 Gene
- Solute Carrier Family 4, Sodium Bicarbonate Transporter, Member 10 2 3
- NCBE 3 4
- Solute Carrier Family 4, Sodium Bicarbonate Cotransporter-Like, Member 10 3
- Solute Carrier Family 4, Sodium Bicarbonate Transporter-Like, Member 10 2
- Sodium-Driven Chloride Bicarbonate Exchanger 3
- Solute Carrier Family 4 Member 10 4
- NBCn2 3
External Ids for SLC4A10 Gene
This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
GeneCards Summary for SLC4A10 Gene
SLC4A10 (Solute Carrier Family 4, Sodium Bicarbonate Transporter, Member 10) is a Protein Coding gene. Diseases associated with SLC4A10 include complex partial epilepsy. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include symporter activity and inorganic anion exchanger activity. An important paralog of this gene is SLC4A8.
UniProtKB/Swiss-Prot for SLC4A10 Gene
Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).