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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC47A1 Gene

protein-coding GIFtS: 53
GCID: GC17P019398

solute carrier family 47, member 1

Explore 2 diseases affiliated with
SLC47A1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 47, Member 1¹ ²		FLJ10847¹ ⁵
MATE1¹ ² ³ ⁵		Multidrug And Toxin Extrusion 1²
MATE-1² ³		Multidrug And Toxin Extrusion Protein 1²
HMATE-1¹		Solute Carrier Family 47 Member 1³

External Ids:	HGNC: 25588¹	Entrez Gene: 55244²	Ensembl: ENSG00000142494⁷	OMIM: 609832⁵	UniProtKB: Q96FL8³

Export aliases for SLC47A1 gene to outside databases

Previous GC identifers: GC17P019378 GC17P019437 GC17P018816

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC47A1:

This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown

function. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: S47A1_HUMAN, Q96FL8

Function: Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine,

N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir,

ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake

of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a

widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes

Gene Wiki entry for SLC47A1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC47A1 gene promoter:
Bach1 Max1 AP-1 Bach2 AP-4 C/EBPalpha CHOP-10 ARP-1 SEF-1 (1) c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC47A1 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC47A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC47A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2

SLC47A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC47A1 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P019398: view genomic region (about GC identifiers)

Start:	19,398,698 bp from pter	End:	19,482,347 bp from pter
Size:	83,650 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S47A1_HUMAN, Q96FL8 (See protein sequence)

Recommended Name: Multidrug and toxin extrusion protein 1

Size: 570 amino acids; 61922 Da

Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Predominantly localized at the plasma membrane

but also found in intracellular organelles

Sequence caution: Sequence=AAH50592.1; Type=Erroneous initiation;

Secondary accessions: Q53HF5 Q6PD77 Q86VL4 Q9NVA3

Alternative splicing: 3 isoforms: Q96FL8-1 Q96FL8-2 Q96FL8-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC47A1: NX_Q96FL8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96FL8

SLC47A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060712.2

ENSEMBL proteins:

ENSP00000462630 ENSP00000407155 ENSP00000270570 ENSP00000460164 ENSP00000378951

ENSP00000462225 ENSP00000415586 ENSP00000440435

Reactome Protein details: Q96FL8
Human Recombinant Protein Products for SLC47A1:

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	Uscn Proteins for SLC47A1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--
GO:0031988	membrane-bounded vesicle	IEA	--

SLC47A1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SLC47A1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC47A1 for domains About GeneDecksing

1 InterPro domain/family:

IPR002528 MATE

Graphical View of Domain Structure for InterPro Entry Q96FL8

ProtoNet protein and cluster: Q96FL8

1 Blocks protein family: IPB002528 Multi antimicrobial extrusion protein MatE

UniProtKB/Swiss-Prot: S47A1_HUMAN, Q96FL8

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: S47A1_HUMAN, Q96FL8

Function: Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine,

N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir,

ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake

of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a

widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes

Biophysicochemical properties: Kinetic parameters: KM=0.38 mM for TEA; KM=0.10 mM for MPP; KM=0.17 mM for cimetidine;

KM=0.78 mM for metformin; KM=2.1 mM for guanidine; KM=1.23 mM for procainamide; KM=0.07 mM for topotecan; KM=0.47 mM

for estrone sulfate; KM=2.64 mM for acyclovir; KM=5.12 mM for ganciclovir; Vmax=1.185 nmol/min/mg enzyme toward TEA;

Vmax=0.735 nmol/min/mg enzyme toward MPP; Vmax=0.135 nmol/min/mg enzyme toward cimetidine; Vmax=2.23 nmol/min/mg

enzyme toward metformin; Vmax=0.89 nmol/min/mg enzyme toward guanidine; Vmax=3.78 nmol/min/mg enzyme toward

procainamide; Vmax=0.21 nmol/min/mg enzyme toward topotecan; Vmax=0.265 nmol/min/mg enzyme toward estrone sulfate;

Vmax=0.62 nmol/min/mg enzyme toward acyclovir; Vmax=1.08 nmol/min/mg enzyme toward ganciclovir; pH dependence: Optimum

pH is 8.5. Active from pH 6 to 8.5;

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005451	monovalent cation:hydrogen antiporter activity	IEA	--
GO:0015238	drug transmembrane transporter activity	IEA	--
GO:0015297	antiporter activity	--	--

SLC47A1 for ontologies About GeneDecksing

Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Slc47a1):

homeostasis/metabolism

SLC47A1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Slc47a1^tm1Kinu for SLC47A1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC47A1

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		hsa-miR-183*
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC47A1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SLC-mediated transmembrane transport

	SLC-mediated transmembrane transport	1.00			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.38
	Transmembrane transport of small molecules	0.50

Bile salt and organic anion SLC transporters

Bile salt and organic anion SLC transporters

1.00

Abacavir transport and metabolism

Metformin Pathway, Pharmacokinetics

0.21

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for SLC47A1

	Bile salt and organic anion SLC transporters
	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

1 PharmGKB Pathway for SLC47A1

Metformin Pathway, Pharmacokinetics

SLC47A1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC47A1

5/13 Interacting proteins for SLC47A1 (Q96FL8³) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARHGDIA	P52565³	I2D: score=1
BCKDK	O14874³	I2D: score=1
DLAT	P10515³	I2D: score=1
EEF1A1	P68104³	I2D: score=1
GMPPB	Q9Y5P6³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006855	drug transmembrane transport	--	--
GO:0015695	organic cation transport	IEA	--
GO:0015893	drug transport	--	--
GO:0055085	transmembrane transport	TAS	--

SLC47A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC47A1

5 DrugBank Compounds for SLC47A1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Bromodiphenhydramine	Ambodryl Hydrochloride (see all 10)	1808-12-4	transporter	inhibitor	8309790
Cephalexin	Cefalessina [DCIT] (see all 12)	15686-71-2	transporter	substrate	20484555
Cimetidine	--	51481-61-9	transporter	inhibitor	20519552
Metformin	Metformin HCL (see all 2)	657-24-9	transporter	inhibitor	20053795
Sirolimus	(-)-Rapamycin (see all 2)	53123-88-9	transporter	--	20053795

Search CenterWatch for drugs/clinical trials and news about SLC47A1 / S47A1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC47A1 gene:

NM_018242.2

Unigene Cluster for SLC47A1:

Solute carrier family 47, member 1

Hs.232054 [show with all ESTs]

Unigene Representative Sequence: BC010661

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000584348 ENST00000571335 ENST00000436810 ENST00000270570(uc002gvx.3 uc002gvy.1 uc010vyz.1 uc010cqp.1 uc010cqq.1 uc010vza.1 uc010vzb.1 uc010vzc.1)

ENST00000574596 ENST00000576095 ENST00000575023 ENST00000497548 ENST00000395585

ENST00000495425 ENST00000575377 ENST00000573009 ENST00000575362 ENST00000581558

ENST00000457293(uc010vyy.1) ENST00000542886

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Additional cDNA sequence:

AK001709.1 AK127534.1 AK222625.1 AK225360.1 AK293196.1 AK298254.1 AK301854.1 AK302620.1

AK304647.1 AK310270.1 BC010661.2 BC050592.1 BC058882.1

7 DOTS entries:

DT.312729 DT.101978955 DT.75118445 DT.120970913 DT.91959328 DT.95323260 DT.91980350

24/77 AceView cDNA sequences (see all 77):

AW263024 AU133139 BC050592 BQ224604 AW025175 BC058882 BC010661 AW340645

AI372881 AW128917 AK001709 AI128127 AW474941 NM_018242 AV720891 AI335099

N78291 BM833678 AA688220 CD245416 AW305279 AI570270 BM749556 N59550

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC47A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAATTCTTTC

About this image

SLC47A1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Sertoli cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Human kidney epithelial cell spheroids (Kidney spheroids for...)

See SLC47A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC47A1

SOURCE GeneReport for Unigene cluster: Hs.232054

UniProtKB/Swiss-Prot: S47A1_HUMAN, Q96FL8

Tissue specificity: Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially

found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes)

SABiosciences Custom PCR Arrays for SLC47A1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC47A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SLC47A1 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC47A2¹	solute carrier family 47, member 2	60.36(n) 54.23(a)		417616 NM_001135679.1 NP_001129151.1
zebrafish (Danio rerio)	Actinopterygii	slc47a2¹	solute carrier family 47, member 2	59.47(n) 54.36(a)		560024 NM_001080179.1 NP_001073648.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	(YDR338C)⁴ ERC1¹	Putative protein of unknown function, member of the more⁴ Erc1p¹	42.44(n)¹ 29.32(a)¹		4(1149466-1147379)⁴ 856427¹ NP_011897.1¹ 851938⁴ NP_010625.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G52450¹	mate efflux domain-containing protein	44.55(n) 35.91(a)		835321 NM_124624.3 NP_200058.1
rice (Oryza sativa)	Liliopsida	Os06g0495500¹	hypothetical protein	47.14(n) 35.93(a)		4341096 NM_001064225.1 NP_001057690.1
E. coli (Escherichia coli)	Gamma proteobacteria	mdtK⁶	multidrug efflux system transporter	21(a)	1 → many	Chromosome(1741481-1742854)

ENSEMBL Gene Tree for SLC47A1 (if available)
TreeFam Gene Tree for SLC47A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC47A1 gene

SLC47A2²

1 SIMAP similar gene for SLC47A1 using alignment to 6 protein entries: S47A1_HUMAN (see all proteins):

SLC47A2

SLC47A1 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for SLC47A1
PGOHUM00000236958 PGOHUM00000237273 PGOHUM00000237277

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2453579^1,2	C,F,A	--	19435278(+)	`GGTTCC/AAGTGA`	1	--	us2k¹		9		NA WA CSA EA	368
rs143002273^1,2		--	19435387(+)	`TTTCTC/TTCCTA`	1	--	us2k¹		0	--	--	--	--
rs147472087^1,2		--	19435495(+)	`TCCTCA/GGGTAT`	1	--	us2k¹		0	--	--	--	--
rs145298681^1,2	C	--	19435647(+)	`TCAGA-/CCCCTA`	1	--	us2k¹		0	--	--	--	--
rs111270877^1,2		--	19435704(+)	`GCAGGA/GCCAAC`	1	--	us2k¹		1		CSA	1
rs182584557^1,2		--	19435935(+)	`AAGAGA/GGACAA`	1	--	us2k¹		0	--	--	--	--
rs199987438^1,2		--	19435962(+)	`TGTTT-/GTTTTT`	1	--	us2k¹		0	--	--	--	--
rs151203636^1,2		--	19436139(+)	`ACGGTA/GTTTCA`	1	--	us2k¹		0	--	--	--	--
rs186962309^1,2		--	19436344(+)	`ACAACA/GGAAGG`	1	--	us2k¹		0	--	--	--	--
rs114707795^1,2		--	19436474(+)	`CTTCAC/TAGCTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC47A1 (19398698 - 19482347 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC47A1: --
Human Gene Mutation Database (HGMD): SLC47A1

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC47A1 for disorders           About GeneDecksing

OMIM gene information: 609832    OMIM disorders: --

2 diseases for SLC47A1:    About MalaCards

smith-magenis syndrome pneumonia

Human Genome Epidemiology (HuGE) Navigator: SLC47A1 (7 documents)

Export disorders for SLC47A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLC47A1 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with SLC47A1)

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The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. (PubMed id 16996621)^{1, 2, 3} Omote H....Moriyama Y. (2006)
A human transporter protein that mediates the final excretion step for toxic organic cations. (PubMed id 16330770)^{1, 2, 3} Otsuka M....Moriyama Y. (2005)
Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. (PubMed id 20053795)^{1, 7} Meyer zu Schwabedissen H.E....Kim R.B. (2010)
Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. (PubMed id 17509534)^{1, 2} Tanihara Y.... Inui K. (2007)
Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. (PubMed id 17495125)^{1, 2} Chen Y.... Giacomini K.M. (2007)
Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney. (PubMed id 16928787)^{1, 3} Ohta K.Y....Yuasa H. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Loss of multidrug and toxin extrusion 1 (MATE1) is ass ociated with metformin-induced lactic acidosis. (PubMed id 22242910)¹ Toyama K....Katsura T. (2012)
Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein. (PubMed id 22722930)¹ Zhang X....Wright S.H. (2012)
OCT2 and MATE1 provide bidirectional agmatine transpo rt. (PubMed id 21128598)¹ Winter T.N....Fairbanks C.A. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55244	HGNC: 25588	AceView: FLJ10847	Ensembl:ENSG00000142494	euGenes: HUgn55244
ECgene: SLC47A1	H-InvDB: SLC47A1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC47A1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC47A1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC47A1 gene:
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SLC47A1 Gene

solute carrier family 47, member 1

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SLC47A1 Gene

solute carrier family 47, member 1

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