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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC4A10 Gene

protein-coding   GIFtS: 60
GCID: GC02P162444

Solute Carrier Family 4, Sodium Bicarbonate Transporter,...

(Previous names: solute carrier family 4, sodium bicarbonate transporter-like,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 4, Sodium Bicarbonate Transporter, Member 101 2     Sodium-Driven Chloride Bicarbonate Exchanger2
NCBE2 3     Solute Carrier Family 4, Sodium Bicarbonate Cotransporter-Like, Member 102
Solute Carrier Family 4, Sodium Bicarbonate Transporter-Like, Member 101     Solute Carrier Family 4 Member 103
NBCn22     

External Ids:    HGNC: 138111   Entrez Gene: 572822   Ensembl: ENSG000001442907   OMIM: 6055565   UniProtKB: Q6U8413   

Export aliases for SLC4A10 gene to outside databases

Previous GC identifers: GC02P160534 GC02P161009 GC02P162683 GC02P162306 GC02P162189 GC02P162281 GC02P154363


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC4A10 Gene:
This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the
intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain
extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride
bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is
independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a
member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple
transcript variants encoding distinct isoforms.(provided by RefSeq, May 2010)

GeneCards Summary for SLC4A10 Gene: 
SLC4A10 (solute carrier family 4, sodium bicarbonate transporter, member 10) is a protein-coding gene. Diseases associated with SLC4A10 include complex partial epilepsy, and choroiditis, and among its related super-pathways are Transmembrane transport of small molecules and Amino acid and oligopeptide SLC transporters. GO annotations related to this gene include inorganic anion exchanger activity and symporter activity. An important paralog of this gene is SLC4A7.

UniProtKB/Swiss-Prot: S4A10_HUMAN, Q6U841
Function: Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important
role in regulating intracellular pH (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC4A10 gene promoter:
         AML1a   AP-4   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Evi-1   AREB6   POU2F1   HSF2   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC4A10 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC4A10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC4A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.2   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q24.2

SLC4A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC4A10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P162444:  view genomic region     (about GC identifiers)

Start:
162,480,845 bp from pter      End:
162,841,792 bp from pter
Size:
360,948 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S4A10_HUMAN, Q6U841 (See protein sequence)
Recommended Name: Sodium-driven chloride bicarbonate exchanger  
Size: 1118 amino acids; 125946 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane (By
similarity)
Secondary accessions: B7Z1R0 B7ZLC5 B9EG69 F8W675 Q4ZFX6 Q8TCP2 Q9HCQ6
Alternative splicing: 3 isoforms:  Q6U841-1   Q6U841-2   Q6U841-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC4A10: NX_Q6U841

Explore proteomics data for SLC4A10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6U841

  • SLC4A10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC4A10 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001171486.1  NP_001171487.1  NP_071341.2  

    ENSEMBL proteins: 
     ENSP00000395797   ENSP00000272716   ENSP00000393066   ENSP00000389180   ENSP00000404486  
     ENSP00000437527   ENSP00000364664  
    Reactome Protein details: Q6U841
    Human Recombinant Protein Products for SLC4A10: 
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    Cloud-Clone Corp. Proteins for SLC4A10 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane NAS10993873
    GO:0016323basolateral plasma membrane IEA--

    SLC4A10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Electroneutral sodium bicarbonate cotransporter 2 
    Sodium-dependent HCO3- transporters

    5 InterPro protein domains:
     IPR011531 HCO3_transpt_C
     IPR003020 HCO3_transpt_euk
     IPR016152 PTrfase/Anion_transptr
     IPR003024 Na/HCO3_transpt
     IPR013769 Band3_cytoplasmic_dom

    Graphical View of Domain Structure for InterPro Entry Q6U841

    ProtoNet protein and cluster: Q6U841

    2 Blocks protein domains:
    IPB003024 Na+/HCO3- co-transporter signature
    IPB013769 HCO3- transporter


    UniProtKB/Swiss-Prot: S4A10_HUMAN, Q6U841
    Similarity: Belongs to the anion exchanger (TC 2.A.31) family


    SLC4A10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S4A10_HUMAN, Q6U841
    Function: Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important
    role in regulating intracellular pH (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005452inorganic anion exchanger activity IEA--
    GO:0008509anion transmembrane transporter activity ----
    GO:0015293symporter activity IEA--
    GO:0015301anion:anion antiporter activity ----
         
    SLC4A10 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc4a10):
     behavior/neurological  growth/size  homeostasis/metabolism  mortality/aging  nervous system 

    SLC4A10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc4a10tm1.1Cahb for SLC4A10

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC4A10 
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    miRNA
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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC4A10 (see all 32):
    hsa-miR-376b hsa-miR-25 hsa-miR-4325 hsa-miR-330-3p hsa-miR-92b hsa-miR-181b hsa-miR-505 hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidSLC4A10 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC4A10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    2Amino acid and oligopeptide SLC transporters
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    3Bicarbonate transporters
    Bicarbonate transporters

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for SLC4A10
        Bicarbonate transporters
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of inorganic cations/anions and amino acids/oligopeptides



    SLC4A10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC4A10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for SLC4A10 (Q6U8413 ENSP000003957974) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBFBQ139513I2D: score=1 
    FOSP011003I2D: score=1 
    YWHABP319463I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006811ion transport TAS--
    GO:0006814sodium ion transport IEA--
    GO:0006820anion transport ----
    GO:0006821chloride transport NAS10993873

    SLC4A10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC4A10 (S4A10)

    3 HMDB Compounds for SLC4A10    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Hydrogen carbonateBicarbonate (see all 19)71-52-3--
    SodiumSodium (see all 2)7440-23-5--

    1 DrugBank Compound for SLC4A10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sodium bicarbonateBicarbonate of soda (see all 6)144-55-8transportersubstrate15014910 17071329 12847417 12027220

    Search CenterWatch for drugs/clinical trials and news about SLC4A10 / S4A10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC4A10 gene (3 alternative transcripts): 
    NM_001178015.1  NM_001178016.1  NM_022058.3  

    Unigene Cluster for SLC4A10:

    Solute carrier family 4, sodium bicarbonate transporter, member 10
    Hs.333958  [show with all ESTs]
    Unigene Representative Sequence: NM_001178016
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000415876 ENST00000493021(uc010fpa.1) ENST00000461456 ENST00000272716
    ENST00000446997 ENST00000481721 ENST00000446228 ENST00000421911 ENST00000535165(uc010zcr.1)
    ENST00000375514(uc002ubx.4 uc010zcs.2 uc002uby.4)
    miRNA
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    hsa-miR-376b hsa-miR-25 hsa-miR-4325 hsa-miR-330-3p hsa-miR-92b hsa-miR-181b hsa-miR-505 hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidSLC4A10 3' UTR sequence
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    Additional mRNA sequence: 

    AK293793.1 AK294767.1 AK308529.1 AK309839.1 AL713680.1 AL832525.1 AY376402.1 BC036415.2 
    BC038298.1 BC051190.1 BC136269.1 BC143714.1 

    5 DOTS entries:

    DT.100730828  DT.102842626  DT.102842625  DT.40293654  DT.100674496 

    24/102 AceView cDNA sequences (see all 102):

    BM696161 BM664443 AL832525 CD631089 CD631074 BC036415 AY376402 AL713680 
    BX951604 BX955341 CD102396 CD631064 BE702100 BX453568 CD631063 CD631060 
    CD631078 CD631080 CD631075 BX952927 NM_022058 CD631091 CA841736 CA775920 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A10    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:                          -               
    SP2:                                          


    ECgene alternative splicing isoforms for SLC4A10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC4A10 expression in normal human tissues (normalized intensities)      SLC4A10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCACCTATT
    SLC4A10 Expression
    About this image


    SLC4A10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
             brain/forebrain/telencephalon   
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Choroid Plexus (Nervous System)
             Mature Choroid Plexus Cells Choroid Plexus

     -- (Nervous System)
             mouse/organ system/nervous system/central nervous system   

    See SLC4A10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC4A10

    SOURCE GeneReport for Unigene cluster: Hs.333958
        SABiosciences Custom PCR Arrays for SLC4A10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC4A10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC4A10 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc4a101 , 5 solute carrier family 4, sodium bicarbonate cotransporter-like, more1, 5 90.07(n)1
    97.5(a)1
      2 (35.79 cM)5
    942291  NM_001242378.11  NP_001229307.11 
     620464625 
    chicken
    (Gallus gallus)
    Aves SLC4A101 solute carrier family 4, sodium bicarbonate transporter, more 82.51(n)
    92.4(a)
      424188  XM_003641613.1  XP_003641661.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC4A106
    solute carrier family 4, sodium bicarbonate transp...
    88(a)
    1 ↔ 1
    GL343359.1(718134-959976)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.193382 Xenopus laevis transcribed sequence with moderate similarity more 76(n)    BQ384734.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc4a10b6
    SLC4A10 (2 of 2)6
    solute carrier family 4, sodium bicarbonate transp...
    solute carrier family 4, sodium bicarbonate transp...
    81(a)
    81(a)
    1 ↔ many
    1 ↔ many
    9(52636193-52713526)
    11(10749677-10803733)
    fruit fly
    (Drosophila melanogaster)
    Insecta Ndae13 sodium:bicarbonate cotransporter 53(a)   27E6   --
    worm
    (Caenorhabditis elegans)
    Secernentea F52B5.13 anion exchange protein 47(a)
    (best of 2)
      I(8305353-8315575)   --


    ENSEMBL Gene Tree for SLC4A10 (if available)
    TreeFam Gene Tree for SLC4A10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC4A10 gene
    SLC4A72  SLC4A42  SLC4A112  SLC4A12  SLC4A52  SLC4A82  SLC4A22  SLC4A92  
    SLC4A32  
    12 SIMAP similar genes for SLC4A10 using alignment to 6 protein entries:     S4A10_HUMAN (see all proteins):
    DKFZp781H1314    SLC4A8    SLC4A7    SLC4A4    NBC    SLC4A5
    SLC4A9    SLC4A2    SLC4A1    SLC4A3    AE    AE1

    SLC4A10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6225 SNPs in SLC4A10 are shown (see all 6225)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs725302581,2
    C--154369753(+) TGACA-/CCCCATT 3 -- int11Minor allele frequency- CC:0.00CSA 2
    rs1995917641,2
    C--154389141(+) AGACA-/TTTTTTT 3 -- int10--------
    rs671460031,2
    C--154396467(+) TTTAG-/AATAAT 3 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs677505831,2
    C--154412658(+) TTAAA-/CAATAT 3 -- int10--------
    rs339658301,2
    C--154415000(+) TGCCT-/ATTAAA 3 -- int10--------
    rs1430021181,2
    C--154424256(+) CAGAA-/AAAC  
            
    AAACA
    3 -- int10--------
    rs767634461,2
    C--154587505(+) TTTTAC/TCTTCT 3 -- int11Minor allele frequency- T:0.50NA 2
    rs58358861,2
    C--154610957(+) TATTC-/AAAAAA 3 -- int1 trp31Minor allele frequency- A:0.00NA 2
    rs113223951,2
    C--154705131(+) GTCTC-/AAAAAA 3 -- int1 trp30--------
    rs1175409221,2
    F--161876048(+) TTCTCC/TACTTT 3 -- us2k11Minor allele frequency- T:0.01EA 120

    HapMap Linkage Disequilibrium report for SLC4A10 (162480845 - 162730845 bp, first 250kb of SLC4A10)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for SLC4A10 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1338019CNV Deletion17803354
    esv2646896CNV Deletion19546169
    esv2721050CNV Deletion23290073
    esv268607CNV Insertion20981092
    nsv3008CNV Insertion18451855
    esv268701CNV Insertion20981092
    nsv3006CNV Insertion18451855
    nsv3007CNV Loss18451855
    nsv875352CNV Loss21882294
    nsv875350CNV Loss21882294


    Human Gene Mutation Database (HGMD): SLC4A10
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC4A10
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC4A10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605556    OMIM disorders: --

    10 diseases for SLC4A10:    About MalaCards
    complex partial epilepsy    choroiditis    endogenous depression    open-angle glaucoma
    primary open angle glaucoma    glaucoma    mental retardation    hepatitis c
    neuronitis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for SLC4A10:
    Complex partial epilepsy

    SLC4A10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC4A10
    Human Genome Epidemiology (HuGE) Navigator: SLC4A10 (3 documents)

    Export disorders for SLC4A10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC4A10 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SLC4A10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    3. AQP1 and SLC4A10 as candidate genes for primary open- angle glaucoma. (PubMed id 20101282)1, 4 Liu W....Allingham R.R. (2010)
    4. Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity. (PubMed id 18319254)1, 3 Parker M.D....Boron W.F. (2008)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    6. The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization. (PubMed id 10993873)1, 2 Wang C.-Z.... Seino S. (2000)
    7. Assignment of the human solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 gene (SLC4A10) to 2q23-->q24 by in situ hybridization and radiation hybrid mapping. (PubMed id 10965143)1, 9 Yano H....Seino S. (2000)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. (PubMed id 18165320)1 Jacobs S....Hubner C.A. (2008)
    10. Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. (PubMed id 18413482)1 Gurnett C.A....Bowcock A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57282 HGNC: 13811 AceView: SLC4A10 Ensembl:ENSG00000144290 euGenes: HUgn57282
    ECgene: SLC4A10 H-InvDB: SLC4A10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC4A10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC4A10 gene:
    Search GeneIP for patents involving SLC4A10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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