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SLC47A2 Gene

protein-coding   GIFtS: 55
GCID: GC17M019582

Solute Carrier Family 47 (Multidrug And Toxin Extrusion),...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 47 (Multidrug And Toxin Extrusion), Member 21 2     MATE2-B2
MATE22 3 5     MATE2-K2
Multidrug And Toxin Extrusion 21 2     H+/Organic Cation Antiporter2
Kidney-Specific H(+)/Organic Cation Antiporter2 3     Multidrug And Toxin Extrusion Protein 22
MATE-22 3     Solute Carrier Family 47, Member 22
hMATE-22 3     Solute Carrier Family 47 Member 23
MATE2K2 5     FLJ311965

External Ids:    HGNC: 264391   Entrez Gene: 1468022   Ensembl: ENSG000001806387   OMIM: 6098335   UniProtKB: Q86VL83   

Export aliases for SLC47A2 gene to outside databases

Previous GC identifers: GC17M019524 GC17M018960


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC47A2 Gene:
This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes,
both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial
MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two
members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript
variants encoding different isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLC47A2 Gene:
SLC47A2 (solute carrier family 47 (multidrug and toxin extrusion), member 2) is a protein-coding gene. GO annotations related to this gene include antiporter activity and drug transmembrane transporter activity. An important paralog of this gene is SLC47A1.

UniProtKB/Swiss-Prot: S47A2_HUMAN, Q86VL8
Function: Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine,
N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and
ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes

Gene Wiki entry for SLC47A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC47A2 gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   STAT1alpha   C/EBPalpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC47A2 promoter sequence
   Search Chromatin IP Primers for SLC47A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC47A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

SLC47A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC47A2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M019582:  view genomic region     (about GC identifiers)

Start:
19,581,601 bp from pter      End:
19,622,292 bp from pter
Size:
40,692 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S47A2_HUMAN, Q86VL8 (See protein sequence)
Recommended Name: Multidrug and toxin extrusion protein 2  
Size: 602 amino acids; 65085 Da
Secondary accessions: A0JBX9 A0P8Z7 Q63HJ9 Q8IV44 Q96NA1
Alternative splicing: 6 isoforms:  Q86VL8-1   Q86VL8-2   Q86VL8-3   Q86VL8-4   Q86VL8-5   Q86VL8-6   (Inactive. Note)

Explore the universe of human proteins at neXtProt for SLC47A2: NX_Q86VL8

Explore proteomics data for SLC47A2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC47A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001093116.1  NP_001243592.1  NP_690872.2  

    ENSEMBL proteins: 
     ENSP00000326671   ENSP00000338084   ENSP00000458694   ENSP00000391848  
    Reactome Protein details: Q86VL8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: MATE2
    SLC47 family of multidrug and toxin extrusion transporters

    1 InterPro protein domain:
     IPR002528 MATE

    Graphical View of Domain Structure for InterPro Entry Q86VL8

    ProtoNet protein and cluster: Q86VL8

    1 Blocks protein domain: IPB002528 Multi antimicrobial extrusion protein MatE

    UniProtKB/Swiss-Prot: S47A2_HUMAN, Q86VL8
    Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family


    Find genes that share domains with SLC47A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S47A2_HUMAN, Q86VL8
    Function: Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine,
    N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and
    ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes
    Biophysicochemical properties: Kinetic parameters: KM=0.76 mM for TEA; KM=0.11 mM for MPP; KM=0.12 mM for
    cimetidine; KM=1.98 mM for metformin; KM=4.2 mM for guanidine; KM=1.58 mM for procainamide; KM=0.06 mM for
    topotecan; KM=0.85 mM for estrone sulfate; KM=4.32 mM for acyclovir; KM=4.28 mM for ganciclovir; Vmax=0.88
    nmol/min/mg enzyme toward TEA; Vmax=0.575 nmol/min/mg enzyme toward MPP; Vmax=0.115 nmol/min/mg enzyme toward
    cimetidine; Vmax=0.845 nmol/min/mg enzyme toward metformin; Vmax=0.58 nmol/min/mg enzyme toward guanidine;
    Vmax=3.385 nmol/min/mg enzyme toward procainamide; Vmax=0.13 nmol/min/mg enzyme toward topotecan; Vmax=0.425
    nmol/min/mg enzyme toward estrone sulfate; Vmax=0.945 nmol/min/mg enzyme toward acyclovir; Vmax=0.805 nmol/min/mg
    enzyme toward ganciclovir; pH dependence: Optimum pH is 9.0. Active from pH 6 to 9;

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015238drug transmembrane transporter activity IEA--
    GO:0015297antiporter activity IEA--
         
    Find genes that share ontologies with SLC47A2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SLC47A2:
     Decreased TP53 protein express  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S47A2_HUMAN, Q86VL8: Cell membrane; Multi-pass membrane protein (Potential). Note=Localized at the brush border
    membranes of the proximal tubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC47A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC47A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with SLC47A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC47A2
        Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds


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    Interactions:

        Search GeneGlobe Interaction Network for SLC47A2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC47A2 (ENSP000003266714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDHXENSP000002278684STRING: ENSP00000227868
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006855drug transmembrane transport ----
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with SLC47A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC47A2 (S47A2)

    1 IUPHAR Ligand for SLC47A2 (MATE2)    About this table
    LigandTypeActionAffinityPubmed IDs
    [14C]TEA
    NoneNone17509534

    1 PharmGKB related drug/compound annotation for SLC47A2 gene    About this table
    Drug/compound PharmGKB Annotation
    metforminCA  



    Find genes that share compounds with SLC47A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC47A2 gene (3 alternative transcripts): 
    NM_001099646.1  NM_001256663.1  NM_152908.3  

    Unigene Cluster for SLC47A2:

    Solute carrier family 47, member 2
    Hs.126830  [show with all ESTs]
    Unigene Representative Sequence: BX648861
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000325411 ENST00000467609 ENST00000463318(uc002gwi.3) ENST00000350657(uc002gwe.4 uc002gwg.4 uc002gwf.4 uc002gwh.4 uc010cqs.1)
    ENST00000574239 ENST00000433844 ENST00000574220(uc010cqt.1) ENST00000467379
    ENST00000483510 ENST00000456947
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    Additional mRNA sequence: 

    AB250364.1 AB250701.1 AK055758.1 AK307647.1 AK310218.1 BC035288.1 BC050578.1 BC062614.1 
    BX648861.1 

    10 DOTS entries:

    DT.97839140  DT.99936361  DT.97815326  DT.100017478  DT.101980033  DT.120981829  DT.40126658  DT.100647363 
    DT.75133123  DT.91860425 

    Selected AceView cDNA sequences (see all 52):

    AI074484 AW006868 BM930596 BC050578 AI245393 AI795956 BC035288 NM_152908 
    AI861851 BF432333 BC062614 AI640517 AK123589 AA931466 AW614840 BM924669 
    AW300335 AL699675 AI240993 BI762150 BX409839 BI760930 AW241621 BQ082434 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC47A2 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                            -                             -                             -                                                   
    SP2:                                            -                                                           -     -                                             
    SP3:                                            -                             -                             -                                                   
    SP4:                                            -                                                                                                               
    SP5:        -     -     -     -     -           -                                                                                                               


    ECgene alternative splicing isoforms for SLC47A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC47A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC47A2 Expression
    About this image

    SLC47A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC47A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.126830

    UniProtKB/Swiss-Prot: S47A2_HUMAN, Q86VL8
    Tissue specificity: Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC47A2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SLC47A21 solute carrier family 47, member 2 63.71(n)
    54.43(a)
      417616  NM_001135679.1  NP_001129151.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC47A26
    solute carrier family 47 (multidrug and toxin extr...
    44(a)
    1 ↔ 1
    AAWZ02039426(443-4021)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-175a17.46
    si:dkey-175a17.4
    35(a)
    many ↔ many
    15(25952345-25973167) ENSDARG00000079340
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    ERC16
    Putative protein of unknown function, member of th...
    Member of the multi-drug and toxin extrusion (MATE...
    18(a)
    17(a)
    many ↔ many
    many ↔ many
    IV(1147379-1149466) YDR338C
    VIII(173344-175089) YHR032W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G230301 AT4G23030 43.72(n)
    33.18(a)
      828402  NM_118432.1  NP_194034.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g05716001 Os04g0571600 46.69(n)
    31.43(a)
      4336717  NM_001060141.2  NP_001053606.2 
            Species with no ortholog for SLC47A2

    ENSEMBL Gene Tree for SLC47A2 (if available)
    TreeFam Gene Tree for SLC47A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC47A2 gene
    SLC47A12  
    1 SIMAP similar gene for SLC47A2 using alignment to 2 protein entries:     S47A2_HUMAN (see all proteins):
    SLC47A1

    Find genes that share paralogs with SLC47A2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SLC47A2
    PGOHUM00000245557


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC47A2 (see all 976)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1818472071,2
    --19581468(+) AGAACA/TGTAGA 3 -- ds50010--------
    rs1870026461,2
    --19581509(+) TGCCCA/TGGTCA 3 -- ds50010--------
    rs1135453401,2
    C,F--19581687(+) CAGTGT/ACCCAT 3 -- ut315Minor allele frequency- A:0.00NA 1088
    rs1127272781,2
    C,F--19581766(+) CTTCTG/ATAGAG 3 -- ut315Minor allele frequency- A:0.01NA 1088
    rs713694351,2
    C,F--19582029(+) ACCGTG/AAGCCC 6 /L syn19Minor allele frequency- A:0.00NA 6072
    rs1382444611,2
    C,F--19582075(+) CCCCAC/TGGCGG 6 H R mis12Minor allele frequency- T:0.00NA EU 5755
    rs2010049621,2
    C--19582079(+) ACGGCA/GGATGA 6 R C mis10--------
    rs1132343351,2
    C--19582127(+) AAGGGC/TGTGGG 6 T A mis16Minor allele frequency- T:0.00NA 1620
    rs355264081,2
    C,F--19582128(+) AGGGCG/ATGGGC 6 /H syn18Minor allele frequency- A:0.00NA 6186
    rs2008521291,2
    C--19582129(+) GGGCGC/TGGGCC 6 H R mis10--------

    HapMap Linkage Disequilibrium report for SLC47A2 (19581601 - 19622292 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC47A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526290CNV Loss19592680
    nsv428337CNV Loss18775914
    dgv3101n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): SLC47A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC47A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC47A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609833    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SLC47A2:
    Dyslexia

    Find genes that share disorders with SLC47A2           About GenesLikeMe

    Genetic Association Database (GAD): SLC47A2
    Human Genome Epidemiology (HuGE) Navigator: SLC47A2 (3 documents)

    Export disorders for SLC47A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC47A2 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SLC47A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and functional characterization of a new human kidney- specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. (PubMed id 16807400)1, 2, 3 Masuda S.... Inui K. (J. Am. Soc. Nephrol. 2006)
    2. The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. (PubMed id 16996621)1, 2, 3 Omote H.... Moriyama Y. (Trends Pharmacol. Sci. 2006)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients. (PubMed id 20016398)1, 4 Toyama K....Inui K. (Pharmacogenet. Genomics 2010)
    5. Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. (PubMed id 17509534)1, 2 Tanihara Y.... Inui K. (Biochem. Pharmacol. 2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Precise comparison of protein localization among OCT, OAT, and MATE in human kidney. (PubMed id 23630107)1 Motohashi H....Inui K. (J Pharm Sci 2013)
    8. The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin. (PubMed id 23267855)1 Stocker S.L....Giacomini K.M. (Clin. Pharmacol. Ther. 2013)
    9. Exploring the transcriptome of ciliated cells using in silico dissection of human tissues. (PubMed id 22558177)1 Ivliev A.E....Sergeeva M.G. (PLoS ONE 2012)
    10. Evaluation of 4',6-diamidino-2-phenylindole as a fluorescent probe substrate for rapid assays of the functionality of human multidrug and toxin extrusion proteins. (PubMed id 20047987)1 Yasujima T....Yuasa H. (Drug Metab. Dispos. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 146802 HGNC: 26439 AceView: FLJ31196 Ensembl:ENSG00000180638 euGenes: HUgn146802
    ECgene: SLC47A2 H-InvDB: SLC47A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC47A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC47A2 gene:
    Search GeneIP for patents involving SLC47A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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