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Aliases for SLC4A10 Gene

Aliases for SLC4A10 Gene

  • Solute Carrier Family 4, Sodium Bicarbonate Transporter, Member 10 2 3
  • NCBE 3 4
  • Solute Carrier Family 4, Sodium Bicarbonate Cotransporter-Like, Member 10 3
  • Solute Carrier Family 4, Sodium Bicarbonate Transporter-Like, Member 10 2
  • Sodium-Driven Chloride Bicarbonate Exchanger 3
  • Solute Carrier Family 4 Member 10 4
  • NBCn2 3

External Ids for SLC4A10 Gene

Previous GeneCards Identifiers for SLC4A10 Gene

  • GC02P160534
  • GC02P161009
  • GC02P162444
  • GC02P162683
  • GC02P162306
  • GC02P162189
  • GC02P162281
  • GC02P154363

Summaries for SLC4A10 Gene

Entrez Gene Summary for SLC4A10 Gene

  • This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

GeneCards Summary for SLC4A10 Gene

SLC4A10 (Solute Carrier Family 4, Sodium Bicarbonate Transporter, Member 10) is a Protein Coding gene. Diseases associated with SLC4A10 include complex partial epilepsy. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include symporter activity and inorganic anion exchanger activity. An important paralog of this gene is SLC4A8.

UniProtKB/Swiss-Prot for SLC4A10 Gene

  • Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A10 Gene

Genomics for SLC4A10 Gene

Regulatory Elements for SLC4A10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC4A10 Gene

Start:
161,424,332 bp from pter
End:
161,985,282 bp from pter
Size:
560,951 bases
Orientation:
Plus strand

Genomic View for SLC4A10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC4A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A10 Gene

Proteins for SLC4A10 Gene

  • Protein details for SLC4A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6U841-S4A10_HUMAN
    Recommended name:
    Sodium-driven chloride bicarbonate exchanger
    Protein Accession:
    Q6U841
    Secondary Accessions:
    • B7Z1R0
    • B7Z2J0
    • B7ZLC5
    • B9EG69
    • F8W675
    • Q4ZFX6
    • Q8TCP2
    • Q9HCQ6

    Protein attributes for SLC4A10 Gene

    Size:
    1118 amino acids
    Molecular mass:
    125946 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC4A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC4A10 Gene

Proteomics data for SLC4A10 Gene at MOPED

Post-translational modifications for SLC4A10 Gene

  • Glycosylation at Asn697
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC4A10 Gene

No data available for DME Specific Peptides for SLC4A10 Gene

Domains for SLC4A10 Gene

Suggested Antigen Peptide Sequences for SLC4A10 Gene

Graphical View of Domain Structure for InterPro Entry

Q6U841

UniProtKB/Swiss-Prot:

S4A10_HUMAN :
  • Q6U841
Family:
  • Belongs to the anion exchanger (TC 2.A.31) family.
genes like me logo Genes that share domains with SLC4A10: view

Function for SLC4A10 Gene

Molecular function for SLC4A10 Gene

UniProtKB/Swiss-Prot Function: Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).

Gene Ontology (GO) - Molecular Function for SLC4A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005452 inorganic anion exchanger activity IEA --
GO:0008509 anion transmembrane transporter activity --
GO:0008510 sodium:bicarbonate symporter activity IBA --
GO:0015293 symporter activity --
genes like me logo Genes that share ontologies with SLC4A10: view
genes like me logo Genes that share phenotypes with SLC4A10: view

Animal Models for SLC4A10 Gene

MGI Knock Outs for SLC4A10:

Animal Model Products

CRISPR Products

miRNA for SLC4A10 Gene

miRTarBase miRNAs that target SLC4A10

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC4A10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC4A10 Gene

Localization for SLC4A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A10 Gene

Cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC4A10 Gene COMPARTMENTS Subcellular localization image for SLC4A10 gene
Compartment Confidence
plasma membrane 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC4A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 10993873
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC4A10: view

Pathways for SLC4A10 Gene

genes like me logo Genes that share pathways with SLC4A10: view

Interacting Proteins for SLC4A10 Gene

Gene Ontology (GO) - Biological Process for SLC4A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport --
GO:0006820 anion transport --
GO:0006821 chloride transport NAS 10993873
genes like me logo Genes that share ontologies with SLC4A10: view

Compounds for SLC4A10 Gene

(3) HMDB Compounds for SLC4A10 Gene

Compound Synonyms Cas Number PubMed IDs
Chlorine
  • Cl2
16887-00-6
Hydrogen carbonate
  • Bicarbonate
71-52-3
Sodium
  • Sodium
7440-23-5

(1) Drugbank Compounds for SLC4A10 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Sodium bicarbonate
  • Bicarbonate of soda
144-55-8 transporter substrate
genes like me logo Genes that share compounds with SLC4A10: view

Transcripts for SLC4A10 Gene

Unigene Clusters for SLC4A10 Gene

Solute carrier family 4, sodium bicarbonate transporter, member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC4A10

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC4A10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A10 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:

Relevant External Links for SLC4A10 Gene

GeneLoc Exon Structure for
SLC4A10
ECgene alternative splicing isoforms for
SLC4A10

Expression for SLC4A10 Gene

mRNA expression in normal human tissues for SLC4A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC4A10 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (9.5), Brain - Anterior cingulate cortex (BA24) (8.5), and Brain - Cortex (6.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC4A10 Gene

SOURCE GeneReport for Unigene cluster for SLC4A10 Gene Hs.333958

genes like me logo Genes that share expressions with SLC4A10: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC4A10 Gene

Orthologs for SLC4A10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC4A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC4A10 35
  • 99.79 (n)
  • 99.91 (a)
SLC4A10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC4A10 35
  • 94.07 (n)
  • 99.18 (a)
SLC4A10 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC4A10 35
  • 95.67 (n)
  • 99.37 (a)
SLC4A10 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc4a10 35
  • 90.27 (n)
  • 97.74 (a)
Slc4a10 16
Slc4a10 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC4A10 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC4A10 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc4a10 35
  • 89.43 (n)
  • 97.38 (a)
chicken
(Gallus gallus)
Aves SLC4A10 35
  • 82.9 (n)
  • 92.95 (a)
SLC4A10 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC4A10 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19338 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc4a10 35
  • 78.49 (n)
  • 88.49 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC557642 35
  • 72.94 (n)
  • 83.35 (a)
SLC4A10 (2 of 2) 36
  • 81 (a)
OneToMany
slc4a10b 36
  • 82 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ndae1 36
  • 46 (a)
OneToMany
Ndae1 37
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea abts-1 36
  • 42 (a)
OneToMany
F52B5.1 37
  • 47 (a)
R03E9.3 37
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for SLC4A10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC4A10 Gene

ENSEMBL:
Gene Tree for SLC4A10 (if available)
TreeFam:
Gene Tree for SLC4A10 (if available)

Paralogs for SLC4A10 Gene

Paralogs for SLC4A10 Gene

Selected SIMAP similar genes for SLC4A10 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC4A10: view

Variants for SLC4A10 Gene

Sequence variations from dbSNP and Humsavar for SLC4A10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs961324 -- 161,840,993(-) ttttc(C/T)gccta intron-variant
rs961421 -- 161,769,589(+) CCTCA(C/G)AAGGT intron-variant
rs971282 -- 161,752,155(-) GATGT(A/G)CTTCC intron-variant
rs971283 -- 161,752,052(-) CAGCA(A/T)AAAAG intron-variant
rs971284 -- 161,751,944(-) ACAAA(A/G)GGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC4A10 Gene

Variant ID Type Subtype PubMed ID
nsv3006 CNV Insertion 18451855
nsv834438 CNV Gain 17160897
dgv4352n71 CNV Loss 21882294
nsv3007 CNV Loss 18451855
nsv875350 CNV Loss 21882294
nsv875351 CNV Loss 21882294
esv2721050 CNV Deletion 23290073
esv1338019 CNV Deletion 17803354
nsv875352 CNV Loss 21882294
esv268607 CNV Insertion 20981092
nsv519410 CNV Gain 19592680
esv268701 CNV Insertion 20981092
esv2646896 CNV Deletion 19546169
nsv3008 CNV Insertion 18451855
nsv819853 CNV Gain 19587683

Relevant External Links for SLC4A10 Gene

HapMap Linkage Disequilibrium report
SLC4A10
Human Gene Mutation Database (HGMD)
SLC4A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A10 Gene

Disorders for SLC4A10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC4A10 Gene including...

Search for SLC4A10 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SLC4A10 Gene

Relevant External Links for SLC4A10

Genetic Association Database (GAD)
SLC4A10
Human Genome Epidemiology (HuGE) Navigator
SLC4A10
genes like me logo Genes that share disorders with SLC4A10: view

No data available for UniProtKB/Swiss-Prot for SLC4A10 Gene

Publications for SLC4A10 Gene

  1. Assignment of the human solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 gene (SLC4A10) to 2q23-->q24 by in situ hybridization and radiation hybrid mapping. (PMID: 10965143) Yano H. … Seino S. (Cytogenet. Cell Genet. 2000) 3 23
  2. The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization. (PMID: 10993873) Wang C.-Z. … Seino S. (J. Biol. Chem. 2000) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. AQP1 and SLC4A10 as candidate genes for primary open-angle glaucoma. (PMID: 20101282) Liu W. … Allingham R.R. (Mol. Vis. 2010) 3 48
  5. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 48

Products for SLC4A10 Gene

Sources for SLC4A10 Gene

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