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Aliases for SLC46A3 Gene

Aliases for SLC46A3 Gene

  • Solute Carrier Family 46, Member 3 2 3
  • Solute Carrier Family 46 Member 3 3
  • FKSG16 3

External Ids for SLC46A3 Gene

Summaries for SLC46A3 Gene

GeneCards Summary for SLC46A3 Gene

SLC46A3 (Solute Carrier Family 46, Member 3) is a Protein Coding gene. An important paralog of this gene is SLC46A2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC46A3 Gene

Genomics for SLC46A3 Gene

Genomic Location for SLC46A3 Gene

Start:
28,700,064 bp from pter
End:
28,719,013 bp from pter
Size:
18,950 bases
Orientation:
Minus strand

Genomic View for SLC46A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC46A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC46A3 Gene

Regulatory Elements for SLC46A3 Gene

Proteins for SLC46A3 Gene

  • Protein details for SLC46A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3Q1-S46A3_HUMAN
    Recommended name:
    Solute carrier family 46 member 3
    Protein Accession:
    Q7Z3Q1
    Secondary Accessions:
    • Q3ZCV8
    • Q6NUK5
    • Q6P9B3
    • Q6ZVG5
    • Q96QA1

    Protein attributes for SLC46A3 Gene

    Size:
    461 amino acids
    Molecular mass:
    51519 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85896.1; Type=Frameshift; Positions=353; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC46A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC46A3 Gene

Proteomics data for SLC46A3 Gene at MOPED

Post-translational modifications for SLC46A3 Gene

  • Glycosylation at Asn38, Asn46, and Asn53

Other Protein References for SLC46A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC46A3 Gene

Domains for SLC46A3 Gene

Gene Families for SLC46A3 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC46A3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

S46A3_HUMAN
Family:
  • Belongs to the major facilitator superfamily. SLC46A family.:
    • Q7Z3Q1
genes like me logo Genes that share domains with SLC46A3: view

Function for SLC46A3 Gene

Gene Ontology (GO) - Molecular Function for SLC46A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SLC46A3: view
genes like me logo Genes that share phenotypes with SLC46A3: view

miRNA for SLC46A3 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC46A3 Gene

Localization for SLC46A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC46A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC46A3 Gene COMPARTMENTS Subcellular localization image for SLC46A3 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC46A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC46A3: view

Pathways for SLC46A3 Gene

SuperPathways for SLC46A3 Gene

No Data Available

Interacting Proteins for SLC46A3 Gene

Gene Ontology (GO) - Biological Process for SLC46A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC46A3: view

No data available for Pathways by source for SLC46A3 Gene

Transcripts for SLC46A3 Gene

Unigene Clusters for SLC46A3 Gene

Solute carrier family 46, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC46A3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:

Relevant External Links for SLC46A3 Gene

GeneLoc Exon Structure for
SLC46A3
ECgene alternative splicing isoforms for
SLC46A3

Expression for SLC46A3 Gene

mRNA expression in normal human tissues for SLC46A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC46A3 Gene

This gene is overexpressed in Liver (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC46A3 Gene

SOURCE GeneReport for Unigene cluster for SLC46A3 Gene Hs.117167

genes like me logo Genes that share expressions with SLC46A3: view

Orthologs for SLC46A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC46A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC46A3 36
  • 99.64 (n)
  • 99.14 (a)
SLC46A3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC46A3 36
  • 83.22 (n)
  • 79.61 (a)
SLC46A3 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC46A3 36
  • 88.29 (n)
  • 86.55 (a)
SLC46A3 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc46a3 36
  • 76.52 (n)
  • 75 (a)
Slc46a3 16
Slc46a3 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC46A3 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 67 (a)
OneToMany
-- 37
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc46a3 36
  • 75.72 (n)
  • 75.65 (a)
chicken
(Gallus gallus)
Aves SLC46A3 36
  • 61.44 (n)
  • 51.63 (a)
SLC46A3 37
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC46A3 37
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc46a3 36
  • 54.75 (n)
  • 44.59 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-5g14.1 36
  • 52.7 (n)
  • 42.76 (a)
slc46a3 37
  • 38 (a)
OneToMany
SLC46A3 (2 of 2) 37
  • 43 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004562 36
  • 41.89 (n)
  • 31.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15553 37
  • 16 (a)
ManyToMany
CG15890 36
  • 39.94 (n)
  • 28.57 (a)
CG15890 37
  • 16 (a)
ManyToMany
CG30344 37
  • 16 (a)
ManyToMany
CG30345 37
  • 17 (a)
ManyToMany
CG31321 37
  • 15 (a)
ManyToMany
CG42514 37
  • 17 (a)
ManyToMany
CG8008 37
  • 15 (a)
ManyToMany
CG8046 37
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y43F8A.5 37
  • 16 (a)
ManyToMany
Y4C6B.5 37
  • 22 (a)
ManyToMany
Species with no ortholog for SLC46A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC46A3 Gene

ENSEMBL:
Gene Tree for SLC46A3 (if available)
TreeFam:
Gene Tree for SLC46A3 (if available)

Paralogs for SLC46A3 Gene

Paralogs for SLC46A3 Gene

Selected SIMAP similar genes for SLC46A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC46A3: view

Variants for SLC46A3 Gene

Sequence variations from dbSNP and Humsavar for SLC46A3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs15724 -- 28,700,208(+) GCACA(C/T)AAAGA utr-variant-3-prime
rs705423 -- 28,700,992(+) AAAAT(C/T)ATACA intron-variant, utr-variant-3-prime
rs913796 -- 28,700,638(-) AAAAG(A/G)ATATT utr-variant-3-prime
rs913798 -- 28,719,544(-) GGCTG(C/T)GTTGT upstream-variant-2KB
rs913799 -- 28,719,072(-) CGTCC(A/G)GGTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC46A3 Gene

Variant ID Type Subtype PubMed ID
nsv832571 CNV Loss 17160897
nsv974 CNV Insertion 18451855

Relevant External Links for SLC46A3 Gene

HapMap Linkage Disequilibrium report
SLC46A3

Disorders for SLC46A3 Gene

Relevant External Links for SLC46A3

Genetic Association Database (GAD)
SLC46A3
genes like me logo Genes that share disorders with SLC46A3: view

No data available for UniProtKB/Swiss-Prot for SLC46A3 Gene

Publications for SLC46A3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PMID: 20708005) Chalasani N. … Rotter J.I. (Gastroenterology 2010) 3 49
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SLC46A3 Gene

  • antibodies-online peptides for SLC46A3
  • antibodies-online antibodies for SLC46A3
  • antibodies-online kits for SLC46A3

Sources for SLC46A3 Gene

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