SLC46A3 Gene
protein-coding GIFtS: 41
GCID: GC13M029274
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|
solute carrier family 46, member 3
| |
Aliases
for SLC46A3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 46, Member 31 2 | | DKFZp686A17751 | | FLJ426131 | | FKSG162 | | Solute Carrier Family 46 Member 32 |
Export aliases for SLC46A3 gene to outside databasesPrevious GC identifers: GC13M028173 GC13M010095 |
Summaries
for SLC46A3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SLC46A3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC46A3 gene promoter:
FOXF2 CUTL1 Meis-1b PPAR-gamma1 POU2F1 POU2F1a Cart-1 PPAR-gamma2 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC46A3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC46A3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q12.3 Ensembl cytogenetic band: 13q12.3 HGNC cytogenetic band: 13q12.3SLC46A3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M029274: view genomic region
(about GC identifiers)
Start:
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29,274,201 bp from pter |
End:
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29,293,150 bp from pter |
Size:
|
18,950 bases |
Orientation:
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minus strand |
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Proteins
for SLC46A3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S46A3_HUMAN, Q7Z3Q1 (See
protein sequence)Recommended Name: Solute carrier family 46 member 3 precursor Size: 461 amino acids; 51519 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAC85896.1; Type=Frameshift; Positions=353;
Secondary accessions: Q3ZCV8 Q6NUK5 Q6P9B3 Q6ZVG5 Q96QA1Alternative splicing: 3 isoforms: Q7Z3Q1-1 Q7Z3Q1-2 Q7Z3Q1-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLC46A3: NX_Q7Z3Q1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z3Q1
SLC46A3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001129391.1 NP_861450.1
ENSEMBL proteins: ENSP00000266943 ENSP00000370192
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLC46A3 for ontologies About GeneDecksing
SLC46A3 Antibody Products:
Assay Products for SLC46A3: |
Protein
Domains /
Families
for SLC46A3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC46A3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z3Q1ProtoNet protein and cluster: Q7Z3Q1 UniProtKB/Swiss-Prot: S46A3_HUMAN, Q7Z3Q1Similarity: Belongs to the major facilitator superfamily. SLC46A family |
Function
for SLC46A3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC46A3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC46A3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC46A3 |
2 GenomeRNAi human phenotypes for SLC46A3:
|
Pathways & Interactions
for SLC46A3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC46A3
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0055085 | transmembrane transport |
IEA | -- |
SLC46A3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC46A3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC46A3
Search CenterWatch for drugs/clinical trials and news about SLC46A3 / S46A3
|
Transcripts
for SLC46A3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC46A3 gene (2 alternative transcripts): NM_001135919.1 NM_181785.3 Unigene Cluster for SLC46A3: Solute carrier family 46, member 3 Hs.117167 [show with all ESTs]Unigene Representative Sequence: BX6491273 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000475385 ENST00000266943(uc001usg.3 uc001usi.3 uc001usj.3 uc001ush.3)
ENST00000380814
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC46A3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC46A3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SLC46A3 (NM_001135919) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC46A3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC46A3 |
Additional cDNA sequence: AF315594.1 AK026720.1 AK093932.1 AK098426.1 AK124604.1 BC036662.1 BC060850.1 BC068556.1 BX537565.1 BX649127.1 8 DOTS entries: DT.441103 DT.100035860 DT.100784637 DT.100784636 DT.40247809 DT.120793778 DT.100784638 DT.40196354 24/89 AceView cDNA sequences (see all 89): BU070379 BM713250 CD107826 BX489263 AI770039 CA943831 CR611527 BM758826 BI599894 AA633352 BQ787388 BQ330012 AA279019 BC068556 AK124604 AW945954 BX537565 CD237026 NM_181785 AF315594 BE827009 AK098426 AW946058 BG705360
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC46A3 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 |
|---|
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| SP1: | | | | | | | | | - | | | | - | | | | | | - | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLC46A3
|
Expression
for SLC46A3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC46A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTTTCACA
About this image
See SLC46A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC46A3
SOURCE GeneReport for Unigene cluster: Hs.117167
SABiosciences Custom PCR Arrays for SLC46A3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC46A3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC46A3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC46A3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC46A3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC46A3 |
Orthologs
for SLC46A3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SLC46A3 gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for SLC46A3 (if available)
TreeFam Gene Tree for SLC46A3 (if available) |
Paralogs
for SLC46A3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC46A3 gene
- SLC46A12 SLC46A22
1 SIMAP similar gene for SLC46A3 using alignment to 1 protein entry: S46A3_HUMAN:SLC46A1
SLC46A3 for paralogs About GeneDecksing
|
Genomic Variants
for SLC46A3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC46A3 (29274201 - 29293150 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC46A3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC46A3 |
|
Disorders
/ Diseases
for SLC46A3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC46A3 for disorders About GeneDecksing
2  diseases for SLC46A3: About MalaCardsfatty liver disease liver disease
Export disorders for SLC46A3 gene to outside databases
|
Publications
for SLC46A3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC46A3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC46A3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genome-wide association study identifies variants ass ociated with histologic features of nonalcoholic Fatty liver disease. (PubMed id 20708005)1 Chalasani N....Rotter J.I. (2010)
- Identification of candidate genes for human pituitary development by EST analysis. (PubMed id 19284880)1 Ma Y....Hao X. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for SLC46A3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC46A3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC46A3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC46A3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC46A3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC46A3 gene:
Search GeneIP for patents involving SLC46A3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC46A3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC46A3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC46A3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC46A3 | | | OriGene Protein Over-expression Lysate for SLC46A3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC46A3 | | OriGene 3'-UTR Clone for SLC46A3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC46A3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC46A3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC46A3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC46A3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC46A3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC46A3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC46A3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC46A3 |
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| |  |  |  |  | | | | |
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 | | | SLC46A3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC46A3 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLC46A3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC46A3 |
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