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Aliases for SLC47A2 Gene

Aliases for SLC47A2 Gene

  • Solute Carrier Family 47 (Multidrug And Toxin Extrusion), Member 2 2 3
  • MATE2 3 4 6
  • Kidney-Specific H(+)/Organic Cation Antiporter 3 4
  • Multidrug And Toxin Extrusion 2 2 3
  • HMATE-2 3 4
  • MATE2K 3 6
  • MATE-2 3 4
  • Multidrug And Toxin Extrusion Protein 2 3
  • Solute Carrier Family 47, Member 2 3
  • Solute Carrier Family 47 Member 2 4
  • H+/Organic Cation Antiporter 3
  • FLJ31196 6
  • MATE2-B 3
  • MATE2-K 3

External Ids for SLC47A2 Gene

Summaries for SLC47A2 Gene

Entrez Gene Summary for SLC47A2 Gene

  • This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC47A2 Gene

SLC47A2 (Solute Carrier Family 47 (Multidrug And Toxin Extrusion), Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include antiporter activity and drug transmembrane transporter activity. An important paralog of this gene is SLC47A1.

UniProtKB/Swiss-Prot for SLC47A2 Gene

  • Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.

Gene Wiki entry for SLC47A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC47A2 Gene

Genomics for SLC47A2 Gene

Genomic Location for SLC47A2 Gene

Start:
19,678,288 bp from pter
End:
19,719,671 bp from pter
Size:
41,384 bases
Orientation:
Minus strand

Genomic View for SLC47A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC47A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC47A2 Gene

Regulatory Elements for SLC47A2 Gene

Proteins for SLC47A2 Gene

  • Protein details for SLC47A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VL8-S47A2_HUMAN
    Recommended name:
    Multidrug and toxin extrusion protein 2
    Protein Accession:
    Q86VL8
    Secondary Accessions:
    • A0JBX9
    • A0P8Z7
    • Q63HJ9
    • Q8IV44
    • Q96NA1

    Protein attributes for SLC47A2 Gene

    Size:
    602 amino acids
    Molecular mass:
    65085 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC47A2 Gene

neXtProt entry for SLC47A2 Gene

Proteomics data for SLC47A2 Gene at MOPED

Post-translational modifications for SLC47A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC47A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC47A2 Gene

Domains for SLC47A2 Gene

Gene Families for SLC47A2 Gene

Protein Domains for SLC47A2 Gene

Suggested Antigen Peptide Sequences for SLC47A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VL8

UniProtKB/Swiss-Prot:

S47A2_HUMAN
Family:
  • Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.:
    • Q86VL8
genes like me logo Genes that share domains with SLC47A2: view

Function for SLC47A2 Gene

Molecular function for SLC47A2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.76 mM for TEA {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=0.11 mM for MPP {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=0.12 mM for cimetidine {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=1.98 mM for metformin {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=4.2 mM for guanidine {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=1.58 mM for procainamide {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=0.06 mM for topotecan {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=0.85 mM for estrone sulfate {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=4.32 mM for acyclovir {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=4.28 mM for ganciclovir {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.88 nmol/min/mg enzyme toward TEA {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.575 nmol/min/mg enzyme toward MPP {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.115 nmol/min/mg enzyme toward cimetidine {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.845 nmol/min/mg enzyme toward metformin {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.58 nmol/min/mg enzyme toward guanidine {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=3.385 nmol/min/mg enzyme toward procainamide {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.13 nmol/min/mg enzyme toward topotecan {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.425 nmol/min/mg enzyme toward estrone sulfate {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.945 nmol/min/mg enzyme toward acyclovir {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.805 nmol/min/mg enzyme toward ganciclovir {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; pH dependence: Optimum pH is 9.0. Active from pH 6 to 9. {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534};
UniProtKB/Swiss-Prot Function: Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.

Gene Ontology (GO) - Molecular Function for SLC47A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015238 drug transmembrane transporter activity IEA --
GO:0015297 antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC47A2: view
genes like me logo Genes that share phenotypes with SLC47A2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC47A2 Gene

Localization for SLC47A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC47A2 Gene

Cell membrane; Multi-pass membrane protein. Note=Localized at the brush border membranes of the proximal tubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC47A2 Gene COMPARTMENTS Subcellular localization image for SLC47A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC47A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC47A2: view

Pathways for SLC47A2 Gene

genes like me logo Genes that share pathways with SLC47A2: view

Interacting Proteins for SLC47A2 Gene

Gene Ontology (GO) - Biological Process for SLC47A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006855 drug transmembrane transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC47A2: view

Compounds for SLC47A2 Gene

(1) IUPHAR Ligand for SLC47A2 Gene

Ligand Type Action Affinity Pubmed IDs
[14C]TEA None None

(1) PharmGKB related drug/compound annotations for SLC47A2 Gene

Drug/compound Annotation
metformin CA
genes like me logo Genes that share compounds with SLC47A2: view

Transcripts for SLC47A2 Gene

Unigene Clusters for SLC47A2 Gene

Solute carrier family 47, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC47A2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - - - - - -
SP6:

Relevant External Links for SLC47A2 Gene

GeneLoc Exon Structure for
SLC47A2
ECgene alternative splicing isoforms for
SLC47A2

Expression for SLC47A2 Gene

mRNA expression in normal human tissues for SLC47A2 Gene

mRNA differential expression in normal tissues according to GTEx for SLC47A2 Gene

This gene is overexpressed in Kidney - Cortex (37.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC47A2 Gene

SOURCE GeneReport for Unigene cluster for SLC47A2 Gene Hs.126830

mRNA Expression by UniProt/SwissProt for SLC47A2 Gene

Q86VL8-S47A2_HUMAN
Tissue specificity: Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain.
genes like me logo Genes that share expressions with SLC47A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC47A2 Gene

Orthologs for SLC47A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC47A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC47A2 35
  • 99.61 (n)
  • 99.67 (a)
SLC47A2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC47A2 35
  • 79.65 (n)
  • 74.51 (a)
SLC47A2 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC47A2 35
  • 82.57 (n)
  • 78.45 (a)
SLC47A2 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc47a2 36
  • 45 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia SLC47A2 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC47A2 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC47A2 35
  • 63.71 (n)
  • 54.43 (a)
SLC47A2 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC47A2 36
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-175a17.4 36
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 18 (a)
ManyToMany
ERC1 36
  • 17 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G23030 35
  • 43.72 (n)
  • 33.18 (a)
rice
(Oryza sativa)
Liliopsida Os04g0571600 35
  • 46.69 (n)
  • 31.43 (a)
Species with no ortholog for SLC47A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC47A2 Gene

ENSEMBL:
Gene Tree for SLC47A2 (if available)
TreeFam:
Gene Tree for SLC47A2 (if available)

Paralogs for SLC47A2 Gene

Paralogs for SLC47A2 Gene

Selected SIMAP similar genes for SLC47A2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SLC47A2 Gene

genes like me logo Genes that share paralogs with SLC47A2: view

Variants for SLC47A2 Gene

Sequence variations from dbSNP and Humsavar for SLC47A2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs758426 -- 19,717,311(-) TCGAG(A/T)CACAG upstream-variant-2KB, intron-variant
rs758427 -- 19,717,164(-) ATCCC(C/T)ATCCC upstream-variant-2KB, intron-variant
rs887238 -- 19,705,098(-) acgtg(C/T)gtaat intron-variant, downstream-variant-500B
rs1812051 -- 19,681,230(-) TTTTT(G/T)TTTGT intron-variant, downstream-variant-500B
rs1968113 -- 19,713,413(-) ATGAT(G/T)ATTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC47A2 Gene

Variant ID Type Subtype PubMed ID
nsv428337 CNV Loss 18775914
dgv3101n71 CNV Loss 21882294
nsv526290 CNV Loss 19592680

Relevant External Links for SLC47A2 Gene

HapMap Linkage Disequilibrium report
SLC47A2
Human Gene Mutation Database (HGMD)
SLC47A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC47A2 Gene

Disorders for SLC47A2 Gene

(1) University of Copenhagen DISEASES for SLC47A2 Gene

Relevant External Links for SLC47A2

Genetic Association Database (GAD)
SLC47A2
Human Genome Epidemiology (HuGE) Navigator
SLC47A2
genes like me logo Genes that share disorders with SLC47A2: view

No data available for UniProtKB/Swiss-Prot for SLC47A2 Gene

Publications for SLC47A2 Gene

  1. Identification and functional characterization of a new human kidney- specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. (PMID: 16807400) Masuda S. … Inui K. (J. Am. Soc. Nephrol. 2006) 2 3 4
  2. The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. (PMID: 16996621) Omote H. … Moriyama Y. (Trends Pharmacol. Sci. 2006) 2 3 4
  3. Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. (PMID: 17509534) Tanihara Y. … Inui K. (Biochem. Pharmacol. 2007) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients. (PMID: 20016398) Toyama K. … Inui K. (Pharmacogenet. Genomics 2010) 3 48

Products for SLC47A2 Gene

  • antibodies-online peptides for SLC47A2
  • antibodies-online antibodies for SLC47A2
  • antibodies-online kits for SLC47A2

Sources for SLC47A2 Gene

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